ChEMBL ligand: CHEMBL20 (Acetamox, Acetazolamide, Acetazolamidum, Atenezo, Defiltran, Diamox, Diamox sr, Didoc, Diuriwas, Donmox, Edemox, Eytazox, Glaupax, L 579486, Nephramide, NSC-145177, Phonurit)
AGAP002992-PA in Anopheles gambiae [ChEMBL: CHEMBL3399914] [UniProtKB: Q5TU56] There should be some charts here, you may need to enable JavaScript!
Alpha carbonic anhydrase in Stylophora pistillata [ChEMBL: CHEMBL1075028] [UniProtKB: B5SU02] There should be some charts here, you may need to enable JavaScript!
Astrosclerin-3 in Astrosclera willeyana [ChEMBL: CHEMBL1944499] [UniProtKB: A6YCJ1] There should be some charts here, you may need to enable JavaScript!
Carbonate dehydratase in Sulfurihydrogenibium sp. (strain YO3AOP1) [ChEMBL: CHEMBL3745586] [UniProtKB: B2V8E3] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase in Mycobacterium tuberculosis [ChEMBL: CHEMBL6068] [UniProtKB: P9WPJ9] Carbonic anhydrase in Methanosarcina thermophila [ChEMBL: CHEMBL3932] [UniProtKB: P40881] Carbonic anhydrase in Flaveria bidentis [ChEMBL: CHEMBL2401609] [UniProtKB: P46510] Carbonic anhydrase in Dicentrarchus labrax [ChEMBL: CHEMBL1795125] [UniProtKB: Q2PCB5] Carbonic anhydrase in Stylophora pistillata [ChEMBL: CHEMBL1649055] [UniProtKB: C0IX24] Carbonic anhydrase in Methanobacterium thermoautotrophicum [ChEMBL: CHEMBL3926] [UniProtKB: Q50565] Carbonic anhydrase in Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) [ChEMBL: CHEMBL3596083] [UniProtKB: Q9HVB9] Carbonic anhydrase in Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [ChEMBL: CHEMBL5337] [UniProtKB: Q5AJ71] Carbonic anhydrase in Candida glabrata CBS 138 [ChEMBL: CHEMBL6185] [UniProtKB: Q6FTL6] Carbonic anhydrase in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL5931] [UniProtKB: P53615] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase 1 in Drosophila melanogaster [ChEMBL: CHEMBL2331046] [UniProtKB: Q9V396] Carbonic anhydrase 1 in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) [ChEMBL: CHEMBL4211] [UniProtKB: O24855] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase 15 in Mouse [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase 2 in Cryptococcus neoformans var. grubii [ChEMBL: CHEMBL1697676] [UniProtKB: Q3I4V7] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase 2, isoform A in Drosophila melanogaster [ChEMBL: CHEMBL2331045] [UniProtKB: Q9VTU8] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase 3 in Bovine [ChEMBL: CHEMBL1944498] [UniProtKB: Q3SZX4] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase, alpha family in Thiomicrospira crunogena (strain XCL-2) [ChEMBL: CHEMBL3621035] [UniProtKB: Q31FD6] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 1/Carbonic anhydrase I in Human [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 2/Carbonic anhydrase II in Human [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] Carbonic anhydrase II in Bovine [ChEMBL: CHEMBL2283] [UniProtKB: P00921] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase III in Human [ChEMBL: CHEMBL2885] [UniProtKB: P07451] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 4/Carbonic anhydrase IV in Human [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748] Carbonic anhydrase IV in Bovine [ChEMBL: CHEMBL281] [UniProtKB: Q95323] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 9/Carbonic anhydrase IX in Human [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase-related protein 2 in Human [ChEMBL: CHEMBL2420] [UniProtKB: O75493] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 5A/Carbonic anhydrase VA in Human [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase VB in Human [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase VI in Human [ChEMBL: CHEMBL3025] [UniProtKB: P23280] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 7/Carbonic anhydrase VII in Human [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166] carbonic anhydrase 7/Carbonic anhydrase VII in Mouse [ChEMBL: CHEMBL2216] [GtoPdb: 2749] [UniProtKB: Q9ERQ8] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 12/Carbonic anhydrase XII in Human [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 13/Carbonic anhydrase XIII in Human [ChEMBL: CHEMBL3912] [GtoPdb: 2748] [UniProtKB: Q8N1Q1] carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 14/Carbonic anhydrase XIV in Human [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7] There should be some charts here, you may need to enable JavaScript!
Delta carbonic anhydrase in Thalassiosira weissflogii [ChEMBL: CHEMBL3097982] [UniProtKB: Q5U9J1] There should be some charts here, you may need to enable JavaScript!
Endochitinase in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL1293195] [UniProtKB: P29029] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) in Mycobacterium tuberculosis [ChEMBL: CHEMBL5767] [UniProtKB: P96878] There should be some charts here, you may need to enable JavaScript!
Uncharacterized protein Rv1284/MT1322 in Mycobacterium tuberculosis [ChEMBL: CHEMBL5631] [UniProtKB: P9WPJ7] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
AGAP002992-PA in Anopheles gambiae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3399914] [UniProtKB: Q5TU56]
ChEMBL	Inhibition of Anopheles gambiae carbonic anhydrase pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.56	pKi	27.3	nM	Ki	Bioorg Med Chem (2015) 23: 2303-2309 [PMID:25882523]
Alpha carbonic anhydrase in Stylophora pistillata (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075028] [UniProtKB: B5SU02]
ChEMBL	Inhibition of cloned Stylophora pistillata alpha-CA expressed in human HEK293 cells by stopped-flow CO2 assay	B	7.8	pKi	16	nM	Ki	Bioorg Med Chem (2009) 17: 5054-5058 [PMID:19520577]
ChEMBL	Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assay	B	7.8	pKi	16	nM	Ki	Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801]
Astrosclerin-3 in Astrosclera willeyana (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1944499] [UniProtKB: A6YCJ1]
ChEMBL	Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay	B	7.29	pKi	51	nM	Ki	Bioorg Med Chem (2012) 20: 1403-1410 [PMID:22285172]
ChEMBL	Inhibition of Astrosclera willeyana recombinant GST-tagged astrosclerin 3 expressed in Escherichia coli BL21-DE3-RIPL cells preincubated for 15 mins measured for 10 to 100 secs by stopped flow CO2 hydration assay	B	7.29	pKi	51	nM	Ki	Bioorg Med Chem Lett (2012) 22: 1314-1316 [PMID:22227210]
Carbonate dehydratase in Sulfurihydrogenibium sp. (strain YO3AOP1) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3745586] [UniProtKB: B2V8E3]
ChEMBL	Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assay	B	8.35	pKi	4.5	nM	Ki	Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758]
Carbonic anhydrase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6068] [UniProtKB: P9WPJ9]
ChEMBL	Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 2 encoded by RV3588c by stopped flow CO2 hydration assay	B	8.05	pKi	9	nM	Ki	Bioorg Med Chem Lett (2009) 19: 6649-6654 [PMID:19846301]
Carbonic anhydrase in Methanosarcina thermophila (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3932] [UniProtKB: P40881]
ChEMBL	Inhibitory activity against alpha carbonic anhydrase (Co-Cam) from Methanosarcina thermophila	B	5.84	pKi	1430	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717]
ChEMBL	Inhibition of Methanosarcina thermophila recombinant gamma-CA by CO2 hydration assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem Lett (2013) 23: 4067-4071 [PMID:23769640]
ChEMBL	Inhibition of archaeon Methanosarcina thermophila gamma-CA after 15 mins by stopped-flow/Co2 hydration assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem (2015) 23: 4405-4409 [PMID:26145820]
ChEMBL	Inhibition of Methanosarcina thermophila gamma carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem (2016) 24: 3413-3417 [PMID:27283786]
ChEMBL	Inhibition of Methanosarcina thermophila recombinant carbonic anhydrase gamma assessed as inhibition of CO2 hydration preincubated for 15 mins by Lineweaver-burk plot method	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem (2017) 25: 575-580 [PMID:27914949]
ChEMBL	Inhibitory activity against alpha carbonic anhydrase (Zn-Cam) from Methanosarcina thermophila	B	7.22	pKi	60	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717]
Carbonic anhydrase in Flaveria bidentis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2401609] [UniProtKB: P46510]
ChEMBL	Inhibition of Flaveria bidentis recombinant CA by CO2 hydration assay	B	7.57	pKi	27	nM	Ki	Bioorg Med Chem Lett (2013) 23: 4067-4071 [PMID:23769640]
ChEMBL	Inhibition of Flaveria bidentis carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.57	pKi	27	nM	Ki	Bioorg Med Chem Lett (2013) 23: 6706-6710 [PMID:24210500]
ChEMBL	Inhibition of Flaveria bidentis carbonic anhydrase-1 by CO2 hydration reaction based colorimetric stopped-flow method	B	7.57	pKi	27	nM	Ki	Bioorg Med Chem (2015) 23: 4831-4838 [PMID:26068018]
ChEMBL	Inhibition of Flaveria bidentis carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.57	pKi	27	nM	Ki	Bioorg Med Chem (2016) 24: 3413-3417 [PMID:27283786]
Carbonic anhydrase in Dicentrarchus labrax (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795125] [UniProtKB: Q2PCB5]
ChEMBL	Inhibition of Dicentrarchus labrax CA using 4-nitrophenylacetate substrate by esterase assay	B	5.24	pKi	5720	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4259-4262 [PMID:21669522]
Carbonic anhydrase in Stylophora pistillata (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1649055] [UniProtKB: C0IX24]
ChEMBL	Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801]
Carbonic anhydrase in Methanobacterium thermoautotrophicum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3926] [UniProtKB: Q50565]
ChEMBL	Inhibitory activity against beta carbonic anhydrase (Cab) from Methanobacterium thermoautotrophicum	B	4.92	pKi	12100	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717]
ChEMBL	Inhibition of Methanobacterium thermoautotrophicum carbonic anhydrase by stopped flow CO2 hydration method	B	4.92	pKi	12100	nM	Ki	J Med Chem (2009) 52: 2226-2232 [PMID:19317447]
ChEMBL	Inhibition of Methanothermobacter thermautotrophicus carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay	B	4.92	pKi	12100	nM	Ki	Bioorg Med Chem (2011) 19: 243-248 [PMID:21163660]
ChEMBL	Inhibition of Methanobacterium thermoautotrophicum beta-carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay	B	4.92	pKi	12100	nM	Ki	Bioorg Med Chem Lett (2013) 23: 6706-6710 [PMID:24210500]
Carbonic anhydrase in Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3596083] [UniProtKB: Q9HVB9]
ChEMBL	Inhibition of Pseudomonas aeruginosa PAO1 type-2 beta-carbonic anhydrase psCA3 expressed in Escherichia coli Tuner BL21 (DE3) cells pre-incubated for 15 mins at pH 8.3 and 293K by CO2 hydration reaction based colorimetric stopped-flow method	B	7.12	pKi	75.9	nM	Ki	Bioorg Med Chem (2015) 23: 4831-4838 [PMID:26068018]
Carbonic anhydrase in Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5337] [UniProtKB: Q5AJ71]
ChEMBL	Inhibition of recombinant Candida albicans beta carbonic anhydrase NCE103 expressed in Escherichia coli preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.88	pKi	132	nM	Ki	Bioorg Med Chem (2016) 24: 1648-1652 [PMID:26951893]
ChEMBL	Inhibition of Candida albicans recombinant Nce103 by stopped-flow CO2 hydration assay	B	6.88	pKi	132	nM	Ki	Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983]
ChEMBL	inhibition of Candida albicans recombinant Nce103 after 15 mins by stopped-flow CO2 hydration assay	B	6.88	pKi	132	nM	Ki	Bioorg Med Chem Lett (2010) 20: 2508-2511 [PMID:20299219]
ChEMBL	Inhibition of Candida albicans recombinant Carbonic anhydrase pre-incubated for 15 mins by CO2 hydration stopped-flow assay	B	6.88	pKi	132	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2642-2645 [PMID:19375309]
ChEMBL	Inhibition of Candida albicans carbonic anhydrase preincubated for 15 mins at pH 8.3 by stopped flow CO2 hydration method	B	6.88	pKi	132	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5210-5213 [PMID:21821413]
ChEMBL	Inhibition of Candida albicans CaNce103 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method	B	6.88	pKi	132	nM	Ki	J Med Chem (2012) 55: 3513-3520 [PMID:22424239]
ChEMBL	Inhibition of Candida albicans recombinant Nce103 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay	B	6.89	pKi	130	nM	Ki	J Med Chem (2011) 54: 1682-1692 [PMID:21332115]
Carbonic anhydrase in Candida glabrata CBS 138 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6185] [UniProtKB: Q6FTL6]
ChEMBL	Inhibition of Candida glabrata carbonic anhydrase by stopped flow CO2 hydration assay	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4802-4805 [PMID:19574046]
ChEMBL	Inhibition of Candida glabrata CgNce103 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method	B	7.96	pKi	11	nM	Ki	J Med Chem (2012) 55: 3513-3520 [PMID:22424239]
ChEMBL	Inhibition of recombinant full length Candida glabrata NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem Lett (2013) 23: 2647-2652 [PMID:23511020]
ChEMBL	Inhibition of recombinant Candida glabrata beta carbonic anhydrase NCE103 expressed in Escherichia coli preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem (2016) 24: 1648-1652 [PMID:26951893]
ChEMBL	Inhibition of Candida glabrata Nce103 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	7.96	pKi	11	nM	Ki	ACS Med Chem Lett (2017) 8: 1194-1198 [PMID:29152053]
Carbonic anhydrase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5931] [UniProtKB: P53615]
ChEMBL	Inhibition of Saccharomyces cerevisiae carbonic anhydrase by oxygen-18 isotope exchange assay	B	4.8	pKi	16000	nM	Ki	Bioorg Med Chem Lett (2008) 18: 6327-6331 [PMID:18993072]
ChEMBL	Inhibition of Saccharomyces cerevisiae recombinant CA expressed in Escherichia coli by stopped-flow CO2 hydrase assay	B	7.08	pKi	82.6	nM	Ki	Bioorg Med Chem (2009) 17: 1158-1163 [PMID:19124253]
ChEMBL	Inhibition of Saccharomyces cerevisiae beta-carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.09	pKi	82	nM	Ki	Bioorg Med Chem Lett (2013) 23: 1626-1630 [PMID:23414801]
ChEMBL	Inhibition of Saccharomyces cerevisiae carbonic anhydrase SceCA preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.09	pKi	82	nM	Ki	Bioorg Med Chem Lett (2013) 23: 6706-6710 [PMID:24210500]
ChEMBL	Inhibition of Saccharomyces cerevisiae carbonic anhydrase by CO2 hydration reaction based colorimetric stopped-flow method	B	7.09	pKi	82	nM	Ki	Bioorg Med Chem (2015) 23: 4831-4838 [PMID:26068018]
Carbonic anhydrase 1 in Drosophila melanogaster (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2331046] [UniProtKB: Q9V396]
ChEMBL	Inhibition of Drosophila melanogaster recombinant carbonic anhydrase-1 expressed in Escherichia coli BL21 (DE3) preincubated for 15 mins by CO2 hydration stopped-flow assay	B	6.97	pKi	106	nM	Ki	Bioorg Med Chem (2013) 21: 1516-1521 [PMID:22989910]
Carbonic anhydrase 1 in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4211] [UniProtKB: O24855]
ChEMBL	Inhibition of Helicobacter pylori recombinant carbonic anhydrase by stopped-flow CO2 hydrase assay	B	7.68	pKi	21	nM	Ki	J Med Chem (2006) 49: 2117-2126 [PMID:16539401]
ChEMBL	Inhibition of Helicobacter pylori recombinant CA	B	7.7	pKi	20	nM	Ki	Bioorg Med Chem Lett (2006) 16: 2182-2188 [PMID:16459077]
Carbonic anhydrase 15 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23]
ChEMBL	Inhibition of mouse recombinant carbonic anhydrase 15 by stopped-flow CO2 hydrase assay	B	7.14	pKi	72	nM	Ki	Bioorg Med Chem Lett (2008) 18: 3593-3596 [PMID:18501600]
ChEMBL	Inhibition of mouse recombinant carbonic anhydrase 15 by stopped flow CO2 hydrase assay	B	7.14	pKi	72	nM	Ki	J Med Chem (2009) 52: 646-654 [PMID:19193158]
ChEMBL	Inhibition of mouse carbonic anhydrase 15 by stopped flow CO2 hydration assay	B	7.14	pKi	72	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4102-4106 [PMID:19527930]
ChEMBL	Inhibition of mouse recombinant CA15 by stopped flow CO2 hydrase assay	B	7.14	pKi	72	nM	Ki	J Med Chem (2010) 53: 850-854 [PMID:20028100]
ChEMBL	Inhibition of full length mouse carbonic anhydrase 15 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.14	pKi	72	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of mouse recombinant carbonic anhydrase 15 after 15 mins by stopped-flow CO2 hydration assay	B	7.14	pKi	72	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of mouse carbonic anhydrase 15 by stopped flow CO2 hydration method	B	7.14	pKi	72	nM	Ki	J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
ChEMBL	Inhibition of mouse CA15 by stopped-flow CO2 hydrase assay	B	7.14	pKi	72	nM	Ki	Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280]
Carbonic anhydrase 2 in Cryptococcus neoformans var. grubii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1697676] [UniProtKB: Q3I4V7]
ChEMBL	Inhibition of Cryptococcus neoformans Can2 assessed as CO2 hydrase activity by stopped-flow assay	B	7.98	pKi	10.5	nM	Ki	Bioorg Med Chem (2014) 22: 2939-2946 [PMID:24792813]
ChEMBL	Inhibition of Cryptococcus neoformans var. grubii beta-carbonic anhydrase incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	7.98	pKi	10.5	nM	Ki	Bioorg Med Chem (2015) 23: 4181-4187 [PMID:26145821]
ChEMBL	Inhibition of Cryptococcus neoformans Can2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method	B	7.98	pKi	10.5	nM	Ki	J Med Chem (2012) 55: 3513-3520 [PMID:22424239]
ChEMBL	Inhibition of Cryptococcus neoformans recombinant Can2 by CO2 hydration assay	B	7.98	pKi	10.5	nM	Ki	Bioorg Med Chem Lett (2013) 23: 4067-4071 [PMID:23769640]
ChEMBL	Inhibition of Cryptococcus neoformans carbonic anhydrase Can2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.98	pKi	10.5	nM	Ki	Bioorg Med Chem Lett (2013) 23: 6706-6710 [PMID:24210500]
ChEMBL	Inhibition of Cryptococcus neoformans beta-carbonic anhydrase Can2	B	7.98	pKi	10.5	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1127-1132 [PMID:24461298]
ChEMBL	Inhibition of Cryptococcus neoformans Can2 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	8	pKi	10	nM	Ki	ACS Med Chem Lett (2017) 8: 1194-1198 [PMID:29152053]
ChEMBL	Inhibition of Cryptococcus neoformans beta carbonic anhydrase Can2 using CO2 as substrate incubated for 6 hrs prior to substrate addition measured for 10 to 100 secs by stopped flow technique	B	8	pKi	10	nM	Ki	Bioorg Med Chem Lett (2012) 22: 5801-5806 [PMID:22901388]
ChEMBL	Inhibition of Cryptococcus neoformans recombinant Can2 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay	B	8	pKi	10	nM	Ki	J Med Chem (2011) 54: 1682-1692 [PMID:21332115]
Carbonic anhydrase 2, isoform A in Drosophila melanogaster (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2331045] [UniProtKB: Q9VTU8]
ChEMBL	Inhibition of Drosophila melanogaster recombinant carbonic anhydrase-2 expressed in Escherichia coli BL21 (DE3) preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.11	pKi	78	nM	Ki	Bioorg Med Chem (2013) 21: 1516-1521 [PMID:22989910]
Carbonic anhydrase 3 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1944498] [UniProtKB: Q3SZX4]
ChEMBL	Inhibition of bovine carbonic anhydrase 3 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis	B	4.08	pKi	83400	nM	Ki	Eur J Med Chem (2012) 49: 68-73 [PMID:22245047]
Carbonic anhydrase, alpha family in Thiomicrospira crunogena (strain XCL-2) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3621035] [UniProtKB: Q31FD6]
ChEMBL	Inhibition of recombinant Thiomicrospira crunogena XCL-2 carbonic anhydrase by stopped flow CO2 hydrase assay	B	8.37	pKi	4.3	nM	Ki	Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758]
carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 1 expressed in Escherichia coli expression system assessed as observed dissociation constant fluorescent thermal shift assay	B	5.62	pKd	2400	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Binding affinity to human recombinant CA1 at 37 degC and pH 7.0 by thermal shift assay	B	5.85	pKd	1400	nM	Kd	Bioorg Med Chem (2013) 21: 2093-2106 [PMID:23394791]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 1 expressed in Escherichia coli BL21 (DE3) by thermal shift assay	B	5.85	pKd	1400	nM	Kd	Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 1 by thermal shift assay	B	5.85	pKd	1400	nM	Kd	Bioorg Med Chem (2010) 18: 7413-7421 [PMID:20889345]
ChEMBL	Inhibition of human carbonic anhydrase 1 at pH7 and 37 degC by fluorescent thermal shift assay	B	5.85	pKd	1400	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 1 expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	B	5.96	pKd	1100	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Inhibition of human carbonic anhydrase 1 at pH7 and 37 degC by isothermal titration calorimetry	B	6.09	pKd	810	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 1 by isothermal titration calorimetry assay	B	6.11	pKd	780	nM	Kd	Bioorg Med Chem (2010) 18: 7413-7421 [PMID:20889345]
ChEMBL	Inhibition of human carbonic anhydrase 1 at pH7 and 25 degC by stopped-flow kinetic inhibition assay	B	6.54	pKd	290	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Inhibition of human erythrocyte CA1 esterase activity using 4-nitrophenyl acetate substrate	B	4.44	pKi	36200	nM	Ki	Bioorg Med Chem (2009) 17: 3207-3211 [PMID:19231207]
ChEMBL	Inhibition of human carbonic anhydrase 1 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis	B	4.44	pKi	36200	nM	Ki	Eur J Med Chem (2012) 49: 68-73 [PMID:22245047]
ChEMBL	Inhibition of human carbonic anhydrase 1 esterase activity using 4-nitrophenylacetate as substrate	B	4.44	pKi	36200	nM	Ki	Bioorg Med Chem Lett (2012) 22: 1352-1357 [PMID:22230050]
ChEMBL	Inhibition of human erythrocytes esterase activity of carbonic anhydrase-1 using 4-nitrophenylacetate as substrate after 3 mins by Lineweaver-Burk plot analysis	B	4.44	pKi	36200	nM	Ki	Bioorg Med Chem (2013) 21: 1379-1385 [PMID:23394864]
ChEMBL	Inhibition of human erythrocytes CA1 using 4-nitrophenylacetate as substrate by esterase assay	B	4.44	pKi	36200	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3261-3263 [PMID:26073005]
ChEMBL	Inhibition of human carbonic anhydrase 1 by Lineweaver-Burke plot analysis	B	5.2	pKi	6300	nM	Ki	Eur J Med Chem (2010) 45: 4769-4773 [PMID:20724038]
ChEMBL	Inhibition of human carbonic anhydrase 1 by Lineweaver-Burke plot	B	5.46	pKi	3500	nM	Ki	Bioorg Med Chem (2009) 17: 3295-3301 [PMID:19362844]
ChEMBL	Inhibition of human carbonic anhydrase 1 using 4-NPA as substrate measured for 3 mins by spectrophotometry	B	5.81	pKi	1532.01	nM	Ki	Bioorg Med Chem Lett (2020) 30: 126874-126874 [PMID:31859159]
ChEMBL	Inhibitory activity against human Carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	J Med Chem (2004) 47: 5224-5229 [PMID:15456265]
ChEMBL	Inhibitory activity against human recombinant carbonic anhydrase I (CA1)	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2002) 12: 1551-1557 [PMID:12039560]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by CO2 hydration stopped-flow assay	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2008) 18: 3475-3480 [PMID:18513964]
ChEMBL	Inhibition constant against human (cloned) isozyme (hCA I) by the CO2 hydration method	B	6.05	pKi	900	nM	Ki	J Med Chem (2005) 48: 4834-4841 [PMID:16033263]
ChEMBL	Inhibition of human recombinant CA1 by stopped flow CO2 hydration assay	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem (2009) 17: 553-557 [PMID:19097911]
ChEMBL	Inhibition of human recombinant CA1 by stopped flow CO2 hydration assay	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2273-2276 [PMID:19286378]
ChEMBL	Inhibition of human recombinant isozyme CA1 by CO2 hydration method	B	6.05	pKi	900	nM	Ki	J Med Chem (2007) 50: 1651-1657 [PMID:17343373]
ChEMBL	Inhibition of cloned human cytosolic isozyme Carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	J Med Chem (2004) 47: 1272-1279 [PMID:14971907]
ChEMBL	Inhibitory activity against human recombinant carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	J Med Chem (2000) 43: 4884-4892 [PMID:11123998]
ChEMBL	Inhibitory effect on human carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	J Med Chem (2002) 45: 312-320 [PMID:11784136]
ChEMBL	Inhibition of cloned isozyme, human carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2001) 11: 575-582 [PMID:11229775]
ChEMBL	Binding affinity towards human cloned carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5781-5786 [PMID:15501040]
ChEMBL	Binding affinity towards human cloned carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5775-5780 [PMID:15501039]
ChEMBL	Inhibitory activity against human carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2004) 14: 2351-2356 [PMID:15081039]
ChEMBL	Inhibitory activity against Human carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	J Med Chem (2002) 45: 1466-1476 [PMID:11906288]
ChEMBL	Inhibition against human carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2004) 14: 231-234 [PMID:14684333]
ChEMBL	Inhibition of human carbonic anhydrase 1 after 6 hrs by Lineweaver-Burk plot analysis	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2011) 21: 2515-2520 [PMID:21420862]
ChEMBL	Inhibition of human recombinant carbonic anhydrase I (CA1)	B	6.05	pKi	900	nM	Ki	J Med Chem (2000) 43: 4542-4551 [PMID:11087579]
ChEMBL	Inhibitory activity against human cloned isoenzyme carbonic anhydrase I (hCA I), by esterase method.	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2003) 13: 837-840 [PMID:12617903]
ChEMBL	Inhibition of human CA1	B	6.05	pKi	900	nM	Ki	J Med Chem (2006) 49: 2743-2749 [PMID:16640335]
ChEMBL	Inhibitory activity against cytosolic human carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2005) 15: 579-584 [PMID:15664816]
ChEMBL	Inhibition of human cloned CA1 by CO2 hydration assay	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2006) 16: 4846-4851 [PMID:16809036]
ChEMBL	Inhibition of human cloned CA1 by CO2 hydration method	B	6.05	pKi	900	nM	Ki	J Med Chem (2006) 49: 6539-6548 [PMID:17064072]
ChEMBL	Inhibitory potency against human cloned Carbonic anhydrase I expressed in Escherichia coli strain BL21	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2005) 15: 367-372 [PMID:15603956]
ChEMBL	Inhibition of human recombinant carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	J Med Chem (2003) 46: 2197-2204 [PMID:12747791]
ChEMBL	Inhibitory constant against human Carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2005) 15: 2359-2364 [PMID:15837325]
ChEMBL	Inhibition of human carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2004) 14: 225-229 [PMID:14684332]
ChEMBL	Inhibitory activity against human carbonic anhydrase I.	B	6.05	pKi	900	nM	Ki	J Med Chem (2003) 46: 5471-5477 [PMID:14640555]
ChEMBL	In vitro inhibitory activity against human carbonic anhydrase I (hCAI)	B	6.05	pKi	900	nM	Ki	J Med Chem (2004) 47: 2796-2804 [PMID:15139757]
ChEMBL	Inhibitory activity against human cloned Carbonic anhydrase I by the CO2 hydration method	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4872-4876 [PMID:16165351]
ChEMBL	Inhibition of human recombinant CA1 by stopped flow CO2 hydration assay	B	6.32	pKi	481	nM	Ki	J Med Chem (2009) 52: 4063-4067 [PMID:19438226]
ChEMBL	Inhibition of esterase activity of human carbonic anhydrase 2 by Lineweaver-Burke plot analysis	B	6.43	pKi	370	nM	Ki	Bioorg Med Chem (2010) 18: 4468-4474 [PMID:20554206]
ChEMBL	Inhibition of human CA1 using 4-nitrophenylacetate as substrate preincubated for 10 mins by spectrophotometric esterase assay	B	6.47	pKi	342	nM	Ki	J Med Chem (2012) 55: 6776-6783 [PMID:22775345]
ChEMBL	Inhibition of human cloned CA1 after 15 mins by stopped-flow CO2 hydration assay	B	6.51	pKi	310	nM	Ki	Eur J Med Chem (2010) 45: 3656-3661 [PMID:20554082]
ChEMBL	Inhibition of human cloned carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.51	pKi	310	nM	Ki	Eur J Med Chem (2010) 45: 2396-2404 [PMID:20202722]
ChEMBL	Inhibition of human cloned carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.51	pKi	310	nM	Ki	Eur J Med Chem (2011) 46: 4403-4410 [PMID:21820216]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by CO2 hydration method	B	6.51	pKi	310	nM	Ki	Bioorg Med Chem (2007) 15: 2298-2311 [PMID:17276072]
ChEMBL	Inhibition of human erythrocyte CA1 b using 4-nitrophenyl acetate as substrate by Lineweaver-Burk plot analysis	B	6.54	pKi	289	nM	Ki	Eur J Med Chem (2020) 198: 112392-112392 [PMID:32388113]
ChEMBL	Inhibition of cytosolic carbonic anhydrase 1 (unknown origin) preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	252.2	nM	Ki	Eur J Med Chem (2013) 66: 372-379 [PMID:23827177]
GtoPdb	-	-	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6 [PMID:15546717]; Bioorg Med Chem Lett (2005) 15: 963-9 [PMID:15686894]; Bioorg Med Chem Lett (2010) 20: 4376-81 [PMID:20605094]
ChEMBL	Inhibition of human carbonic anhydrase 1 pre-incubated for 15 mins by stopped flow carbon dioxide hydrase assay	B	6.6	pKi	250.2	nM	Ki	J Med Chem (2016) 59: 10692-10704 [PMID:27933963]
ChEMBL	Inhibition of human erythrocytes carbonic anhydrase 1 by CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2009) 52: 4853-4859 [PMID:19580287]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2642-2645 [PMID:19375309]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4102-4106 [PMID:19527930]
ChEMBL	Inhibition of human recombinant CA1 by stopped-flow CO2 assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2009) 17: 5054-5058 [PMID:19520577]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2009) 17: 4894-4899 [PMID:19539481]
ChEMBL	Inhibition of human full length cytosolic carbonic anhydrase 1 after 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2009) 52: 5990-5998 [PMID:19731956]
ChEMBL	Inhibition of human cloned CA1 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2009) 52: 6421-6432 [PMID:19827837]
ChEMBL	Inhibition of human recombinant CA1 by stopped-flow hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2009) 19: 6649-6654 [PMID:19846301]
ChEMBL	Inhibition of human recombinant CA1 by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2010) 53: 850-854 [PMID:20028100]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 expressed in Escherichia coli by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2009) 19: 5825-5828 [PMID:19751975]
ChEMBL	Inhibition of human CA1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318]
ChEMBL	Inhibition of human recombinant carbonic anhydrase1 after 15 mins by stopped flow carbon dioxide hydrase assay method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2010) 20: 2178-2182 [PMID:20211561]
ChEMBL	Inhibition of human recombinant CA1 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2010) 53: 2913-2926 [PMID:20201556]
ChEMBL	Inhibition of full length human carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human carbonic anhydrase 1	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3623-3627 [PMID:20478708]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2010) 18: 4873-4878 [PMID:20598552]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 after 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
ChEMBL	Inhibition of wild type human recombinant carbonic anhydrase 1 expressed in Escherichia coli BL21 (DE3) after 15 mins by CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2010) 18: 5498-5503 [PMID:20624682]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2010) 18: 5081-5089 [PMID:20580561]
ChEMBL	Inhibition of human recombinant CA1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801]
ChEMBL	Inhibition of human carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2011) 19: 243-248 [PMID:21163660]
ChEMBL	Inhibition of human carbonic anhydrase I by spectrophotometry at pH 7.5	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2011) 19: 1172-1178 [PMID:21251841]
ChEMBL	Inhibition of human recombinant CA1 cytosolic isoform by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2011) 21: 1334-1337 [PMID:21300547]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 min by CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2011) 54: 1896-1902 [PMID:21361354]
ChEMBL	Inhibition of human carbonic anhydrase 1 after 15 mins by Lineweaver-Burk plot	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2011) 19: 1847-1851 [PMID:21377369]
ChEMBL	Inhibition of human carbonic anhydrase 1 after 15 mins by CO2 hydrase assay at pH 7.5	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2011) 19: 1847-1851 [PMID:21377369]
ChEMBL	Inhibition of human recombinant alpha-carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2011) 54: 1682-1692 [PMID:21332115]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2011) 21: 2521-2526 [PMID:21402476]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay at pH 8.3	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2011) 21: 3591-3595 [PMID:21570835]
ChEMBL	Inhibition of human CA1 by CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2011) 21: 3216-3221 [PMID:21549597]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2009) 19: 3170-3173 [PMID:19435663]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated with compound for 15 mins by carbon dioxide hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2011) 54: 3977-3981 [PMID:21506569]
ChEMBL	Inhibition of human full length cytosolic isoform of carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2011) 21: 2975-2979 [PMID:21470859]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2011) 19: 3732-3738 [PMID:21620713]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2011) 19: 3105-3119 [PMID:21515057]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 at pH 7.5 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2011) 19: 5023-5030 [PMID:21757360]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins at pH 7.5 by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5210-5213 [PMID:21821413]
ChEMBL	Inhibition of human recombinant CA1 by CO2 hydration based stopped flow assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2011) 54: 6905-6918 [PMID:21851094]
ChEMBL	Inhibition of human carbonic anhydrase 1-catalyzed CO2 hydration activity by stopped flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5892-5896 [PMID:21852133]
ChEMBL	Inhibition of human cloned carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2012) 20: 2392-2404 [PMID:22370338]
ChEMBL	Inhibition of human CA1 pre-incubated for 15 mins by stopped-flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	J Med Chem (2012) 55: 1721-1730 [PMID:22276570]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method	B	6.6	pKi	250	nM	Ki	J Med Chem (2012) 55: 3513-3520 [PMID:22424239]
ChEMBL	Inhibition of human recombinant full length CA1-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2012) 55: 3891-3899 [PMID:22443141]
ChEMBL	Inhibition of human CA1 using CO2 as substrate incubated for 6 hrs prior to substrate addition measured for 10 to 100 secs by stopped flow technique	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2012) 22: 5801-5806 [PMID:22901388]
ChEMBL	Inhibition of full length human CA1 cytosolic isoform preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2012) 55: 6776-6783 [PMID:22775345]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2012) 22: 7142-7145 [PMID:23072866]
ChEMBL	Inhibition of human recombinant wild type CA1 by stopped-flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2013) 23: 256-260 [PMID:23200251]
ChEMBL	Inhibition of full length human recombinant CA1 cytosolic isoform after 6 hrs by stopped-flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	J Med Chem (2013) 56: 293-300 [PMID:23241068]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2013) 56: 1761-1771 [PMID:23391336]
ChEMBL	Inhibition of human CA1 by stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2013) 23: 715-719 [PMID:23265898]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-1-mediated CO2 hydration preincubated for 10 mins by stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 1386-1391 [PMID:23352754]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 10 mins by CO2 hydration stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 1451-1464 [PMID:23168081]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase-1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2013) 23: 1626-1630 [PMID:23414801]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 1396-1403 [PMID:23290254]
ChEMBL	Inhibition of human carbonic anhydrase-1 cytosolic isoform after 15 mins by Stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 2314-2318 [PMID:23490152]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 1534-1538 [PMID:22883029]
ChEMBL	Inhibition of recombinant human CA1 cytosolic isoform preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2013) 56: 4691-4700 [PMID:23647428]
ChEMBL	Inhibition of human carbonic anhydrase-1 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 2925-2931 [PMID:23623256]
