codeine [Ligand Id: 1673] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL485 (Codeine, Codeine monohydrate, Codeinum, Codeinum monohydricum, Dea no. 9050, IDS-NC-005(SECT.-2)) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] | ||||||||
| ChEMBL | Displacement of [3H]diprenorphine from recombinant delta opioid receptor expressed in C6 cells | B | 4.28 | pKi | 52207 | nM | Ki | J Med Chem (2008) 51: 2316-2320 [PMID:18311899] |
| ChEMBL | In vitro binding affinity against cloned human Opioid receptor delta 1 expressed in HEK 293S cells | B | 5.03 | pIC50 | >9300 | nM | IC50 | J Med Chem (2003) 46: 34-48 [PMID:12502358] |
| κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] | ||||||||
| ChEMBL | Displacement of [3H]diprenorphine from recombinant kappa opioid receptor expressed in CHO cells | B | 4.59 | pKi | 25411 | nM | Ki | J Med Chem (2008) 51: 2316-2320 [PMID:18311899] |
| ChEMBL | In vitro binding affinity against cloned human Opioid receptor kappa 1 expressed in HEK 293S cells | B | 4.82 | pIC50 | 15000 | nM | IC50 | J Med Chem (2003) 46: 34-48 [PMID:12502358] |
| μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] | ||||||||
| ChEMBL | Displacement of [3H]naloxone from human mu poioid receptor expressed in HEK293 cells | B | 5.2 | pKi | 6300 | nM | Ki | J Biol Chem (2007) 282: 27126-27132 [PMID:17616524] |
| ChEMBL | Displacement of [3H]diprenorphine from recombinant mu opioid receptor expressed in C6 cells | B | 6.14 | pKi | 727 | nM | Ki | J Med Chem (2008) 51: 2316-2320 [PMID:18311899] |
| GtoPdb | - | - | 6.9 | pKi | - | - | - | NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407] |
| ChEMBL | In vitro binding affinity against cloned human Opioid receptor mu 1 expressed in HEK 293S cells | B | 6.98 | pIC50 | 105 | nM | IC50 | J Med Chem (2003) 46: 34-48 [PMID:12502358] |
| ChEMBL | Activation of human mu opioid receptor expressed in HEK293a cells co-expressing YFP-labelled alphai1 and CFP-labelled beta1gamma2 Gi subunits assessed as Gi protein activation by fluorescence resonance energy transfer | B | 5.21 | pEC50 | 6100 | nM | EC50 | J Biol Chem (2007) 282: 27126-27132 [PMID:17616524] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
