acetazolamide [Ligand Id: 6792] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL20 (NSC-145177, Acetazolamide, L 579486, Diamox SR, Eytazox, Diamox)
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  • Alpha carbonic anhydrase in Stylophora pistillata [ChEMBL: CHEMBL1075028] [UniProtKB: B5SU02]
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  • Carbonate dehydratase in Sulfurihydrogenibium sp. (strain YO3AOP1) [ChEMBL: CHEMBL3745586] [UniProtKB: B2V8E3]
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  • Carbonic anhydrase in Mycobacterium tuberculosis [ChEMBL: CHEMBL6068] [UniProtKB: P9WPJ9]
  • Carbonic anhydrase in Methanosarcina thermophila [ChEMBL: CHEMBL3932] [UniProtKB: P40881]
  • Carbonic anhydrase in Flaveria bidentis [ChEMBL: CHEMBL2401609] [UniProtKB: P46510]
  • Carbonic anhydrase in Dicentrarchus labrax [ChEMBL: CHEMBL1795125] [UniProtKB: Q2PCB5]
  • Carbonic anhydrase in Stylophora pistillata [ChEMBL: CHEMBL1649055] [UniProtKB: C0IX24]
  • Carbonic anhydrase in Methanobacterium thermoautotrophicum [ChEMBL: CHEMBL3926] [UniProtKB: Q50565]
  • Carbonic anhydrase in Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) [ChEMBL: CHEMBL3596083] [UniProtKB: Q9HVB9]
  • Carbonic anhydrase in Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [ChEMBL: CHEMBL5337] [UniProtKB: Q5AJ71]
  • Carbonic anhydrase in Candida glabrata CBS 138 [ChEMBL: CHEMBL6185] [UniProtKB: Q6FTL6]
  • Carbonic anhydrase in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL5931] [UniProtKB: P53615]
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  • Carbonic anhydrase 1 in Drosophila melanogaster [ChEMBL: CHEMBL2331046] [UniProtKB: Q9V396]
  • Carbonic anhydrase 1 in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) [ChEMBL: CHEMBL4211] [UniProtKB: O24855]
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  • Carbonic anhydrase 2 in Cryptococcus neoformans var. grubii [ChEMBL: CHEMBL1697676] [UniProtKB: Q3I4V7]
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  • Carbonic anhydrase 2, isoform A in Drosophila melanogaster [ChEMBL: CHEMBL2331045] [UniProtKB: Q9VTU8]
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  • Carbonic anhydrase, alpha family in Thiomicrospira crunogena (strain XCL-2) [ChEMBL: CHEMBL3621035] [UniProtKB: Q31FD6]
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  • carbonic anhydrase 1/Carbonic anhydrase I in Human [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
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  • carbonic anhydrase 2/Carbonic anhydrase II in Human [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
  • Carbonic anhydrase II in Bovine [ChEMBL: CHEMBL2283] [UniProtKB: P00921]
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  • carbonic anhydrase 4/Carbonic anhydrase IV in Human [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748]
  • Carbonic anhydrase IV in Bovine [ChEMBL: CHEMBL281] [UniProtKB: Q95323]
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  • carbonic anhydrase 9/Carbonic anhydrase IX in Human [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
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  • Carbonic anhydrase-related protein 2 in Human [ChEMBL: CHEMBL2420] [UniProtKB: O75493]
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  • carbonic anhydrase 5A/Carbonic anhydrase VA in Human [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218]
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  • carbonic anhydrase 7/Carbonic anhydrase VII in Human [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166]
  • carbonic anhydrase 7/Carbonic anhydrase VII in Mouse [ChEMBL: CHEMBL2216] [GtoPdb: 2749] [UniProtKB: Q9ERQ8]
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  • carbonic anhydrase 12/Carbonic anhydrase XII in Human [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
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  • carbonic anhydrase 13/Carbonic anhydrase XIII in Human [ChEMBL: CHEMBL3912] [GtoPdb: 2748] [UniProtKB: Q8N1Q1]
  • carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1]
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  • carbonic anhydrase 14/Carbonic anhydrase XIV in Human [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7]