ChEMBL	Inhibition of human recombinant CA1 by CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2013) 23: 4067-4071 [PMID:23769640]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins to 6 hrs by CO2 hydration stopped-flow assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2013) 56: 5773-5781 [PMID:23815159]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 3949-3957 [PMID:23706268]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 after 6 hrs by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 4502-4510 [PMID:23769167]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 10 mins by CO2 hydration stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 5228-5232 [PMID:23842519]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 5130-5138 [PMID:23859774]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 5168-5174 [PMID:23867389]
ChEMBL	Inhibition of recombinant human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 5799-5805 [PMID:23910989]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175]
ChEMBL	Inhibition of full length human cytosolic carbonic anhydrase-1 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2013) 56: 8512-8520 [PMID:24128000]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2013) 23: 6706-6710 [PMID:24210500]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2013) 23: 6759-6763 [PMID:24189056]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2013) 56: 9623-9634 [PMID:24200125]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2014) 71: 105-111 [PMID:24287559]
ChEMBL	Inhibition of human CA1 cytosolic isoform preincubated for 15 mins by stopped-flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 334-340 [PMID:24300919]
ChEMBL	Inhibition of human carbonic anhydrase 1 cytosolic isoform preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 141-147 [PMID:24332658]
ChEMBL	Inhibition of human CA1 cytosolic isoform after 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2014) 71: 135-147 [PMID:24291567]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1127-1132 [PMID:24461298]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 1 after 6 hrs by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 1522-1528 [PMID:24513186]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 1873-1882 [PMID:24560737]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1310-1314 [PMID:24507918]
ChEMBL	Inhibition of human carbonic anhydrase 1-mediated CO2 hydration preincubated for 10 mins by stopped-flow assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2014) 76: 284-290 [PMID:24589484]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 1821-1831 [PMID:24560739]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1-mediated CO2 hydration after 6 hrs by stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1256-1260 [PMID:24518190]
ChEMBL	Inhibition of human recombinant cytosolic human carbonic anhydrase-1 incubated for 15 mins prior to testing by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1776-1779 [PMID:24589511]
ChEMBL	Inhibition of human carbonic anhydrase 1-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 2643-2647 [PMID:24713308]
ChEMBL	Inhibition of human carbonic anhydrase-1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 2939-2946 [PMID:24792813]
ChEMBL	Inhibition of human cloned cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2014) 82: 47-55 [PMID:24871996]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 3684-3695 [PMID:24878360]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 6768-6775 [PMID:25468040]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped flow CO2 hydrase assay method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 6945-6952 [PMID:25456084]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2014) 24: 4006-4010 [PMID:25011913]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 3982-3988 [PMID:25027802]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2014) 5: 793-796 [PMID:25050167]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2014) 5: 826-830 [PMID:25050173]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2014) 84: 240-246 [PMID:25019479]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydrase Assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2014) 5: 927-930 [PMID:25147616]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2014) 24: 5185-5189 [PMID:25442309]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	J Med Chem (2014) 57: 9152-9167 [PMID:25310626]
ChEMBL	Inhibition of human CA-1 by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2014) 57: 9673-9686 [PMID:25358036]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2014) 24: 4389-4396 [PMID:25168745]
ChEMBL	Inhibition of human full length CA1 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 6353-6359 [PMID:25438758]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2014) 24: 4402-4406 [PMID:25168748]
ChEMBL	Inhibition of human recombinant Carbonic anhydrase 1 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 4537-4543 [PMID:25129169]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2014) 87: 186-196 [PMID:25255434]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 5133-5140 [PMID:25194929]
ChEMBL	Inhibition of human CA-1 after 15 mins by stopped-flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 5883-5890 [PMID:25267005]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 526-531 [PMID:25533402]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 1728-1734 [PMID:25773015]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 1430-1436 [PMID:25753329]
ChEMBL	Inhibition of human carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 2303-2309 [PMID:25882523]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 1421-1429 [PMID:25757603]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 expressed in Escherichia coli pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 2368-2376 [PMID:25846066]
ChEMBL	Inhibition of human recombinant CA-1 after 15 mins by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 1828-1840 [PMID:25766630]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 by CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2015) 58: 1494-1501 [PMID:25581127]
ChEMBL	Inhibition of human cytosolic form of carbonic anhydrase-1 assessed as CO2 hydration activity incubated for 15 mins prior to testing by stopped flow method	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2015) 96: 425-435 [PMID:25912674]
ChEMBL	Inhibition of human recombinant carbonic anhdydrase-1 expressed in Escherichia coli pre-incubated for 6 hrs by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2015) 58: 3975-3983 [PMID:25875209]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 2975-2981 [PMID:26007302]
ChEMBL	Inhibition of human carbonic anhydrase-1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay based Lineweaver-Burk plot method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 3674-3680 [PMID:25921266]
ChEMBL	Inhibition of human CA1 after 15 mins by stopped-flow/Co2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 4405-4409 [PMID:26145820]
ChEMBL	Inhibition of human carbonic anhydrase 1 by by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 4989-4999 [PMID:26048024]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 expressed in Escherichia coli preincubated for 15 mins by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 4649-4659 [PMID:26088336]
ChEMBL	Inhibition of human carbonic anhydrase-1 by CO2 hydration reaction based colorimetric stopped-flow method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 4831-4838 [PMID:26068018]
ChEMBL	Inhibition of human carbonic anhydrase-1 incubated for 10 mins prior to testing by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3208-3212 [PMID:26105196]
ChEMBL	Inhibition of human recombinant CA1 expressed in Escherichia coli by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2015) 58: 6630-6638 [PMID:26203869]
ChEMBL	Inhibition of human CA1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2022) 228: 113997-113997 [PMID:34902732]
ChEMBL	Compound was evaluated for inhibition against human carbonic anhydrase I	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2004) 14: 217-223 [PMID:14684331]
ChEMBL	Inhibition constant determined against human cloned carbonic anhydrase I	B	6.6	pKi	250	nM	Ki	J Med Chem (2003) 46: 2187-2196 [PMID:12747790]
ChEMBL	Inhibitory activity against human carbonic anhydrase I	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2004) 14: 869-873 [PMID:15012984]
ChEMBL	Inhibitory activity against human cloned carbonic anhydrase I (hCA I)	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2003) 13: 841-845 [PMID:12617904]
ChEMBL	Inhibitory activity against human cloned carbonic anhydrase isozyme I by esterase assay method.	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2003) 13: 1005-1009 [PMID:12643899]
ChEMBL	Inhibition constant evaluated for the inhibition of human CA I (Carbonic anhydrase I)	B	6.6	pKi	250	nM	Ki	J Med Chem (2004) 47: 2337-2347 [PMID:15084132]
ChEMBL	Inhibitory activity against Carbonic anhydrase I	B	6.6	pKi	250	nM	Ki	J Med Chem (2005) 48: 2121-2125 [PMID:15771455]
ChEMBL	Inhibitory constant against cytosolic human Carbonic anhydrase I using CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3828-3833 [PMID:16039848]
ChEMBL	Inhibitory activity against human carbonic anhydrase I	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3821-3827 [PMID:16039853]
ChEMBL	Ki value against carbonic anhydrase I	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 971-976 [PMID:15686895]
ChEMBL	Ki value against human carbonic anhydrase I	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 971-976 [PMID:15686895]
ChEMBL	Ki value against human carbonic anhydrase I (hCA I)	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 963-969 [PMID:15686894]
ChEMBL	Inhibitory activity against human carbonic anhydrase I (hCAI)	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1149-1154 [PMID:15686931]
ChEMBL	Inhibitory activity against human carbonic anhydrase I expressed in Escherichia coli BL21	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5427-5433 [PMID:15454239]
ChEMBL	Inhibitory activity against human carbonic anhydrase I at 0.09 uM	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717]
ChEMBL	Inhibitory constant against human Carbonic anhydrase I	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3102-3108 [PMID:15905091]
ChEMBL	Inhibition constant against human recombinant carbonic anhydrase I	F	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3302-3306 [PMID:15908201]
ChEMBL	Inhibitory constant against human Carbonic anhydrase I	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 2347-2352 [PMID:15837323]
ChEMBL	Inhibition constant against human carbonic anhydrase I	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3096-3101 [PMID:15908204]
ChEMBL	Inhibitory activity against human Carbonic anhydrase I (hCA I)	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4862-4866 [PMID:16168653]
ChEMBL	Inhibition of recombinant human cytosolic isozyme CA I	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 5192-5196 [PMID:16203142]
ChEMBL	Inhibitory activity against cloned human CA1	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2006) 16: 437-442 [PMID:16290146]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2006) 49: 2117-2126 [PMID:16539401]
ChEMBL	Inhibition of human recombinant CA1	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2006) 16: 2182-2188 [PMID:16459077]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2006) 49: 5544-5551 [PMID:16942027]
ChEMBL	Inhibition of human cloned CA1 by stopped-flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibition of human recombinant cytosolic isozyme CA I by stopped-flow CO2 hydrase method	B	6.6	pKi	250	nM	Ki	J Med Chem (2007) 50: 381-388 [PMID:17228881]
ChEMBL	Inhibition of human recombinant CA1 after 15 mins by CO2 hydration stopped flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2007) 17: 2685-2691 [PMID:17376683]
ChEMBL	Inhibition of human cloned CA1 by CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2007) 17: 5032-5035 [PMID:17681760]
ChEMBL	Inhibition of human cloned carbonic anhydrase1 by CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2007) 15: 6975-6984 [PMID:17822907]
ChEMBL	Inhibition of human recombinant CA 1 assessed as CO2 hydration by stopped flow kinetic assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2007) 15: 7229-7236 [PMID:17826101]
ChEMBL	Inhibition of human carbonic anhydrase 1	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human recombinant CA1 by CO2 hydration stopped flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2008) 18: 836-841 [PMID:18042384]
ChEMBL	Inhibition of human cloned CA1 by CO2 hydration method	B	6.6	pKi	250	nM	Ki	J Med Chem (2008) 51: 1945-1953 [PMID:18307288]
ChEMBL	Inhibition of human full length carbonic anhydrase 1 by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2008) 18: 3593-3596 [PMID:18501600]
ChEMBL	Inhibition of human recombinant full length CA1 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	J Med Chem (2009) 52: 2226-2232 [PMID:19317447]
ChEMBL	Inhibition of human recombinant full length CA1 by stopped-flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of human carbonic anhydrase 1 measured by CO2 hydration reaction assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2009) 19: 650-653 [PMID:19121582]
ChEMBL	Inhibition of human recombinant CA1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2009) 17: 1158-1163 [PMID:19124253]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2009) 52: 646-654 [PMID:19193158]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2008) 18: 6332-6335 [PMID:18990571]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2009) 52: 3116-3120 [PMID:19338333]
ChEMBL	Inhibition of human cloned CA1 by stopped-flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2008) 18: 4282-4286 [PMID:18640037]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL	Inhibition of human recombinant CA1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2008) 51: 7968-7979 [PMID:19053764]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 222: 113589-113589 [PMID:34147910]
ChEMBL	Inhibition of recombinant human CA1 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 220: 113490-113490 [PMID:33975138]
ChEMBL	Inhibition of recombinant human CA1 pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 225: 113793-113793 [PMID:34507012]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 221: 113486-113486 [PMID:33965860]
ChEMBL	Inhibition of human CA1 measured after 15 mins by stopped flow carbon dioxide anhydrase assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 225: 113800-113800 [PMID:34482273]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2021) 64: 11432-11444 [PMID:34283610]
ChEMBL	Inhibition of human CA1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2022) 228: 114004-114004 [PMID:34847409]
ChEMBL	Inhibition of human CA1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2022) 228: 114008-114008 [PMID:34871842]
ChEMBL	Inhibition of human CA1 incubated for 15 mins prior to testing by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2022) 228: 114026-114026 [PMID:34920169]
ChEMBL	Inhibition of human CA1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2022) 65: 824-837 [PMID:34958217]
ChEMBL	Inhibitory activity against human carbonic anhydrase I (hCA I) by using esterase assay method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2004) 14: 3757-3762 [PMID:15203157]
ChEMBL	Inhibition of human carbonic anhydrase-1	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3281-3284 [PMID:26073006]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 5619-5625 [PMID:26233796]
ChEMBL	Inhibition of human carbonic anhydrase-1 incubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 5311-5318 [PMID:26264840]
ChEMBL	Inhibition of human carbonic anhydrase-1 by CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3550-3555 [PMID:26174556]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3850-3853 [PMID:26233435]
ChEMBL	Inhibition of full length human carbonic anhydrase-1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2015) 6: 819-821 [PMID:26191373]
ChEMBL	Inhibition of carbonic anhydrase-1 (unknown origin)	B	6.6	pKi	250	nM	Ki	J Med Chem (2015) 58: 7580-7590 [PMID:26347950]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 expressed in Escherichia coli incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 6573-6580 [PMID:26422787]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 6 hrs by stopped flow carbon-di-oxide hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 6955-6966 [PMID:26432607]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 7219-7225 [PMID:26498393]
ChEMBL	Inhibition of human carbonic anhydrase-1 assessed as CO2 hydration activity by stopped-flow method	B	6.6	pKi	250	nM	Ki	J Med Chem (2015) 58: 8564-8572 [PMID:26497049]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2015) 25: 5636-5641 [PMID:26520662]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 expressed in Escherichia coli preincubated for 6 hrs by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2015) 103: 583-593 [PMID:26408817]
ChEMBL	Inhibition of human CA1 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2015) 25: 5485-5489 [PMID:26525863]
ChEMBL	Inhibition of human carbonic anhydrase-1 preincubated for 15 mins by stopped flow CO2 dehydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 20-25 [PMID:26678172]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-1 by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 921-927 [PMID:26796953]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 894-901 [PMID:26795114]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 982-988 [PMID:26803577]
ChEMBL	Inhibition of human carbonic anhydrase-1 using p-nitrophenyl acetate as substrate by esterase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2016) 26: 1337-1341 [PMID:26804228]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 1095-1105 [PMID:26810710]
ChEMBL	Inhibition of human carbonic anhydrase 1 for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 976-981 [PMID:26810836]
ChEMBL	Inhibition of human Carbonic anhydrase1 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 1115-1120 [PMID:26850377]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 15 mins prior to testing by CO2 hydration-based stopped flow assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2016) 59: 721-732 [PMID:26741028]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 1402-1407 [PMID:26875933]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2016) 26: 1253-1259 [PMID:26832216]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped flow carbon dioxide hydrase assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2016) 110: 259-266 [PMID:26840366]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2016) 26: 1821-1826 [PMID:26920803]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 expressed in Escherichia coli preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 1648-1652 [PMID:26951893]
ChEMBL	Inhibition of human carbonic anhydrase 1 using saturated CO2 as substrate incubated for 10 mins prior to testing by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 2882-2886 [PMID:27137360]
ChEMBL	Inhibition of human recombinant CA1 preincubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 3043-3051 [PMID:27234893]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated for 15 min to 72 hrs by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 2907-2913 [PMID:27166574]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 3413-3417 [PMID:27283786]
ChEMBL	Inhibition of human recombinant CA1 expressed in Escherichia coli preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 3548-3555 [PMID:27298005]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 6 hrs at 4 degC measured for 10 to 100 secs by stopped-flow carbon dioxide hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 3643-3648 [PMID:27316543]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2016) 59: 5462-5470 [PMID:27172398]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2016) 59: 5077-5088 [PMID:27144971]
ChEMBL	Inhibition of human carbonic anhydrase-1 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 4406-4409 [PMID:27469982]
ChEMBL	Inhibition of human CA1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 4100-4107 [PMID:27396930]
ChEMBL	Inhibition of human full length carbonic anhydrase 1	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2016) 26: 5867-5870 [PMID:27884694]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 expressed in Escherichia coli assessed as reduction in CO2 hydration preincubated for 15 mins prior to testing measured for 10 to 100 secs by stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2017) 27: 86-89 [PMID:27876475]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-1 preincubated for 6 hrs by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 677-683 [PMID:27939347]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 1 preincubated for 10 mins prior to testing by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 857-863 [PMID:28024887]
ChEMBL	Inhibition of human erythrocyte carbonic anhydrase 1 preincubated for 15 mins prior to testing by bromothymol blue-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 1260-1265 [PMID:28057408]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-1 using CO2 as substrate preincubated for 10 mins by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 539-544 [PMID:27919611]
ChEMBL	Inhibition of recombinant human erythrocyte cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 1286-1293 [PMID:28065499]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 assessed as reduction in CO2 hydration preincubated for 15 mins by stopped flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 1456-1464 [PMID:28111158]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 1 after 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2017) 127: 691-702 [PMID:27823879]
ChEMBL	Inhibition of recombinant human CA1 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2017) 60: 1159-1170 [PMID:28075587]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2017) 127: 521-530 [PMID:28109946]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-1 assessed as reduction in enzyme-catalyzed hydration activity using CO2 as substrate preincubated for 15 mins followed substrate addition measured after 10 to 100 sec by phenol red dye based stopped flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 1914-1925 [PMID:28237553]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 assessed as inhibition of CO2 hydration incubated for 15 mins prior to testing by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 2010-2015 [PMID:28238511]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2017) 27: 490-495 [PMID:28025002]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 10 mins prior to testing by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 1666-1671 [PMID:28161252]
ChEMBL	Inhibition of recombinant human cytosolic carbonic anhydrase 1 assessed as inhibition of CO2 hydration preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 2210-2217 [PMID:28256371]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2017) 60: 2456-2469 [PMID:28253618]
ChEMBL	Inhibition of recombinant human Carbonic anhydrase 1 assessed as reduction in CO2 hydration preincubated for 15 mins prior to testing measured for 10 to 100 secs by stopped-flow assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2017) 60: 3154-3164 [PMID:28272885]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 2577-2582 [PMID:28343756]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 2569-2576 [PMID:28347633]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-1 assessed as reduction in CO2 hydration preincubated for 10 mins measured for 5 to 10 secs by stopped flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 3583-3589 [PMID:28416101]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 2782-2788 [PMID:28389112]
ChEMBL	Inhibition of recombinant human cytosolic carbonic anhydrase 1 pretreated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 2518-2523 [PMID:28302505]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 10 mins by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 3093-3097 [PMID:28400084]
ChEMBL	Inhibition of human carbonic anhydrase-1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 3555-3561 [PMID:28511911]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 3567-3573 [PMID:28522267]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 2524-2529 [PMID:28318894]
ChEMBL	Inhibition of human CA1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280]
ChEMBL	Inhibition of human CA1 incubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 4800-4804 [PMID:28754318]
ChEMBL	Inhibition of human CA1 pre-incubated for 10 mins by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 5373-5379 [PMID:28789908]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-1 preincubated for 10 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 5726-5732 [PMID:28887000]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 assessed as reduction in CO2 hydration pretreated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2017) 8: 792-796 [PMID:28835790]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2017) 8: 1105-1109 [PMID:29057059]
ChEMBL	Inhibition of human carbonic anhydrase-1 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2017) 8: 1194-1198 [PMID:29152053]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2017) 8: 1213-1217 [PMID:29259736]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2017) 8: 1314-1319 [PMID:29259754]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2018) 61: 5380-5394 [PMID:29851481]
ChEMBL	Inhibition of human carbonic anhydrase 1 after 15 mins by stopped flow carbon dioxide hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2018) 9: 462-467 [PMID:29795760]
ChEMBL	Inhibition of recombinant human cytosolic CA1 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2018) 61: 5765-5770 [PMID:29912561]
ChEMBL	Binding affinity to human carbonic anhydrase 1 by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2018) 9: 725-729 [PMID:30034608]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 assessed as inhibition of CO2 hydration preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2018) 151: 363-375 [PMID:29635168]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 assessed as inhibition of CO2 hydration preincubated for 15 mins prior to testing by phenol red based stopped-flow assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2018) 152: 1-9 [PMID:29684705]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2018) 154: 210-219 [PMID:29803994]
ChEMBL	Binding affinity to human carbonic anhydrase 1 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2018) 155: 545-551 [PMID:29909339]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-1 incubated for 15 mins by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2018) 61: 4961-4977 [PMID:29746127]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2017) 139: 250-262 [PMID:28802125]
ChEMBL	Inhibition of recombinant human full-length carbonic anhydrase 1 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2017) 8: 941-946 [PMID:28947941]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2017) 8: 963-968 [PMID:28947945]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated 15 mins prior to testing by CO2 hydration based stopped-flow assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2018) 9: 947-951 [PMID:30258546]
ChEMBL	Inhibition of cytosolic human carbonic anhydrase 1 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2018) 150: 678-686 [PMID:29571155]
ChEMBL	Inhibition of human CA1 assessed as enzyme inhibitor complex formation preincubated for 15 mins and measured for 10 to 100 secs by phenol red dye based stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2018) 61: 6328-6338 [PMID:29962205]
ChEMBL	Inhibition of recombinant human CA1 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2018) 9: 1035-1038 [PMID:30344913]
ChEMBL	Inhibition of human CA1 by Lineweaver-Burk plot analysis	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2018) 9: 1045-1050 [PMID:30344915]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 assessed as CO2 hydration preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red dye-based stopped-flow assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2018) 156: 430-443 [PMID:30015076]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2018) 157: 28-36 [PMID:30071407]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2018) 157: 1214-1222 [PMID:30193219]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as reduction in CO2 hydration incubated for 1 hr by phenol red staining-based stopped flow assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 183: 111698-111698 [PMID:31539777]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 10 mins prior to testing measured for 5 to 10 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 183: 111702-111702 [PMID:31542715]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 184: 111768-111768 [PMID:31629164]
ChEMBL	Inhibition of recombinant full length human carbonic anhydrase-1 assessed as reduction in CO2 hydration after 15 mins by phenol red dye based stopped flow assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 163: 443-452 [PMID:30530195]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2019) 62: 4174-4192 [PMID:30925064]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 177: 188-197 [PMID:31136893]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2020) 63: 2470-2488 [PMID:31972093]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2019) 62: 7233-7249 [PMID:31287314]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 181: 111565-111565 [PMID:31387062]
ChEMBL	Inhibition of recombinant human CA1 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 181: 111573-111573 [PMID:31394463]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 181: 111586-111586 [PMID:31401537]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as inhibitory constant incubated for 15 mins by phenol red dye based stopped flow assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 182: 111638-111638 [PMID:31472471]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 182: 111642-111642 [PMID:31476557]
ChEMBL	Inhibition of recombinant human CA1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 182: 111600-111600 [PMID:31419777]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 15 mins by phenol red staining-based stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2019) 27: 115086-115086 [PMID:31515057]
ChEMBL	Inhibition of recombinant human carbonic anhydrase1 preincubated for 10 mins followed by CO2 solution addition by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2019) 27: 115090-115090 [PMID:31515058]
ChEMBL	Inhibition of recombinant human CA1 incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2020) 185: 111811-111811 [PMID:31693947]
ChEMBL	Inhibition of full length human CA 1	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 168: 301-314 [PMID:30826507]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as inhibitory constant preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 175: 40-48 [PMID:31071549]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing measured for 5 to 10 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2019) 27: 1588-1594 [PMID:30846402]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as reduction in CO2 hydration after 15 mins by phenol red staining-based stopped flow assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 164: 92-105 [PMID:30594030]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2016) 59: 5857-5867 [PMID:27253845]
ChEMBL	Inhibition of full length human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stop flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2016) 26: 4184-4190 [PMID:27485387]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2016) 26: 3892-3895 [PMID:27423482]
ChEMBL	Inhibition of human CA1 preincubated for 15 mins by stopped-flow carbon dioxide hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2020) 11: 1000-1005 [PMID:32435417]
ChEMBL	Inhibition of human CA1 pre-incubated for 15 mins by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2020) 63: 7392-7409 [PMID:32463228]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated with enzyme for 10 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2020) 11: 633-637 [PMID:32435363]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2020) 11: 727-731 [PMID:32435377]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 6 hrs prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2020) 11: 852-856 [PMID:32435395]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2020) 11: 1022-1027 [PMID:32435420]
ChEMBL	Inhibition of human CA1 preincubated for 15 mins by stopped-flow CO2 hydration kinetic assay based Cheng-Prusoff equation analysis	B	6.6	pKi	250	nM	Ki	J Med Chem (2020) 63: 7422-7444 [PMID:32519851]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as inhibitory constant incubated for 6 hrs by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2020) 28: 115496-115496 [PMID:32327349]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red dye based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2020) 28: 115329-115329 [PMID:32007388]
ChEMBL	Inhibition of recombinant human CA1 expressed in Escherichia coli BL21 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2020) 63: 13064-13075 [PMID:33085484]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2018) 61: 3151-3165 [PMID:29566486]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2020) 188: 112021-112021 [PMID:31901743]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 6 hrs prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2020) 200: 112300-112300 [PMID:32460112]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2020) 200: 112449-112449 [PMID:32485534]
ChEMBL	Inhibition of human CA1 incubated for 15 mins by stopped- flow CO2 hydrase assay method	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2020) 201: 112478-112478 [PMID:32659606]
ChEMBL	Inhibition of human CA1 preincubated for 15 mins prior to testing by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2020) 207: 112745-112745 [PMID:32877804]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 212: 113035-113035 [PMID:33303238]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2021) 37: 127856-127856 [PMID:33609663]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 assessed as inhibition constant preincubated with enzyme for 10 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2020) 28: 115586-115586 [PMID:32631564]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 209: 112875-112875 [PMID:33059188]
ChEMBL	Inhibition of human CA1 incubated for 15 mins by stopped-flow CO2 hydration kinetic assay based Cheng-Prusoff equation analysis	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 214: 113260-113260 [PMID:33581552]
ChEMBL	Inhibition of recombinant human CA1 pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2020) 190: 112112-112112 [PMID:32044580]
ChEMBL	Inhibition of human CA1 by stopped-flow carbon dioxide hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2020) 200: 112439-112439 [PMID:32485532]
ChEMBL	Inhibition of human CA1 measured by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2021) 48: 128249-128249 [PMID:34237441]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2021) 49: 128309-128309 [PMID:34371130]
ChEMBL	Inhibition of recombinant human CA1 pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 218: 113360-113360 [PMID:33773285]
ChEMBL	Inhibition of recombinant human CA1 pre-incubated for 15 mins prior to testing by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 218: 113352-113352 [PMID:33774343]
ChEMBL	Inhibition of recombinant human CA 1 preincubated for 15 mins by measured for 10 to 100 secs by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2021) 45: 128147-128147 [PMID:34052322]
ChEMBL	Inhibition of recombinant human CA1 incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2021) 44: 116279-116279 [PMID:34216985]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 210: 112994-112994 [PMID:33234343]
ChEMBL	Inhibition of human CA1 by stopped- flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 216: 113283-113283 [PMID:33667848]
ChEMBL	Inhibition of human CA1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 217: 113351-113351 [PMID:33744685]
ChEMBL	Inhibition of recombinant human CA1 pre-incubated for 15 mins measured by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2021) 64: 3100-3114 [PMID:33721499]
ChEMBL	Inhibition of human carbonic anhydrase 1 using 4-nitrophenylacetate as substrate by Lineweaver-Burk plot analysis	B	6.69	pKi	204.03	nM	Ki	Bioorg Med Chem (2016) 24: 2318-2329 [PMID:27068142]
ChEMBL	Inhibitory activity against human carbonic anhydrase I (hCA I)	B	6.7	pKi	200	nM	Ki	Bioorg Med Chem Lett (2003) 13: 2867-2873 [PMID:14611846]
