codeine [Ligand Id: 1673] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL485 (Codeine monohydrate, Codeine, IDS-NC-005(SECT.-2))
  • δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
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  • κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
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  • μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL Displacement of [3H]diprenorphine from recombinant delta opioid receptor expressed in C6 cells B 4.28 pKi 52207 nM Ki J. Med. Chem. (2008) 51: 2316-2320 [PMID:18311899]
ChEMBL In vitro binding affinity against cloned human Opioid receptor delta 1 expressed in HEK 293S cells B 5.03 pIC50 >9300 nM IC50 J. Med. Chem. (2003) 46: 34-48 [PMID:12502358]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL Displacement of [3H]diprenorphine from recombinant kappa opioid receptor expressed in CHO cells B 4.59 pKi 25411 nM Ki J. Med. Chem. (2008) 51: 2316-2320 [PMID:18311899]
ChEMBL In vitro binding affinity against cloned human Opioid receptor kappa 1 expressed in HEK 293S cells B 4.82 pIC50 15000 nM IC50 J. Med. Chem. (2003) 46: 34-48 [PMID:12502358]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL Displacement of [3H]naloxone from human mu poioid receptor expressed in HEK293 cells B 5.2 pKi 6300 nM Ki J. Biol. Chem. (2007) 282: 27126-27132 [PMID:17616524]
ChEMBL Displacement of [3H]diprenorphine from recombinant mu opioid receptor expressed in C6 cells B 6.14 pKi 727 nM Ki J. Med. Chem. (2008) 51: 2316-2320 [PMID:18311899]
GtoPdb - - 6.9 pKi - - - NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]
ChEMBL In vitro binding affinity against cloned human Opioid receptor mu 1 expressed in HEK 293S cells B 6.98 pIC50 105 nM IC50 J. Med. Chem. (2003) 46: 34-48 [PMID:12502358]
ChEMBL Activation of human mu opioid receptor expressed in HEK293a cells co-expressing YFP-labelled alphai1 and CFP-labelled beta1gamma2 Gi subunits assessed as Gi protein activation by fluorescence resonance energy transfer B 5.21 pEC50 6100 nM EC50 J. Biol. Chem. (2007) 282: 27126-27132 [PMID:17616524]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]