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  • Delta carbonic anhydrase in Thalassiosira weissflogii [ChEMBL: CHEMBL3097982] [UniProtKB: Q5U9J1]
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  • PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) in Mycobacterium tuberculosis [ChEMBL: CHEMBL5767] [UniProtKB: P96878]
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  • Uncharacterized protein Rv1284/MT1322 in Mycobacterium tuberculosis [ChEMBL: CHEMBL5631] [UniProtKB: P9WPJ7]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
AGAP002992-PA in Anopheles gambiae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3399914] [UniProtKB: Q5TU56]
ChEMBL Inhibition of Anopheles gambiae carbonic anhydrase pre-incubated for 15 mins by stopped-flow CO2 hydration assay B 7.56 pKi 27.3 nM Ki Bioorg. Med. Chem. (2015) 23: 2303-2309 [PMID:25882523]
Alpha carbonic anhydrase in Stylophora pistillata (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075028] [UniProtKB: B5SU02]
ChEMBL Inhibition of cloned Stylophora pistillata alpha-CA expressed in human HEK293 cells by stopped-flow CO2 assay B 7.8 pKi 16 nM Ki Bioorg. Med. Chem. (2009) 17: 5054-5058 [PMID:19520577]
ChEMBL Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assay B 7.8 pKi 16 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 710-714 [PMID:21208801]
Astrosclerin-3 in Astrosclera willeyana (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1944499] [UniProtKB: A6YCJ1]
ChEMBL Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay B 7.29 pKi 51 nM Ki Bioorg. Med. Chem. (2012) 20: 1403-1410 [PMID:22285172]
ChEMBL Inhibition of Astrosclera willeyana recombinant GST-tagged astrosclerin 3 expressed in Escherichia coli BL21-DE3-RIPL cells preincubated for 15 mins measured for 10 to 100 secs by stopped flow CO2 hydration assay B 7.29 pKi 51 nM Ki Bioorg. Med. Chem. Lett. (2012) 22: 1314-1316 [PMID:22227210]
Carbonate dehydratase in Sulfurihydrogenibium sp. (strain YO3AOP1) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3745586] [UniProtKB: B2V8E3]
ChEMBL Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assay B 8.35 pKi 4.5 nM Ki Bioorg. Med. Chem. Lett. (2016) 26: 401-405 [PMID:26691758]
Carbonic anhydrase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6068] [UniProtKB: P9WPJ9]
ChEMBL Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 2 encoded by RV3588c by stopped flow CO2 hydration assay B 8.05 pKi 9 nM Ki Bioorg. Med. Chem. Lett. (2009) 19: 6649-6654 [PMID:19846301]
Carbonic anhydrase in Methanosarcina thermophila (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3932] [UniProtKB: P40881]
ChEMBL Inhibitory activity against alpha carbonic anhydrase (Co-Cam) from Methanosarcina thermophila B 5.84 pKi 1430 nM Ki Bioorg. Med. Chem. Lett. (2004) 14: 6001-6006 [PMID:15546717]
ChEMBL Inhibition of Methanosarcina thermophila recombinant gamma-CA by CO2 hydration assay B 7.2 pKi 63 nM Ki Bioorg. Med. Chem. Lett. (2013) 23: 4067-4071 [PMID:23769640]
ChEMBL Inhibition of archaeon Methanosarcina thermophila gamma-CA after 15 mins by stopped-flow/Co2 hydration assay B 7.2 pKi 63 nM Ki Bioorg. Med. Chem. (2015) 23: 4405-4409 [PMID:26145820]
ChEMBL Inhibition of Methanosarcina thermophila gamma carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydrase assay B 7.2 pKi 63 nM Ki Bioorg. Med. Chem. (2016) 24: 3413-3417 [PMID:27283786]
ChEMBL Inhibition of Methanosarcina thermophila recombinant carbonic anhydrase gamma assessed as inhibition of CO2 hydration preincubated for 15 mins by Lineweaver-burk plot method B 7.2 pKi 63 nM Ki Bioorg Med Chem (2017) 25: 575-580 [PMID:27914949]
ChEMBL Inhibitory activity against alpha carbonic anhydrase (Zn-Cam) from Methanosarcina thermophila B 7.22 pKi 60 nM Ki Bioorg. Med. Chem. Lett. (2004) 14: 6001-6006 [PMID:15546717]
Carbonic anhydrase in Flaveria bidentis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2401609] [UniProtKB: P46510]
ChEMBL Inhibition of Flaveria bidentis recombinant CA by CO2 hydration assay B 7.57 pKi 27 nM Ki Bioorg. Med. Chem. Lett. (2013) 23: 4067-4071 [PMID:23769640]