ChEMBL	Inhibition of human carbonic anhydrase 1 by Stopped-Flow CO2 Hydrase assay	B	6.7	pKi	200	nM	Ki	J Med Chem (2016) 59: 462-473 [PMID:26688270]
ChEMBL	Inhibition of human CA1 using para-nitrophenylacetate as substrate measured over 3 mins by UV-vis spectrophotometric method	B	6.73	pKi	184.3	nM	Ki	J Med Chem (2015) 58: 640-650 [PMID:25432060]
ChEMBL	Inhibition of human CA-1 using p-nitro-phenylacetate as substrate by Lineweaver-Burk plot analysis	B	6.73	pKi	184.3	nM	Ki	Bioorg Med Chem (2015) 23: 2598-2605 [PMID:25863492]
ChEMBL	Inhibition of human CA1 by stopped-flow assay	B	6.74	pKi	182.09	nM	Ki	Bioorg Med Chem (2021) 39: 116140-116140 [PMID:33905966]
ChEMBL	Inhibition of esterase activity of carbonic anhydrase 1 in human erythrocytes using PNF as substrate by spectrophotometer analysis	B	7.21	pKi	61.1	nM	Ki	Bioorg Med Chem (2015) 23: 3592-3602 [PMID:25921269]
ChEMBL	Inhibition of human carbonic anhydrase 1-catalyzed CO2 hydration preincubated for 10 mins by stopped-flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2014) 22: 2867-2874 [PMID:24746465]
ChEMBL	Inhibition of carbonic anhydrase-1 in human erythrocyte membranes assessed as reduction in H+ release using CO2 as substrate by bromine thymol blue indicator based assay	B	8.05	pKi	8.89	nM	Ki	Bioorg Med Chem (2017) 25: 3547-3554 [PMID:28511907]
ChEMBL	Inhibition of human CAH1 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	8.36	pKi	4.4	nM	Ki	J Med Chem (2021) 64: 1713-1724 [PMID:33523653]
ChEMBL	Inhibition of human carbonic anhydrase-1 preincubated for 15 mins by stopped flow CO2 dehydration method	B	9.6	pKi	0.25	nM	Ki	Bioorg Med Chem (2016) 24: 104-112 [PMID:26682703]
ChEMBL	Inhibition of esterase-activity of CA1 from human erythrocytes by spectrophotometry	B	5.21	pIC50	6100	nM	IC50	Bioorg Med Chem (2010) 18: 930-938 [PMID:20006931]
ChEMBL	Inhibition of CA1 from human erythrocytes by Lineweaver-Burke analysis	B	5.28	pIC50	5200	nM	IC50	Bioorg Med Chem (2010) 18: 930-938 [PMID:20006931]
ChEMBL	Inhibition of human carbonic anhydrase 1 esterase activity by spectrophotometry	B	5.42	pIC50	3800	nM	IC50	Eur J Med Chem (2010) 45: 4769-4773 [PMID:20724038]
ChEMBL	Inhibition of CO2-hydratase activity of human carbonic anhydrase 1 by CO2 hydration method	B	5.43	pIC50	3750	nM	IC50	Bioorg Med Chem (2009) 17: 3295-3301 [PMID:19362844]
ChEMBL	Inhibition of hydratase-activity of CA1 from human erythrocytes by CO2-hydration method	B	5.44	pIC50	3600	nM	IC50	Bioorg Med Chem (2010) 18: 930-938 [PMID:20006931]
ChEMBL	Inhibition of human carbonic anhydrase 1 hydratase activity by spectrophotometry	B	5.51	pIC50	3100	nM	IC50	Eur J Med Chem (2010) 45: 4769-4773 [PMID:20724038]
ChEMBL	Inhibition of esterase activity of human carbonic anhydrase 1 by CO2 hydration method	B	5.54	pIC50	2900	nM	IC50	Bioorg Med Chem (2009) 17: 3295-3301 [PMID:19362844]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as 4-nitrophenyl acetate hydrolysis	B	5.92	pIC50	1210	nM	IC50	Bioorg Med Chem Lett (2008) 18: 2267-2271 [PMID:18353640]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay	B	6.29	pIC50	509.6	nM	IC50	Eur J Med Chem (2013) 62: 597-604 [PMID:23429054]
ChEMBL	Inhibition of human erythrocyte CA1 using 4-nitrophenyl acetate as substrate by spectrophotometry	B	6.44	pIC50	361	nM	IC50	Eur J Med Chem (2020) 198: 112392-112392 [PMID:32388113]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as 4-nitrophenyl phosphate hydrolysis	B	6.48	pIC50	330	nM	IC50	Bioorg Med Chem Lett (2008) 18: 2267-2271 [PMID:18353640]
ChEMBL	Inhibition of human CA-1 using p-nitro-phenylacetate as substrate after 3 mins by UV-Vis spectrophotometry	B	6.5	pIC50	315.5	nM	IC50	Bioorg Med Chem (2015) 23: 2598-2605 [PMID:25863492]
ChEMBL	Inhibition of recombinant human CA1 using 4-nitrophenylacetate as substrate by esterase assay	B	6.52	pIC50	300	nM	IC50	Bioorg Med Chem Lett (2021) 53: 128420-128420 [PMID:34728369]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 using 4-nitrophenylacetate as substrate	B	6.52	pIC50	300	nM	IC50	Bioorg Med Chem Lett (2021) 51: 128291-128291 [PMID:34324968]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 pretreated for 15 mins by stopped flow CO2 hydrase assay	B	6.52	pIC50	299	nM	IC50	Bioorg Med Chem Lett (2014) 24: 2617-2620 [PMID:24813742]
ChEMBL	Inhibition of CA-1 (unknown origin) after 15 mins by CO2 hydration assay	B	6.53	pIC50	295	nM	IC50	Bioorg Med Chem Lett (2014) 24: 3422-3425 [PMID:24948563]
ChEMBL	Inhibitory activity against human carbonic anhydrase I was determined	B	6.6	pIC50	250	nM	IC50	J Med Chem (2004) 47: 550-557 [PMID:14736236]
ChEMBL	Inhibitory activity of compound against human carbonic anhydrase I	F	6.6	pIC50	250	nM	IC50	Bioorg Med Chem Lett (2004) 14: 337-341 [PMID:14698154]
ChEMBL	Inhibition of human carbonic anhydrase 1 using 4-nitrophenylacetate as substrate by spectrophotometric analysis	B	6.68	pIC50	210.11	nM	IC50	Bioorg Med Chem (2016) 24: 2318-2329 [PMID:27068142]
ChEMBL	Inhibition of human CA1 by stopped-flow assay	B	6.71	pIC50	197.1	nM	IC50	Bioorg Med Chem (2021) 39: 116140-116140 [PMID:33905966]
ChEMBL	Inhibition of full length carbonic anhydrase-1 in human erythrocytes	B	6.79	pIC50	161.11	nM	IC50	Bioorg Med Chem Lett (2013) 23: 3496-3499 [PMID:23664215]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration method	B	7.32	pIC50	48	nM	IC50	Bioorg Med Chem Lett (2014) 24: 1941-1943 [PMID:24650641]
ChEMBL	Inhibition of carbonic anhydrase-1 in human erythrocyte membranes assessed as reduction in H+ release using CO2 as substrate by bromine thymol blue indicator based assay	B	8.24	pIC50	5.8	nM	IC50	Bioorg Med Chem (2017) 25: 3547-3554 [PMID:28511907]
ChEMBL	Inhibition of human erythrocyte carbonic anhydrase-1	B	8.24	pIC50	5.8	nM	IC50	Eur J Med Chem (2017) 125: 190-196 [PMID:27657811]
carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 2 expressed in Escherichia coli expression system assessed as observed dissociation constant fluorescent thermal shift assay	B	7.34	pKd	46	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Inhibition of human carbonic anhydrase 2 at pH7 and 37 degC by isothermal titration calorimetry	B	7.34	pKd	46	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Inhibition of human carbonic anhydrase 2 at pH7 and 37 degC by fluorescent thermal shift assay	B	7.42	pKd	38	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to human recombinant CA2 at 37 degC and pH 7.0 by thermal shift assay	B	7.42	pKd	38	nM	Kd	Bioorg Med Chem (2013) 21: 2093-2106 [PMID:23394791]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 2 by isothermal titration calorimetry assay	B	7.74	pKd	18	nM	Kd	Bioorg Med Chem (2010) 18: 7413-7421 [PMID:20889345]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 2 by thermal shift assay	B	7.77	pKd	17	nM	Kd	Bioorg Med Chem (2010) 18: 7413-7421 [PMID:20889345]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 2 by thermal shift assay	B	7.77	pKd	17	nM	Kd	Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428]
ChEMBL	Binding affinity to human full length His-tagged CA2 (1 to 260 residues) expressed in Escherichia coli BL21(DE3) assessed as thermodynamic equilibrium constant at pH 7 by SPR assay	B	7.82	pKd	15	nM	Kd	J Med Chem (2018) 61: 2292-2302 [PMID:29466001]
ChEMBL	Inhibition of human carbonic anhydrase 2 at pH7 and 25 degC by stopped-flow kinetic inhibition assay	B	8	pKd	10	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 2 expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	B	8.01	pKd	9.8	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Dissociation constant against human Carbonic anhydrase II (HCA II)	B	8.17	pKd	6.8	nM	Kd	J Med Chem (1994) 37: 2100-2105 [PMID:8027991]
ChEMBL	Binding affinity to human full length His-tagged CA2 (1 to 260 residues) expressed in Escherichia coli BL21(DE3) assessed as intrinsic thermodynamic equilibrium constant at pH 7 by SPR assay	B	8.59	pKd	2.6	nM	Kd	J Med Chem (2018) 61: 2292-2302 [PMID:29466001]
ChEMBL	Inhibition of carbonic anhydrase 2 assessed as inhibition of carbon dioxide hydration	B	1.08	pKi	1.08	-	logKi	Eur J Med Chem (2009) 44: 3439-3444 [PMID:19303173]
ChEMBL	Inhibition of esterase activity of human carbonic anhydrase 1 by Lineweaver-Burke plot analysis	B	4.44	pKi	36200	nM	Ki	Bioorg Med Chem (2010) 18: 4468-4474 [PMID:20554206]
ChEMBL	Inhibitory activity against human carbonic anhydrase II at 0.01 uM	B	4.92	pKi	12000	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717]
ChEMBL	Inhibition of human erythrocytes esterase activity of carbonic anhydrase-2 using 4-nitrophenylacetate as substrate after 3 mins by Lineweaver-Burk plot analysis	B	5.43	pKi	3700	nM	Ki	Bioorg Med Chem (2013) 21: 1379-1385 [PMID:23394864]
ChEMBL	Inhibition of human carbonic anhydrase 2 by Lineweaver-Burke plot analysis	B	5.48	pKi	3300	nM	Ki	Eur J Med Chem (2010) 45: 4769-4773 [PMID:20724038]
ChEMBL	Inhibition of human carbonic anhydrase 2 by Lineweaver-Burke plot	B	5.7	pKi	2000	nM	Ki	Bioorg Med Chem (2009) 17: 3295-3301 [PMID:19362844]
ChEMBL	Inhibition of human erythrocyte CA2 esterase activity using 4-nitrophenyl acetate substrate	B	6.43	pKi	370	nM	Ki	Bioorg Med Chem (2009) 17: 3207-3211 [PMID:19231207]
ChEMBL	Inhibition of human erythrocytes CA2 using 4-nitrophenylacetate as substrate by esterase assay	B	6.43	pKi	370	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3261-3263 [PMID:26073005]
ChEMBL	Inhibition of human carbonic anhydrase 2 esterase activity using 4-nitrophenylacetate as substrate	B	6.43	pKi	370	nM	Ki	Bioorg Med Chem Lett (2012) 22: 1352-1357 [PMID:22230050]
ChEMBL	Inhibition of human carbonic anhydrase 2 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis	B	6.43	pKi	370	nM	Ki	Eur J Med Chem (2012) 49: 68-73 [PMID:22245047]
ChEMBL	Inhibition of human carbonic anhydrase 2-catalyzed CO2 hydration preincubated for 10 mins by stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 2867-2874 [PMID:24746465]
ChEMBL	Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 2975-2981 [PMID:26007302]
ChEMBL	Inhibition of esterase activity of carbonic anhydrase 2 in human erythrocytes using PNF as substrate by spectrophotometer analysis	B	6.73	pKi	184.3	nM	Ki	Bioorg Med Chem (2015) 23: 3592-3602 [PMID:25921269]
ChEMBL	Inhibition of human CA2 using 4-nitrophenylacetate as substrate preincubated for 10 mins by spectrophotometric esterase assay	B	6.8	pKi	159	nM	Ki	J Med Chem (2012) 55: 6776-6783 [PMID:22775345]
ChEMBL	Inhibition of human erythrocyte CA2 using 4-nitrophenyl acetate as substrate by Lineweaver-Burk plot analysis	B	6.87	pKi	135	nM	Ki	Eur J Med Chem (2020) 198: 112392-112392 [PMID:32388113]
ChEMBL	Inhibition of recombinant human CA2 pre-incubated for 15 mins measured by stopped flow CO2 hydration assay	B	6.9	pKi	125	nM	Ki	J Med Chem (2021) 64: 3100-3114 [PMID:33721499]
ChEMBL	Inhibition of human recombinant CA2 by stopped flow CO2 hydration assay	B	6.98	pKi	104	nM	Ki	J Med Chem (2009) 52: 4063-4067 [PMID:19438226]
ChEMBL	Inhibition of human CA2 by stopped-flow assay	B	6.98	pKi	103.6	nM	Ki	Bioorg Med Chem (2021) 39: 116140-116140 [PMID:33905966]
ChEMBL	Inhibition of human CA2 using para-nitrophenylacetate as substrate measured over 3 mins by UV-vis spectrophotometric method	B	7.21	pKi	61.1	nM	Ki	J Med Chem (2015) 58: 640-650 [PMID:25432060]
ChEMBL	Inhibition of human CA-2 using p-nitro-phenylacetate as substrate by Lineweaver-Burk plot analysis	B	7.21	pKi	61.1	nM	Ki	Bioorg Med Chem (2015) 23: 2598-2605 [PMID:25863492]
ChEMBL	Inhibition of human wild type carbonic anhydrase 2 Asn67Ile mutant expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay	B	7.27	pKi	54.1	nM	Ki	Bioorg Med Chem (2012) 20: 2208-2213 [PMID:22386980]
ChEMBL	Inhibition of Helicobacter pylori beta-carbonic anhydrase by stopped-flow CO2 hydration assay	B	7.4	pKi	40	nM	Ki	Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983]
ChEMBL	Inhibition of human carbonic anhydrase 2 using 4-nitrophenylacetate as substrate by Lineweaver-Burk plot analysis	B	7.48	pKi	32.91	nM	Ki	Bioorg Med Chem (2016) 24: 2318-2329 [PMID:27068142]
ChEMBL	Inhibition of human wild type carbonic anhydrase 2 Gln92Val mutant expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay	B	7.53	pKi	29.7	nM	Ki	Bioorg Med Chem (2012) 20: 2208-2213 [PMID:22386980]
ChEMBL	Inhibition of recombinant human CA2 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2019) 181: 111573-111573 [PMID:31394463]
ChEMBL	Inhibition of human CA2	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2017) 25: 4560-4565 [PMID:28728897]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 6 hrs prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2020) 63: 3317-3326 [PMID:32031797]
ChEMBL	Dissociation constant against Carbonic anhydrase II was reported in experiment 2	B	7.66	pKi	22	nM	Ki	J Med Chem (2002) 45: 3588-3602 [PMID:12166932]
ChEMBL	The equilibrium dissociation constant of the inhibitor-enzyme complex of human carbonic anhydrase	B	7.66	pKi	22	nM	Ki	J Med Chem (1989) 32: 2510-2513 [PMID:2585439]
ChEMBL	Inhibitory constant value for Carbonic anhydrase II in human determined in esterase assay	B	7.74	pKi	18	nM	Ki	J Med Chem (2005) 48: 1941-1947 [PMID:15771438]
ChEMBL	Inhibition of human carbonic anhydrase 2 using 4-NPA as substrate measured for 3 mins by spectrophotometry	B	7.87	pKi	13.52	nM	Ki	Bioorg Med Chem Lett (2020) 30: 126874-126874 [PMID:31859159]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.89	pKi	12.8	nM	Ki	Eur J Med Chem (2021) 212: 113035-113035 [PMID:33303238]
ChEMBL	Inhibition of recombinant human CA2 pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	7.89	pKi	12.8	nM	Ki	Eur J Med Chem (2021) 225: 113793-113793 [PMID:34507012]
ChEMBL	Inhibition of recombinant human CA2 pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	7.9	pKi	12.5	nM	Ki	Eur J Med Chem (2020) 190: 112112-112112 [PMID:32044580]
ChEMBL	Inhibition of human CA2 preincubated for 15 mins by stopped-flow carbon dioxide hydration assay	B	7.9	pKi	12.5	nM	Ki	ACS Med Chem Lett (2020) 11: 1000-1005 [PMID:32435417]
ChEMBL	Inhibition of human CA2 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.9	pKi	12.5	nM	Ki	Eur J Med Chem (2022) 228: 114008-114008 [PMID:34871842]
ChEMBL	Inhibition of human carbonic anhydrase 2 assessed as reduction in CO2 hydration incubated for 1 hr by phenol red staining-based stopped flow assay	B	7.9	pKi	12.5	nM	Ki	Eur J Med Chem (2019) 183: 111698-111698 [PMID:31539777]
ChEMBL	Inhibition of human CA2 measured after 15 mins by stopped flow carbon dioxide anhydrase assay	B	7.9	pKi	12.5	nM	Ki	Eur J Med Chem (2021) 225: 113800-113800 [PMID:34482273]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.9	pKi	12.5	nM	Ki	Eur J Med Chem (2020) 188: 112021-112021 [PMID:31901743]
ChEMBL	Inhibition of cytosolic carbonic anhydrase 2 (unknown origin) preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.9	pKi	12.5	nM	Ki	Eur J Med Chem (2013) 66: 372-379 [PMID:23827177]
ChEMBL	Inhibition of human carbonic anhydrase 2 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	7.9	pKi	12.5	nM	Ki	Eur J Med Chem (2021) 222: 113589-113589 [PMID:34147910]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.9	pKi	12.5	nM	Ki	Eur J Med Chem (2020) 200: 112449-112449 [PMID:32485534]
ChEMBL	Inhibition of recombinant human CA2 pre-incubated for 15 mins prior to testing by phenol red-based stopped-flow CO2 hydration assay	B	7.9	pKi	12.5	nM	Ki	Eur J Med Chem (2021) 218: 113352-113352 [PMID:33774343]
ChEMBL	Inhibition of human carbonic anhydrase 2 assessed as inhibitory constant incubated for 15 mins by phenol red dye based stopped flow assay	B	7.9	pKi	12.5	nM	Ki	Eur J Med Chem (2019) 182: 111638-111638 [PMID:31472471]
ChEMBL	Inhibition of recombinant human CA2 incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.9	pKi	12.5	nM	Ki	Bioorg Med Chem (2021) 44: 116279-116279 [PMID:34216985]
ChEMBL	Mean inhibitory constant towards human carbonic anhydrase II determined by stopped-flow method	B	7.91	pKi	12.3	nM	Ki	Bioorg Med Chem Lett (2005) 15: 2315-2320 [PMID:15837316]
ChEMBL	Inhibition of human carbonic anhydrase 2 using saturated CO2 as substrate incubated for 10 mins prior to testing by stopped-flow CO2 hydrase assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem (2016) 24: 2882-2886 [PMID:27137360]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2019) 181: 111565-111565 [PMID:31387062]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2019) 181: 111586-111586 [PMID:31401537]
ChEMBL	Inhibition of human recombinant CA2 preincubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem (2016) 24: 3043-3051 [PMID:27234893]
ChEMBL	Inhibition of recombinant human CA2 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2019) 182: 111600-111600 [PMID:31419777]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 preincubated for 15 min to 72 hrs by stopped flow CO2 hydrase assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem (2016) 24: 2907-2913 [PMID:27166574]
ChEMBL	Inhibition of human CA-2 by stopped flow CO2 hydrase assay	B	7.92	pKi	12.1	nM	Ki	J Med Chem (2014) 57: 9673-9686 [PMID:25358036]
ChEMBL	Inhibition of recombinant human Carbonic anhydrase 2 assessed as reduction in CO2 hydration preincubated for 15 mins prior to testing measured for 10 to 100 secs by stopped-flow assay	B	7.92	pKi	12.1	nM	Ki	J Med Chem (2017) 60: 3154-3164 [PMID:28272885]
ChEMBL	Inhibition of human carbonic anhydrase-2 incubated for 10 mins prior to testing by stopped-flow CO2 hydrase assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3208-3212 [PMID:26105196]
ChEMBL	Inhibition of human CA2 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2022) 228: 113997-113997 [PMID:34902732]
ChEMBL	Inhibition of human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem Lett (2016) 26: 3892-3895 [PMID:27423482]
ChEMBL	Inhibition of human CA2 pre-incubated for 15 mins by stopped flow CO2 hydrase assay	B	7.92	pKi	12.1	nM	Ki	J Med Chem (2020) 63: 7392-7409 [PMID:32463228]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	J Med Chem (2017) 60: 2456-2469 [PMID:28253618]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	ACS Med Chem Lett (2020) 11: 727-731 [PMID:32435377]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 6 hrs prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	ACS Med Chem Lett (2020) 11: 852-856 [PMID:32435395]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 by stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2021) 221: 113486-113486 [PMID:33965860]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem (2014) 22: 3684-3695 [PMID:24878360]
ChEMBL	Inhibition of human CA2 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	J Med Chem (2022) 65: 824-837 [PMID:34958217]
ChEMBL	Inhibition of recombinant human CA2 expressed in Escherichia coli BL21 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	J Med Chem (2020) 63: 13064-13075 [PMID:33085484]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 by stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	J Med Chem (2018) 61: 3151-3165 [PMID:29566486]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 10 mins prior to testing by stopped flow CO2 hydrase assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem (2017) 25: 1666-1671 [PMID:28161252]
ChEMBL	Inhibition of human erythrocyte carbonic anhydrase 2 preincubated for 15 mins prior to testing by bromothymol blue-based stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem (2017) 25: 1260-1265 [PMID:28057408]
ChEMBL	Inhibition of human CA2 incubated for 15 mins by stopped- flow CO2 hydrase assay method	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2020) 201: 112478-112478 [PMID:32659606]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-2 using CO2 as substrate preincubated for 10 mins by stopped-flow CO2 hydrase assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem (2017) 25: 539-544 [PMID:27919611]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 by stopped flow CO2 hydrase assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem Lett (2021) 37: 127856-127856 [PMID:33609663]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 assessed as inhibition constant preincubated with enzyme for 10 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	>12.1	nM	Ki	Bioorg Med Chem (2020) 28: 115586-115586 [PMID:32631564]
ChEMBL	Inhibition of recombinant human erythrocyte cytosolic carbonic anhydrase 2 by stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem (2017) 25: 1286-1293 [PMID:28065499]
ChEMBL	Inhibition of human CA2 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2021) 217: 113351-113351 [PMID:33744685]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 10 mins by CO2 hydration stopped-flow assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem (2013) 21: 5228-5232 [PMID:23842519]
ChEMBL	Inhibition of human CA2 by stopped-flow carbon dioxide hydration assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2020) 200: 112439-112439 [PMID:32485532]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 2 after 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2017) 127: 691-702 [PMID:27823879]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 by stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem Lett (2021) 49: 128309-128309 [PMID:34371130]
ChEMBL	Inhibition of recombinant human CA2 preincubated for 15 mins by measured for 10 to 100 secs by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem Lett (2021) 45: 128147-128147 [PMID:34052322]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2014) 84: 240-246 [PMID:25019479]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2014) 87: 186-196 [PMID:25255434]
ChEMBL	Inhibition of human CA2 incubated for 15 mins prior to testing by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2022) 228: 114026-114026 [PMID:34920169]
ChEMBL	Inhibition of human CA2 pre-incubated for 10 mins by stopped-flow CO2 hydrase assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem (2017) 25: 5373-5379 [PMID:28789908]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-2 preincubated for 10 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem (2017) 25: 5726-5732 [PMID:28887000]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem (2014) 22: 141-147 [PMID:24332658]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins by stopped flow CO2 hydrase assay	B	7.92	pKi	12.1	nM	Ki	ACS Med Chem Lett (2017) 8: 1213-1217 [PMID:29259736]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem (2017) 25: 3567-3573 [PMID:28522267]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-2-mediated CO2 hydration preincubated for 10 mins by stopped-flow assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem (2013) 21: 1386-1391 [PMID:23352754]
ChEMBL	Inhibition of recombinant human CA2 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	J Med Chem (2018) 61: 5765-5770 [PMID:29912561]
ChEMBL	Binding affinity to human carbonic anhydrase 2 by stopped flow CO2 hydration method	B	7.92	pKi	12.1	nM	Ki	ACS Med Chem Lett (2018) 9: 725-729 [PMID:30034608]
ChEMBL	Inhibition of human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2018) 154: 210-219 [PMID:29803994]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 expressed in Escherichia coli pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem (2015) 23: 2368-2376 [PMID:25846066]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-2 incubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.92	pKi	12.1	nM	Ki	J Med Chem (2018) 61: 4961-4977 [PMID:29746127]
ChEMBL	Inhibition of human carbonic anhydrase 2 incubated for 15 mins prior to testing by CO2 hydration-based stopped flow assay	B	7.92	pKi	12.1	nM	Ki	J Med Chem (2016) 59: 721-732 [PMID:26741028]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 by stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem (2014) 22: 1873-1882 [PMID:24560737]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	ACS Med Chem Lett (2017) 8: 963-968 [PMID:28947945]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated 15 mins prior to testing by CO2 hydration based stopped-flow assay	B	7.92	pKi	12.1	nM	Ki	ACS Med Chem Lett (2018) 9: 947-951 [PMID:30258546]
ChEMBL	Inhibition of cytosolic human carbonic anhydrase 2 by stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2018) 150: 678-686 [PMID:29571155]
ChEMBL	Inhibition of recombinant human CA2 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	ACS Med Chem Lett (2018) 9: 1035-1038 [PMID:30344913]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 assessed as CO2 hydration preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red dye-based stopped-flow assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2018) 156: 430-443 [PMID:30015076]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1310-1314 [PMID:24507918]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2018) 157: 1214-1222 [PMID:30193219]
ChEMBL	Inhibition of human carbonic anhydrase 2 incubated for 10 mins prior to testing measured for 5 to 10 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2019) 183: 111702-111702 [PMID:31542715]
ChEMBL	Inhibition of human carbonic anhydrase 2-mediated CO2 hydration preincubated for 10 mins by stopped-flow assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2014) 76: 284-290 [PMID:24589484]
ChEMBL	Inhibition of recombinant full length human carbonic anhydrase-2 assessed as reduction in CO2 hydration after 15 mins by phenol red dye based stopped flow assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2019) 163: 443-452 [PMID:30530195]
ChEMBL	Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	J Med Chem (2021) 64: 11432-11444 [PMID:34283610]
ChEMBL	Inhibition of human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	7.92	pKi	12.1	nM	Ki	Eur J Med Chem (2019) 177: 188-197 [PMID:31136893]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 min by CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2011) 54: 1896-1902 [PMID:21361354]
ChEMBL	Inhibition of human carbonic anhydrase 2 after 15 mins by Lineweaver-Burk plot	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2011) 19: 1847-1851 [PMID:21377369]
ChEMBL	Inhibition of human carbonic anhydrase 2 after 15 mins by CO2 hydrase assay at pH 7.5	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2011) 19: 1847-1851 [PMID:21377369]
ChEMBL	Inhibition of human recombinant alpha-carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2011) 54: 1682-1692 [PMID:21332115]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2011) 21: 2521-2526 [PMID:21402476]
ChEMBL	Inhibition of human carbonic anhydrase 2 after 6 hrs by Lineweaver-Burk plot analysis	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2011) 21: 2515-2520 [PMID:21420862]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay at pH 8.3	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2011) 21: 3591-3595 [PMID:21570835]
ChEMBL	Inhibition of human CA2 by CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2011) 21: 3216-3221 [PMID:21549597]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2009) 19: 3170-3173 [PMID:19435663]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated with compound for 15 mins by carbon dioxide hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2011) 54: 3977-3981 [PMID:21506569]
ChEMBL	Inhibition of human full length cytosolic isoform of carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2011) 21: 2975-2979 [PMID:21470859]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2011) 19: 3732-3738 [PMID:21620713]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2011) 19: 3105-3119 [PMID:21515057]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 at pH 7.5 by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2011) 19: 5023-5030 [PMID:21757360]
ChEMBL	Inhibition of human cloned carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2011) 46: 4403-4410 [PMID:21820216]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins at pH 7.5 by stopped flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5210-5213 [PMID:21821413]
ChEMBL	Inhibition of human recombinant CA2 by CO2 hydration based stopped flow assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2011) 54: 6905-6918 [PMID:21851094]
ChEMBL	Inhibition of human carbonic anhydrase 2-catalyzed CO2 hydration activity by stopped flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5892-5896 [PMID:21852133]
ChEMBL	Inhibition of human cloned carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2012) 20: 2392-2404 [PMID:22370338]
ChEMBL	Inhibition of human CA2 pre-incubated for 15 mins by stopped-flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	J Med Chem (2012) 55: 1721-1730 [PMID:22276570]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method	B	7.92	pKi	12	nM	Ki	J Med Chem (2012) 55: 3513-3520 [PMID:22424239]
ChEMBL	Inhibition of human recombinant full length CA2-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2012) 55: 3891-3899 [PMID:22443141]
ChEMBL	Inhibition of human CA2 using CO2 as substrate incubated for 6 hrs prior to substrate addition measured for 10 to 100 secs by stopped flow technique	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2012) 22: 5801-5806 [PMID:22901388]
ChEMBL	Inhibition of full length human CA2 cytosolic isoform preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2012) 55: 6776-6783 [PMID:22775345]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2012) 22: 7142-7145 [PMID:23072866]
ChEMBL	Inhibition of human recombinant wild type CA2 by stopped-flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2013) 23: 256-260 [PMID:23200251]
ChEMBL	Inhibition of full length human recombinant CA2 cytosolic isoform after 6 hrs by stopped-flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	J Med Chem (2013) 56: 293-300 [PMID:23241068]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2013) 56: 1761-1771 [PMID:23391336]
ChEMBL	Inhibition of human CA2 by stopped-flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2013) 23: 715-719 [PMID:23265898]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2013) 21: 1465-1469 [PMID:23078755]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 10 mins by CO2 hydration stopped-flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2013) 21: 1451-1464 [PMID:23168081]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase-2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2013) 23: 1626-1630 [PMID:23414801]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2013) 21: 1396-1403 [PMID:23290254]
ChEMBL	Inhibition of human carbonic anhydrase-2 cytosolic isoform after 15 mins by Stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2013) 21: 2314-2318 [PMID:23490152]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2013) 21: 1534-1538 [PMID:22883029]
ChEMBL	Inhibition of recombinant human CA2 cytosolic isoform preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2013) 56: 4691-4700 [PMID:23647428]
ChEMBL	Inhibition of human carbonic anhydrase-2 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2013) 21: 2925-2931 [PMID:23623256]
ChEMBL	Inhibition of human recombinant CA2 by CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2013) 23: 4067-4071 [PMID:23769640]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins to 6 hrs by CO2 hydration stopped-flow assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2013) 56: 5773-5781 [PMID:23815159]
ChEMBL	Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2013) 21: 3949-3957 [PMID:23706268]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 after 6 hrs by stopped flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2013) 21: 4502-4510 [PMID:23769167]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2013) 21: 5130-5138 [PMID:23859774]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2013) 21: 5168-5174 [PMID:23867389]
ChEMBL	Inhibition of recombinant human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2013) 21: 5799-5805 [PMID:23910989]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175]
ChEMBL	Inhibition of human carbonic anhydrase2 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2013) 21: 7210-7215 [PMID:24090602]
ChEMBL	Inhibition of full length human cytosolic carbonic anhydrase-2 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2013) 56: 8512-8520 [PMID:24128000]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2013) 23: 6706-6710 [PMID:24210500]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2013) 23: 6759-6763 [PMID:24189056]
ChEMBL	Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2013) 56: 9623-9634 [PMID:24200125]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2014) 71: 105-111 [PMID:24287559]
ChEMBL	Inhibition of human CA2 cytosolic isoform preincubated for 15 mins by stopped-flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2014) 22: 334-340 [PMID:24300919]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2014) 24: 275-279 [PMID:24314394]
ChEMBL	Inhibition of human CA2 cytosolic isoform after 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2014) 71: 135-147 [PMID:24291567]
ChEMBL	Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1127-1132 [PMID:24461298]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 2 after 6 hrs by stopped flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2014) 22: 1522-1528 [PMID:24513186]
ChEMBL	Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2014) 22: 1821-1831 [PMID:24560739]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2-mediated CO2 hydration after 6 hrs by stopped-flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1256-1260 [PMID:24518190]
ChEMBL	Inhibition of human recombinant cytosolic human carbonic anhydrase-2 incubated for 15 mins prior to testing by stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1776-1779 [PMID:24589511]
ChEMBL	Inhibition of human carbonic anhydrase 2-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2014) 22: 2643-2647 [PMID:24713308]
ChEMBL	Inhibition of human carbonic anhydrase-2 by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2014) 22: 2939-2946 [PMID:24792813]
ChEMBL	Inhibition of human cloned cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2014) 82: 47-55 [PMID:24871996]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2014) 22: 6768-6775 [PMID:25468040]
ChEMBL	Inhibition of human carbonic anhydrase 2 by stopped flow CO2 hydrase assay method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2014) 22: 6945-6952 [PMID:25456084]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2014) 24: 4006-4010 [PMID:25011913]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2014) 22: 3982-3988 [PMID:25027802]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	ACS Med Chem Lett (2014) 5: 793-796 [PMID:25050167]
ChEMBL	Inhibition of human carbonic anhydrase 2 by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	ACS Med Chem Lett (2014) 5: 826-830 [PMID:25050173]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase Assay	B	7.92	pKi	12	nM	Ki	ACS Med Chem Lett (2014) 5: 927-930 [PMID:25147616]
ChEMBL	Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2014) 24: 5185-5189 [PMID:25442309]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	J Med Chem (2014) 57: 9152-9167 [PMID:25310626]
ChEMBL	Inhibition of human full length CA2 by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2014) 22: 6353-6359 [PMID:25438758]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2014) 24: 4389-4396 [PMID:25168745]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2014) 24: 4402-4406 [PMID:25168748]
ChEMBL	Inhibition of human recombinant Carbonic anhydrase 2 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2014) 22: 4537-4543 [PMID:25129169]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2014) 22: 5133-5140 [PMID:25194929]
ChEMBL	Inhibition of human CA-2 after 15 mins by stopped-flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2014) 22: 5883-5890 [PMID:25267005]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2015) 23: 526-531 [PMID:25533402]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2015) 23: 1728-1734 [PMID:25773015]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 by stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2015) 23: 1430-1436 [PMID:25753329]
ChEMBL	Inhibition of human carbonic anhydrase 2 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2015) 23: 2303-2309 [PMID:25882523]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2015) 23: 1421-1429 [PMID:25757603]
ChEMBL	Inhibition of human recombinant CA-2 after 15 mins by stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2015) 23: 1828-1840 [PMID:25766630]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 by CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2015) 58: 1494-1501 [PMID:25581127]
ChEMBL	Inhibition of human cytosolic form of carbonic anhydrase-2 assessed as CO2 hydration activity incubated for 15 mins prior to testing by stopped flow method	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2015) 96: 425-435 [PMID:25912674]
ChEMBL	Inhibition of human recombinant carbonic anhdydrase-2 expressed in Escherichia coli pre-incubated for 6 hrs by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2015) 58: 3975-3983 [PMID:25875209]
