finasteride [Ligand Id: 6818] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL710 (MK-906, Propecia, Proscar, Finasteride, Prostide, Aindeem)
  • 3-beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I in Human [ChEMBL: CHEMBL1958] [UniProtKB: P14060]
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  • Androgen receptor/Androgen Receptor in Rat [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207]
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  • steroid 5 alpha-reductase 2/Steroid 5-alpha-reductase 2 in Human [ChEMBL: CHEMBL1856] [GtoPdb: 2633] [UniProtKB: P31213]
  • steroid 5 alpha-reductase 2/Steroid 5-alpha-reductase 2 in Rat [ChEMBL: CHEMBL5099] [GtoPdb: 2633] [UniProtKB: P31214]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
3-beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1958] [UniProtKB: P14060]
ChEMBL Binding affinity for 3-beta-hydroxysteroid dehydrogenase B 4.96 pKi 11000 nM Ki J. Med. Chem. (1997) 40: 1293-1315 [PMID:9135028]
Androgen receptor/Androgen Receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207]
ChEMBL In vitro antagonist activity against rat prostatic androgen receptor (AR) F 4 pIC50 >100000 nM IC50 J. Med. Chem. (1986) 29: 2298-2315 [PMID:3783591]
CYP2C19/Cytochrome P450 2C19 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3622] [GtoPdb: 1328] [UniProtKB: P33261]
ChEMBL DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) B 6 pIC50 1000 nM IC50 DrugMatrix in vitro pharmacology data
CYP2C9/Cytochrome P450 2C9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3397] [GtoPdb: 1326] [UniProtKB: P11712]
ChEMBL DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) B 5.7 pIC50 2000 nM IC50 DrugMatrix in vitro pharmacology data
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay F 5 pIC50 10000 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay F 5 pIC50 10000 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay F 5.1 pIC50 7943.28 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
Steroid 5-alpha-reductase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1787] [UniProtKB: P18405]
ChEMBL Inhibitory activity against recombinant Steroid 5-alpha-reductase type I expressed in CHO cells B 6.44 pKi 366 nM Ki J. Med. Chem. (2000) 43: 3718-3735 [PMID:11020287]
ChEMBL Binding affinity for human 5 alpha reductase 1 isozyme B 6.82 pKi 150 nM Ki J. Med. Chem. (1997) 40: 1293-1315 [PMID:9135028]
ChEMBL Apparent inhibition constant towards human Steroid 5-alpha-reductase type I B 7 pKi 100 nM Ki Bioorg. Med. Chem. Lett. (1994) 4: 2327-2330
ChEMBL Inhibitory activity against 5-alpha-reductase type 1 in cell culture system using LNCaP cells (androgen-sensitive human prostatic cancer cell line) B 4.28 pIC50 53000 nM IC50 Bioorg. Med. Chem. Lett. (2001) 11: 2361-2364 [PMID:11527731]
ChEMBL Compound was evaluated for the inhibition of human Steroid 5-alpha-reductase type 1 from recombinant CHO cells B 6.04 pIC50 911 nM IC50 Bioorg. Med. Chem. Lett. (1998) 8: 2871-2876 [PMID:9873639]
ChEMBL Inhibitory concentration against human recombinant steroid 5-alpha-reductase type I in stably transfected chinese hamster ovary (CHO) 1827 cells using [3H]testosterone. B 6.04 pIC50 911 nM IC50 J. Med. Chem. (2004) 47: 3546-3560 [PMID:15214782]
ChEMBL Inhibition of Human steroid 5-alpha-reductase type I expressed in HEK293 cells B 6.27 pIC50 540 nM IC50 J. Med. Chem. (2000) 43: 4266-4277 [PMID:11063622]
ChEMBL Inhibitory activity against type-1 human steroid 5-alpha-reductase. B 6.3 pIC50 500 nM IC50 Bioorg. Med. Chem. Lett. (1996) 6: 481-484