ChEMBL Inhibition of Flaveria bidentis carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay B 7.57 pKi 27 nM Ki Bioorg. Med. Chem. Lett. (2013) 23: 6706-6710 [PMID:24210500]
ChEMBL Inhibition of Flaveria bidentis carbonic anhydrase-1 by CO2 hydration reaction based colorimetric stopped-flow method B 7.57 pKi 27 nM Ki Bioorg. Med. Chem. (2015) 23: 4831-4838 [PMID:26068018]
ChEMBL Inhibition of Flaveria bidentis carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydrase assay B 7.57 pKi 27 nM Ki Bioorg. Med. Chem. (2016) 24: 3413-3417 [PMID:27283786]
Carbonic anhydrase in Dicentrarchus labrax (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795125] [UniProtKB: Q2PCB5]
ChEMBL Inhibition of Dicentrarchus labrax CA using 4-nitrophenylacetate substrate by esterase assay B 5.24 pKi 5720 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 4259-4262 [PMID:21669522]
Carbonic anhydrase in Stylophora pistillata (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1649055] [UniProtKB: C0IX24]
ChEMBL Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assay B 7.13 pKi 74 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 710-714 [PMID:21208801]
Carbonic anhydrase in Methanobacterium thermoautotrophicum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3926] [UniProtKB: Q50565]
ChEMBL Inhibitory activity against beta carbonic anhydrase (Cab) from Methanobacterium thermoautotrophicum B 4.92 pKi 12100 nM Ki Bioorg. Med. Chem. Lett. (2004) 14: 6001-6006 [PMID:15546717]
ChEMBL Inhibition of Methanobacterium thermoautotrophicum carbonic anhydrase by stopped flow CO2 hydration method B 4.92 pKi 12100 nM Ki J. Med. Chem. (2009) 52: 2226-2232 [PMID:19317447]
ChEMBL Inhibition of Methanothermobacter thermautotrophicus carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay B 4.92 pKi 12100 nM Ki Bioorg. Med. Chem. (2011) 19: 243-248 [PMID:21163660]
ChEMBL Inhibition of Methanobacterium thermoautotrophicum beta-carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay B 4.92 pKi 12100 nM Ki Bioorg. Med. Chem. Lett. (2013) 23: 6706-6710 [PMID:24210500]
Carbonic anhydrase in Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3596083] [UniProtKB: Q9HVB9]
ChEMBL Inhibition of Pseudomonas aeruginosa PAO1 type-2 beta-carbonic anhydrase psCA3 expressed in Escherichia coli Tuner BL21 (DE3) cells pre-incubated for 15 mins at pH 8.3 and 293K by CO2 hydration reaction based colorimetric stopped-flow method B 7.12 pKi 75.9 nM Ki Bioorg. Med. Chem. (2015) 23: 4831-4838 [PMID:26068018]
Carbonic anhydrase in Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5337] [UniProtKB: Q5AJ71]
ChEMBL Inhibition of recombinant Candida albicans beta carbonic anhydrase NCE103 expressed in Escherichia coli preincubated for 15 mins by stopped-flow CO2 hydration assay B 6.88 pKi 132 nM Ki Bioorg. Med. Chem. (2016) 24: 1648-1652 [PMID:26951893]
ChEMBL Inhibition of Candida albicans recombinant Nce103 by stopped-flow CO2 hydration assay B 6.88 pKi 132 nM Ki Bioorg. Med. Chem. (2009) 17: 4503-4509 [PMID:19450983]
ChEMBL inhibition of Candida albicans recombinant Nce103 after 15 mins by stopped-flow CO2 hydration assay B 6.88 pKi 132 nM Ki Bioorg. Med. Chem. Lett. (2010) 20: 2508-2511 [PMID:20299219]
ChEMBL Inhibition of Candida albicans recombinant Carbonic anhydrase pre-incubated for 15 mins by CO2 hydration stopped-flow assay B 6.88 pKi 132 nM Ki Bioorg. Med. Chem. Lett. (2009) 19: 2642-2645 [PMID:19375309]
ChEMBL Inhibition of Candida albicans carbonic anhydrase preincubated for 15 mins at pH 8.3 by stopped flow CO2 hydration method B 6.88 pKi 132 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 5210-5213 [PMID:21821413]
ChEMBL Inhibition of Candida albicans CaNce103 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method B 6.88 pKi 132 nM Ki J. Med. Chem. (2012) 55: 3513-3520 [PMID:22424239]
ChEMBL Inhibition of Candida albicans recombinant Nce103 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay B 6.89 pKi 130 nM Ki J. Med. Chem. (2011) 54: 1682-1692 [PMID:21332115]
Carbonic anhydrase in Candida glabrata CBS 138 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6185] [UniProtKB: Q6FTL6]