ChEMBL	Inhibition of human carbonic anhydrase-2 pre-incubated for 15 mins by stopped-flow CO2 hydration assay based Lineweaver-Burk plot method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2015) 23: 3674-3680 [PMID:25921266]
ChEMBL	Inhibition of human CA2 after 15 mins by stopped-flow/Co2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2015) 23: 4405-4409 [PMID:26145820]
ChEMBL	Inhibition of human carbonic anhydrase 2 by by stopped flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2015) 23: 4989-4999 [PMID:26048024]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 expressed in Escherichia coli preincubated for 15 mins by stopped flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2015) 23: 4649-4659 [PMID:26088336]
ChEMBL	Inhibition of human carbonic anhydrase-2 by CO2 hydration reaction based colorimetric stopped-flow method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2015) 23: 4831-4838 [PMID:26068018]
ChEMBL	Inhibition of human recombinant CA2 expressed in Escherichia coli by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2015) 58: 6630-6638 [PMID:26203869]
ChEMBL	Inhibition of human carbonic anhydrase-2	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3281-3284 [PMID:26073006]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-2 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2015) 23: 5619-5625 [PMID:26233796]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-2 by stopped flow CO2 hydrase assay method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3550-3555 [PMID:26174556]
ChEMBL	Inhibition of human carbonic anhydrase-2 incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2015) 23: 5311-5318 [PMID:26264840]
ChEMBL	Inhibition of human carbonic anhydrase-2 by CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3550-3555 [PMID:26174556]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3850-3853 [PMID:26233435]
ChEMBL	Inhibition of full length human carbonic anhydrase-2 by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	ACS Med Chem Lett (2015) 6: 819-821 [PMID:26191373]
ChEMBL	Inhibition of carbonic anhydrase-2 (unknown origin)	B	7.92	pKi	12	nM	Ki	J Med Chem (2015) 58: 7580-7590 [PMID:26347950]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 expressed in Escherichia coli incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2015) 23: 6573-6580 [PMID:26422787]
ChEMBL	Inhibition of human carbonic anhydrase 2 incubated for 6 hrs by stopped flow carbon-di-oxide hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2015) 23: 6955-6966 [PMID:26432607]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2015) 23: 7219-7225 [PMID:26498393]
ChEMBL	Inhibition of human carbonic anhydrase-2 assessed as CO2 hydration activity by stopped-flow method	B	7.92	pKi	12	nM	Ki	J Med Chem (2015) 58: 8564-8572 [PMID:26497049]
ChEMBL	Inhibition of human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2015) 25: 5636-5641 [PMID:26520662]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 expressed in Escherichia coli preincubated for 6 hrs by stopped flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2015) 103: 583-593 [PMID:26408817]
ChEMBL	Inhibition of human CA2 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2015) 25: 5485-5489 [PMID:26525863]
ChEMBL	Inhibition of human carbonic anhydrase-2 preincubated for 15 mins by stopped flow CO2 dehydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2016) 24: 20-25 [PMID:26678172]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-2 by stopped flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2016) 24: 921-927 [PMID:26796953]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2016) 24: 894-901 [PMID:26795114]
ChEMBL	Inhibition of human Carbonic anhydrase2 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2016) 24: 1115-1120 [PMID:26850377]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2016) 24: 982-988 [PMID:26803577]
ChEMBL	Inhibition of human carbonic anhydrase-2 using p-nitrophenyl acetate as substrate by esterase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2016) 26: 1337-1341 [PMID:26804228]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2016) 24: 1095-1105 [PMID:26810710]
ChEMBL	Inhibition of human carbonic anhydrase 2 for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2016) 24: 976-981 [PMID:26810836]
ChEMBL	Inhibition of human carbonic anhydrase 2 by Stopped-Flow CO2 Hydrase assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2016) 59: 462-473 [PMID:26688270]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2016) 24: 1402-1407 [PMID:26875933]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydrase stopped flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2016) 26: 1253-1259 [PMID:26832216]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow carbon dioxide hydrase assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2016) 110: 259-266 [PMID:26840366]
ChEMBL	Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2016) 26: 1821-1826 [PMID:26920803]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 expressed in Escherichia coli preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2016) 24: 1648-1652 [PMID:26951893]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2016) 24: 3413-3417 [PMID:27283786]
ChEMBL	Inhibition of human recombinant CA2 expressed in Escherichia coli preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2016) 24: 3548-3555 [PMID:27298005]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 6 hrs at 4 degC measured for 10 to 100 secs by stopped-flow carbon dioxide hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2016) 24: 3643-3648 [PMID:27316543]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2016) 59: 5462-5470 [PMID:27172398]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2016) 24: 3612-3617 [PMID:27290692]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2016) 59: 5077-5088 [PMID:27144971]
ChEMBL	Inhibition of human carbonic anhydrase-2 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2016) 24: 4406-4409 [PMID:27469982]
ChEMBL	Inhibition of human CA2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2016) 24: 4100-4107 [PMID:27396930]
ChEMBL	Inhibition of human carbonic anhydrase 2 pre-incubated for 15 mins by stopped flow carbon dioxide hydrase assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2016) 59: 10692-10704 [PMID:27933963]
ChEMBL	Inhibition of human full length carbonic anhydrase 2	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2016) 26: 5867-5870 [PMID:27884694]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 expressed in Escherichia coli assessed as reduction in CO2 hydration preincubated for 15 mins prior to testing measured for 10 to 100 secs by stopped-flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2017) 27: 86-89 [PMID:27876475]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-2 preincubated for 6 hrs by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2017) 25: 677-683 [PMID:27939347]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 2 preincubated for 10 mins prior to testing by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2017) 25: 857-863 [PMID:28024887]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 assessed as reduction in CO2 hydration preincubated for 15 mins by stopped flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2017) 25: 1456-1464 [PMID:28111158]
ChEMBL	Inhibition of recombinant human CA2 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2017) 60: 1159-1170 [PMID:28075587]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2017) 127: 521-530 [PMID:28109946]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-2 assessed as reduction in enzyme-catalyzed hydration activity using CO2 as substrate preincubated for 15 mins followed substrate addition measured after 10 to 100 sec by phenol red dye based stopped flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2017) 25: 1914-1925 [PMID:28237553]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 assessed as inhibition of CO2 hydration incubated for 15 mins prior to testing by stopped flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2017) 25: 2010-2015 [PMID:28238511]
ChEMBL	Inhibition of human carbonic anhydrase 2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2017) 27: 490-495 [PMID:28025002]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2017) 25: 2577-2582 [PMID:28343756]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2017) 25: 2569-2576 [PMID:28347633]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-2 assessed as reduction in CO2 hydration preincubated for 10 mins measured for 5 to 10 secs by stopped flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2017) 25: 3583-3589 [PMID:28416101]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2017) 25: 2782-2788 [PMID:28389112]
ChEMBL	Inhibition of recombinant human cytosolic carbonic anhydrase 2 pretreated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2017) 25: 2518-2523 [PMID:28302505]
ChEMBL	Inhibition of human carbonic anhydrase 2 incubated for 10 mins by stopped flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2017) 25: 3093-3097 [PMID:28400084]
ChEMBL	Inhibition of human carbonic anhydrase-2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2017) 25: 3555-3561 [PMID:28511911]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2017) 25: 2524-2529 [PMID:28318894]
ChEMBL	Inhibition of human CA2 by stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280]
ChEMBL	Inhibition of human CA2 incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2017) 25: 4800-4804 [PMID:28754318]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 assessed as reduction in CO2 hydration pretreated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis	B	7.92	pKi	12	nM	Ki	ACS Med Chem Lett (2017) 8: 792-796 [PMID:28835790]
ChEMBL	Inhibition of human carbonic anhydrase-2 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	ACS Med Chem Lett (2017) 8: 1194-1198 [PMID:29152053]
ChEMBL	Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	ACS Med Chem Lett (2017) 8: 1314-1319 [PMID:29259754]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2018) 61: 5380-5394 [PMID:29851481]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 assessed as inhibition of CO2 hydration preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2018) 151: 363-375 [PMID:29635168]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 assessed as inhibition of CO2 hydration preincubated for 15 mins prior to testing by phenol red based stopped-flow assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2018) 152: 1-9 [PMID:29684705]
ChEMBL	Binding affinity to human carbonic anhydrase 2 by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2018) 155: 545-551 [PMID:29909339]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 by stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2017) 139: 250-262 [PMID:28802125]
ChEMBL	Inhibition of recombinant human full-length carbonic anhydrase 2 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	ACS Med Chem Lett (2017) 8: 941-946 [PMID:28947941]
ChEMBL	Inhibition of human CA2 assessed as enzyme inhibitor complex formation preincubated for 15 mins and measured for 10 to 100 secs by phenol red dye based stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2018) 61: 6328-6338 [PMID:29962205]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2018) 157: 28-36 [PMID:30071407]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2019) 184: 111768-111768 [PMID:31629164]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2019) 62: 4174-4192 [PMID:30925064]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2020) 63: 2470-2488 [PMID:31972093]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2019) 62: 7233-7249 [PMID:31287314]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2019) 182: 111642-111642 [PMID:31476557]
ChEMBL	Inhibition of human carbonic anhydrase 2 incubated for 15 mins by phenol red staining-based stopped flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2019) 27: 115086-115086 [PMID:31515057]
ChEMBL	Inhibition of recombinant human carbonic anhydrase2 preincubated for 10 mins followed by CO2 solution addition by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2019) 27: 115090-115090 [PMID:31515058]
ChEMBL	Inhibition of recombinant human CA2 incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2020) 185: 111811-111811 [PMID:31693947]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2019) 162: 147-160 [PMID:30445264]
ChEMBL	Inhibition of full length human CA 2	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2019) 168: 301-314 [PMID:30826507]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing measured for 5 to 10 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2019) 27: 1588-1594 [PMID:30846402]
ChEMBL	Inhibitory activity against human carbonic anhydrase II (hCA II) by using esterase assay method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2004) 14: 3757-3762 [PMID:15203157]
ChEMBL	Inhibition of human carbonic anhydrase 2 assessed as reduction in CO2 hydration after 15 mins by phenol red staining-based stopped flow assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2019) 164: 92-105 [PMID:30594030]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2016) 59: 5857-5867 [PMID:27253845]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stop flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2016) 26: 4184-4190 [PMID:27485387]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 preincubated with enzyme for 10 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	ACS Med Chem Lett (2020) 11: 633-637 [PMID:32435363]
ChEMBL	Inhibition of human CA2 preincubated for 15 mins by stopped-flow CO2 hydration kinetic assay based Cheng-Prusoff equation analysis	B	7.92	pKi	12	nM	Ki	J Med Chem (2020) 63: 7422-7444 [PMID:32519851]
ChEMBL	Inhibition of human carbonic anhydrase 2 assessed as inhibitory constant incubated for 6 hrs by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2020) 28: 115496-115496 [PMID:32327349]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red dye based stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2020) 28: 115329-115329 [PMID:32007388]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 incubated for 6 hrs prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2020) 200: 112300-112300 [PMID:32460112]
ChEMBL	Inhibition of human CA2 preincubated for 15 mins prior to testing by phenol red-based stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2020) 207: 112745-112745 [PMID:32877804]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2021) 209: 112875-112875 [PMID:33059188]
ChEMBL	Inhibition of human CA2 incubated for 15 mins by stopped-flow CO2 hydration kinetic assay based Cheng-Prusoff equation analysis	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2021) 214: 113260-113260 [PMID:33581552]
ChEMBL	Inhibition of human CA2 measured by stopped flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2021) 48: 128249-128249 [PMID:34237441]
ChEMBL	Inhibition of recombinant human CA2 pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2021) 218: 113360-113360 [PMID:33773285]
ChEMBL	Inhibition of human CA2 by stopped- flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2021) 216: 113283-113283 [PMID:33667848]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated with enzyme for 1 hr prior to testing by phenol red-based stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2020) 63: 5185-5200 [PMID:32364386]
ChEMBL	Inhibitory activity against human recombinant carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	J Med Chem (2000) 43: 4884-4892 [PMID:11123998]
ChEMBL	Inhibition against human carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2004) 14: 231-234 [PMID:14684333]
ChEMBL	Compound was evaluated for inhibition against human carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2004) 14: 217-223 [PMID:14684331]
ChEMBL	Inhibition of cloned isozyme, human carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2001) 11: 575-582 [PMID:11229775]
ChEMBL	Inhibition of human carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2004) 14: 225-229 [PMID:14684332]
ChEMBL	Inhibition constant (Ki) against human cloned carbonic anhydrase II (CAH)	B	7.92	pKi	12	nM	Ki	J Med Chem (2003) 46: 2187-2196 [PMID:12747790]
ChEMBL	Inhibition of human recombinant carbonic anhydrase II (CA2)	B	7.92	pKi	12	nM	Ki	J Med Chem (2000) 43: 4542-4551 [PMID:11087579]
ChEMBL	Inhibitory activity against human cloned isoenzyme carbonic anhydrase II (hCA II), by esterase method.	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2003) 13: 837-840 [PMID:12617903]
ChEMBL	Inhibitory activity against human carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2004) 14: 869-873 [PMID:15012984]
ChEMBL	Inhibition of human cytosolic isozyme Carbonic anhydrase II at 20 degree C	B	7.92	pKi	12	nM	Ki	J Med Chem (2004) 47: 1272-1279 [PMID:14971907]
ChEMBL	Inhibitory activity against human cloned carbonic anhydrase II (hCA II)	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2003) 13: 841-845 [PMID:12617904]
ChEMBL	Inhibitory effect on human Carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	J Med Chem (2002) 45: 312-320 [PMID:11784136]
ChEMBL	Inhibition of human carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2003) 13: 1005-1009 [PMID:12643899]
ChEMBL	Inhibitory activity against human carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2004) 14: 2351-2356 [PMID:15081039]
ChEMBL	Inhibitory activity against human recombinant carbonic anhydrase II (CA2)	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2002) 12: 1551-1557 [PMID:12039560]
ChEMBL	Inhibition of human carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	J Med Chem (2003) 46: 2197-2204 [PMID:12747791]
ChEMBL	Inhibition constant evaluated for the inhibition of human CA II (Carbonic anhydrase II)	B	7.92	pKi	12	nM	Ki	J Med Chem (2004) 47: 2337-2347 [PMID:15084132]
ChEMBL	Inhibitory activity against human carbonic anhydrase II.	B	7.92	pKi	12	nM	Ki	J Med Chem (2003) 46: 5471-5477 [PMID:14640555]
ChEMBL	In vitro inhibitory activity against human carbonic anhydrase II (hCAII)	B	7.92	pKi	12	nM	Ki	J Med Chem (2004) 47: 2796-2804 [PMID:15139757]
ChEMBL	Inhibitory activity against Human carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	J Med Chem (2002) 45: 1466-1476 [PMID:11906288]
ChEMBL	Inhibitory activity against Carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	J Med Chem (2005) 48: 2121-2125 [PMID:15771455]
ChEMBL	Inhibitory constant against cytosolic human Carbonic anhydrase II using CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3828-3833 [PMID:16039848]
ChEMBL	Inhibitory activity against human carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3821-3827 [PMID:16039853]
ChEMBL	Inhibitory activity against cytosolic human carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2005) 15: 579-584 [PMID:15664816]
ChEMBL	Inhibitory potency against human cloned Carbonic anhydrase II expressed in Escherichia coli strain BL21	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2005) 15: 367-372 [PMID:15603956]
ChEMBL	Ki value against human carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2005) 15: 971-976 [PMID:15686895]
ChEMBL	Ki value against human carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2005) 15: 971-976 [PMID:15686895]
ChEMBL	Ki value against human carbonic anhydrase II (hCA II)	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2005) 15: 963-969 [PMID:15686894]
ChEMBL	Inhibitory activity against human carbonic anhydrase II (hCAII)	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1149-1154 [PMID:15686931]
ChEMBL	Inhibitory activity against human carbonic anhydrase II expressed in Escherichia coli BL21	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5427-5433 [PMID:15454239]
ChEMBL	Binding affinity towards human cloned carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5781-5786 [PMID:15501040]
ChEMBL	Binding affinity towards human cloned carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5775-5780 [PMID:15501039]
ChEMBL	Inhibitory activity against human Carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	J Med Chem (2004) 47: 5224-5229 [PMID:15456265]
ChEMBL	Inhibitory constant against human Carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3102-3108 [PMID:15905091]
ChEMBL	Inhibition constant against human (cloned) isozyme (hCA II) by CO2 hydration method	B	7.92	pKi	12	nM	Ki	J Med Chem (2005) 48: 4834-4841 [PMID:16033263]
ChEMBL	Inhibition constant against human recombinant carbonic anhydrase II	F	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3302-3306 [PMID:15908201]
ChEMBL	Inhibitory constant against human Carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2005) 15: 2359-2364 [PMID:15837325]
ChEMBL	Inhibitory constant against human Carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2005) 15: 2347-2352 [PMID:15837323]
ChEMBL	Inhibition constant against human carbonic anhydrase II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3096-3101 [PMID:15908204]
ChEMBL	Inhibitory activity against human Carbonic anhydrase II (hCA II)	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4862-4866 [PMID:16168653]
ChEMBL	Inhibitory activity against human cloned Carbonic anhydrase II by the CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4872-4876 [PMID:16165351]
ChEMBL	Inhibitory activity against human recombinant cytosolic CA2	B	7.92	pKi	12	nM	Ki	J Med Chem (2005) 48: 7860-7866 [PMID:16302824]
ChEMBL	Inhibition of recombinant human cytosolic isozyme CA II	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2005) 15: 5192-5196 [PMID:16203142]
ChEMBL	Inhibitory activity against cloned human CA2	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2006) 16: 437-442 [PMID:16290146]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2006) 49: 2117-2126 [PMID:16539401]
ChEMBL	Inhibition of human recombinant CA2	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2006) 16: 2182-2188 [PMID:16459077]
ChEMBL	Inhibition of human CA2	B	7.92	pKi	12	nM	Ki	J Med Chem (2006) 49: 2743-2749 [PMID:16640335]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2006) 49: 5544-5551 [PMID:16942027]
ChEMBL	Inhibition of human cloned CA2 by CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2006) 16: 4846-4851 [PMID:16809036]
ChEMBL	Inhibition of human cloned CA2 by CO2 hydration method	B	7.92	pKi	12	nM	Ki	J Med Chem (2006) 49: 6539-6548 [PMID:17064072]
ChEMBL	Inhibition of human cloned CA2 by stopped-flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibition of human recombinant cytosolic isozyme CA II by stopped-flow CO2 hydrase method	B	7.92	pKi	12	nM	Ki	J Med Chem (2007) 50: 381-388 [PMID:17228881]
ChEMBL	Inhibition of human recombinant isozyme CA2 by CO2 hydration method	B	7.92	pKi	12	nM	Ki	J Med Chem (2007) 50: 1651-1657 [PMID:17343373]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2007) 15: 2298-2311 [PMID:17276072]
ChEMBL	Inhibition of human recombinant CA2 after 15 mins by CO2 hydration stopped flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2007) 17: 2685-2691 [PMID:17376683]
ChEMBL	Inhibition of human cloned CA2 by CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2007) 17: 5032-5035 [PMID:17681760]
ChEMBL	Inhibition of human cloned carbonic anhydrase2 by CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2007) 15: 6975-6984 [PMID:17822907]
ChEMBL	Inhibition of human recombinant CA 2 assessed as CO2 hydration by stopped flow kinetic assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2007) 15: 7229-7236 [PMID:17826101]
ChEMBL	Inhibition of human carbonic anhydrase 2	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human cloned CA2 by CO2 hydration method	B	7.92	pKi	12	nM	Ki	J Med Chem (2008) 51: 1945-1953 [PMID:18307288]
ChEMBL	Inhibition of human full length carbonic anhydrase 2 by stopped flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2008) 18: 3593-3596 [PMID:18501600]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by CO2 hydration stopped-flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2008) 18: 3475-3480 [PMID:18513964]
ChEMBL	Inhibition of human recombinant full length CA2 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human recombinant CA2 by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2009) 17: 553-557 [PMID:19097911]
ChEMBL	Inhibition of human recombinant CA2 by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2273-2276 [PMID:19286378]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	J Med Chem (2009) 52: 2226-2232 [PMID:19317447]
ChEMBL	Inhibition of human recombinant full length CA2 by stopped-flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of human carbonic anhydrase 2 measured by CO2 hydration reaction assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2009) 19: 650-653 [PMID:19121582]
ChEMBL	Inhibition of human recombinant CA2 by stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2009) 17: 1158-1163 [PMID:19124253]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2009) 52: 646-654 [PMID:19193158]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 2 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2008) 18: 6332-6335 [PMID:18990571]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2009) 52: 3116-3120 [PMID:19338333]
ChEMBL	Inhibition of human cloned CA2 by stopped-flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2008) 18: 4282-4286 [PMID:18640037]
ChEMBL	Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL	Inhibition of human recombinant CA2 by stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2008) 51: 7968-7979 [PMID:19053764]
ChEMBL	Inhibition of human erythrocytes carbonic anhydrase 2 by CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2009) 52: 4853-4859 [PMID:19580287]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2642-2645 [PMID:19375309]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983]
ChEMBL	Inhibition of human carbonic anhydrase 2 by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4102-4106 [PMID:19527930]
ChEMBL	Inhibition of human recombinant CA2 by stopped-flow CO2 assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2009) 17: 5054-5058 [PMID:19520577]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 2 by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2009) 17: 4894-4899 [PMID:19539481]
ChEMBL	Inhibition of human full length cytosolic carbonic anhydrase 2 after 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2009) 52: 5990-5998 [PMID:19731956]
ChEMBL	Inhibition of human cloned CA2 by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2009) 52: 6421-6432 [PMID:19827837]
ChEMBL	Inhibition of human recombinant CA2 by stopped-flow hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2009) 19: 6649-6654 [PMID:19846301]
ChEMBL	Inhibition of human recombinant CA2 by stopped flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2010) 53: 850-854 [PMID:20028100]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 expressed in Escherichia coli by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2009) 19: 5825-5828 [PMID:19751975]
ChEMBL	Inhibition of human cloned full length carbonic anhydrase 2 by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4929-4932 [PMID:19651511]
ChEMBL	Inhibition of human CA2 by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow carbon dioxide hydrase assay method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2010) 20: 2178-2182 [PMID:20211561]
ChEMBL	Inhibition of human recombinant CA2 by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2010) 53: 2913-2926 [PMID:20201556]
ChEMBL	Inhibition of full length human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human carbonic anhydrase 2	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3623-3627 [PMID:20478708]
ChEMBL	Inhibition of human cloned carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2010) 45: 2396-2404 [PMID:20202722]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2010) 18: 4873-4878 [PMID:20598552]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of human carbonic anhydrase 2 by stopped flow CO2 hydration method	B	7.92	pKi	12	nM	Ki	J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by CO2 hydration method	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2010) 18: 5498-5503 [PMID:20624682]
ChEMBL	Inhibition of human cloned CA2 after 15 mins by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2010) 45: 3656-3661 [PMID:20554082]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2010) 18: 5081-5089 [PMID:20580561]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2011) 21: 102-105 [PMID:21145236]
ChEMBL	Inhibition of human carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2011) 19: 243-248 [PMID:21163660]
ChEMBL	Inhibition of human recombinant CA2 by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801]
ChEMBL	Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2011) 19: 1172-1178 [PMID:21251841]
ChEMBL	Inhibition of human recombinant CA2 cytosolic isoform by stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem Lett (2011) 21: 1334-1337 [PMID:21300547]
ChEMBL	Inhibition of recombinant human CA2 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2021) 220: 113490-113490 [PMID:33975138]
ChEMBL	Inhibition of human CA2 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2022) 228: 114004-114004 [PMID:34847409]
ChEMBL	Inhibition of carbonic anhydrase-2 in human erythrocyte membranes assessed as reduction in H+ release using CO2 as substrate by bromine thymol blue indicator based assay	B	7.97	pKi	10.7	nM	Ki	Bioorg Med Chem (2017) 25: 3547-3554 [PMID:28511907]
ChEMBL	Inhibition of human carbonic anhydrase 2 after 15 mins by stopped flow carbon dioxide hydration assay	B	8	pKi	10	nM	Ki	ACS Med Chem Lett (2018) 9: 462-467 [PMID:29795760]
ChEMBL	Inhibition of human CA2 by Lineweaver-Burk plot analysis	B	8	pKi	10	nM	Ki	ACS Med Chem Lett (2018) 9: 1045-1050 [PMID:30344915]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 assessed as inhibition of CO2 hydration preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	8	pKi	10	nM	Ki	Bioorg Med Chem (2017) 25: 2210-2217 [PMID:28256371]
ChEMBL	Inhibition of human recombinant CA2 by CO2 hydration stopped flow assay	B	8	pKi	10	nM	Ki	Bioorg Med Chem Lett (2008) 18: 836-841 [PMID:18042384]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8	pKi	10	nM	Ki	ACS Med Chem Lett (2020) 11: 1022-1027 [PMID:32435420]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by dansylamide (DNSA) competition assay	B	8.1	pKi	7.94	nM	Ki	Bioorg Med Chem Lett (2013) 23: 939-943 [PMID:23317571]
ChEMBL	Inhibitory activity against human carbonic anhydrase II	B	8.15	pKi	7	nM	Ki	Bioorg Med Chem Lett (2003) 13: 2867-2873 [PMID:14611846]
ChEMBL	Dissociation constant against Carbonic anhydrase II was reported in experiment 1	B	8.22	pKi	6	nM	Ki	J Med Chem (2002) 45: 3588-3602 [PMID:12166932]
ChEMBL	Inhibitory constant value for Carbonic anhydrase II in human determined in pH-shift assay	B	8.48	pKi	3.3	nM	Ki	J Med Chem (2005) 48: 1941-1947 [PMID:15771438]
ChEMBL	Inhibition of human CAH2 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	9.03	pKi	0.94	nM	Ki	J Med Chem (2021) 64: 1713-1724 [PMID:33523653]
ChEMBL	Inhibition of human carbonic anhydrase-2 preincubated for 15 mins by stopped flow CO2 dehydration method	B	10.92	pKi	0.01	nM	Ki	Bioorg Med Chem (2016) 24: 104-112 [PMID:26682703]
ChEMBL	Inhibition of esterase activity of human carbonic anhydrase 2 by CO2 hydration method	B	5.08	pIC50	8300	nM	IC50	Bioorg Med Chem (2009) 17: 3295-3301 [PMID:19362844]
ChEMBL	Inhibition of human carbonic anhydrase 2 hydratase activity by spectrophotometry	B	5.09	pIC50	8200	nM	IC50	Eur J Med Chem (2010) 45: 4769-4773 [PMID:20724038]
ChEMBL	Inhibition of esterase-activity of human erythrocytes CA2 by spectrophotometry	B	5.35	pIC50	4500	nM	IC50	Bioorg Med Chem (2010) 18: 930-938 [PMID:20006931]
ChEMBL	Inhibition of human carbonic anhydrase 2 esterase activity by spectrophotometry	B	5.39	pIC50	4100	nM	IC50	Eur J Med Chem (2010) 45: 4769-4773 [PMID:20724038]
ChEMBL	Inhibition of CO2-hydratase activity of human carbonic anhydrase 2 by CO2 hydration method	B	5.41	pIC50	3900	nM	IC50	Bioorg Med Chem (2009) 17: 3295-3301 [PMID:19362844]
ChEMBL	Inhibition of human erythrocytes CA2 by Lineweaver-Burke analysis	B	5.42	pIC50	3800	nM	IC50	Bioorg Med Chem (2010) 18: 930-938 [PMID:20006931]
ChEMBL	Inhibition of hydratase-activity of human erythrocytes CA2 by CO2-hydration method	B	5.55	pIC50	2800	nM	IC50	Bioorg Med Chem (2010) 18: 930-938 [PMID:20006931]
ChEMBL	Inhibition of human recombinant N-HA-tagged carbonic anhydrase 2 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after 30 mins by colorimetric analysis	B	5.92	pIC50	1190	nM	IC50	Bioorg Med Chem (2019) 27: 3889-3901 [PMID:31345748]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 10 mM dithiothreitol	B	6.36	pIC50	441	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 1.00 mM dithiothreitol	B	6.44	pIC50	362	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 0.25 mM dithiothreitol	B	6.45	pIC50	351	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 0.10 mM dithiothreitol	B	6.55	pIC50	285	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 0.05 mM dithiothreitol	B	6.55	pIC50	283	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human full length CAH2 expressed in Escherichia coli BL21 (DE3) assessed as reduction in esterase activity using p-nitrophenyl acetate substrate by stopped flow CO2 hydration assay	B	6.62	pIC50	240	nM	IC50	J Med Chem (2021) 64: 1713-1724 [PMID:33523653]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration method	B	6.66	pIC50	220	nM	IC50	Bioorg Med Chem Lett (2014) 24: 1941-1943 [PMID:24650641]
ChEMBL	Inhibition of human erythrocyte CA2 using 4-nitrophenyl acetate as substrate by spectrophotometry	B	6.76	pIC50	175	nM	IC50	Eur J Med Chem (2020) 198: 112392-112392 [PMID:32388113]
ChEMBL	Inhibition of human carbonic anhydrase 2 assessed as conversion of 4-nitrophenyl acetate to 4-nitrophnolate after 5 mins	B	6.82	pIC50	152	nM	IC50	Eur J Med Chem (2010) 45: 1225-1229 [PMID:20036446]
ChEMBL	Inhibition of human CA-2 using p-nitro-phenylacetate as substrate after 3 mins by UV-Vis spectrophotometry	B	6.91	pIC50	123.5	nM	IC50	Bioorg Med Chem (2015) 23: 2598-2605 [PMID:25863492]
ChEMBL	Inhibition of human CA2 by stopped-flow assay	B	6.94	pIC50	115.05	nM	IC50	Bioorg Med Chem (2021) 39: 116140-116140 [PMID:33905966]
ChEMBL	DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA))	B	7	pIC50	101	nM	IC50	DrugMatrix in vitro pharmacology data
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 10 mM beta-mercaptoethanol	B	7.01	pIC50	98.3	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 10 mM threitol	B	7.03	pIC50	92.5	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 1.00 mM threitol	B	7.05	pIC50	89.9	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 0.25 mM threitol	B	7.11	pIC50	77.8	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 1.00 mM beta-mercaptoethanol	B	7.16	pIC50	69.7	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 0.10 mM threitol	B	7.16	pIC50	68.6	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 0.01 mM dithiothreitol	B	7.17	pIC50	68	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 assessed as 4-nitrophenyl phosphate hydrolysis	B	7.2	pIC50	63	nM	IC50	Bioorg Med Chem Lett (2008) 18: 2267-2271 [PMID:18353640]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 0.25 mM beta-mercaptoethanol	B	7.22	pIC50	60.4	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 10 mM tris-(carboxyethyl)-phosphine	B	7.25	pIC50	56.5	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 0.10 mM beta-mercaptoethanol	B	7.27	pIC50	53.1	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 0.05 mM beta-mercaptoethanol	B	7.31	pIC50	48.9	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 1.00 mM tris-(carboxyethyl)-phosphine	B	7.32	pIC50	48.3	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 0.25 mM tris-(carboxyethyl)-phosphine	B	7.32	pIC50	48.1	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 0.10 mM tris-(carboxyethyl)-phosphine	B	7.32	pIC50	47.6	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 using p-nitrophenyl acetate as substrate by UV-VIS spectrophotometric analysis	B	7.35	pIC50	45.1	nM	IC50	Eur J Med Chem (2021) 216: 113300-113300 [PMID:33640672]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay	B	7.43	pIC50	37.5	nM	IC50	Eur J Med Chem (2013) 62: 597-604 [PMID:23429054]
ChEMBL	Inhibition of human carbonic anhydrase 2 using 4-nitrophenylacetate as substrate by spectrophotometric analysis	B	7.43	pIC50	36.85	nM	IC50	Bioorg Med Chem (2016) 24: 2318-2329 [PMID:27068142]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 0.05 mM threitol	B	7.44	pIC50	36	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 0.05 mM tris-(carboxyethyl)-phosphine	B	7.46	pIC50	34.3	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human erythrocyte carbonic anhydrase-2 assessed as hydrolysis of 4-nitrophenylacetate	B	7.54	pIC50	29	nM	IC50	J Med Chem (2012) 55: 10909-10917 [PMID:23176597]
