chlortetracycline [Ligand Id: 13537] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL404520 (Chlorotetracycline, Chlortetracycline, Clortetraciclina, E702)
  • phosphodiesterase 4A/Phosphodiesterase 4A in Human [ChEMBL: CHEMBL254] [GtoPdb: 1300] [UniProtKB: P27815]
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  • peptidyl arginine deiminase 4/Protein-arginine deiminase type-4 in Human [ChEMBL: CHEMBL6111] [GtoPdb: 2877] [UniProtKB: Q9UM07]
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  • P2Y12 receptor/Purinergic receptor P2Y12 in Human [ChEMBL: CHEMBL2001] [GtoPdb: 328] [UniProtKB: Q9H244]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
phosphodiesterase 4A/Phosphodiesterase 4A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL254] [GtoPdb: 1300] [UniProtKB: P27815]
ChEMBL Inhibition of PAD4 (unknown origin) B 4 pIC50 100000 nM IC50 J Med Chem (2013) 56: 1715-1722 [PMID:23421315]
peptidyl arginine deiminase 4/Protein-arginine deiminase type-4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6111] [GtoPdb: 2877] [UniProtKB: Q9UM07]
ChEMBL Inhibition of PAD4 by ABPP-based assay B 4 pIC50 100000 nM IC50 Bioorg Med Chem (2008) 16: 739-745 [PMID:17964793]
P2Y12 receptor/Purinergic receptor P2Y12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2001] [GtoPdb: 328] [UniProtKB: Q9H244]
ChEMBL Displacement of [3H]PSB0413 from human platelet P2Y12 receptor B 5 pKi >10000 nM Ki J Med Chem (2009) 52: 3784-3793 [PMID:19463000]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]