ChEMBL Inhibition of steroid 5-alpha reductase type 1 expressed in HEK 293 cells B 6.34 pIC50 453 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 3603-3607 [PMID:17490876]
ChEMBL Inhibition of human 5alpha-1 reductase expressed in HEK293 cells assessed as suppression of conversion of [3]androstenedione incubated for 30 mins by radioactivity-based HPLC analysis B 6.34 pIC50 453 nM IC50 Bioorg. Med. Chem. (2016) 24: 779-788 [PMID:26780831]
ChEMBL Inhibition of human type-1 5-alpha reductase expressed in HEK293 cells using [3H]-androstenedione as substrate after 30 mins by HPLC analysis B 6.34 pIC50 453 nM IC50 Eur. J. Med. Chem. (2012) 54: 728-739 [PMID:22776417]
ChEMBL In vitro inhibition of human Steroid 5-alpha-reductase type I in transfected 293 cells using [3H]- delta4-Androstenedione as substrate B 6.66 pIC50 218 nM IC50 J. Med. Chem. (1995) 38: 1456-1461 [PMID:7739004]
ChEMBL Inhibition of recombinant human 5-alpha reductase-1 at a concentration of 5 microL after pre-incubation for 10 minutes B 6.82 pIC50 150 nM IC50 J. Med. Chem. (1993) 36: 4313-4315 [PMID:8277514]
ChEMBL Binding affinity to recombinant human Steroid 5-alpha-reductase type I was evaluated B 6.82 pIC50 150 nM IC50 J. Med. Chem. (1995) 38: 2621-2627 [PMID:7629802]
ChEMBL In vitro inhibitory activity against human type 1 5-alpha reductase B 6.82 pIC50 150 nM IC50 J. Med. Chem. (1994) 37: 2352-2360 [PMID:8057283]
ChEMBL Compound was tested for inhibition of Type I 5-alpha-reductase in Human genital skin (Hs68) foreskin fibroblast cells. B 7.21 pIC50 62 nM IC50 J. Med. Chem. (1993) 36: 421-423 [PMID:8381185]
ChEMBL Inhibition of [1-beta-3H]-androstenedione binding to human steroid 5-alpha-reductase type I expressed in DU-145 cells at 10 uM F 7.22 pIC50 60 nM IC50 J. Med. Chem. (2005) 48: 2972-2984 [PMID:15828836]
ChEMBL Inhibition of type 1 steroid-5-alpha-reductase B 7.28 pIC50 52 nM IC50 J. Med. Chem. (1994) 37: 3871-3874 [PMID:7966146]
ChEMBL Inhibition of recombinant human Steroid 5-alpha-reductase type I B 7.28 pIC50 52 nM IC50 J. Med. Chem. (1995) 38: 3189-3192 [PMID:7650670]
ChEMBL In vitro inhibitory activity against Steroid 5-alpha-reductase type I of human DU 145 prostatic tumor cell line B 7.39 pIC50 41 nM IC50 J. Med. Chem. (2002) 45: 3406-3417 [PMID:12139451]
ChEMBL Evaluated for the inhibitory activity against human steroid 5-alpha-reductase type I in human DU-145 cell assay at 5 nM of androstenedione B 7.4 pIC50 40 nM IC50 J. Med. Chem. (2000) 43: 4266-4277 [PMID:11063622]
ChEMBL In vitro inhibition of human steroid 5-alpha-reductase type I in Du-145 cells B 7.58 pIC50 26.3 nM IC50 J. Med. Chem. (1995) 38: 1158-1173 [PMID:7707319]
Steroid 5-alpha-reductase 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3422] [UniProtKB: P24008]
ChEMBL Inhibition of recombinant Steroid 5-alpha-reductase type I was evaluated as binding affinity (in vitro) B 8.17 pKi 6.8 nM Ki J. Med. Chem. (1995) 38: 2621-2627 [PMID:7629802]
ChEMBL Compound was tested for its inhibitory potency against rat Steroid 5-alpha-reductase type 1 expressed in transformed yeast Saccharomyces cerevisiae B 4.4 pIC50 40000 nM IC50 Bioorg. Med. Chem. Lett. (1996) 6: 1997-2002
ChEMBL Inhibition of Steroid 5-alpha-reductase type I from rat ventral prostate (RVP) B 8 pIC50 10 nM IC50 J. Med. Chem. (2002) 45: 3406-3417 [PMID:12139451]
ChEMBL Compound was tested for the inhibitory activity against Steroid 5-alpha-reductase type 1 in rat B 8.38 pIC50 4.2 nM IC50 Bioorg. Med. Chem. Lett. (1998) 8: 409-414 [PMID:9871588]