ChEMBL	Inhibition of human carbonic anhydrase 2 assessed as 4-nitrophenyl acetate hydrolysis	B	7.55	pIC50	28	nM	IC50	Bioorg Med Chem Lett (2008) 18: 2267-2271 [PMID:18353640]
ChEMBL	Inhibition of human carbonic anhydrase 2 assessed as p-nitrophenyl acetate conversion to p-nitrophenolate anion preincubated for 10 mins prior to substrate addition measured for 20 mins by spectrophotometric analysis	B	7.6	pIC50	25	nM	IC50	J Med Chem (2013) 56: 7997-8007 [PMID:24074025]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 pretreated for 15 mins by stopped flow CO2 hydrase assay	B	7.64	pIC50	23	nM	IC50	Bioorg Med Chem Lett (2014) 24: 2617-2620 [PMID:24813742]
ChEMBL	Inhibition of full length carbonic anhydrase-2 in human erythrocytes	B	7.7	pIC50	20.02	nM	IC50	Bioorg Med Chem Lett (2013) 23: 3496-3499 [PMID:23664215]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 0.01 mM threitol	B	7.73	pIC50	18.5	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 0.01 mM tris-(carboxyethyl)-phosphine	B	7.79	pIC50	16.2	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 2 in presence of 0.01 mM beta-mercaptoethanol	B	7.79	pIC50	16.2	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.8	pIC50	16	nM	IC50	Eur J Med Chem (2021) 210: 112994-112994 [PMID:33234343]
ChEMBL	Inhibition of human recombinant CA2 using 4-nitrophenylacetate as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.8	pIC50	16	nM	IC50	Eur J Med Chem (2013) 66: 1-11 [PMID:23777898]
ChEMBL	Inhibition of human carbonic anhydrase 2 using p-nitrophenyl acetate as substrate by UV-VIS spectrophotometric analysis	B	7.82	pIC50	15	nM	IC50	Bioorg Med Chem (2020) 28: 115424-115424 [PMID:32209296]
ChEMBL	Inhibition of CA-2 (unknown origin) after 15 mins by CO2 hydration assay	B	7.82	pIC50	15	nM	IC50	Bioorg Med Chem Lett (2014) 24: 3422-3425 [PMID:24948563]
ChEMBL	Compound was tested for inhibition of human carbonic anhydrase (hCA II)	B	7.86	pIC50	13.7	nM	IC50	Bioorg Med Chem Lett (2003) 13: 863-865 [PMID:12617909]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 using 4-nitrophenylacetate as substrate pretreated for 15 mins prior to test by spectrophotometric method	B	7.89	pIC50	13	nM	IC50	Eur J Med Chem (2017) 132: 1-10 [PMID:28334643]
ChEMBL	Inhibition of human carbonic anhydrase 2 expressed in Escherichia coli BL21 D3 strain using p-nitrophenyl acetate as substrate by UV/visible spectrophotometry	B	7.89	pIC50	13	nM	IC50	Eur J Med Chem (2018) 155: 13-23 [PMID:29852328]
ChEMBL	Inhibition of recombinant human CA2 using 4-nitrophenylacetate as substrate by esterase assay	B	7.92	pIC50	12	nM	IC50	Bioorg Med Chem Lett (2021) 53: 128420-128420 [PMID:34728369]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 using 4-nitrophenylacetate as substrate	B	7.92	pIC50	12	nM	IC50	Bioorg Med Chem Lett (2021) 51: 128291-128291 [PMID:34324968]
ChEMBL	Inhibitory activity against human carbonic anhydrase II was determined	B	7.92	pIC50	12	nM	IC50	J Med Chem (2004) 47: 550-557 [PMID:14736236]
ChEMBL	Inhibitory activity of compound against human carbonic anhydrase II	F	7.92	pIC50	12	nM	IC50	Bioorg Med Chem Lett (2004) 14: 337-341 [PMID:14698154]
ChEMBL	In vitro inhibition of human Carbonic Anhydrase II	B	8	pIC50	10	nM	IC50	J Med Chem (1989) 32: 2486-2492 [PMID:2810337]
ChEMBL	50% inhibition of human carbonic anhydrase II assayed by CO2 hydration catalyzed by human erythrocytes	B	8	pIC50	10	nM	IC50	J Med Chem (1989) 32: 2548-2554 [PMID:2585443]
ChEMBL	Inhibition of carbonic anhydrase 2 in human erythrocytes by CO2 hydration-based fluorimetric assay	B	8	pIC50	<10	nM	IC50	J Med Chem (2013) 56: 9019-9030 [PMID:24205976]
ChEMBL	In vitro inhibition of purified human erythrocyte carbonic anhydrase II	B	8	pIC50	10	nM	IC50	J Med Chem (1993) 36: 2134-2141 [PMID:8340917]
ChEMBL	50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation at 3 degree C	B	8	pIC50	9.9	nM	IC50	J Med Chem (1989) 32: 2510-2513 [PMID:2585439]
ChEMBL	Inhibition of human carbonic anhydrase 2	B	8.05	pIC50	8.9	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of carbonic anhydrase-2 in human erythrocyte membranes assessed as reduction in H+ release using CO2 as substrate by bromine thymol blue indicator based assay	B	8.17	pIC50	6.7	nM	IC50	Bioorg Med Chem (2017) 25: 3547-3554 [PMID:28511907]
ChEMBL	Inhibition of human erythrocyte carbonic anhydrase-2	B	8.17	pIC50	6.7	nM	IC50	Eur J Med Chem (2017) 125: 190-196 [PMID:27657811]
ChEMBL	Activity against human carbonic anhydrase II	B	8.22	pIC50	6	nM	IC50	J Med Chem (1994) 37: 1646-1651 [PMID:8201598]
ChEMBL	50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation for 4 min at 37 degree C	B	8.47	pIC50	3.4	nM	IC50	J Med Chem (1989) 32: 2510-2513 [PMID:2585439]
ChEMBL	Inhibitory activity towards Carbonic anhydrase II	F	8.47	pIC50	3.4	nM	IC50	J Med Chem (2002) 45: 3588-3602 [PMID:12166932]
Carbonic anhydrase II in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2283] [UniProtKB: P00921]
ChEMBL	Inhibition of bovine erythrocyte carbonic anhydrase 2 using 4-nitrophenyl acetate substrate by photometric assay	B	6.86	pKi	137	nM	Ki	Eur J Med Chem (2014) 86: 95-102 [PMID:25147151]
ChEMBL	Inhibition of bovine erythrocyte carbonic anhydrase 2 using p-nitrophenyl acetate as substrate preincubated for 10 mins before substrate addition measured after 30 mins by spectrophotometric analysis	B	6.02	pIC50	960	nM	IC50	Eur J Med Chem (2014) 78: 140-150 [PMID:24681391]
ChEMBL	Inhibition of bovine carbonic anhydrase 2 assessed as hydrolysis of p-nitrophenyl acetate after 30 mins by spectrophotometric method	B	6.02	pIC50	960	nM	IC50	Bioorg Med Chem (2015) 23: 2435-2444 [PMID:25865133]
Carbonic anhydrase III in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2885] [UniProtKB: P07451]
ChEMBL	Inhibition of human carbonic anhydrase 3 at pH7 and 37 degC by fluorescent thermal shift assay	B	4.4	pKd	40000	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 3 expressed in Escherichia coli expression system assessed as observed dissociation constant fluorescent thermal shift assay	B	4.4	pKd	40000	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 3 expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	B	5.34	pKd	4600	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Inhibition of carbonic anhydrase-3 (unknown origin)	B	4.6	pKi	>25000	nM	Ki	J Med Chem (2015) 58: 7580-7590 [PMID:26347950]
ChEMBL	Inhibition of human CA3 by stopped-flow CO2 hydrase assay	B	4.7	pKi	20000	nM	Ki	Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280]
ChEMBL	Inhibition of human carbonic anhydrase 3 preincubated for 15 mins at pH 7.5 by stopped flow CO2 hydration method	B	4.7	pKi	20000	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5210-5213 [PMID:21821413]
ChEMBL	Inhibition of human recombinant carbonic anhydrase3 cytosolic isoform expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	4.7	pKi	20000	nM	Ki	Bioorg Med Chem (2013) 21: 6929-6936 [PMID:24103430]
ChEMBL	Inhibition of human CA3 cytosolic isoform preincubated for 15 mins by stopped-flow CO2 hydration method	B	4.7	pKi	20000	nM	Ki	Bioorg Med Chem (2014) 22: 334-340 [PMID:24300919]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 3 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	4.7	pKi	20000	nM	Ki	Bioorg Med Chem (2014) 22: 6768-6775 [PMID:25468040]
ChEMBL	Inhibition of human CAH3 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	5	pKi	>10000	nM	Ki	J Med Chem (2021) 64: 1713-1724 [PMID:33523653]
ChEMBL	Inhibition of recombinant human CA3 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	5	pKi	>10000	nM	Ki	ACS Med Chem Lett (2018) 9: 1035-1038 [PMID:30344913]
ChEMBL	Inhibition of human carbonic anhydrase 3 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	5	pKi	>10000	nM	Ki	Eur J Med Chem (2019) 177: 188-197 [PMID:31136893]
ChEMBL	Inhibition of human carbonic anhydrase 3	B	8.51	pKi	3.1	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 3 phosphatase activity using 4-nitrophenyl phosphate as substrate preincubated for 10 mins prior to substrate addition by stopped flow cytometry	B	5.19	pIC50	6500	nM	IC50	Bioorg Med Chem Lett (2012) 22: 1560-1564 [PMID:22277279]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 3 hydrolysis activity using 4-nitrophenyl acetate as substrate preincubated for 10 mins prior to substrate addition by stopped flow cytometry	B	6.08	pIC50	840	nM	IC50	Bioorg Med Chem Lett (2012) 22: 1560-1564 [PMID:22277279]
carbonic anhydrase 4/Carbonic anhydrase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748]
ChEMBL	Inhibition of human carbonic anhydrase 4 at pH7 and 37 degC by fluorescent thermal shift assay	B	7	pKd	100	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 4 expressed in Escherichia coli expression system assessed as observed dissociation constant fluorescent thermal shift assay	B	7.06	pKd	87	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 4 expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	B	7.92	pKd	12	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Inhibition of human CA4 using 4NPA as substrate for 3 mins by Lineweaver burk plot analysis	B	6.24	pKi	578	nM	Ki	Eur J Med Chem (2012) 54: 423-428 [PMID:22687439]
ChEMBL	Inhibition of human carbonic anhydrase 4 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis	B	6.24	pKi	578	nM	Ki	Eur J Med Chem (2012) 49: 68-73 [PMID:22245047]
ChEMBL	Inhibition of human carbonic anhydrase 4 esterase activity using 4-nitrophenylacetate as substrate	B	6.24	pKi	578	nM	Ki	Bioorg Med Chem Lett (2012) 22: 1352-1357 [PMID:22230050]
ChEMBL	Inhibition of cloned isozyme, human carbonic anhydrase IV	B	6.66	pKi	220	nM	Ki	Bioorg Med Chem Lett (2001) 11: 575-582 [PMID:11229775]
ChEMBL	Inhibition of human carbonic anhydrase 4 assessed as reduction in CO2 hydration preincubated for 15 mins to 2 hrs by phenol red dye based stopped flow CO2 hydrase assay	B	7.12	pKi	75.4	nM	Ki	ACS Med Chem Lett (2019) 10: 1205-1210 [PMID:31413806]
ChEMBL	Inhibition of human carbonic anhydrase 4 incubated for 15 mins by phenol red staining-based stopped flow CO2 hydrase assay	B	7.12	pKi	75	nM	Ki	Bioorg Med Chem (2019) 27: 115086-115086 [PMID:31515057]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-4 using CO2 as substrate preincubated for 10 mins by stopped-flow CO2 hydrase assay	B	7.13	pKi	74.3	nM	Ki	Bioorg Med Chem (2017) 25: 539-544 [PMID:27919611]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 4 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay	B	7.13	pKi	74.2	nM	Ki	J Med Chem (2016) 59: 5462-5470 [PMID:27172398]
ChEMBL	Inhibition of recombinant human CA4 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.13	pKi	74.2	nM	Ki	J Med Chem (2017) 60: 1159-1170 [PMID:28075587]
ChEMBL	Inhibition of human cloned CA4 by stopped-flow CO2 hydration method	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem Lett (2008) 18: 4282-4286 [PMID:18640037]
ChEMBL	Inhibition of human carbonic anhydrase 4 by stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL	Inhibition of human carbonic anhydrase 4 by stopped flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4102-4106 [PMID:19527930]
ChEMBL	Inhibition of human full length membrane-bound carbonic anhydrase 4 after 15 mins by stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	J Med Chem (2009) 52: 5990-5998 [PMID:19731956]
ChEMBL	Inhibition of human recombinant CA4 by stopped flow CO2 hydrase assay	B	7.13	pKi	74	nM	Ki	J Med Chem (2010) 53: 850-854 [PMID:20028100]
ChEMBL	Inhibition of human CA4 by stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318]
ChEMBL	Inhibition of full length human carbonic anhydrase 4 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 4 after 15 mins by stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of human carbonic anhydrase 4 by stopped flow CO2 hydration method	B	7.13	pKi	74	nM	Ki	J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
ChEMBL	Inhibition of human carbonic anhydrase 4 after 15 mins by Lineweaver-Burk plot	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem (2011) 19: 1847-1851 [PMID:21377369]
ChEMBL	Inhibition of human CA4 by CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem Lett (2011) 21: 3216-3221 [PMID:21549597]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 4 preincubated for 15 mins by CO2 hydration method	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem (2011) 19: 3105-3119 [PMID:21515057]
ChEMBL	Inhibition of human carbonic anhydrase 4 preincubated for 15 mins at pH 7.5 by stopped flow CO2 hydration method	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5210-5213 [PMID:21821413]
ChEMBL	Inhibition of human CA4 preincubated for 15 mins by stopped-flow CO2 hydration method	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem (2014) 22: 334-340 [PMID:24300919]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 4 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem (2014) 22: 6768-6775 [PMID:25468040]
ChEMBL	Inhibition of carbonic anhydrase-4 (unknown origin)	B	7.13	pKi	74	nM	Ki	J Med Chem (2015) 58: 7580-7590 [PMID:26347950]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 4 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem (2015) 23: 7219-7225 [PMID:26498393]
ChEMBL	Inhibition of human carbonic anhydrase-4 preincubated for 15 mins by stopped flow CO2 dehydration assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem (2016) 24: 20-25 [PMID:26678172]
ChEMBL	Inhibition of human recombinant CA4 expressed in Escherichia coli preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem (2016) 24: 3548-3555 [PMID:27298005]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 4 preincubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	J Med Chem (2016) 59: 5077-5088 [PMID:27144971]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 4 expressed in Escherichia coli assessed as reduction in CO2 hydration preincubated for 15 mins prior to testing measured for 10 to 100 secs by stopped-flow assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem Lett (2017) 27: 86-89 [PMID:27876475]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 4 assessed as reduction in CO2 hydration preincubated for 15 mins by stopped flow assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem (2017) 25: 1456-1464 [PMID:28111158]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 4 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2017) 127: 521-530 [PMID:28109946]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-4 assessed as reduction in enzyme-catalyzed hydration activity using CO2 as substrate preincubated for 15 mins followed substrate addition measured after 10 to 100 sec by phenol red dye based stopped flow assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem (2017) 25: 1914-1925 [PMID:28237553]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 4 incubated for 10 mins prior to testing by stopped flow CO2 hydrase assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem (2017) 25: 1666-1671 [PMID:28161252]
ChEMBL	Inhibition of recombinant human membrane bound carbonic anhydrase 4 pretreated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem (2017) 25: 2518-2523 [PMID:28302505]
ChEMBL	Inhibition of human CA4 by stopped-flow CO2 hydrase assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 4 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	ACS Med Chem Lett (2017) 8: 1105-1109 [PMID:29057059]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 4 incubated for 15 mins by stopped flow CO2 hydrase assay	B	7.13	pKi	74	nM	Ki	ACS Med Chem Lett (2017) 8: 1213-1217 [PMID:29259736]
ChEMBL	Inhibition of human carbonic anhydrase 4 incubated for 15 mins by stopped flow CO2 hydrase assay	B	7.13	pKi	74	nM	Ki	ACS Med Chem Lett (2017) 8: 1314-1319 [PMID:29259754]
ChEMBL	Inhibition of recombinant human CA4 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	J Med Chem (2018) 61: 5765-5770 [PMID:29912561]
ChEMBL	Inhibition of human membrane-anchored carbonic anhydrase 4 assessed as inhibition of CO2 hydration preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2018) 151: 363-375 [PMID:29635168]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 4 assessed as inhibition of CO2 hydration preincubated for 15 mins prior to testing by phenol red based stopped-flow assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2018) 152: 1-9 [PMID:29684705]
ChEMBL	Binding affinity to human carbonic anhydrase 4 by stopped flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2018) 155: 545-551 [PMID:29909339]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-4 incubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.13	pKi	74	nM	Ki	J Med Chem (2018) 61: 4961-4977 [PMID:29746127]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 4 by stopped-flow CO2 hydrase assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2017) 139: 250-262 [PMID:28802125]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 4 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	ACS Med Chem Lett (2017) 8: 963-968 [PMID:28947945]
ChEMBL	Inhibition of membrane bound human carbonic anhydrase 4 by stopped flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2018) 150: 678-686 [PMID:29571155]
ChEMBL	Inhibition of recombinant human CA4 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	ACS Med Chem Lett (2018) 9: 1035-1038 [PMID:30344913]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 4 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2018) 157: 1214-1222 [PMID:30193219]
ChEMBL	Inhibition of human carbonic anhydrase 4 assessed as reduction in CO2 hydration incubated for 1 hr by phenol red staining-based stopped flow assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2019) 183: 111698-111698 [PMID:31539777]
ChEMBL	Inhibition of human carbonic anhydrase 4 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2019) 177: 188-197 [PMID:31136893]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 4 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	J Med Chem (2019) 62: 7233-7249 [PMID:31287314]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 4 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2019) 181: 111586-111586 [PMID:31401537]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 4 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2019) 182: 111642-111642 [PMID:31476557]
ChEMBL	Inhibition of human CA4 incubated for 15 mins prior to testing by phenol red dye based stopped flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2022) 228: 114026-114026 [PMID:34920169]
ChEMBL	Inhibitory activity against human carbonic anhydrase IV (hCAIV)	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1149-1154 [PMID:15686931]
ChEMBL	Inhibition of human cloned CA4 by stopped-flow CO2 hydration method	B	7.13	pKi	74	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibition of human recombinant CA4 after 15 mins by CO2 hydration stopped flow assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem Lett (2007) 17: 2685-2691 [PMID:17376683]
ChEMBL	Inhibition of human carbonic anhydrase 4	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human full length carbonic anhydrase 4 by stopped flow CO2 hydrase assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human recombinant full length CA4 by stopped flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human recombinant full length CA4 by stopped-flow CO2 hydration method	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of truncated human cloned membrane-associated carbonic anhydrase 4 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem Lett (2008) 18: 6332-6335 [PMID:18990571]
ChEMBL	Inhibition of recombinant human CA4 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2021) 220: 113490-113490 [PMID:33975138]
ChEMBL	Inhibition of recombinant human CA4 pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2021) 225: 113793-113793 [PMID:34507012]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 4 by stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2021) 221: 113486-113486 [PMID:33965860]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 4 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	ACS Med Chem Lett (2020) 11: 727-731 [PMID:32435377]
ChEMBL	Inhibition of human CA4 preincubated for 15 mins by stopped-flow CO2 hydration kinetic assay based Cheng-Prusoff equation analysis	B	7.13	pKi	74	nM	Ki	J Med Chem (2020) 63: 7422-7444 [PMID:32519851]
ChEMBL	Inhibition of recombinant human CA4 expressed in Escherichia coli BL21 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	J Med Chem (2020) 63: 13064-13075 [PMID:33085484]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 4 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2021) 212: 113035-113035 [PMID:33303238]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 4 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Eur J Med Chem (2021) 209: 112875-112875 [PMID:33059188]
ChEMBL	Inhibition of recombinant human CA4 preincubated for 15 mins by measured for 10 to 100 secs by phenol red dye based stopped flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem Lett (2021) 45: 128147-128147 [PMID:34052322]
ChEMBL	Inhibition of recombinant human membrane-associated carbonic anhydrase 4 assessed as inhibition of CO2 hydration preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	7.15	pKi	70	nM	Ki	Bioorg Med Chem (2017) 25: 2210-2217 [PMID:28256371]
GtoPdb	-	-	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 367-72 [PMID:15603956]; Bioorg Med Chem Lett (2010) 20: 4376-81 [PMID:20605094]
ChEMBL	Inhibition of human secreted carbonic anhydrase 4 measured by CO2 hydration reaction assay	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem Lett (2009) 19: 650-653 [PMID:19121582]
ChEMBL	Inhibition of human CAH4 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	8.07	pKi	8.6	nM	Ki	J Med Chem (2021) 64: 1713-1724 [PMID:33523653]
Carbonic anhydrase IV in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL281] [UniProtKB: Q95323]
ChEMBL	Inhibitory activity against bovine carbonic anhydrase IV from lung microsomes	B	6.66	pKi	220	nM	Ki	J Med Chem (2000) 43: 4884-4892 [PMID:11123998]
ChEMBL	Inhibition of bovine carbonic anhydrase IV (CA4) from bovine lung microsomes	B	6.66	pKi	220	nM	Ki	J Med Chem (2000) 43: 4542-4551 [PMID:11087579]
ChEMBL	Inhibition of bovine membrane bound isozyme carbonic anhydrase IV isolated from microsomes at 20 degree C	B	6.66	pKi	220	nM	Ki	J Med Chem (2004) 47: 1272-1279 [PMID:14971907]
ChEMBL	Inhibitory effect on bovine Carbonic anhydrase IV	B	6.66	pKi	220	nM	Ki	J Med Chem (2002) 45: 312-320 [PMID:11784136]
ChEMBL	Inhibitory activity against bovine carbonic anhydrase IV (CA4), obtained from bovine lung microsomes	B	6.66	pKi	220	nM	Ki	Bioorg Med Chem Lett (2002) 12: 1551-1557 [PMID:12039560]
ChEMBL	In vitro inhibitory activity against bovine carbonic anhydrase IV (CAIV)	B	6.66	pKi	220	nM	Ki	J Med Chem (2004) 47: 2796-2804 [PMID:15139757]
ChEMBL	Inhibitory activity against bovine carbonic anhydrase IV	B	6.66	pKi	220	nM	Ki	J Med Chem (2002) 45: 1466-1476 [PMID:11906288]
ChEMBL	Inhibitory activity against Carbonic anhydrase IV isolated from bovine lung	B	6.92	pKi	120	nM	Ki	Bioorg Med Chem Lett (2003) 13: 2867-2873 [PMID:14611846]
ChEMBL	Inhibitory activity against bovine carbonic anhydrase IV (bCAIV)	B	7.15	pKi	70	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1149-1154 [PMID:15686931]
ChEMBL	Inhibitory activity against bovine carbonic anhydrase isozyme IV isolated from bovine lung microsomes, by esterase assay method.	B	7.15	pKi	70	nM	Ki	Bioorg Med Chem Lett (2003) 13: 1005-1009 [PMID:12643899]
ChEMBL	Compound was evaluated for inhibition against bovine carbonic anhydrase IV	B	7.15	pKi	70	nM	Ki	Bioorg Med Chem Lett (2004) 14: 217-223 [PMID:14684331]
ChEMBL	Inhibition constant against bovine Carbonic anhydrase IV, isolated from lung microsomes	B	7.15	pKi	70	nM	Ki	J Med Chem (2003) 46: 2187-2196 [PMID:12747790]
ChEMBL	Inhibitory activity against CA4 isolated from bovine lung microsomes	B	7.15	pKi	70	nM	Ki	Bioorg Med Chem Lett (2006) 16: 437-442 [PMID:16290146]
ChEMBL	Inhibitory activity against carbonic anhydrase IV from bovine lung microsomes	B	7.15	pKi	70	nM	Ki	Bioorg Med Chem Lett (2004) 14: 869-873 [PMID:15012984]
ChEMBL	Inhibitory activity against carbonic anhydrase isolated from bovine lung microsome (bCA IV)	B	7.15	pKi	70	nM	Ki	Bioorg Med Chem Lett (2003) 13: 841-845 [PMID:12617904]
ChEMBL	Inhibition constant evaluated for the inhibition of bovine CA IV (Carbonic anhydrase IV)	B	7.15	pKi	70	nM	Ki	J Med Chem (2004) 47: 2337-2347 [PMID:15084132]
ChEMBL	Inhibitory activity against bovine carbonic anhydrase IV was determined	B	7.15	pIC50	70	nM	IC50	J Med Chem (2004) 47: 550-557 [PMID:14736236]
ChEMBL	Inhibitory activity of compound against bovine carbonic anhydrase IV	F	7.15	pIC50	70	nM	IC50	Bioorg Med Chem Lett (2004) 14: 337-341 [PMID:14698154]
carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
ChEMBL	Inhibition of chimeric carbonic anhydrase 9 (unknown origin) expressing with full length CA2 (1 to 260) at pH7 and 37 degC by fluorescent thermal shift assay	B	7.3	pKd	50	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Inhibition of human carbonic anhydrase 9 at pH7 and 37 degC by isothermal titration calorimetry	B	7.66	pKd	22	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 9 expressed in mammalian cell expression system assessed as observed dissociation constant fluorescent thermal shift assay	B	7.68	pKd	21	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Inhibition of human carbonic anhydrase 9 at pH7 and 37 degC by fluorescent thermal shift assay	B	7.7	pKd	20	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Inhibition of chimeric carbonic anhydrase 9 (unknown origin) expressing with full length CA2 (1 to 260) at pH7 and 37 degC by isothermal titration calorimetry	B	7.85	pKd	14	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to human CA9 catalytic domain expressed in mammalian expression system assessed as thermodynamic equilibrium constant at pH 7 by SPR assay	B	8.07	pKd	8.5	nM	Kd	J Med Chem (2018) 61: 2292-2302 [PMID:29466001]
ChEMBL	Inhibition of human carbonic anhydrase 9 at pH7 and 25 degC by stopped-flow kinetic inhibition assay	B	8.17	pKd	6.7	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Inhibition of chimeric carbonic anhydrase 9 (unknown origin) expressing with full length CA2 (1 to 260) at pH7 and 25 degC by stopped-flow kinetic inhibition assay	B	8.3	pKd	<5	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 9 expressed in mammalian cell expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	B	8.54	pKd	2.9	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Binding affinity to human CA9 catalytic domain expressed in mammalian expression system assessed as intrinsic thermodynamic equilibrium constant at pH 7 by SPR assay	B	9	pKd	1	nM	Kd	J Med Chem (2018) 61: 2292-2302 [PMID:29466001]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	4.6	pKi	25000	nM	Ki	Eur J Med Chem (2020) 186: 111896-111896 [PMID:31784185]
ChEMBL	Inhibitory activity against human carbonic anhydrase IX at 0.09 uM	B	4.6	pKi	25000	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717]
ChEMBL	Inhibition of recombinant human tumor-associated carbonic anhydrase 9 assessed as inhibition of CO2 hydration preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	7.52	pKi	30	nM	Ki	Bioorg Med Chem (2017) 25: 2210-2217 [PMID:28256371]
ChEMBL	Inhibition of human CA9 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.59	pKi	26	nM	Ki	Eur J Med Chem (2022) 228: 114008-114008 [PMID:34871842]
ChEMBL	Inhibition of recombinant human CA9 incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.59	pKi	26	nM	Ki	Eur J Med Chem (2020) 185: 111811-111811 [PMID:31693947]
ChEMBL	Inhibition of recombinant human carbonic anhydrase9 preincubated for 10 mins followed by CO2 solution addition by phenol red dye based stopped flow CO2 hydration assay	B	7.59	pKi	26	nM	Ki	Bioorg Med Chem (2019) 27: 115090-115090 [PMID:31515058]
ChEMBL	Inhibition of recombinant human CA9 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	7.59	pKi	26	nM	Ki	Eur J Med Chem (2021) 220: 113490-113490 [PMID:33975138]
ChEMBL	Inhibition of human CA9 measured after 15 mins by stopped flow carbon dioxide anhydrase assay	B	7.59	pKi	26	nM	Ki	Eur J Med Chem (2021) 225: 113800-113800 [PMID:34482273]
ChEMBL	Inhibition of human CA9 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	J Med Chem (2022) 65: 824-837 [PMID:34958217]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	J Med Chem (2019) 62: 7233-7249 [PMID:31287314]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2019) 181: 111586-111586 [PMID:31401537]
ChEMBL	Inhibition of human CA9 pre-incubated for 10 mins by stopped-flow CO2 hydrase assay	B	7.59	pKi	25.8	nM	Ki	Bioorg Med Chem (2017) 25: 5373-5379 [PMID:28789908]
ChEMBL	Inhibition of recombinant human CA9 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2019) 182: 111600-111600 [PMID:31419777]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated 15 mins prior to testing by CO2 hydration based stopped-flow assay	B	7.59	pKi	25.8	nM	Ki	ACS Med Chem Lett (2018) 9: 947-951 [PMID:30258546]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 assessed as CO2 hydration preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red dye-based stopped-flow assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2018) 156: 430-443 [PMID:30015076]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2018) 157: 1214-1222 [PMID:30193219]
ChEMBL	Inhibition of human recombinant CA9 preincubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	7.59	pKi	25.8	nM	Ki	Bioorg Med Chem (2016) 24: 3043-3051 [PMID:27234893]
ChEMBL	Inhibition of human carbonic anhydrase 9 incubated for 10 mins prior to testing measured for 5 to 10 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2019) 183: 111702-111702 [PMID:31542715]
ChEMBL	Inhibition of human carbonic anhydrase-9 catalytic domain assessed as reduction in CO2 hydration after 15 mins by phenol red dye based stopped flow assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2019) 163: 443-452 [PMID:30530195]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-9 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay	B	7.59	pKi	25.8	nM	Ki	Bioorg Med Chem (2017) 25: 3567-3573 [PMID:28522267]
ChEMBL	Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2019) 177: 188-197 [PMID:31136893]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 6 hrs prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	ACS Med Chem Lett (2020) 11: 852-856 [PMID:32435395]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 by stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2021) 221: 113486-113486 [PMID:33965860]
ChEMBL	Inhibition of recombinant human CA9 expressed in Escherichia coli BL21 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	J Med Chem (2020) 63: 13064-13075 [PMID:33085484]
ChEMBL	Inhibition of human carbonic anhydrase 9 after 15 mins by stopped flow carbon dioxide hydration assay	B	7.59	pKi	25.8	nM	Ki	ACS Med Chem Lett (2018) 9: 462-467 [PMID:29795760]
ChEMBL	Inhibition of recombinant human CA9 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	J Med Chem (2018) 61: 5765-5770 [PMID:29912561]
ChEMBL	Binding affinity to human carbonic anhydrase 9 by stopped flow CO2 hydration method	B	7.59	pKi	25.8	nM	Ki	ACS Med Chem Lett (2018) 9: 725-729 [PMID:30034608]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 10 mins prior to testing measured for 5 to 10 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2020) 193: 112219-112219 [PMID:32203788]
ChEMBL	Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2018) 154: 210-219 [PMID:29803994]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2021) 212: 113035-113035 [PMID:33303238]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 by stopped flow CO2 hydrase assay	B	7.59	pKi	25.8	nM	Ki	Bioorg Med Chem Lett (2021) 37: 127856-127856 [PMID:33609663]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 assessed as inhibition constant preincubated with enzyme for 10 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Bioorg Med Chem (2020) 28: 115586-115586 [PMID:32631564]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-9 catalytic domain incubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.59	pKi	25.8	nM	Ki	J Med Chem (2018) 61: 4961-4977 [PMID:29746127]
ChEMBL	Inhibition of human CA9 by stopped-flow carbon dioxide hydration assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2020) 200: 112439-112439 [PMID:32485532]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 catalytic domain preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	ACS Med Chem Lett (2017) 8: 963-968 [PMID:28947945]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 by stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Bioorg Med Chem Lett (2021) 49: 128309-128309 [PMID:34371130]
ChEMBL	Inhibition of human carbonic anhydrase 9 by stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	J Med Chem (2021) 64: 11432-11444 [PMID:34283610]
ChEMBL	Inhibition of transmembrane human carbonic anhydrase 9 by stopped flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2018) 150: 678-686 [PMID:29571155]
ChEMBL	Inhibition of full length human CA9 incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Bioorg Med Chem (2021) 44: 116279-116279 [PMID:34216985]
ChEMBL	Inhibition of human CA9 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2021) 217: 113351-113351 [PMID:33744685]
ChEMBL	Inhibition of recombinant human CA9 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	ACS Med Chem Lett (2018) 9: 1035-1038 [PMID:30344913]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-9 preincubated for 10 mins by stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Bioorg Med Chem (2017) 25: 5726-5732 [PMID:28887000]
ChEMBL	Inhibition of human CA9 incubated for 15 mins prior to testing by phenol red dye based stopped flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2022) 228: 114026-114026 [PMID:34920169]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins by stopped flow CO2 hydrase assay	B	7.59	pKi	25.8	nM	Ki	ACS Med Chem Lett (2017) 8: 1213-1217 [PMID:29259736]
ChEMBL	Inhibition of human carbonic anhydrase 9 by stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2018) 143: 1931-1941 [PMID:29146134]
ChEMBL	Inhibition of human CA9 preincubated for 15 mins by stopped-flow carbon dioxide hydration assay	B	7.59	pKi	25.8	nM	Ki	ACS Med Chem Lett (2020) 11: 1000-1005 [PMID:32435417]
ChEMBL	Inhibition of human CA9 pre-incubated for 15 mins by stopped flow CO2 hydrase assay	B	7.59	pKi	25.8	nM	Ki	J Med Chem (2020) 63: 7392-7409 [PMID:32463228]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	ACS Med Chem Lett (2020) 11: 727-731 [PMID:32435377]
ChEMBL	Inhibition of human CA9 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.59	pKi	25.7	nM	Ki	Eur J Med Chem (2022) 228: 113997-113997 [PMID:34902732]
ChEMBL	Inhibition of recombinant human CA9 pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	7.59	pKi	25.7	nM	Ki	Eur J Med Chem (2021) 225: 113793-113793 [PMID:34507012]
ChEMBL	Inhibition of recombinant human CA9 preincubated for 15 mins by measured for 10 to 100 secs by phenol red dye based stopped flow CO2 hydration assay	B	7.59	pKi	25.7	nM	Ki	Bioorg Med Chem Lett (2021) 45: 128147-128147 [PMID:34052322]
ChEMBL	Inhibition of recombinant human Carbonic anhydrase 9 assessed as reduction in CO2 hydration preincubated for 15 mins prior to testing measured for 10 to 100 secs by stopped-flow assay	B	7.6	pKi	25.4	nM	Ki	J Med Chem (2017) 60: 3154-3164 [PMID:28272885]
ChEMBL	Inhibition of human CA9 incubated for 15 mins by stopped- flow CO2 hydrase assay method	B	7.6	pKi	25.4	nM	Ki	Eur J Med Chem (2020) 201: 112478-112478 [PMID:32659606]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 preincubated for 10 mins by CO2 hydration stopped-flow assay	B	7.6	pKi	25.4	nM	Ki	Bioorg Med Chem (2013) 21: 5228-5232 [PMID:23842519]
ChEMBL	Inhibition of human CA9 after 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25.4	nM	Ki	Eur J Med Chem (2018) 146: 47-59 [PMID:29407972]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	7.6	pKi	25.4	nM	Ki	J Med Chem (2017) 60: 6428-6439 [PMID:28658574]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-9-mediated CO2 hydration preincubated for 10 mins by stopped-flow assay	B	7.6	pKi	25.4	nM	Ki	Bioorg Med Chem (2013) 21: 1386-1391 [PMID:23352754]
ChEMBL	Inhibition of recombinant human membrane bound carbonic anhydrase 9 by stopped-flow CO2 hydration assay	B	7.6	pKi	25.3	nM	Ki	Bioorg Med Chem (2017) 25: 1286-1293 [PMID:28065499]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 9 after 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25.3	nM	Ki	Eur J Med Chem (2017) 127: 691-702 [PMID:27823879]
ChEMBL	Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	7.6	pKi	25.3	nM	Ki	Bioorg Med Chem Lett (2016) 26: 3892-3895 [PMID:27423482]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 10 mins prior to testing by stopped flow CO2 hydrase assay	B	7.6	pKi	25.2	nM	Ki	Bioorg Med Chem (2017) 25: 1666-1671 [PMID:28161252]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.6	pKi	25.2	nM	Ki	Bioorg Med Chem (2017) 25: 2569-2576 [PMID:28347633]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 by stopped flow CO2 hydration assay	B	7.6	pKi	25.2	nM	Ki	Eur J Med Chem (2019) 162: 147-160 [PMID:30445264]
