indoramin [Ligand Id: 501] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL279516 (Baratol, Doralese tiltab, Indoramin, WY 21901, WY-21901)
  • α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348]
  • Alpha-1a adrenergic receptor in Bovine [ChEMBL: CHEMBL4892] [UniProtKB: P18130]
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  • α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368]
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  • α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100]
  • α1D-adrenoceptor/Alpha-1d adrenergic receptor in Rat [ChEMBL: CHEMBL326] [GtoPdb: 24] [UniProtKB: P23944]
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  • α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
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  • α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
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  • α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348]
GtoPdb - - 8.4 pKi - - - Br J Pharmacol (1997) 121: 1127-35 [PMID:9249248];
Eur J Pharmacol (1999) 370: 337-43 [PMID:10334511]
ChEMBL Binding affinity was tested on human Alpha-1A adrenergic receptor B 8.4 pKi 3.98 nM Ki J. Med. Chem. (1997) 40: 1293-1315 [PMID:9135028]
ChEMBL The compound was tested for binding affinity against Alpha-1A adrenergic receptor from human clones. B 8.43 pKi 3.7 nM Ki J. Med. Chem. (1995) 38: 3415-3444 [PMID:7658428]
Alpha-1a adrenergic receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4892] [UniProtKB: P18130]
ChEMBL The compound was tested for binding affinity against Alpha-1A adrenergic receptor from bovine clones. B 7.92 pKi 12 nM Ki J. Med. Chem. (1995) 38: 3415-3444 [PMID:7658428]
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368]
GtoPdb - - 7.4 pKi - - - Br J Pharmacol (1997) 121: 1127-35 [PMID:9249248]
ChEMBL Binding affinity was tested on human Alpha-1B adrenergic receptor B 7.4 pKi 39.81 nM Ki J. Med. Chem. (1997) 40: 1293-1315 [PMID:9135028]
ChEMBL The compound was tested for binding affinity against Alpha-1B adrenergic receptor, from human clones. B 7.54 pKi 29 nM Ki J. Med. Chem. (1995) 38: 3415-3444 [PMID:7658428]
ChEMBL The compound was tested for binding affinity against Alpha-1B adrenergic receptor, from hamster clones. B 7.6 pKi 25 nM Ki J. Med. Chem. (1995) 38: 3415-3444 [PMID:7658428]
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100]
GtoPdb - - 6.7 pKi - - - Br J Pharmacol (1997) 121: 1127-35 [PMID:9249248]
ChEMBL Binding affinity was tested on human Alpha-1D adrenergic receptor B 6.8 pKi 158.49 nM Ki J. Med. Chem. (1997) 40: 1293-1315 [PMID:9135028]
ChEMBL Binding affinity against Alpha-1D adrenergic receptor, from human clones. B 6.96 pKi 110 nM Ki J. Med. Chem. (1995) 38: 3415-3444 [PMID:7658428]
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL326] [GtoPdb: 24] [UniProtKB: P23944]
ChEMBL Binding affinity against Alpha-1D adrenergic receptor, from rat clones. B 6.21 pKi 611 nM Ki J. Med. Chem. (1995) 38: 3415-3444 [PMID:7658428]
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
ChEMBL The compound was tested for binding affinity against Alpha-2A adrenergic receptor from human clones. B 5.65 pKi 2240 nM Ki J. Med. Chem. (1995) 38: 3415-3444 [PMID:7658428]
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
ChEMBL Binding affinity against Alpha-2B adrenergic receptor from human clones. B 6.28 pKi 528 nM Ki J. Med. Chem. (1995) 38: 3415-3444 [PMID:7658428]
α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825]
ChEMBL Binding affinity against Alpha-2C adrenergic receptor from human clones. B 6.32 pKi 476 nM Ki J. Med. Chem. (1995) 38: 3415-3444 [PMID:7658428]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]