toludesvenlafaxine [Ligand Id: 12766] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4227736 (LPM-570065 FREE BASE, LPM570065 FREE BASE, Ly03005, LY-03005, LY03005, ODVP2, Toludesvenlafaxine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| DAT/Dopamine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959] | ||||||||
| ChEMBL | Binding affinity to DAT (unknown origin) | B | 6.31 | pIC50 | 491 | nM | IC50 | J Med Chem (2018) 61: 2133-2165 [PMID:28731336] |
| ChEMBL | Inhibition of human DAT expressed in CHO cells assessed as reduction of [3H]-DA re-uptake preincubated for 10 mins followed by [3H]-DA addition measured after 10 mins by liquid scintillation counting | B | 6.31 | pIC50 | 491 | nM | IC50 | J Med Chem (2018) 61: 2133-2165 [PMID:28731336] |
| GtoPdb | - | - | 6.31 | pIC50 | 491 | nM | IC50 | J Med Chem (2019) 62: 10003 [PMID:31617718] |
| NET/Norepinephrine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975] | ||||||||
| ChEMBL | Binding affinity to NET (unknown origin) | B | 6.12 | pIC50 | 763 | nM | IC50 | J Med Chem (2018) 61: 2133-2165 [PMID:28731336] |
| ChEMBL | Inhibition of human NET expressed in CHO cells assessed as reduction of [3H]-NE re-uptake preincubated for 10 mins followed by [3H]-NE addition measured after 10 mins by liquid scintillation counting | B | 6.12 | pIC50 | 763 | nM | IC50 | J Med Chem (2018) 61: 2133-2165 [PMID:28731336] |
| GtoPdb | - | - | 6.12 | pIC50 | 763 | nM | IC50 | J Med Chem (2019) 62: 10003 [PMID:31617718] |
| SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645] | ||||||||
| GtoPdb | - | - | 6.14 | pIC50 | 723 | nM | IC50 | J Med Chem (2019) 62: 10003 [PMID:31617718] |
| ChEMBL | Binding affinity to SERT (unknown origin) | B | 6.14 | pIC50 | 723 | nM | IC50 | J Med Chem (2018) 61: 2133-2165 [PMID:28731336] |
| ChEMBL | Inhibition of human SERT expressed in CHO cells assessed as reduction of [3H]-5-HT re-uptake preincubated for 10 mins followed by [3H]-5-HT addition measured after 10 mins by liquid scintillation counting | B | 6.14 | pIC50 | 723 | nM | IC50 | J Med Chem (2018) 61: 2133-2165 [PMID:28731336] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