ChEMBL	Inhibition of human carbonic anhydrase 9 pre-incubated for 15 mins by stopped flow carbon dioxide hydrase assay	B	7.6	pKi	25.2	nM	Ki	J Med Chem (2016) 59: 10692-10704 [PMID:27933963]
ChEMBL	Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	7.6	pKi	25.2	nM	Ki	J Med Chem (2017) 60: 9003-9011 [PMID:29048889]
ChEMBL	Inhibition of carbonic anhydrase 9 (unknown origin) preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25.2	nM	Ki	Eur J Med Chem (2013) 66: 372-379 [PMID:23827177]
ChEMBL	Inhibition of recombinant human CA9 catalytic domain preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25.1	nM	Ki	J Med Chem (2017) 60: 1159-1170 [PMID:28075587]
ChEMBL	Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	7.6	pKi	25.1	nM	Ki	Bioorg Med Chem Lett (2015) 25: 5636-5641 [PMID:26520662]
ChEMBL	Inhibition of human recombinant catalytic domain of carbonic anhydrase 9 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2011) 21: 2975-2979 [PMID:21470859]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2011) 19: 3105-3119 [PMID:21515057]
ChEMBL	Inhibition of human cloned carbonic anhydrase 9 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2011) 46: 4403-4410 [PMID:21820216]
ChEMBL	Inhibition of human carbonic anhydrase 9 preincubated for 15 mins at pH 7.5 by stopped flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5210-5213 [PMID:21821413]
ChEMBL	Inhibition of human recombinant CA9 by CO2 hydration based stopped flow assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2011) 54: 6905-6918 [PMID:21851094]
ChEMBL	Inhibition of human carbonic anhydrase 9-catalyzed CO2 hydration activity by stopped flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5892-5896 [PMID:21852133]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2012) 20: 2392-2404 [PMID:22370338]
ChEMBL	Inhibition of human CA9 pre-incubated for 15 mins by stopped-flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2012) 55: 1721-1730 [PMID:22276570]
ChEMBL	Inhibition of human recombinant CA9 catalytic domain-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2012) 55: 3891-3899 [PMID:22443141]
ChEMBL	Inhibition of human CA9 using CO2 as substrate incubated for 6 hrs prior to substrate addition measured for 10 to 100 secs by stopped flow technique	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2012) 22: 5801-5806 [PMID:22901388]
ChEMBL	Inhibition of human recombinant CA9 catalytic domain preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2012) 55: 6776-6783 [PMID:22775345]
ChEMBL	Inhibition of human recombinant transmembrane CA9 catalytic domain after 6 hrs by stopped-flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2013) 56: 293-300 [PMID:23241068]
ChEMBL	Inhibition of human CA9 by stopped-flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2013) 23: 715-719 [PMID:23265898]
ChEMBL	Inhibition of human carbonic anhydrase 9 preincubated for 10 mins by CO2 hydration stopped-flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2013) 21: 1451-1464 [PMID:23168081]
ChEMBL	Inhibition of human carbonic anhydrase 9 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2013) 21: 1396-1403 [PMID:23290254]
ChEMBL	Inhibition of tumor-associated transmembrane human carbonic anhydrase-9 after 15 mins by Stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2013) 21: 2314-2318 [PMID:23490152]
ChEMBL	Inhibition of recombinant human CA9 transmembrane isoform preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2013) 56: 4691-4700 [PMID:23647428]
ChEMBL	Inhibition of human carbonic anhydrase-9 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2013) 21: 2925-2931 [PMID:23623256]
ChEMBL	Inhibition of human carbonic anhydrase 9 by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2013) 21: 3949-3957 [PMID:23706268]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 9 after 6 hrs by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2013) 21: 4502-4510 [PMID:23769167]
ChEMBL	Inhibition of human carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2013) 21: 5130-5138 [PMID:23859774]
ChEMBL	Inhibition of human membrane bound carbonic anhydrase 9 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175]
ChEMBL	Inhibition of human carbonic anhydrase-9 by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2013) 23: 5646-5649 [PMID:23993330]
ChEMBL	Inhibition of human carbonic anhydrase9 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2013) 21: 7210-7215 [PMID:24090602]
ChEMBL	Inhibition of recombinant human catalytic domain of carbonic anhydrase-9 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2013) 56: 8512-8520 [PMID:24128000]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2013) 23: 6759-6763 [PMID:24189056]
ChEMBL	Inhibition of human carbonic anhydrase 9 by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2013) 56: 9623-9634 [PMID:24200125]
ChEMBL	Inhibition of human catalytic domain of carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2014) 71: 105-111 [PMID:24287559]
ChEMBL	Inhibition of human CA9 preincubated for 15 mins by stopped-flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2014) 22: 334-340 [PMID:24300919]
ChEMBL	Inhibition of human CA9 after 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2014) 71: 135-147 [PMID:24291567]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 9 by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184]
ChEMBL	Inhibition of human recombinant transmembrane carbonic anhydrase 9 after 6 hrs by stopped flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2014) 22: 1522-1528 [PMID:24513186]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 9 by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2014) 22: 1873-1882 [PMID:24560737]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1310-1314 [PMID:24507918]
ChEMBL	Inhibition of human carbonic anhydrase 9-mediated CO2 hydration preincubated for 10 mins by stopped-flow assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2014) 76: 284-290 [PMID:24589484]
ChEMBL	Inhibition of human carbonic anhydrase 9 by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2014) 22: 1821-1831 [PMID:24560739]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9-mediated CO2 hydration after 6 hrs by stopped-flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1256-1260 [PMID:24518190]
ChEMBL	Inhibition of human recombinant transmembrane tumor associated carbonic anhydrase-9 incubated for 15 mins prior to testing by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1776-1779 [PMID:24589511]
ChEMBL	Inhibition of human carbonic anhydrase 9-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2014) 22: 2643-2647 [PMID:24713308]
ChEMBL	Inhibition of human cloned transmembrane tumor-associated catalytic domain of carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2014) 82: 47-55 [PMID:24871996]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2014) 22: 3684-3695 [PMID:24878360]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2014) 22: 6768-6775 [PMID:25468040]
ChEMBL	Inhibition of human carbonic anhydrase 9 by stopped flow CO2 hydrase assay method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2014) 22: 6945-6952 [PMID:25456084]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 after 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2014) 22: 3982-3988 [PMID:25027802]
ChEMBL	Inhibition of human carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	ACS Med Chem Lett (2014) 5: 793-796 [PMID:25050167]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 by stopped flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2014) 84: 240-246 [PMID:25019479]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 preincubated for 15 mins by stopped-flow CO2 hydrase Assay	B	7.6	pKi	25	nM	Ki	ACS Med Chem Lett (2014) 5: 927-930 [PMID:25147616]
ChEMBL	Inhibition of human carbonic anhydrase 9 by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2014) 24: 5185-5189 [PMID:25442309]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2014) 57: 9152-9167 [PMID:25310626]
ChEMBL	Inhibition of human CA-9 by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2014) 57: 9673-9686 [PMID:25358036]
ChEMBL	Inhibition of human recombinant CA9 catalytic domain by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2014) 22: 6353-6359 [PMID:25438758]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2014) 87: 186-196 [PMID:25255434]
ChEMBL	Inhibition of human CA-9 after 15 mins by stopped-flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2014) 22: 5883-5890 [PMID:25267005]
ChEMBL	Inhibition of human tumor-associated carbonic anhydrase 9 by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2015) 23: 1430-1436 [PMID:25753329]
ChEMBL	Inhibition of human carbonic anhydrase 9 preincubated for 15 mins by CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2015) 23: 1421-1429 [PMID:25757603]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 expressed in Escherichia coli pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2015) 23: 2368-2376 [PMID:25846066]
ChEMBL	Inhibition of human recombinant CA-9 after 15 mins by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2015) 23: 1828-1840 [PMID:25766630]
ChEMBL	Inhibition of human membrane associated form of carbonic anhydrase-9 assessed as CO2 hydration activity incubated for 15 mins prior to testing by stopped flow method	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2015) 96: 425-435 [PMID:25912674]
ChEMBL	Inhibition of human recombinant carbonic anhdydrase-9 expressed in Escherichia coli pre-incubated for 6 hrs by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2015) 58: 3975-3983 [PMID:25875209]
ChEMBL	Inhibition of human carbonic anhydrase 9 by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2015) 23: 2975-2981 [PMID:26007302]
ChEMBL	Inhibition of human carbonic anhydrase-9 pre-incubated for 15 mins by stopped-flow CO2 hydration assay based Lineweaver-Burk plot method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2015) 23: 3674-3680 [PMID:25921266]
ChEMBL	Inhibition of human carbonic anhydrase 9 by by stopped flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2015) 23: 4989-4999 [PMID:26048024]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 expressed in Escherichia coli preincubated for 15 mins by stopped flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2015) 23: 4649-4659 [PMID:26088336]
ChEMBL	Inhibition of human carbonic anhydrase-9 incubated for 10 mins prior to testing by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3208-3212 [PMID:26105196]
ChEMBL	Inhibition of human recombinant CA9 expressed in Escherichia coli by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2015) 58: 6630-6638 [PMID:26203869]
ChEMBL	Inhibition of human carbonic anhydrase-9	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3281-3284 [PMID:26073006]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-9 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2015) 23: 5619-5625 [PMID:26233796]
ChEMBL	Inhibition of human carbonic anhydrase-9 incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2015) 23: 5311-5318 [PMID:26264840]
ChEMBL	Inhibition of human carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3850-3853 [PMID:26233435]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-9 catalytic domain by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	ACS Med Chem Lett (2015) 6: 819-821 [PMID:26191373]
ChEMBL	Inhibition of carbonic anhydrase-9 (unknown origin)	B	7.6	pKi	25	nM	Ki	J Med Chem (2015) 58: 7580-7590 [PMID:26347950]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 catalytic domain expressed in Escherichia coli incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2015) 23: 6573-6580 [PMID:26422787]
ChEMBL	Inhibition of human carbonic anhydrase 9 incubated for 6 hrs by stopped flow carbon-di-oxide hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2015) 23: 6955-6966 [PMID:26432607]
ChEMBL	Inhibition of human carbonic anhydrase-9 assessed as CO2 hydration activity by stopped-flow method	B	7.6	pKi	25	nM	Ki	J Med Chem (2015) 58: 8564-8572 [PMID:26497049]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 expressed in Escherichia coli preincubated for 6 hrs by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2015) 103: 583-593 [PMID:26408817]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2016) 24: 921-927 [PMID:26796953]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2016) 24: 894-901 [PMID:26795114]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2016) 24: 982-988 [PMID:26803577]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2016) 24: 1095-1105 [PMID:26810710]
ChEMBL	Inhibition of human carbonic anhydrase 9 for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2016) 24: 976-981 [PMID:26810836]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain by Stopped-Flow CO2 Hydrase assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2016) 59: 462-473 [PMID:26688270]
ChEMBL	Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by CO2 hydration-based stopped flow assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2016) 59: 721-732 [PMID:26741028]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2016) 24: 1402-1407 [PMID:26875933]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow carbon dioxide hydrase assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2016) 110: 259-266 [PMID:26840366]
ChEMBL	Inhibition of human carbonic anhydrase 9 using saturated CO2 as substrate incubated for 10 mins prior to testing by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2016) 24: 2882-2886 [PMID:27137360]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 preincubated for 15 min to 72 hrs by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2016) 24: 2907-2913 [PMID:27166574]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain preincubated for 6 hrs at 4 degC measured for 10 to 100 secs by stopped-flow carbon dioxide hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2016) 24: 3643-3648 [PMID:27316543]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2016) 59: 5462-5470 [PMID:27172398]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2016) 24: 3612-3617 [PMID:27290692]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2016) 59: 5077-5088 [PMID:27144971]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-9 preincubated for 6 hrs by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2017) 25: 677-683 [PMID:27939347]
ChEMBL	Inhibition of human recombinant transmembrane tumor associated carbonic anhydrase 9 preincubated for 10 mins prior to testing by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2017) 25: 857-863 [PMID:28024887]
ChEMBL	Inhibition of human CA9 by stopped-flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2015) 58: 640-650 [PMID:25432060]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-9 assessed as reduction in CO2 hydration preincubated for 10 mins measured for 5 to 10 secs by stopped flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2017) 25: 3583-3589 [PMID:28416101]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2017) 25: 2782-2788 [PMID:28389112]
ChEMBL	Inhibition of recombinant human transmembrane carbonic anhydrase 9 pretreated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2017) 25: 2518-2523 [PMID:28302505]
ChEMBL	Inhibition of human carbonic anhydrase 9 incubated for 10 mins by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2017) 25: 3093-3097 [PMID:28400084]
ChEMBL	Inhibition of recombinant human membrane bound carbonic anhydrase 9 expressed in Escherichia coli pretreated for 15 mins prior to testing by stopped-flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2017) 25: 3714-3718 [PMID:28545816]
ChEMBL	Inhibition of human CA9 by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 assessed as reduction in CO2 hydration pretreated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis	B	7.6	pKi	25	nM	Ki	ACS Med Chem Lett (2017) 8: 792-796 [PMID:28835790]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 assessed as reduction in CO2 hydration preincubated for 10 mins by stopped flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2018) 26: 3731-3762 [PMID:30017112]
ChEMBL	Inhibition of human carbonic anhydrase 9 incubated for 15 mins by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	ACS Med Chem Lett (2017) 8: 1314-1319 [PMID:29259754]
ChEMBL	Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2018) 143: 276-282 [PMID:29197732]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2018) 61: 5380-5394 [PMID:29851481]
ChEMBL	Inhibition of human transmembrane tumor-associated carbonic anhydrase 9 assessed as inhibition of CO2 hydration preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2018) 151: 363-375 [PMID:29635168]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 assessed as inhibition of CO2 hydration preincubated for 15 mins prior to testing by phenol red based stopped-flow assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2018) 152: 1-9 [PMID:29684705]
ChEMBL	Binding affinity to human carbonic anhydrase 9 by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2018) 155: 545-551 [PMID:29909339]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 9 by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2017) 139: 250-262 [PMID:28802125]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 catalytic domain preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	ACS Med Chem Lett (2017) 8: 941-946 [PMID:28947941]
ChEMBL	Inhibition of human CA9 assessed as enzyme inhibitor complex formation preincubated for 15 mins and measured for 10 to 100 secs by phenol red dye based stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2018) 61: 6328-6338 [PMID:29962205]
ChEMBL	Inhibition of carbonic anhydrase 9 (unknown origin) preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2018) 61: 10860-10874 [PMID:30433782]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2018) 157: 28-36 [PMID:30071407]
ChEMBL	Inhibition of human carbonic anhydrase 9 assessed as reduction in CO2 hydration preincubated for 15 mins to 2 hrs by phenol red dye based stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	ACS Med Chem Lett (2019) 10: 1205-1210 [PMID:31413806]
ChEMBL	Inhibition of human carbonic anhydrase 9 assessed as reduction in CO2 hydration incubated for 1 hr by phenol red staining-based stopped flow assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2019) 183: 111698-111698 [PMID:31539777]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2019) 184: 111768-111768 [PMID:31629164]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-9 incubated for 15 mins by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2020) 185: 111843-111843 [PMID:31718943]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 expressed in Escherichia coli GOLD BL21 (DE3) by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2019) 62: 4174-4192 [PMID:30925064]
ChEMBL	Inhibition of human carbonic anhydrase 9 incubated for 15 mins by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	ACS Med Chem Lett (2019) 10: 661-665 [PMID:30996814]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 expressed in Escherichia coli by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2019) 179: 547-556 [PMID:31276899]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2020) 63: 2470-2488 [PMID:31972093]
ChEMBL	Inhibition of human carbonic anhydrase 9 assessed as inhibitory constant incubated for 15 mins by phenol red dye based stopped flow assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2019) 182: 111638-111638 [PMID:31472471]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 1 hr prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2020) 63: 321-333 [PMID:31794211]
ChEMBL	Inhibition of human CA 9 catalytic domain	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2019) 168: 301-314 [PMID:30826507]
ChEMBL	Inhibition of human carbonic anhydrase 9 assessed as inhibitory constant preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2019) 175: 40-48 [PMID:31071549]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing measured for 5 to 10 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2019) 27: 1588-1594 [PMID:30846402]
ChEMBL	Inhibition of human carbonic anhydrase 9 assessed as reduction in CO2 hydration after 15 mins by phenol red staining-based stopped flow assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2019) 164: 92-105 [PMID:30594030]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2016) 59: 5857-5867 [PMID:27253845]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 preincubated with enzyme for 10 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	ACS Med Chem Lett (2020) 11: 633-637 [PMID:32435363]
ChEMBL	Inhibition of human carbonic anhydrase 9 assessed as inhibitory constant incubated for 6 hrs by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2020) 28: 115496-115496 [PMID:32327349]
ChEMBL	Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red dye based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2020) 28: 115329-115329 [PMID:32007388]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2018) 61: 3151-3165 [PMID:29566486]
ChEMBL	Inhibitory activity against human carbonic anhydrase IX (hCA IX) by using CO2 hydrase assay method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2004) 14: 3757-3762 [PMID:15203157]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2020) 189: 112019-112019 [PMID:31972394]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 6 hrs prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2020) 200: 112300-112300 [PMID:32460112]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2020) 200: 112449-112449 [PMID:32485534]
ChEMBL	Inhibition of human CA9 preincubated for 15 mins prior to testing by phenol red-based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2020) 207: 112745-112745 [PMID:32877804]
ChEMBL	Inhibition of human CA9 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2021) 209: 112897-112897 [PMID:33038795]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2021) 209: 112875-112875 [PMID:33059188]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 preincubated for 10 mins by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2021) 39: 127877-127877 [PMID:33640442]
ChEMBL	Inhibition of recombinant human CA9 pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2020) 190: 112112-112112 [PMID:32044580]
ChEMBL	Inhibition of human CA9 measured by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2021) 48: 128249-128249 [PMID:34237441]
ChEMBL	Inhibition of recombinant human CA9 pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2021) 218: 113360-113360 [PMID:33773285]
ChEMBL	Inhibition of recombinant human CA9 pre-incubated for 15 mins prior to testing by phenol red-based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2021) 218: 113352-113352 [PMID:33774343]
ChEMBL	Inhibition of human CA9 by stopped- flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2021) 216: 113283-113283 [PMID:33667848]
ChEMBL	Inhibition of human CA9 by stopped-flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2021) 39: 116140-116140 [PMID:33905966]
ChEMBL	Inhibition of human carbonic anhydrase 9 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2021) 222: 113589-113589 [PMID:34147910]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2020) 188: 112021-112021 [PMID:31901743]
ChEMBL	Inhibition against human carbonic anhydrase IX	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2004) 14: 231-234 [PMID:14684333]
ChEMBL	Inhibitory activity against human tumor-associated transmembrane carbonic anhydrase IX.	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2004) 14: 3283-3290 [PMID:15149691]
ChEMBL	Compound was evaluated for inhibition against human carbonic anhydrase IX	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2004) 14: 217-223 [PMID:14684331]
ChEMBL	Inhibition constant determined against catalytic domain of human cloned carbonic anhydrase IX	B	7.6	pKi	25	nM	Ki	J Med Chem (2003) 46: 2187-2196 [PMID:12747790]
ChEMBL	Inhibitory activity against human carbonic anhydrase IX	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2004) 14: 869-873 [PMID:15012984]
ChEMBL	Inhibitory activity against human cloned carbonic anhydrase isozyme IX, by CO2 hydrase assay method.	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2003) 13: 1005-1009 [PMID:12643899]
ChEMBL	Inhibitory activity against human carbonic anhydrase IX	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2004) 14: 2351-2356 [PMID:15081039]
ChEMBL	Inhibitory concentration against catalytic domain of human cloned carbonic anhydrase IX.	B	7.6	pKi	25	nM	Ki	J Med Chem (2003) 46: 2197-2204 [PMID:12747791]
ChEMBL	Inhibition constant evaluated for the inhibition of human CA IX (Carbonic anhydrase IX)	B	7.6	pKi	25	nM	Ki	J Med Chem (2004) 47: 2337-2347 [PMID:15084132]
ChEMBL	Inhibitory activity against human carbonic anhydrase IX.	B	7.6	pKi	25	nM	Ki	J Med Chem (2003) 46: 5471-5477 [PMID:14640555]
ChEMBL	Inhibitory activity against Carbonic anhydrase IX	B	7.6	pKi	25	nM	Ki	J Med Chem (2005) 48: 2121-2125 [PMID:15771455]
ChEMBL	Inhibitory constant against catalytic domain of human carbonic anhydrase IX	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3828-3833 [PMID:16039848]
ChEMBL	Inhibitory activity against membrane bound tumor associated human carbonic anhydrase IX	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 579-584 [PMID:15664816]
ChEMBL	Inhibitory potency against catalytic domain of human Carbonic anhydrase IX expressed in Escherichia coli strain BL21	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 367-372 [PMID:15603956]
ChEMBL	Inhibitory activity against human carbonic anhydrase IX expressed in Escherichia coli BL21	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5427-5433 [PMID:15454239]
ChEMBL	Binding affinity towards human cloned carbonic anhydrase IX	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5775-5780 [PMID:15501039]
ChEMBL	Inhibitory constant against human Carbonic anhydrase IX	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3102-3108 [PMID:15905091]
ChEMBL	Inhibition constant against human cloned isozyme (hCA IX) by CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2005) 48: 4834-4841 [PMID:16033263]
ChEMBL	Inhibition constant against human recombinant carbonic anhydrase IX catalytic domain	F	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3302-3306 [PMID:15908201]
ChEMBL	Inhibitory constant against human Carbonic anhydrase IX	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 2359-2364 [PMID:15837325]
ChEMBL	Inhibitory constant against human Carbonic anhydrase IX	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 2347-2352 [PMID:15837323]
ChEMBL	Inhibition constant against human carbonic anhydrase IX	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3096-3101 [PMID:15908204]
ChEMBL	Inhibitory activity against human Carbonic anhydrase IX (hCA IX)	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4862-4866 [PMID:16168653]
ChEMBL	Inhibitory activity against catalytic domain of human cloned Carbonic anhydrase IX by the CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4872-4876 [PMID:16165351]
ChEMBL	Inhibition of cloned human transmembrane, tumor-associated isozyme CA IX	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 5192-5196 [PMID:16203142]
ChEMBL	Inhibitory activity against cloned human CA9	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2006) 16: 437-442 [PMID:16290146]
ChEMBL	Inhibition of human CA9	B	7.6	pKi	25	nM	Ki	J Med Chem (2006) 49: 2743-2749 [PMID:16640335]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2006) 49: 5544-5551 [PMID:16942027]
ChEMBL	Inhibition of human cloned CA9 catalytic domain by CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2006) 16: 4846-4851 [PMID:16809036]
ChEMBL	Inhibition of human cloned CA9 catalytic domain by CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2006) 49: 6539-6548 [PMID:17064072]
ChEMBL	Inhibition of catalytic domain of human cloned CA9 by stopped-flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibition of catalytic domain of human recombinant CA IX	B	7.6	pKi	25	nM	Ki	J Med Chem (2007) 50: 381-388 [PMID:17228881]
ChEMBL	Inhibition of catalytic domain of human recombinant isozyme CA9 by CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2007) 50: 1651-1657 [PMID:17343373]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 by CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2007) 15: 2298-2311 [PMID:17276072]
ChEMBL	Inhibition of human recombinant CA9 after 15 mins by CO2 hydration stopped flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2007) 17: 2685-2691 [PMID:17376683]
ChEMBL	Inhibition of human cloned catalytic domain CA9 by CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2007) 17: 5032-5035 [PMID:17681760]
ChEMBL	Inhibition of catalytic domain of human cloned carbonic anhydrase9 by CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2007) 15: 6975-6984 [PMID:17822907]
ChEMBL	Inhibition of human carbonic anhydrase 9	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human recombinant CA9 by CO2 hydration stopped flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2008) 18: 836-841 [PMID:18042384]
ChEMBL	Inhibition of human CA9 catalytic domain by CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2008) 51: 1945-1953 [PMID:18307288]
ChEMBL	Inhibition of human catalytic domain carbonic anhydrase 9 by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human cloned carbonic anhydrase 9 by CO2 hydration stopped-flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2008) 18: 3475-3480 [PMID:18513964]
ChEMBL	Inhibition of human recombinant CA9 catalytic domain by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human recombinant CA9 by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2009) 17: 553-557 [PMID:19097911]
ChEMBL	Inhibition of human recombinant CA9 by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2273-2276 [PMID:19286378]
ChEMBL	Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 catalytic domain by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2009) 52: 646-654 [PMID:19193158]
ChEMBL	Inhibition of human cloned CA9 catalytic domain by stopped-flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2008) 18: 4282-4286 [PMID:18640037]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL	Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2008) 51: 7968-7979 [PMID:19053764]
ChEMBL	Inhibition of human carbonic anhydrase 9 by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4102-4106 [PMID:19527930]
ChEMBL	Inhibition of human membrane-bound carbonic anhydrase 9 catalytic domain after 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2009) 52: 5990-5998 [PMID:19731956]
ChEMBL	Inhibition of human cloned CA9 catalytic domain by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2009) 52: 6421-6432 [PMID:19827837]
ChEMBL	Inhibition of human recombinant CA9 by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2010) 53: 850-854 [PMID:20028100]
ChEMBL	Inhibition of human recombinant CA9 catalytic domain expressed in Sf9 cells by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2009) 17: 7093-7099 [PMID:19773173]
ChEMBL	Inhibition of human CA9 by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318]
ChEMBL	Inhibition of human recombinant CA9 by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2010) 53: 2913-2926 [PMID:20201556]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human carbonic anhydrase 9	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3623-3627 [PMID:20478708]
ChEMBL	Inhibition of human cloned carbonic anhydrase 9 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2010) 45: 2396-2404 [PMID:20202722]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 catalytic domain preincubated for 15 mins by CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2010) 18: 4873-4878 [PMID:20598552]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 after 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of human carbonic anhydrase 9 by stopped flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
ChEMBL	Inhibition of human cloned catalytic domain of CA9 after 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2010) 45: 3656-3661 [PMID:20554082]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 after 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2010) 18: 5081-5089 [PMID:20580561]
ChEMBL	Inhibition of tumor-associated human carbonic anhydrase 9 preincubated for 15 min by CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2011) 54: 1896-1902 [PMID:21361354]
ChEMBL	Inhibition of human recombinant CA9 catalytic domain by CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2011) 21: 3216-3221 [PMID:21549597]
ChEMBL	Inhibition of human CA9 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2022) 228: 114004-114004 [PMID:34847409]
ChEMBL	Inhibition of human CA9 by Lineweaver-Burk plot analysis	B	7.7	pKi	20	nM	Ki	ACS Med Chem Lett (2018) 9: 1045-1050 [PMID:30344915]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.7	pKi	20	nM	Ki	ACS Med Chem Lett (2020) 11: 1022-1027 [PMID:32435420]
ChEMBL	Inhibition of human carbonic anhydrase 9 by stopped-flow CO2 hydration assay	B	7.8	pKi	16	nM	Ki	Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983]
ChEMBL	Inhibition of full length human recombinant carbonic anhydrase 9 expressed in Escherichia coli by stopped-flow CO2 hydration assay	B	7.8	pKi	16	nM	Ki	Bioorg Med Chem Lett (2009) 19: 5825-5828 [PMID:19751975]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 catalytic domain expressed in Escherichia coli by stopped-flow CO2 hydration assay	B	8.05	pKi	9	nM	Ki	Bioorg Med Chem Lett (2009) 19: 5825-5828 [PMID:19751975]
ChEMBL	Inhibition of recombinant human CA9 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2019) 181: 111573-111573 [PMID:31394463]
ChEMBL	Inhibition of human CAH9 catalytic domain expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	8.39	pKi	4.1	nM	Ki	J Med Chem (2021) 64: 1713-1724 [PMID:33523653]
ChEMBL	Inhibition of human carbonic anhydrase-9 preincubated for 15 mins by stopped flow CO2 dehydration method	B	10.22	pKi	0.06	nM	Ki	Bioorg Med Chem (2016) 24: 104-112 [PMID:26682703]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 10 mM tris-(carboxyethyl)-phosphine	B	5.67	pIC50	2134	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 10 mM beta-mercaptoethanol	B	5.7	pIC50	1997	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 1.00 mM tris-(carboxyethyl)-phosphine	B	5.75	pIC50	1764	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 10 mM dithiothreitol	B	5.82	pIC50	1524	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 0.10 mM dithiothreitol	B	5.82	pIC50	1520	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 1.00 mM dithiothreitol	B	5.82	pIC50	1520	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 0.25 mM dithiothreitol	B	5.82	pIC50	1513	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 1.00 mM beta-mercaptoethanol	B	5.89	pIC50	1297	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 10 mM threitol	B	5.89	pIC50	1294	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human CAH9 catalytic domain expressed in Escherichia coli BL21 (DE3) assessed as reduction in esterase activity using p-nitrophenyl acetate substrate by stopped flow CO2 hydration assay	B	5.89	pIC50	1280	nM	IC50	J Med Chem (2021) 64: 1713-1724 [PMID:33523653]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 1.00 mM threitol	B	5.93	pIC50	1165	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 0.25 mM tris-(carboxyethyl)-phosphine	B	5.99	pIC50	1024	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 0.25 mM threitol	B	6	pIC50	999.8	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 0.05 mM dithiothreitol	B	6.01	pIC50	973	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 pretreated for 15 mins by stopped flow CO2 hydrase assay	B	6.04	pIC50	903	nM	IC50	Bioorg Med Chem Lett (2014) 24: 2617-2620 [PMID:24813742]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 10 mM dithiothreitol	B	6.11	pIC50	775	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 1.00 mM dithiothreitol	B	6.12	pIC50	763	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 10 mM tris-(carboxyethyl)-phosphine	B	6.13	pIC50	746.9	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 0.25 mM dithiothreitol	B	6.13	pIC50	735	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 0.10 mM dithiothreitol	B	6.14	pIC50	721	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 0.05 mM dithiothreitol	B	6.15	pIC50	700	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 0.10 mM tris-(carboxyethyl)-phosphine	B	6.16	pIC50	694.5	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 10 mM beta-mercaptoethanol	B	6.17	pIC50	680	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 0.05 mM tris-(carboxyethyl)-phosphine	B	6.17	pIC50	670.3	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 1.00 mM beta-mercaptoethanol	B	6.21	pIC50	622	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 0.25 mM beta-mercaptoethanol	B	6.39	pIC50	410.3	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 1.00 mM tris-(carboxyethyl)-phosphine	B	6.5	pIC50	318.6	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 0.10 mM beta-mercaptoethanol	B	6.52	pIC50	304.6	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 0.25 mM beta-mercaptoethanol	B	6.54	pIC50	286.5	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 0.10 mM beta-mercaptoethanol	B	6.61	pIC50	243.1	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 0.10 mM threitol	B	6.63	pIC50	236.1	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 0.01 mM tris-(carboxyethyl)-phosphine	B	6.66	pIC50	218.8	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 10 mM threitol	B	6.68	pIC50	208.1	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 0.05 mM threitol	B	6.7	pIC50	200.6	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 0.01 mM threitol	B	6.74	pIC50	183.3	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 1.00 mM threitol	B	6.75	pIC50	176.8	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 0.05 mM beta-mercaptoethanol	B	6.76	pIC50	174.8	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 0.01 mM dithiothreitol	B	6.88	pIC50	132	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 0.25 mM threitol	B	6.91	pIC50	123.6	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration method	B	7.03	pIC50	94	nM	IC50	Bioorg Med Chem Lett (2014) 24: 1941-1943 [PMID:24650641]