ChEMBL Inhibition of Candida glabrata carbonic anhydrase by stopped flow CO2 hydration assay B 7.96 pKi 11 nM Ki Bioorg. Med. Chem. Lett. (2009) 19: 4802-4805 [PMID:19574046]
ChEMBL Inhibition of Candida glabrata CgNce103 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method B 7.96 pKi 11 nM Ki J. Med. Chem. (2012) 55: 3513-3520 [PMID:22424239]
ChEMBL Inhibition of recombinant full length Candida glabrata NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay B 7.96 pKi 11 nM Ki Bioorg. Med. Chem. Lett. (2013) 23: 2647-2652 [PMID:23511020]
ChEMBL Inhibition of recombinant Candida glabrata beta carbonic anhydrase NCE103 expressed in Escherichia coli preincubated for 15 mins by stopped-flow CO2 hydration assay B 7.96 pKi 11 nM Ki Bioorg. Med. Chem. (2016) 24: 1648-1652 [PMID:26951893]
ChEMBL Inhibition of Candida glabrata Nce103 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay B 7.96 pKi 11 nM Ki ACS Med Chem Lett (2017) 8: 1194-1198 [PMID:29152053]
Carbonic anhydrase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5931] [UniProtKB: P53615]
ChEMBL Inhibition of Saccharomyces cerevisiae carbonic anhydrase by oxygen-18 isotope exchange assay B 4.8 pKi 16000 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 6327-6331 [PMID:18993072]
ChEMBL Inhibition of Saccharomyces cerevisiae recombinant CA expressed in Escherichia coli by stopped-flow CO2 hydrase assay B 7.08 pKi 82.6 nM Ki Bioorg. Med. Chem. (2009) 17: 1158-1163 [PMID:19124253]
ChEMBL Inhibition of Saccharomyces cerevisiae beta-carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay B 7.09 pKi 82 nM Ki Bioorg. Med. Chem. Lett. (2013) 23: 1626-1630 [PMID:23414801]
ChEMBL Inhibition of Saccharomyces cerevisiae carbonic anhydrase SceCA preincubated for 15 mins by stopped flow CO2 hydration assay B 7.09 pKi 82 nM Ki Bioorg. Med. Chem. Lett. (2013) 23: 6706-6710 [PMID:24210500]
ChEMBL Inhibition of Saccharomyces cerevisiae carbonic anhydrase by CO2 hydration reaction based colorimetric stopped-flow method B 7.09 pKi 82 nM Ki Bioorg. Med. Chem. (2015) 23: 4831-4838 [PMID:26068018]
Carbonic anhydrase 1 in Drosophila melanogaster (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2331046] [UniProtKB: Q9V396]
ChEMBL Inhibition of Drosophila melanogaster recombinant carbonic anhydrase-1 expressed in Escherichia coli BL21 (DE3) preincubated for 15 mins by CO2 hydration stopped-flow assay B 6.97 pKi 106 nM Ki Bioorg. Med. Chem. (2013) 21: 1516-1521 [PMID:22989910]
Carbonic anhydrase 1 in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4211] [UniProtKB: O24855]
ChEMBL Inhibition of Helicobacter pylori recombinant carbonic anhydrase by stopped-flow CO2 hydrase assay B 7.68 pKi 21 nM Ki J. Med. Chem. (2006) 49: 2117-2126 [PMID:16539401]
ChEMBL Inhibition of Helicobacter pylori recombinant CA B 7.7 pKi 20 nM Ki Bioorg. Med. Chem. Lett. (2006) 16: 2182-2188 [PMID:16459077]
Carbonic anhydrase 15 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23]
ChEMBL Inhibition of mouse recombinant carbonic anhydrase 15 by stopped-flow CO2 hydrase assay B 7.14 pKi 72 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 3593-3596 [PMID:18501600]
ChEMBL Inhibition of mouse recombinant carbonic anhydrase 15 by stopped flow CO2 hydrase assay B 7.14 pKi 72 nM Ki J. Med. Chem. (2009) 52: 646-654 [PMID:19193158]
ChEMBL Inhibition of mouse carbonic anhydrase 15 by stopped flow CO2 hydration assay B 7.14 pKi 72 nM Ki Bioorg. Med. Chem. Lett. (2009) 19: 4102-4106 [PMID:19527930]
ChEMBL Inhibition of mouse recombinant CA15 by stopped flow CO2 hydrase assay B 7.14 pKi 72 nM Ki J. Med. Chem. (2010) 53: 850-854 [PMID:20028100]
ChEMBL Inhibition of full length mouse carbonic anhydrase 15 preincubated for 15 mins by CO2 hydration stopped-flow assay B 7.14 pKi 72 nM Ki Bioorg. Med. Chem. Lett. (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL Inhibition of mouse recombinant carbonic anhydrase 15 after 15 mins by stopped-flow CO2 hydration assay B 7.14 pKi 72 nM Ki Bioorg. Med. Chem. Lett. (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL Inhibition of mouse carbonic anhydrase 15 by stopped flow CO2 hydration method B 7.14 pKi 72 nM Ki J. Med. Chem. (2010) 53: 5511-5522 [PMID:20590092]
ChEMBL Inhibition of mouse CA15 by stopped-flow CO2 hydrase assay B