steroid 5 alpha-reductase 2/Steroid 5-alpha-reductase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1856] [GtoPdb: 2633] [UniProtKB: P31213]
ChEMBL Apparent inhibition constant towards human Steroid 5-alpha-reductase type 2 B 8.7 pKi 2 nM Ki Bioorg. Med. Chem. Lett. (1994) 4: 2327-2330
ChEMBL Inhibition of Human steroid 5-alpha-reductase type II expressed in HEK293 cells B 7.22 pIC50 60 nM IC50 J. Med. Chem. (2000) 43: 4266-4277 [PMID:11063622]
ChEMBL Inhibitory activity against human 5-alpha Reductase-1 expressed in DU-145 cells B 7.38 pIC50 42 nM IC50 J. Med. Chem. (1997) 40: 1112-1129 [PMID:9089333]
ChEMBL Inhibition of human 5alpha-2 reductase expressed in HEK293 cells assessed as suppression of conversion of [3]androstenedione incubated for 30 mins by radioactivity-based HPLC analysis B 7.4 pIC50 40 nM IC50 Bioorg. Med. Chem. (2016) 24: 779-788 [PMID:26780831]
ChEMBL Inhibition of human prostate 5alpha-reductase type 2 assessed as formation dihydrotestosterone from [4-14C] testosterone B 7.46 pIC50 35 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 475-478 [PMID:21094046]
ChEMBL Inhibition of human type-2 5-alpha reductase expressed in HEK293 cells using [3H]-androstenedione as substrate after 30 mins by HPLC analysis B 7.52 pIC50 30.3 nM IC50 Eur. J. Med. Chem. (2012) 54: 728-739 [PMID:22776417]
ChEMBL Inhibition of steroid 5-alpha reductase type 2 expressed in HEK 293 cells B 7.6 pIC50 25 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 3603-3607 [PMID:17490876]
ChEMBL In Vitro Inhibition Assay: This work was performed at the MDS Pharma Services, Pharmacology Laboratories, Taiwan. The assay was an in vitro evaluation of the ability of an extract or a pure compound to inhibit the steroid 5alpha -reductase enzyme from metabolizing testosterone into dihydrotestosterone. This is an enzyme-immunoassay (EIA) for quantitative determination of testosterone in human serum or plasma. The significance of this type of inhibition is that it can lead to eradication of benign prostatic hyperplasia (BPH). Two distinct isozymes are found in mice, rats, monkeys and humans: type 1 and II. Each of these isozymes is differentially expressed in tissues and developmental stages. In human, type 1 steroid 5alpha -reductase is predominant in the sebaceous glands of most regions of skin, including scalp and liver and is responsible for approximately one third of circulating DHT. Inhibitors of steroid 5alpha -reductase may be of benefit in the treatment of androgenetic alopecia. B 7.6 pIC50 25 nM IC50 US-9061023-B2. Management and treatment of benign prostatic hyperplasia (2015)
ChEMBL Inhibitory concentration against human recombinant steroid 5-alpha-reductase type 2 in stably transfected chinese hamster ovary 1827 cells using [3H]testosterone B 7.68 pIC50 21 nM IC50 J. Med. Chem. (2004) 47: 3546-3560 [PMID:15214782]
GtoPdb - - 7.84 pIC50 14.6 nM IC50 J. Med. Chem. (1986) 29: 2298-315 [PMID:3783591]
ChEMBL Compound was tested for inhibition of Type II 5-alpha-reductase in Human Prostate Homogenates (HPH). B 8 pIC50 10 nM IC50 J. Med. Chem. (1993) 36: 421-423 [PMID:8381185]
ChEMBL Inhibition of human prostate type 2 5alpha-reductase assessed as transformation of testosterone to dihydrotestosterone B 8.07 pIC50 8.5 nM IC50 Bioorg. Med. Chem. (2015) 23: 7535-7542 [PMID:26631442]
ChEMBL Inhibition of human prostate 5alpha-reductase type 2 assessed as conversion of [3H]testosterone to dihydrotestosterone B 8.07 pIC50 8.5 nM IC50 Bioorg. Med. Chem. (2014) 22: 6233-6241 [PMID:25261928]