ChEMBL	Inhibition of human carbonic anhydrase 9 using p-nitrophenyl acetate as substrate by UV-VIS spectrophotometric analysis	B	7.06	pIC50	87.2	nM	IC50	Eur J Med Chem (2021) 216: 113300-113300 [PMID:33640672]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 0.01 mM dithiothreitol	B	7.09	pIC50	82	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of CA-9 (unknown origin) after 15 mins by CO2 hydration assay	B	7.14	pIC50	73	nM	IC50	Bioorg Med Chem Lett (2014) 24: 3422-3425 [PMID:24948563]
ChEMBL	Inhibition of human carbonic anhydrase 9 using 4-NPA as substrate after 3 mins by spectrophotometric analysis	B	7.15	pIC50	70.9	nM	IC50	Eur J Med Chem (2018) 144: 544-556 [PMID:29289880]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 0.25 mM tris-(carboxyethyl)-phosphine	B	7.19	pIC50	65.2	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 0.10 mM threitol	B	7.25	pIC50	56.7	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 0.05 mM beta-mercaptoethanol	B	7.27	pIC50	54	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 0.10 mM tris-(carboxyethyl)-phosphine	B	7.27	pIC50	53.4	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 0.05 mM threitol	B	7.28	pIC50	52.5	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 0.05 mM tris-(carboxyethyl)-phosphine	B	7.31	pIC50	48.7	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain in presence of 0.01 mM beta-mercaptoethanol	B	7.35	pIC50	44.3	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 0.01 mM beta-mercaptoethanol	B	7.38	pIC50	42.1	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 0.01 mM threitol	B	7.44	pIC50	36.7	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 in presence of 0.01 mM tris-(carboxyethyl)-phosphine	B	7.44	pIC50	36.2	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain	B	7.49	pIC50	32	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase 9 using p-nitrophenyl acetate as substrate by UV-VIS spectrophotometric analysis	B	7.51	pIC50	31	nM	IC50	Bioorg Med Chem (2020) 28: 115424-115424 [PMID:32209296]
ChEMBL	Inhibition of recombinant human CA9 using 4-nitrophenylacetate as substrate by esterase assay	B	7.52	pIC50	30	nM	IC50	Bioorg Med Chem Lett (2021) 53: 128420-128420 [PMID:34728369]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 using 4-nitrophenylacetate as substrate pretreated for 15 mins prior to test by spectrophotometric method	B	7.52	pIC50	30	nM	IC50	Eur J Med Chem (2017) 132: 1-10 [PMID:28334643]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 using 4-nitrophenylacetate as substrate	B	7.52	pIC50	30	nM	IC50	Bioorg Med Chem Lett (2021) 51: 128291-128291 [PMID:34324968]
ChEMBL	Inhibition of human recombinant CA9 using 4-nitrophenylacetate as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.55	pIC50	28	nM	IC50	Eur J Med Chem (2013) 66: 1-11 [PMID:23777898]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.55	pIC50	28	nM	IC50	Eur J Med Chem (2021) 210: 112994-112994 [PMID:33234343]
ChEMBL	Inhibition of human carbonic anhydrase 9 expressed in Escherichia coli BL21 D3 strain using p-nitrophenyl acetate as substrate by UV/visible spectrophotometry	B	7.57	pIC50	27	nM	IC50	Eur J Med Chem (2018) 155: 13-23 [PMID:29852328]
ChEMBL	Inhibitory activity against human carbonic anhydrase IX was determined	B	7.6	pIC50	25	nM	IC50	J Med Chem (2004) 47: 550-557 [PMID:14736236]
ChEMBL	Inhibition of human carbonic anhydrase 9	B	7.68	pIC50	21	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1898-1903 [PMID:18295485]
ChEMBL	Inhibition of human carbonic anhydrase-9 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	8.11	pIC50	7.72	nM	IC50	Medchemcomm (2018) 9: 2100-2105 [PMID:30746068]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 9 after 15 mins by stopped flow CO2 hydration assay	B	8.11	pIC50	7.7	nM	IC50	Eur J Med Chem (2013) 62: 597-604 [PMID:23429054]
ChEMBL	Inhibition of GST-tagged recombinant carbonic anhydrase-9 catalytic domain (unknown origin)	B	8.59	pIC50	2.58	nM	IC50	Bioorg Med Chem Lett (2013) 23: 3496-3499 [PMID:23664215]
Carbonic anhydrase-related protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2420] [UniProtKB: O75493]
ChEMBL	Inhibition of recombinant human membrane bound carbonic anhydrase 11 expressed in Escherichia coli pretreated for 15 mins prior to testing by stopped-flow assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2017) 25: 3714-3718 [PMID:28545816]
carbonic anhydrase 5A/Carbonic anhydrase VA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218]
ChEMBL	Inhibition of human carbonic anhydrase 5A at pH7 and 37 degC by fluorescent thermal shift assay	B	6	pKd	1000	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to recombinant human full length N-terminal His6-tagged mitochondrial carbonic anhydrase 5A expressed in Escherichia coli BL21 (DE3) in presence of ANS by fluorescent thermal shift assay	B	6	pKd	1000	nM	Kd	Bioorg Med Chem (2018) 26: 675-687 [PMID:29305297]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 5a expressed in Escherichia coli expression system assessed as observed dissociation constant fluorescent thermal shift assay	B	6.08	pKd	840	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Binding affinity to recombinant human full length N-terminal His6-tagged mitochondrial carbonic anhydrase 5A expressed in Escherichia coli BL21 (DE3) assessed as intrinsic dissociation constant in presence of ANS by fluorescent thermal shift assay	B	6.48	pKd	333	nM	Kd	Bioorg Med Chem (2018) 26: 675-687 [PMID:29305297]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 5a expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	B	6.57	pKd	270	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Inhibition of full length human recombinant mitochondrial carbonic anhydrase 5A pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	4.2	pKi	63000	nM	Ki	Bioorg Med Chem Lett (2008) 18: 6332-6335 [PMID:18990571]
ChEMBL	Inhibition of human CAH5A expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	6.96	pKi	108.7	nM	Ki	J Med Chem (2021) 64: 1713-1724 [PMID:33523653]
ChEMBL	Inhibition of human mitochondrial carbonic anhydrase 5a after 6 hrs by stopped flow CO2 hydrase assay	B	7.19	pKi	64	nM	Ki	Bioorg Med Chem (2013) 21: 4502-4510 [PMID:23769167]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 5A expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay	B	7.2	pKi	63.1	nM	Ki	J Med Chem (2016) 59: 5462-5470 [PMID:27172398]
ChEMBL	Inhibition of recombinant human Carbonic anhydrase 5A assessed as reduction in CO2 hydration preincubated for 15 mins prior to testing measured for 10 to 100 secs by stopped-flow assay	B	7.2	pKi	63.1	nM	Ki	J Med Chem (2017) 60: 3154-3164 [PMID:28272885]
ChEMBL	Inhibition of human full length carbonic anhydrase 5A by stopped flow CO2 hydrase assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human recombinant full length CA5A by stopped flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human mitochondrial carbonic anhydrase 5A by stopped flow CO2 hydration method	B	7.2	pKi	63	nM	Ki	J Med Chem (2009) 52: 2226-2232 [PMID:19317447]
ChEMBL	Inhibition of human recombinant full length CA5A by stopped-flow CO2 hydration method	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of human cloned CA5A by stopped-flow CO2 hydration method	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem Lett (2008) 18: 4282-4286 [PMID:18640037]
ChEMBL	Inhibition of human carbonic anhydrase 5A by stopped-flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL	Inhibition of human carbonic anhydrase 5A by stopped-flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983]
ChEMBL	Inhibition of human carbonic anhydrase 5A by stopped flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4102-4106 [PMID:19527930]
ChEMBL	Inhibition of human recombinant full length mitochondrial carbonic anhydrase 5A by stopped-flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem (2009) 17: 4894-4899 [PMID:19539481]
ChEMBL	Inhibition of human full length mitochondrial carbonic anhydrase 5A after 15 mins by stopped-flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	J Med Chem (2009) 52: 5990-5998 [PMID:19731956]
ChEMBL	Inhibition of human recombinant CA5A by stopped flow CO2 hydrase assay	B	7.2	pKi	63	nM	Ki	J Med Chem (2010) 53: 850-854 [PMID:20028100]
ChEMBL	Inhibition of human CA5A by stopped-flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318]
ChEMBL	Inhibition of full length human carbonic anhydrase 5a preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 5a after 15 mins by stopped-flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of human carbonic anhydrase 5A by stopped flow CO2 hydration method	B	7.2	pKi	63	nM	Ki	J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
ChEMBL	Inhibition of human carbonic anhydrase VA by spectrophotometry at pH 7.5	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem (2011) 19: 1172-1178 [PMID:21251841]
ChEMBL	Inhibition of human recombinant CA5A mitochondrial isoform by stopped-flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem Lett (2011) 21: 1334-1337 [PMID:21300547]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 5a preincubated for 15 mins by CO2 hydration method	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem (2011) 19: 3105-3119 [PMID:21515057]
ChEMBL	Inhibition of human carbonic anhydrase 5A preincubated for 15 mins at pH 7.5 by stopped flow CO2 hydration method	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5210-5213 [PMID:21821413]
ChEMBL	Inhibition of human carbonic anhydrase-5A preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem (2013) 21: 2925-2931 [PMID:23623256]
ChEMBL	Inhibition of human mitochondrial CA5A preincubated for 15 mins by stopped-flow CO2 hydration method	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem (2014) 22: 334-340 [PMID:24300919]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 5A pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem (2014) 22: 6768-6775 [PMID:25468040]
ChEMBL	Inhibition of carbonic anhydrase-5A (unknown origin)	B	7.2	pKi	63	nM	Ki	J Med Chem (2015) 58: 7580-7590 [PMID:26347950]
ChEMBL	Inhibition of human CA5A by stopped-flow CO2 hydrase assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280]
ChEMBL	Inhibition of human carbonic anhydrase 5A after 15 mins by stopped flow carbon dioxide hydration assay	B	7.2	pKi	63	nM	Ki	ACS Med Chem Lett (2018) 9: 462-467 [PMID:29795760]
ChEMBL	Inhibition of recombinant human CA5a preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	ACS Med Chem Lett (2018) 9: 1035-1038 [PMID:30344913]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 5a incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	Eur J Med Chem (2018) 157: 1214-1222 [PMID:30193219]
ChEMBL	Inhibition of human carbonic anhydrase 5A incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	Eur J Med Chem (2019) 177: 188-197 [PMID:31136893]
ChEMBL	Inhibition of recombinant human carbonic anhydrase VA preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	Eur J Med Chem (2019) 181: 111565-111565 [PMID:31387062]
ChEMBL	Inhibition of human CA5A pre-incubated for 15 mins by stopped flow CO2 hydrase assay	B	7.2	pKi	63	nM	Ki	J Med Chem (2020) 63: 7392-7409 [PMID:32463228]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 5A preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	ACS Med Chem Lett (2020) 11: 727-731 [PMID:32435377]
ChEMBL	Inhibition of human carbonic anhydrase 5A by stopped-flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	J Med Chem (2021) 64: 11432-11444 [PMID:34283610]
ChEMBL	Inhibition of human cloned CA5A by stopped-flow CO2 hydration method	B	7.2	pKi	63	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibition of human mitochondrail isozyme CA VA	B	7.2	pKi	63	nM	Ki	J Med Chem (2007) 50: 381-388 [PMID:17228881]
ChEMBL	Inhibition of human recombinant CA5A after 15 mins by CO2 hydration stopped flow assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem Lett (2007) 17: 2685-2691 [PMID:17376683]
ChEMBL	Inhibition of human carbonic anhydrase 5A	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibitory activity against human recombinant mitochondrial isozyme CA VA	B	7.2	pKi	63	nM	Ki	J Med Chem (2005) 48: 7860-7866 [PMID:16302824]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 5A by stopped-flow CO2 hydration assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem Lett (2021) 49: 128309-128309 [PMID:34371130]
ChEMBL	Inhibition of recombinant human mitochondrial isozyme CA VA	B	7.22	pKi	60	nM	Ki	Bioorg Med Chem Lett (2005) 15: 5192-5196 [PMID:16203142]
ChEMBL	Inhibition of human carbonic anhydrase 5A using p-nitrophenyl acetate as substrate by UV-VIS spectrophotometric analysis	B	7.16	pIC50	69	nM	IC50	Bioorg Med Chem (2020) 28: 115424-115424 [PMID:32209296]
Carbonic anhydrase VB in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0]
ChEMBL	Inhibition of human carbonic anhydrase 5B at pH7 and 37 degC by fluorescent thermal shift assay	B	6.51	pKd	310	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to recombinant human full length N-terminal His6-tagged mitochondrial carbonic anhydrase 5B (40 to 317 residues) expressed in Escherichia coli Rosetta 2 (DE3) in presence of ANS by fluorescent thermal shift assay	B	6.51	pKd	310	nM	Kd	Bioorg Med Chem (2018) 26: 675-687 [PMID:29305297]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 5b expressed in Escherichia coli expression system assessed as observed dissociation constant fluorescent thermal shift assay	B	6.85	pKd	140	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Binding affinity to recombinant human full length N-terminal His6-tagged mitochondrial carbonic anhydrase 5B (40 to 317 residues) expressed in Escherichia coli Rosetta 2 (DE3) assessed as intrinsic dissociation constant in presence of ANS by fluorescent thermal shift assay	B	7.11	pKd	77.2	nM	Kd	Bioorg Med Chem (2018) 26: 675-687 [PMID:29305297]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 5b expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	B	7.47	pKd	34	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Inhibition of full length human recombinant mitochondrial carbonic anhydrase 5B preincubated for 15 mins by stopped-flow CO2 hydration assay	B	4.27	pKi	54000	nM	Ki	Bioorg Med Chem Lett (2008) 18: 6332-6335 [PMID:18990571]
ChEMBL	Inhibition of recombinant human Carbonic anhydrase 5B assessed as reduction in CO2 hydration preincubated for 15 mins prior to testing measured for 10 to 100 secs by stopped-flow assay	B	7.27	pKi	54.2	nM	Ki	J Med Chem (2017) 60: 3154-3164 [PMID:28272885]
ChEMBL	Inhibition of human mitochondrail isozyme CA VB	B	7.27	pKi	54	nM	Ki	J Med Chem (2007) 50: 381-388 [PMID:17228881]
ChEMBL	Inhibition of human carbonic anhydrase 5B	B	7.27	pKi	54	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human full length carbonic anhydrase 5B by stopped flow CO2 hydrase assay	B	7.27	pKi	54	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human recombinant full length CA5B by stopped flow CO2 hydration assay	B	7.27	pKi	54	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human mitochondrial carbonic anhydrase 5B by stopped flow CO2 hydration method	B	7.27	pKi	54	nM	Ki	J Med Chem (2009) 52: 2226-2232 [PMID:19317447]
ChEMBL	Inhibition of human recombinant full length CA5B by stopped-flow CO2 hydration method	B	7.27	pKi	54	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of human cloned CA5B by stopped-flow CO2 hydration method	B	7.27	pKi	54	nM	Ki	Bioorg Med Chem Lett (2008) 18: 4282-4286 [PMID:18640037]
ChEMBL	Inhibition of human carbonic anhydrase 5B by stopped-flow CO2 hydration assay	B	7.27	pKi	54	nM	Ki	Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL	Inhibition of human carbonic anhydrase 5B by stopped-flow CO2 hydration assay	B	7.27	pKi	54	nM	Ki	Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983]
ChEMBL	Inhibition of human carbonic anhydrase 5B by stopped flow CO2 hydration assay	B	7.27	pKi	54	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4102-4106 [PMID:19527930]
ChEMBL	Inhibition of human recombinant full length mitochondrial carbonic anhydrase 5B by stopped-flow CO2 hydration assay	B	7.27	pKi	54	nM	Ki	Bioorg Med Chem (2009) 17: 4894-4899 [PMID:19539481]
ChEMBL	Inhibition of human full length mitochondrial carbonic anhydrase 5B after 15 mins by stopped-flow CO2 hydration assay	B	7.27	pKi	54	nM	Ki	J Med Chem (2009) 52: 5990-5998 [PMID:19731956]
ChEMBL	Inhibition of human recombinant CA5B by stopped flow CO2 hydrase assay	B	7.27	pKi	54	nM	Ki	J Med Chem (2010) 53: 850-854 [PMID:20028100]
ChEMBL	Inhibition of human CA5B by stopped-flow CO2 hydration assay	B	7.27	pKi	54	nM	Ki	Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318]
ChEMBL	Inhibition of full length human carbonic anhydrase 5b preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.27	pKi	54	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 5b after 15 mins by stopped-flow CO2 hydration assay	B	7.27	pKi	54	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of human carbonic anhydrase 5B by stopped flow CO2 hydration method	B	7.27	pKi	54	nM	Ki	J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
ChEMBL	Inhibition of human recombinant CA5B mitochondrial isoform by stopped-flow CO2 hydration assay	B	7.27	pKi	54	nM	Ki	Bioorg Med Chem Lett (2011) 21: 1334-1337 [PMID:21300547]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 5b preincubated for 15 mins by CO2 hydration method	B	7.27	pKi	54	nM	Ki	Bioorg Med Chem (2011) 19: 3105-3119 [PMID:21515057]
ChEMBL	Inhibition of human carbonic anhydrase 5B preincubated for 15 mins at pH 7.5 by stopped flow CO2 hydration method	B	7.27	pKi	54	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5210-5213 [PMID:21821413]
ChEMBL	Inhibition of carbonic anhydrase-5B (unknown origin)	B	7.27	pKi	54	nM	Ki	J Med Chem (2015) 58: 7580-7590 [PMID:26347950]
ChEMBL	Inhibition of human CA5B by stopped-flow CO2 hydrase assay	B	7.27	pKi	54	nM	Ki	Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280]
ChEMBL	Inhibition of human carbonic anhydrase 5B after 15 mins by stopped flow carbon dioxide hydration assay	B	7.27	pKi	54	nM	Ki	ACS Med Chem Lett (2018) 9: 462-467 [PMID:29795760]
ChEMBL	Inhibition of recombinant human CA5b preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	7.27	pKi	54	nM	Ki	ACS Med Chem Lett (2018) 9: 1035-1038 [PMID:30344913]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 5b incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	7.27	pKi	54	nM	Ki	Eur J Med Chem (2018) 157: 1214-1222 [PMID:30193219]
ChEMBL	Inhibition of human carbonic anhydrase 5B incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	7.27	pKi	54	nM	Ki	Eur J Med Chem (2019) 177: 188-197 [PMID:31136893]
ChEMBL	Inhibition of human CA5B pre-incubated for 15 mins by stopped flow CO2 hydrase assay	B	7.27	pKi	54	nM	Ki	J Med Chem (2020) 63: 7392-7409 [PMID:32463228]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 5B preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.27	pKi	54	nM	Ki	ACS Med Chem Lett (2020) 11: 727-731 [PMID:32435377]
ChEMBL	Inhibition of human carbonic anhydrase 5B by stopped-flow CO2 hydration assay	B	7.27	pKi	54	nM	Ki	J Med Chem (2021) 64: 11432-11444 [PMID:34283610]
ChEMBL	Inhibition of human cloned CA5B by stopped-flow CO2 hydration method	B	7.27	pKi	54	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibitory activity against human recombinant mitochondrial isozyme CA VB	B	7.27	pKi	54	nM	Ki	J Med Chem (2005) 48: 7860-7866 [PMID:16302824]
ChEMBL	Inhibition of human CAH5B expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	7.61	pKi	24.6	nM	Ki	J Med Chem (2021) 64: 1713-1724 [PMID:33523653]
Carbonic anhydrase VI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280]
ChEMBL	Inhibition of human carbonic anhydrase 6 at pH7 and 37 degC by fluorescent thermal shift assay	B	6.51	pKd	310	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 6 expressed in Escherichia coli expression system assessed as observed dissociation constant fluorescent thermal shift assay	B	6.66	pKd	220	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 6 expressed in Escherichia coli Rosetta2 (DE3) by thermal shift assay	B	6.74	pKd	180	nM	Kd	Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 6 expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	B	8.01	pKd	9.8	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Inhibition of human CA6 using 4-nitrophenylacetate substrate by esterase assay	B	6.47	pKi	340	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4259-4262 [PMID:21669522]
ChEMBL	Inhibition of human carbonic anhydrase 6 esterase activity using 4-nitrophenylacetate as substrate	B	6.47	pKi	340	nM	Ki	Bioorg Med Chem Lett (2012) 22: 1352-1357 [PMID:22230050]
ChEMBL	Inhibition of human carbonic anhydrase 6 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis	B	6.47	pKi	340	nM	Ki	Eur J Med Chem (2012) 49: 68-73 [PMID:22245047]
ChEMBL	Inhibition of human CAH6 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	7.01	pKi	98.2	nM	Ki	J Med Chem (2021) 64: 1713-1724 [PMID:33523653]
ChEMBL	Inhibition of human recombinant full length CA6 by stopped-flow CO2 hydration method	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of human full length recombinant carbonic anhydrase 6 by stopped flow CO2 hydrase assay	B	7.96	pKi	11	nM	Ki	J Med Chem (2009) 52: 646-654 [PMID:19193158]
ChEMBL	Inhibition of human cloned CA6 by stopped-flow CO2 hydration method	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem Lett (2008) 18: 4282-4286 [PMID:18640037]
ChEMBL	Inhibition of human carbonic anhydrase 6 by stopped-flow CO2 hydration assay	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL	Inhibition of human carbonic anhydrase 6 by stopped flow CO2 hydration assay	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4102-4106 [PMID:19527930]
ChEMBL	Inhibition of human full length carbonic anhydrase 6 after 15 mins by stopped-flow CO2 hydration assay	B	7.96	pKi	11	nM	Ki	J Med Chem (2009) 52: 5990-5998 [PMID:19731956]
ChEMBL	Inhibition of human recombinant CA6 by stopped flow CO2 hydrase assay	B	7.96	pKi	11	nM	Ki	J Med Chem (2010) 53: 850-854 [PMID:20028100]
ChEMBL	Inhibition of human CA6 by stopped-flow CO2 hydration assay	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318]
ChEMBL	Inhibition of human carbonic anhydrase 6 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 6 after 15 mins by stopped-flow CO2 hydration assay	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of human carbonic anhydrase 6 by stopped flow CO2 hydration method	B	7.96	pKi	11	nM	Ki	J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
ChEMBL	Inhibition of full length human recombinant CA VI	B	7.96	pKi	11	nM	Ki	J Med Chem (2007) 50: 381-388 [PMID:17228881]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 6 preincubated for 15 mins by CO2 hydration method	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem (2011) 19: 3105-3119 [PMID:21515057]
ChEMBL	Inhibition of human carbonic anhydrase 6 preincubated for 15 mins at pH 7.5 by stopped flow CO2 hydration method	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5210-5213 [PMID:21821413]
ChEMBL	Inhibition of human carbonic anhydrase6 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem (2013) 21: 7210-7215 [PMID:24090602]
ChEMBL	Inhibition of human CA6 preincubated for 15 mins by stopped-flow CO2 hydration method	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem (2014) 22: 334-340 [PMID:24300919]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 6 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem (2014) 22: 6768-6775 [PMID:25468040]
ChEMBL	Inhibition of carbonic anhydrase-6 (unknown origin)	B	7.96	pKi	11	nM	Ki	J Med Chem (2015) 58: 7580-7590 [PMID:26347950]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 6 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay	B	7.96	pKi	11	nM	Ki	J Med Chem (2016) 59: 5462-5470 [PMID:27172398]
ChEMBL	Inhibition of human CA6 by stopped-flow CO2 hydrase assay	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280]
ChEMBL	Inhibition of recombinant human CA6 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	7.96	pKi	11	nM	Ki	ACS Med Chem Lett (2018) 9: 1035-1038 [PMID:30344913]
ChEMBL	Inhibition of human carbonic anhydrase 6 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	7.96	pKi	11	nM	Ki	Eur J Med Chem (2019) 177: 188-197 [PMID:31136893]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 6 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.96	pKi	11	nM	Ki	ACS Med Chem Lett (2020) 11: 727-731 [PMID:32435377]
ChEMBL	Inhibition of human recombinant CA6 by stopped-flow CO2 hydration assay	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801]
ChEMBL	Inhibition of human carbonic anhydrase 6	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human full length carbonic anhydrase 6 by stopped flow CO2 hydrase assay	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human recombinant full length CA6 by stopped flow CO2 hydration assay	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166]
ChEMBL	Inhibition of human carbonic anhydrase 7 at pH7 and 37 degC by isothermal titration calorimetry	B	7.2	pKd	63	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to human recombinant CA7 at 37 degC and pH 7.0 by thermal shift assay	B	7.77	pKd	17	nM	Kd	Bioorg Med Chem (2013) 21: 2093-2106 [PMID:23394791]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 7 by thermal shift assay	B	7.77	pKd	17	nM	Kd	Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428]
ChEMBL	Inhibition of human carbonic anhydrase 7 at pH7 and 37 degC by fluorescent thermal shift assay	B	7.77	pKd	17	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 7 expressed in Escherichia coli expression system assessed as observed dissociation constant fluorescent thermal shift assay	B	7.89	pKd	13	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 7 expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	B	8.62	pKd	2.4	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Inhibition of human CAH7 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	7.16	pKi	69.2	nM	Ki	J Med Chem (2021) 64: 1713-1724 [PMID:33523653]
ChEMBL	Inhibition of recombinant human cytosolic carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.55	pKi	28	nM	Ki	Bioorg Med Chem (2013) 21: 5799-5805 [PMID:23910989]
ChEMBL	Inhibition of recombinant human CA7 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	Eur J Med Chem (2019) 182: 111600-111600 [PMID:31419777]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 7 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	ACS Med Chem Lett (2017) 8: 1105-1109 [PMID:29057059]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 7 incubated for 15 mins by stopped flow CO2 hydrase assay	B	8.22	pKi	6	nM	Ki	ACS Med Chem Lett (2017) 8: 1213-1217 [PMID:29259736]
ChEMBL	Inhibition of recombinant human cytosolic carbonic anhydrase 7 pretreated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem (2017) 25: 2518-2523 [PMID:28302505]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 7 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	Eur J Med Chem (2021) 209: 112875-112875 [PMID:33059188]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-7 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2017) 25: 3567-3573 [PMID:28522267]
ChEMBL	Inhibition of recombinant human CA7 incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.52	pKi	3	nM	Ki	Eur J Med Chem (2020) 185: 111811-111811 [PMID:31693947]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 using carbon-dioxide as substrate preincubated for 10 mins prior to substrate addition by stopped flow cytometry	B	8.55	pKi	2.8	nM	Ki	Bioorg Med Chem Lett (2012) 22: 1560-1564 [PMID:22277279]
ChEMBL	Inhibition of S-glutathionylated form of human recombinant carbonic anhydrase 7 using carbon-dioxide as substrate preincubated for 10 mins prior to substrate addition by stopped flow cytometry	B	8.57	pKi	2.7	nM	Ki	Bioorg Med Chem Lett (2012) 22: 1560-1564 [PMID:22277279]
GtoPdb	-	-	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-81 [PMID:20605094]
ChEMBL	Inhibition of human full length cytosolic carbonic anhydrase 7 after 15 mins by stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2009) 52: 5990-5998 [PMID:19731956]
ChEMBL	Inhibition of human recombinant CA7 by stopped flow CO2 hydrase assay	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2010) 53: 850-854 [PMID:20028100]
ChEMBL	Inhibition of human CA7 by stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318]
ChEMBL	Inhibition of full length human carbonic anhydrase 7 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 after 15 mins by stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of human carbonic anhydrase 7 by stopped flow CO2 hydration method	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
ChEMBL	Inhibition of human recombinant CAH7	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2011) 54: 2522-2526 [PMID:21395315]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 by stopped flow CO2 hydration method	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem Lett (2009) 19: 3170-3173 [PMID:19435663]
ChEMBL	Inhibition of human carbonic anhydrase 7 preincubated with compound for 15 mins by carbon dioxide hydration assay	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2011) 54: 3977-3981 [PMID:21506569]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 7 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2011) 19: 3732-3738 [PMID:21620713]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins by CO2 hydration method	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2011) 19: 3105-3119 [PMID:21515057]
ChEMBL	Inhibition of human carbonic anhydrase 7 preincubated for 15 mins at pH 7.5 by stopped flow CO2 hydration method	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5210-5213 [PMID:21821413]
ChEMBL	Inhibition of human recombinant full length CA7-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2012) 55: 3891-3899 [PMID:22443141]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2013) 21: 5168-5174 [PMID:23867389]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 7 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175]
ChEMBL	Inhibition of human carbonic anhydrase7 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2013) 21: 7210-7215 [PMID:24090602]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Eur J Med Chem (2014) 71: 105-111 [PMID:24287559]
ChEMBL	Inhibition of human CA7 preincubated for 15 mins by stopped-flow CO2 hydration method	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2014) 22: 334-340 [PMID:24300919]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2014) 22: 6768-6775 [PMID:25468040]
ChEMBL	Inhibition of human recombinant CA-7 after 15 mins by stopped-flow CO2 hydrase assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2015) 23: 1828-1840 [PMID:25766630]
ChEMBL	Inhibition of carbonic anhydrase-7 (unknown origin)	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2015) 58: 7580-7590 [PMID:26347950]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2015) 23: 7219-7225 [PMID:26498393]
ChEMBL	Inhibition of human carbonic anhydrase-7 preincubated for 15 mins by stopped flow CO2 dehydration assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2016) 24: 20-25 [PMID:26678172]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 7 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2016) 24: 894-901 [PMID:26795114]
ChEMBL	Inhibition of human recombinant membrane bound CA7 expressed in Escherichia coli preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2016) 24: 3548-3555 [PMID:27298005]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2016) 59: 5462-5470 [PMID:27172398]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 expressed in Escherichia coli assessed as reduction in CO2 hydration preincubated for 15 mins prior to testing measured for 10 to 100 secs by stopped-flow assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem Lett (2017) 27: 86-89 [PMID:27876475]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-7 using CO2 as substrate preincubated for 10 mins by stopped-flow CO2 hydrase assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2017) 25: 539-544 [PMID:27919611]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 7 assessed as reduction in CO2 hydration preincubated for 15 mins by stopped flow assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2017) 25: 1456-1464 [PMID:28111158]
ChEMBL	Inhibition of recombinant human CA7 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2017) 60: 1159-1170 [PMID:28075587]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Eur J Med Chem (2017) 127: 521-530 [PMID:28109946]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-7 assessed as reduction in enzyme-catalyzed hydration activity using CO2 as substrate preincubated for 15 mins followed substrate addition measured after 10 to 100 sec by phenol red dye based stopped flow assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2017) 25: 1914-1925 [PMID:28237553]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 7 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2017) 60: 2456-2469 [PMID:28253618]
ChEMBL	Inhibition of human carbonic anhydrase 7 incubated for 10 mins by stopped flow CO2 hydrase assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2017) 25: 3093-3097 [PMID:28400084]
ChEMBL	Inhibition of human carbonic anhydrase 7 after 15 mins by stopped flow carbon dioxide hydration assay	B	8.6	pKi	2.5	nM	Ki	ACS Med Chem Lett (2018) 9: 462-467 [PMID:29795760]
ChEMBL	Inhibition of human carbonic anhydrase 7 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Eur J Med Chem (2018) 154: 210-219 [PMID:29803994]
ChEMBL	Inhibition of recombinant human CA7 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	ACS Med Chem Lett (2018) 9: 1035-1038 [PMID:30344913]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 assessed as CO2 hydration preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red dye-based stopped-flow assay	B	8.6	pKi	2.5	nM	Ki	Eur J Med Chem (2018) 156: 430-443 [PMID:30015076]
ChEMBL	Inhibition of recombinant full length human carbonic anhydrase-7 assessed as reduction in CO2 hydration after 15 mins by phenol red dye based stopped flow assay	B	8.6	pKi	2.5	nM	Ki	Eur J Med Chem (2019) 163: 443-452 [PMID:30530195]
ChEMBL	Inhibition of human carbonic anhydrase 7 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Eur J Med Chem (2019) 177: 188-197 [PMID:31136893]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 7 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Eur J Med Chem (2019) 181: 111586-111586 [PMID:31401537]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Eur J Med Chem (2019) 182: 111642-111642 [PMID:31476557]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 preincubated with enzyme for 1 hr prior to testing by phenol red-based stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2020) 63: 5185-5200 [PMID:32364386]
ChEMBL	Inhibition of human CA7 preincubated for 15 mins by stopped-flow carbon dioxide hydration assay	B	8.6	pKi	2.5	nM	Ki	ACS Med Chem Lett (2020) 11: 1000-1005 [PMID:32435417]
