ChEMBL ligand: CHEMBL485 (Codeine, Codeine monohydrate, Codeinum, Codeinum monohydricum, Dea no. 9050, IDS-NC-005(SECT.-2))
δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL	Displacement of [3H]diprenorphine from recombinant delta opioid receptor expressed in C6 cells	B	4.28	pKi	52207	nM	Ki	J. Med. Chem. (2008) 51: 2316-2320 [PMID:18311899]
ChEMBL	In vitro binding affinity against cloned human Opioid receptor delta 1 expressed in HEK 293S cells	B	5.03	pIC50	>9300	nM	IC50	J. Med. Chem. (2003) 46: 34-48 [PMID:12502358]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	Displacement of [3H]diprenorphine from recombinant kappa opioid receptor expressed in CHO cells	B	4.59	pKi	25411	nM	Ki	J. Med. Chem. (2008) 51: 2316-2320 [PMID:18311899]
ChEMBL	In vitro binding affinity against cloned human Opioid receptor kappa 1 expressed in HEK 293S cells	B	4.82	pIC50	15000	nM	IC50	J. Med. Chem. (2003) 46: 34-48 [PMID:12502358]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	Displacement of [3H]naloxone from human mu poioid receptor expressed in HEK293 cells	B	5.2	pKi	6300	nM	Ki	J. Biol. Chem. (2007) 282: 27126-27132 [PMID:17616524]
ChEMBL	Displacement of [3H]diprenorphine from recombinant mu opioid receptor expressed in C6 cells	B	6.14	pKi	727	nM	Ki	J. Med. Chem. (2008) 51: 2316-2320 [PMID:18311899]
GtoPdb	-	-	6.9	pKi	-	-	-	NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]
ChEMBL	In vitro binding affinity against cloned human Opioid receptor mu 1 expressed in HEK 293S cells	B	6.98	pIC50	105	nM	IC50	J. Med. Chem. (2003) 46: 34-48 [PMID:12502358]
ChEMBL	Activation of human mu opioid receptor expressed in HEK293a cells co-expressing YFP-labelled alphai1 and CFP-labelled beta1gamma2 Gi subunits assessed as Gi protein activation by fluorescence resonance energy transfer	B	5.21	pEC50	6100	nM	EC50	J. Biol. Chem. (2007) 282: 27126-27132 [PMID:17616524]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]