Compound class:
Synthetic organic
Comment: YT47R is an experimental PROTAC that targets FKBP12 (via a SLF ligand moiety) to the E3 ligase substrate binding component DCAF1 (via a selective ligand that binds to reactive cysteine C1113 in DCAF1's WD40 repeat domain) [1]. This mediates selective degradation of the FKBP12 protein in in vitro models, and confirms DCAF1 as a novel and targetable E3 ligase component for targeted protein degradation applications.
|
|
Classification ![]() |
|
Compound class | Synthetic organic |
Ligand families/groups | PROTACs, molecular glues and other degraders |
Database Links ![]() |
|
GtoPdb PubChem SID | 483123364 |
PubChem CID | 168433310 |
Search Google for chemical match using the InChIKey | VZENWBGKIMOEQI-GIBQHNRWSA-N |
Search Google for chemicals with the same backbone | VZENWBGKIMOEQI |
UniChem Compound Search for chemical match using the InChIKey | VZENWBGKIMOEQI-GIBQHNRWSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | VZENWBGKIMOEQI-GIBQHNRWSA-N |