ChEMBL In vitro inhibition of human Steroid 5-alpha-reductase type 2 in transfected SW-13 cells using [3H]- delta4-Androstenedione as substrate B 8.07 pIC50 8.47 nM IC50 J. Med. Chem. (1995) 38: 1456-1461 [PMID:7739004]
ChEMBL Inhibition of Steroid 5-alpha-reductase type 2 from human benign prostatic hyperplasia (BPH) tissue B 8.3 pIC50 5 nM IC50 J. Med. Chem. (2002) 45: 3406-3417 [PMID:12139451]
ChEMBL In vitro inhibition of human steroid 5-alpha-reductase type 2 in SW-13-transfected cells B 8.34 pIC50 4.53 nM IC50 J. Med. Chem. (1995) 38: 1158-1173 [PMID:7707319]
ChEMBL Inhibitory activity against type-2 human steroid 5-alpha-reductase. B 8.38 pIC50 4.2 nM IC50 Bioorg. Med. Chem. Lett. (1996) 6: 481-484
ChEMBL Evaluated for the inhibitory activity against human steroid 5-alpha-reductase type 2 from human BPH tissue at 210 nM of testosterone B 8.52 pIC50 3 nM IC50 J. Med. Chem. (2000) 43: 4266-4277 [PMID:11063622]
ChEMBL Inhibitory activity against 5-alpha Reductase-2 on human prostate homogenates from surgically derived benign hyperplastic tissue B 8.52 pIC50 3 nM IC50 J. Med. Chem. (1997) 40: 1112-1129 [PMID:9089333]
ChEMBL Inhibitory activity against steroid 5-alpha-reductase type 2 in human prostate homogenates B 8.66 pIC50 2.2 nM IC50 J. Med. Chem. (2000) 43: 3718-3735 [PMID:11020287]
ChEMBL Inhibition of [1-beta-2beta-3H]- -testosterone binding to human steroid 5-alpha-reductase type 2 of BPH tissue at 10 uM F 8.7 pIC50 2 nM IC50 J. Med. Chem. (2005) 48: 2972-2984 [PMID:15828836]
ChEMBL Compound was evaluated for the inhibition of human Steroid 5-alpha-reductase type 2 receptor from human prostate homogenates B 8.92 pIC50 1.2 nM IC50 Bioorg. Med. Chem. Lett. (1998) 8: 2871-2876 [PMID:9873639]
ChEMBL Inhibition of recombinant human 5-alpha reductase-2 at a concentration of 5 microL after pre-incubation for 10 minutes B 9.74 pIC50 0.18 nM IC50 J. Med. Chem. (1993) 36: 4313-4315 [PMID:8277514]
ChEMBL In vitro inhibitory activity against human type 2 5-alpha reductase B 9.74 pIC50 0.18 nM IC50 J. Med. Chem. (1994) 37: 2352-2360 [PMID:8057283]
ChEMBL Inhibitory activity measured on human steroid 5-alpha-reductase type 2 B 9.74 pIC50 0.18 nM IC50 J. Med. Chem. (1995) 38: 2621-2627 [PMID:7629802]
ChEMBL Binding affinity for human 5-alpha reductase 2 isozyme B 9.74 pIC50 0.18 nM IC50 J. Med. Chem. (1997) 40: 1293-1315 [PMID:9135028]
ChEMBL Inhibition of type 2 steroid-5-alpha-reductase B 10 pIC50 <0.1 nM IC50 J. Med. Chem. (1994) 37: 3871-3874 [PMID:7966146]
ChEMBL Inhibition of recombinant human Steroid 5-alpha-reductase type 2 B 10 pIC50 <0.1 nM IC50 J. Med. Chem. (1995) 38: 3189-3192 [PMID:7650670]
steroid 5 alpha-reductase 2/Steroid 5-alpha-reductase 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5099] [GtoPdb: 2633] [UniProtKB: P31214]
ChEMBL Compound was tested in vitro for inhibitory activity against type 2 5-alpha reductase Isozyme homogenated from rat epididymis F 5.68 pIC50 2100 nM IC50 J. Med. Chem. (1996) 39: 5047-5052 [PMID:8978835]
ChEMBL Inhibition of rat 5-alpha-reductase type 2 by Lineweaver-Burk plot B 6.83 pIC50 147.49 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 3439-3442 [PMID:21515045]
ChEMBL Inhibition of Steroid 5-alpha-reductase type 2 of rat ventral prostate (RVP) B 7.96 pIC50 11 nM IC50 J. Med. Chem. (2002) 45: 3406-3417 [PMID:12139451]
ChEMBL Inhibitory activity was measured on rat Steroid 5-alpha-reductase type 2 B 9.55 pIC50 0.28 nM IC50 J. Med. Chem. (1995) 38: 2621-2627 [PMID:7629802]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]