ChEMBL	Inhibition of human CA7 pre-incubated for 15 mins by stopped flow CO2 hydrase assay	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2020) 63: 7392-7409 [PMID:32463228]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 7 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	ACS Med Chem Lett (2020) 11: 727-731 [PMID:32435377]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 7 by stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2018) 61: 3151-3165 [PMID:29566486]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 7 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Eur J Med Chem (2021) 212: 113035-113035 [PMID:33303238]
ChEMBL	Inhibition of human carbonic anhydrase 7 by stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2021) 64: 11432-11444 [PMID:34283610]
ChEMBL	Inhibition of human cloned CA7 by stopped-flow CO2 hydration method	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibition of human recombinant CA7 after 15 mins by CO2 hydration stopped flow assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem Lett (2007) 17: 2685-2691 [PMID:17376683]
ChEMBL	Inhibition of human carbonic anhydrase 7	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human full length carbonic anhydrase 7 by stopped flow CO2 hydrase assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human recombinant full length CA7 by stopped flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human recombinant full length CA7 by stopped-flow CO2 hydration method	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of human cloned CA7 by stopped-flow CO2 hydration method	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem Lett (2008) 18: 4282-4286 [PMID:18640037]
ChEMBL	Inhibition of human carbonic anhydrase 7 by stopped-flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL	Inhibition of human carbonic anhydrase 7 by CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Eur J Med Chem (2008) 43: 2853-2860 [PMID:18406497]
ChEMBL	Inhibition of human carbonic anhydrase 7 by stopped flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4102-4106 [PMID:19527930]
ChEMBL	Ki value against human carbonic anhydrase VII	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem Lett (2005) 15: 971-976 [PMID:15686895]
ChEMBL	Inhibition of recombinant human CA7 preincubated for 15 mins by measured for 10 to 100 secs by phenol red dye based stopped flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem Lett (2021) 45: 128147-128147 [PMID:34052322]
ChEMBL	Inhibition of recombinant human CA7 incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2021) 44: 116279-116279 [PMID:34216985]
ChEMBL	Inhibition of recombinant human CA7 pre-incubated for 15 mins measured by stopped flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	J Med Chem (2021) 64: 3100-3114 [PMID:33721499]
ChEMBL	Inhibition of recombinant human CA7 pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Eur J Med Chem (2021) 225: 113793-113793 [PMID:34507012]
ChEMBL	Inhibition of human CA7 by stopped-flow CO2 hydrase assay	B	8.7	pKi	2	nM	Ki	Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 phosphatase activity using 4-nitrophenyl phosphate as substrate preincubated for 10 mins prior to substrate addition by stopped flow cytometry	B	5.46	pIC50	3440	nM	IC50	Bioorg Med Chem Lett (2012) 22: 1560-1564 [PMID:22277279]
ChEMBL	Inhibition of S-glutathionylated form of human recombinant carbonic anhydrase 7 phosphatase activity using 4-nitrophenyl phosphate as substrate preincubated for 10 mins prior to substrate addition by stopped flow cytometry	B	5.6	pIC50	2520	nM	IC50	Bioorg Med Chem Lett (2012) 22: 1560-1564 [PMID:22277279]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 hydrolysis activity using 4-nitrophenyl acetate as substrate preincubated for 10 mins prior to substrate addition by stopped flow cytometry	B	6.45	pIC50	357	nM	IC50	Bioorg Med Chem Lett (2012) 22: 1560-1564 [PMID:22277279]
ChEMBL	Inhibition of S-glutathionylated form of human recombinant carbonic anhydrase 7 hydrolysis activity using 4-nitrophenyl acetate as substrate preincubated for 10 mins prior to substrate addition by stopped flow cytometry	B	6.58	pIC50	265	nM	IC50	Bioorg Med Chem Lett (2012) 22: 1560-1564 [PMID:22277279]
carbonic anhydrase 7/Carbonic anhydrase VII in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2216] [GtoPdb: 2749] [UniProtKB: Q9ERQ8]
ChEMBL	Ki value against mouse carbonic anhydrase VII	B	7.8	pKi	16	nM	Ki	Bioorg Med Chem Lett (2005) 15: 971-976 [PMID:15686895]
carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
ChEMBL	Inhibition of chimeric carbonic anhydrase 12 (unknown origin) expressing with full length CA2 (1 to 260) at pH7 and 37 degC by fluorescent thermal shift assay	B	6.48	pKd	330	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 12 by thermal shift assay	B	6.88	pKd	133	nM	Kd	Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428]
ChEMBL	Binding affinity to human recombinant CA12 at 37 degC and pH 7.0 by thermal shift assay	B	6.88	pKd	133	nM	Kd	Bioorg Med Chem (2013) 21: 2093-2106 [PMID:23394791]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 12 expressed in Escherichia coli expression system assessed as observed dissociation constant fluorescent thermal shift assay	B	6.89	pKd	130	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Inhibition of human carbonic anhydrase 12 at pH7 and 37 degC by fluorescent thermal shift assay	B	6.89	pKd	130	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Inhibition of human carbonic anhydrase 12 at pH7 and 37 degC by isothermal titration calorimetry	B	6.89	pKd	130	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Inhibition of human carbonic anhydrase 12 at pH7 and 25 degC by stopped-flow kinetic inhibition assay	B	7.6	pKd	25	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 12 expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	B	7.62	pKd	24	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Inhibition of human CA12	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 4560-4565 [PMID:28728897]
ChEMBL	Inhibition of human carbonic anhydrase-12 preincubated for 15 mins by stopped flow CO2 dehydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2016) 24: 104-112 [PMID:26682703]
ChEMBL	Inhibition of recombinant human CA12 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2019) 181: 111573-111573 [PMID:31394463]
ChEMBL	Inhibition of human carbonic anhydrase 12 catalytic domain by Stopped-Flow CO2 Hydrase assay	B	8.22	pKi	6	nM	Ki	J Med Chem (2016) 59: 462-473 [PMID:26688270]
ChEMBL	Inhibition of recombinant human transmembrane, tumor-associated form of carbonic anhydrase-12 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem Lett (2015) 25: 2377-2381 [PMID:25913118]
ChEMBL	Inhibition of human CA12 by Lineweaver-Burk plot analysis	B	8.22	pKi	6	nM	Ki	ACS Med Chem Lett (2018) 9: 1045-1050 [PMID:30344915]
ChEMBL	Inhibition of human carbonic anhydrase-12 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem (2013) 21: 2925-2931 [PMID:23623256]
ChEMBL	Inhibition of human CA12 by stopped-flow CO2 hydration method	B	8.22	pKi	6	nM	Ki	J Med Chem (2015) 58: 640-650 [PMID:25432060]
ChEMBL	Inhibition of human CA12 using CO2 as substrate incubated for 6 hrs prior to substrate addition measured for 10 to 100 secs by stopped flow technique	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem Lett (2012) 22: 5801-5806 [PMID:22901388]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem (2016) 24: 982-988 [PMID:26803577]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem (2016) 24: 1095-1105 [PMID:26810710]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	ACS Med Chem Lett (2020) 11: 1022-1027 [PMID:32435420]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 expressed in Escherichia coli preincubated for 15 mins by stopped flow CO2 hydration method	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem (2015) 23: 4649-4659 [PMID:26088336]
ChEMBL	Inhibition of human recombinant CA12 expressed in Escherichia coli by stopped flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	J Med Chem (2015) 58: 6630-6638 [PMID:26203869]
ChEMBL	Inhibition of recombinant human carbonic anhydrase12 preincubated for 10 mins followed by CO2 solution addition by phenol red dye based stopped flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem (2019) 27: 115090-115090 [PMID:31515058]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 6 hrs prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	Eur J Med Chem (2020) 200: 112300-112300 [PMID:32460112]
ChEMBL	Inhibition of human carbonic anhydrase 12 by stopped-flow CO2 hydrase assay	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem (2014) 22: 1821-1831 [PMID:24560739]
ChEMBL	Inhibition of human CA12 by stopped-flow CO2 hydrase assay	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-12 catalytic domain by stopped-flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	ACS Med Chem Lett (2015) 6: 819-821 [PMID:26191373]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 catalytic domain preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	ACS Med Chem Lett (2017) 8: 941-946 [PMID:28947941]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 catalytic domain expressed in Escherichia coli incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem (2015) 23: 6573-6580 [PMID:26422787]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem Lett (2013) 23: 6759-6763 [PMID:24189056]
ChEMBL	Inhibition of human carbonic anhydrase 12 by by stopped flow CO2 hydration method	B	8.24	pKi	5.8	nM	Ki	Bioorg Med Chem (2015) 23: 4989-4999 [PMID:26048024]
ChEMBL	Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.24	pKi	5.8	nM	Ki	ACS Med Chem Lett (2014) 5: 793-796 [PMID:25050167]
ChEMBL	Inhibition of human CA12 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.24	pKi	5.8	nM	Ki	J Med Chem (2022) 65: 824-837 [PMID:34958217]
ChEMBL	Inhibition of human carbonic anhydrase-12 pre-incubated for 15 mins by stopped-flow CO2 hydration assay based Lineweaver-Burk plot method	B	8.24	pKi	5.8	nM	Ki	Bioorg Med Chem (2015) 23: 3674-3680 [PMID:25921266]
ChEMBL	Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration assay	B	8.24	pKi	5.8	nM	Ki	Bioorg Med Chem (2015) 23: 1421-1429 [PMID:25757603]
ChEMBL	Inhibition of human carbonic anhydrase 12-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay	B	8.24	pKi	5.8	nM	Ki	Bioorg Med Chem (2014) 22: 2643-2647 [PMID:24713308]
GtoPdb	-	-	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2005) 15: 963-9 [PMID:15686894]; Bioorg Med Chem Lett (2010) 20: 4376-81 [PMID:20605094]
ChEMBL	Inhibition of human cloned carbonic anhydrase 12 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2010) 45: 2396-2404 [PMID:20202722]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 after 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of human carbonic anhydrase 12 by stopped flow CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
ChEMBL	Inhibition of human cloned catalytic domain of CA12 after 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2010) 45: 3656-3661 [PMID:20554082]
ChEMBL	Inhibition of human carbonic anhydrase XII by spectrophotometry at pH 7.5	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2011) 19: 1172-1178 [PMID:21251841]
ChEMBL	Inhibition of tumor-associated human carbonic anhydrase 12 preincubated for 15 min by CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2011) 54: 1896-1902 [PMID:21361354]
ChEMBL	Inhibition of human recombinant CA12 catalytic domain by CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2011) 21: 3216-3221 [PMID:21549597]
ChEMBL	Inhibition of human recombinant catalytic domain of carbonic anhydrase 12 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2011) 21: 2975-2979 [PMID:21470859]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2011) 19: 3105-3119 [PMID:21515057]
ChEMBL	Inhibition of human cloned carbonic anhydrase 12 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2011) 46: 4403-4410 [PMID:21820216]
ChEMBL	Inhibition of human carbonic anhydrase 12 preincubated for 15 mins at pH 7.5 by stopped flow CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5210-5213 [PMID:21821413]
ChEMBL	Inhibition of human recombinant CA12 by CO2 hydration based stopped flow assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2011) 54: 6905-6918 [PMID:21851094]
ChEMBL	Inhibition of human carbonic anhydrase 12-catalyzed CO2 hydration activity by stopped flow assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5892-5896 [PMID:21852133]
ChEMBL	Inhibition of human carbonic anhydrase 12 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2012) 20: 2392-2404 [PMID:22370338]
ChEMBL	Inhibition of human CA12 pre-incubated for 15 mins by stopped-flow CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2012) 55: 1721-1730 [PMID:22276570]
ChEMBL	Inhibition of human recombinant CA12 catalytic domain preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2012) 55: 6776-6783 [PMID:22775345]
ChEMBL	Inhibition of human CA12 by stopped-flow assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2013) 23: 715-719 [PMID:23265898]
ChEMBL	Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2013) 21: 1396-1403 [PMID:23290254]
ChEMBL	Inhibition of recombinant human CA12 transmembrane isoform preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2013) 56: 4691-4700 [PMID:23647428]
ChEMBL	Inhibition of human carbonic anhydrase 12 by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2013) 21: 3949-3957 [PMID:23706268]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 12 after 6 hrs by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2013) 21: 4502-4510 [PMID:23769167]
ChEMBL	Inhibition of human membrane bound carbonic anhydrase 12 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175]
ChEMBL	Inhibition of human carbonic anhydrase-12 by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2013) 23: 5646-5649 [PMID:23993330]
ChEMBL	Inhibition of human carbonic anhydrase12 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2013) 21: 7210-7215 [PMID:24090602]
ChEMBL	Inhibition of human carbonic anhydrase 12 by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2013) 56: 9623-9634 [PMID:24200125]
ChEMBL	Inhibition of human CA12 preincubated for 15 mins by stopped-flow CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2014) 22: 334-340 [PMID:24300919]
ChEMBL	Inhibition of human CA12 after 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2014) 71: 135-147 [PMID:24291567]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 12 by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184]
ChEMBL	Inhibition of human recombinant transmembrane carbonic anhydrase 12 after 6 hrs by stopped flow CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2014) 22: 1522-1528 [PMID:24513186]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 12 by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2014) 22: 1873-1882 [PMID:24560737]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1310-1314 [PMID:24507918]
ChEMBL	Inhibition of human carbonic anhydrase 12-mediated CO2 hydration preincubated for 10 mins by stopped-flow assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2014) 76: 284-290 [PMID:24589484]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12-mediated CO2 hydration after 6 hrs by stopped-flow assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1256-1260 [PMID:24518190]
ChEMBL	Inhibition of human recombinant transmembrane tumor associated carbonic anhydrase-12 incubated for 15 mins prior to testing by stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1776-1779 [PMID:24589511]
ChEMBL	Inhibition of human cloned transmembrane tumor-associated catalytic domain of carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2014) 82: 47-55 [PMID:24871996]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2014) 22: 3684-3695 [PMID:24878360]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2014) 22: 6768-6775 [PMID:25468040]
ChEMBL	Inhibition of human carbonic anhydrase 12 by stopped flow CO2 hydrase assay method	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2014) 22: 6945-6952 [PMID:25456084]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 after 15 mins by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2014) 22: 3982-3988 [PMID:25027802]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 by stopped flow CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2014) 84: 240-246 [PMID:25019479]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 preincubated for 15 mins by stopped-flow CO2 hydrase Assay	B	8.24	pKi	5.7	nM	Ki	ACS Med Chem Lett (2014) 5: 927-930 [PMID:25147616]
ChEMBL	Inhibition of human carbonic anhydrase 12 by stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2014) 24: 5185-5189 [PMID:25442309]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2014) 57: 9152-9167 [PMID:25310626]
ChEMBL	Inhibition of human CA-12 by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2014) 57: 9673-9686 [PMID:25358036]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2014) 87: 186-196 [PMID:25255434]
ChEMBL	Inhibition of human CA-12 after 15 mins by stopped-flow CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2014) 22: 5883-5890 [PMID:25267005]
ChEMBL	Inhibition of human tumor-associated carbonic anhydrase 12 by stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2015) 23: 1430-1436 [PMID:25753329]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 expressed in Escherichia coli pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2015) 23: 2368-2376 [PMID:25846066]
ChEMBL	Inhibition of human recombinant CA-12 after 15 mins by stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2015) 23: 1828-1840 [PMID:25766630]
ChEMBL	Inhibition of human membrane associated form of carbonic anhydrase-12 assessed as CO2 hydration activity incubated for 15 mins prior to testing by stopped flow method	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2015) 96: 425-435 [PMID:25912674]
ChEMBL	Inhibition of human recombinant carbonic anhdydrase-12 expressed in Escherichia coli pre-incubated for 6 hrs by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2015) 58: 3975-3983 [PMID:25875209]
ChEMBL	Inhibition of human carbonic anhydrase 12 by stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2015) 23: 2975-2981 [PMID:26007302]
ChEMBL	Inhibition of human carbonic anhydrase-12 incubated for 10 mins prior to testing by stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3208-3212 [PMID:26105196]
ChEMBL	Inhibition of human carbonic anhydrase-12	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3281-3284 [PMID:26073006]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-12 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2015) 23: 5619-5625 [PMID:26233796]
ChEMBL	Inhibition of human carbonic anhydrase-12 incubated for 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2015) 23: 5311-5318 [PMID:26264840]
ChEMBL	Inhibition of carbonic anhydrase-12 (unknown origin)	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2015) 58: 7580-7590 [PMID:26347950]
ChEMBL	Inhibition of human carbonic anhydrase 12 incubated for 6 hrs by stopped flow carbon-di-oxide hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2015) 23: 6955-6966 [PMID:26432607]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2015) 23: 7219-7225 [PMID:26498393]
ChEMBL	Inhibition of human carbonic anhydrase-12 assessed as CO2 hydration activity by stopped-flow method	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2015) 58: 8564-8572 [PMID:26497049]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 expressed in Escherichia coli preincubated for 6 hrs by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2015) 103: 583-593 [PMID:26408817]
ChEMBL	Inhibition of human carbonic anhydrase-12 preincubated for 15 mins by stopped flow CO2 dehydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2016) 24: 20-25 [PMID:26678172]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2016) 24: 894-901 [PMID:26795114]
ChEMBL	Inhibition of human CA12 preincubated for 15 mins by phenol red based stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2022) 228: 113997-113997 [PMID:34902732]
ChEMBL	Inhibitory activity against catalytic domain of human carbonic anhydrase XII	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3821-3827 [PMID:16039853]
ChEMBL	Ki value against human carbonic anhydrase XII (hCA XII)	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2005) 15: 963-969 [PMID:15686894]
ChEMBL	Inhibition constant against human carbonic anhydrase XII	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3096-3101 [PMID:15908204]
ChEMBL	Inhibitory activity against human Carbonic anhydrase XII (hCA XII)	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4862-4866 [PMID:16168653]
ChEMBL	Inhibitory activity against cloned human CA12	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2006) 16: 437-442 [PMID:16290146]
ChEMBL	Inhibition of human cloned CA12 catalytic domain by CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2006) 16: 4846-4851 [PMID:16809036]
ChEMBL	Inhibition of catalytic domain of human cloned CA12 by stopped-flow CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibition of catalytic domain of human CA XII	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2007) 50: 381-388 [PMID:17228881]
ChEMBL	Inhibition of human recombinant CA12 by CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2007) 17: 987-992 [PMID:17157501]
ChEMBL	Inhibition of human carbonic anhydrase 12	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human recombinant CA12 by CO2 hydration stopped flow assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2008) 18: 836-841 [PMID:18042384]
ChEMBL	Inhibition of human catalytic domain carbonic anhydrase 12 by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human recombinant CA12 catalytic domain by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human recombinant CA12 by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2273-2276 [PMID:19286378]
ChEMBL	Inhibition of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of human cloned CA12 catalytic domain by stopped-flow CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2008) 18: 4282-4286 [PMID:18640037]
ChEMBL	Inhibition of human carbonic anhydrase 12 catalytic domain by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL	Inhibition of human carbonic anhydrase 12 by CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2008) 43: 2853-2860 [PMID:18406497]
ChEMBL	Inhibition of human carbonic anhydrase 12 by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4102-4106 [PMID:19527930]
ChEMBL	Inhibition of human membrane-bound carbonic anhydrase 12 catalytic domain after 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2009) 52: 5990-5998 [PMID:19731956]
ChEMBL	Inhibition of human cloned CA12 catalytic domain by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2009) 52: 6421-6432 [PMID:19827837]
ChEMBL	Inhibition of human recombinant CA12 by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2010) 53: 850-854 [PMID:20028100]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 expressed in Escherichia coli by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2009) 19: 5825-5828 [PMID:19751975]
ChEMBL	Inhibition of human recombinant CA12 catalytic domain expressed in Sf9 cells by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2009) 17: 7093-7099 [PMID:19773173]
ChEMBL	Inhibition of human CA12 by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318]
ChEMBL	Inhibition of human recombinant CA12 by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2010) 53: 2913-2926 [PMID:20201556]
ChEMBL	Inhibition of human carbonic anhydrase 12 catalytic domain preincubated for 15 mins by CO2 hydration stopped-flow assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2020) 188: 112021-112021 [PMID:31901743]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2020) 189: 112019-112019 [PMID:31972394]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 10 mins prior to testing measured for 5 to 10 secs by phenol red-based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2020) 193: 112219-112219 [PMID:32203788]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2020) 200: 112449-112449 [PMID:32485534]
ChEMBL	Inhibition of human CA12 preincubated for 15 mins prior to testing by phenol red-based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2020) 207: 112745-112745 [PMID:32877804]
ChEMBL	Inhibition of human CA12 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2021) 209: 112897-112897 [PMID:33038795]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2021) 212: 113035-113035 [PMID:33303238]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 assessed as inhibition constant preincubated with enzyme for 10 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2020) 28: 115586-115586 [PMID:32631564]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 preincubated for 10 mins by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2021) 39: 127877-127877 [PMID:33640442]
ChEMBL	Inhibition of recombinant human CA12 pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2020) 190: 112112-112112 [PMID:32044580]
ChEMBL	Inhibition of human CA12 by stopped-flow carbon dioxide hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2020) 200: 112439-112439 [PMID:32485532]
ChEMBL	Inhibition of human CA12 measured by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2021) 48: 128249-128249 [PMID:34237441]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2021) 49: 128309-128309 [PMID:34371130]
ChEMBL	Inhibition of recombinant human CA12 pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2021) 218: 113360-113360 [PMID:33773285]
ChEMBL	Inhibition of recombinant human CA12 pre-incubated for 15 mins prior to testing by phenol red-based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2021) 218: 113352-113352 [PMID:33774343]
ChEMBL	Inhibition of full length human CA12 incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2021) 44: 116279-116279 [PMID:34216985]
ChEMBL	Inhibition of human CA12 by stopped- flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2021) 216: 113283-113283 [PMID:33667848]
ChEMBL	Inhibition of recombinant human CA12 pre-incubated for 15 mins measured by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2021) 64: 3100-3114 [PMID:33721499]
ChEMBL	Inhibition of human carbonic anhydrase 12 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2021) 222: 113589-113589 [PMID:34147910]
ChEMBL	Inhibition of human CA12 measured after 15 mins by stopped flow carbon dioxide anhydrase assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2021) 225: 113800-113800 [PMID:34482273]
ChEMBL	Inhibition of human carbonic anhydrase 12 by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2021) 64: 11432-11444 [PMID:34283610]
ChEMBL	Inhibition of human CA12 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2022) 228: 114004-114004 [PMID:34847409]
ChEMBL	Inhibitory constant against catalytic domain of human carbonic anhydrase XII	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3828-3833 [PMID:16039848]
ChEMBL	Inhibition of human carbonic anhydrase 12 incubated for 15 mins prior to testing by CO2 hydration-based stopped flow assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2016) 59: 721-732 [PMID:26741028]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2016) 24: 1402-1407 [PMID:26875933]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow carbon dioxide hydrase assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2016) 110: 259-266 [PMID:26840366]
ChEMBL	Inhibition of human carbonic anhydrase 12 using saturated CO2 as substrate incubated for 10 mins prior to testing by stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2016) 24: 2882-2886 [PMID:27137360]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 preincubated for 15 min to 72 hrs by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2016) 24: 2907-2913 [PMID:27166574]
ChEMBL	Inhibition of human carbonic anhydrase 12 preincubated for 6 hrs at 4 degC measured for 10 to 100 secs by stopped-flow carbon dioxide hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2016) 24: 3643-3648 [PMID:27316543]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2016) 59: 5462-5470 [PMID:27172398]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2016) 59: 5077-5088 [PMID:27144971]
ChEMBL	Inhibition of human CA12 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2016) 24: 4100-4107 [PMID:27396930]
ChEMBL	Inhibition of human carbonic anhydrase 12 pre-incubated for 15 mins by stopped flow carbon dioxide hydrase assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2016) 59: 10692-10704 [PMID:27933963]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-12 preincubated for 6 hrs by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2017) 25: 677-683 [PMID:27939347]
ChEMBL	Inhibition of recombinant human membrane bound carbonic anhydrase 12 by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2017) 25: 1286-1293 [PMID:28065499]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 12 after 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2017) 127: 691-702 [PMID:27823879]
ChEMBL	Inhibition of recombinant human CA12 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2017) 60: 1159-1170 [PMID:28075587]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2017) 60: 2456-2469 [PMID:28253618]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2017) 25: 2782-2788 [PMID:28389112]
ChEMBL	Inhibition of human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2017) 60: 9003-9011 [PMID:29048889]
ChEMBL	Inhibition of human CA12 pre-incubated for 10 mins by stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2017) 25: 5373-5379 [PMID:28789908]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-12 preincubated for 10 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2017) 25: 5726-5732 [PMID:28887000]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 assessed as reduction in CO2 hydration pretreated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis	B	8.24	pKi	5.7	nM	Ki	ACS Med Chem Lett (2017) 8: 792-796 [PMID:28835790]
ChEMBL	Inhibition of human carbonic anhydrase 12 by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2018) 143: 1931-1941 [PMID:29146134]
ChEMBL	Inhibition of human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2018) 143: 276-282 [PMID:29197732]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2018) 61: 5380-5394 [PMID:29851481]
ChEMBL	Binding affinity to human carbonic anhydrase 12 by stopped flow CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	ACS Med Chem Lett (2018) 9: 725-729 [PMID:30034608]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-12 incubated for 15 mins by stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2018) 61: 4961-4977 [PMID:29746127]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated 15 mins prior to testing by CO2 hydration based stopped-flow assay	B	8.24	pKi	5.7	nM	Ki	ACS Med Chem Lett (2018) 9: 947-951 [PMID:30258546]
ChEMBL	Inhibition of human CA12 assessed as enzyme inhibitor complex formation preincubated for 15 mins and measured for 10 to 100 secs by phenol red dye based stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2018) 61: 6328-6338 [PMID:29962205]
ChEMBL	Inhibition of recombinant human CA12 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	ACS Med Chem Lett (2018) 9: 1035-1038 [PMID:30344913]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2018) 157: 28-36 [PMID:30071407]
ChEMBL	Inhibition of human carbonic anhydrase 12 incubated for 10 mins prior to testing measured for 5 to 10 secs by phenol red-based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2019) 183: 111702-111702 [PMID:31542715]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2019) 184: 111768-111768 [PMID:31629164]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-12 incubated for 15 mins by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2020) 185: 111843-111843 [PMID:31718943]
ChEMBL	Inhibition of human carbonic anhydrase-12 catalytic domain assessed as reduction in CO2 hydration after 15 mins by phenol red dye based stopped flow assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2019) 163: 443-452 [PMID:30530195]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 expressed in Escherichia coli by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2019) 62: 4174-4192 [PMID:30925064]
ChEMBL	Inhibition of human carbonic anhydrase 12 incubated for 15 mins by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	ACS Med Chem Lett (2019) 10: 661-665 [PMID:30996814]
ChEMBL	Inhibition of human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2019) 177: 188-197 [PMID:31136893]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 expressed in Escherichia coli by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2019) 179: 547-556 [PMID:31276899]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2020) 63: 2470-2488 [PMID:31972093]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2019) 62: 7233-7249 [PMID:31287314]
ChEMBL	Inhibition of human carbonic anhydrase 12 assessed as inhibitory constant incubated for 15 mins by phenol red dye based stopped flow assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2019) 182: 111638-111638 [PMID:31472471]
ChEMBL	Inhibition of human carbonic anhydrase 12 incubated for 15 mins by phenol red staining-based stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2019) 27: 115086-115086 [PMID:31515057]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 1 hr prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2020) 63: 321-333 [PMID:31794211]
ChEMBL	Inhibition of human CA 12 catalytic domain	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2019) 168: 301-314 [PMID:30826507]
ChEMBL	Inhibition of human carbonic anhydrase 12 assessed as inhibitory constant preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2019) 175: 40-48 [PMID:31071549]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing measured for 5 to 10 secs by phenol red-based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2019) 27: 1588-1594 [PMID:30846402]
ChEMBL	Inhibition of human carbonic anhydrase 12 assessed as reduction in CO2 hydration after 15 mins by phenol red staining-based stopped flow assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2019) 164: 92-105 [PMID:30594030]
ChEMBL	Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2016) 59: 5857-5867 [PMID:27253845]
ChEMBL	Inhibition of human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2016) 26: 3892-3895 [PMID:27423482]
ChEMBL	Inhibition of human CA12 preincubated for 15 mins by stopped-flow carbon dioxide hydration assay	B	8.24	pKi	5.7	nM	Ki	ACS Med Chem Lett (2020) 11: 1000-1005 [PMID:32435417]
ChEMBL	Inhibition of human CA12 pre-incubated for 15 mins by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2020) 63: 7392-7409 [PMID:32463228]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	ACS Med Chem Lett (2020) 11: 727-731 [PMID:32435377]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 6 hrs prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	ACS Med Chem Lett (2020) 11: 852-856 [PMID:32435395]
ChEMBL	Inhibition of human CA12 preincubated for 15 mins by stopped-flow CO2 hydration kinetic assay based Cheng-Prusoff equation analysis	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2020) 63: 7422-7444 [PMID:32519851]
ChEMBL	Inhibition of human carbonic anhydrase 12 assessed as inhibitory constant incubated for 6 hrs by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2020) 28: 115496-115496 [PMID:32327349]
ChEMBL	Inhibition of human carbonic anhydrase 12 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red dye based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2020) 28: 115329-115329 [PMID:32007388]
ChEMBL	Inhibition of human carbonic anhydrase 12 for 15 mins by stopped flow CO2 hydration assay	B	8.25	pKi	5.6	nM	Ki	Bioorg Med Chem (2016) 24: 976-981 [PMID:26810836]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.25	pKi	5.6	nM	Ki	Bioorg Med Chem (2016) 24: 921-927 [PMID:26796953]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 by stopped flow CO2 hydration assay	B	8.25	pKi	5.6	nM	Ki	Eur J Med Chem (2019) 162: 147-160 [PMID:30445264]
ChEMBL	Inhibition of recombinant human Carbonic anhydrase 12 assessed as reduction in CO2 hydration preincubated for 15 mins prior to testing measured for 10 to 100 secs by stopped-flow assay	B	8.25	pKi	5.6	nM	Ki	J Med Chem (2017) 60: 3154-3164 [PMID:28272885]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	8.25	pKi	5.6	nM	Ki	J Med Chem (2017) 60: 6428-6439 [PMID:28658574]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	8.25	pKi	5.6	nM	Ki	Bioorg Med Chem (2017) 25: 2569-2576 [PMID:28347633]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-12 assessed as reduction in CO2 hydration preincubated for 10 mins measured for 5 to 10 secs by stopped flow assay	B	8.25	pKi	5.6	nM	Ki	Bioorg Med Chem (2017) 25: 3583-3589 [PMID:28416101]
ChEMBL	Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration method	B	8.25	pKi	5.6	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3850-3853 [PMID:26233435]
ChEMBL	Inhibition of human recombinant CA12 catalytic domain by stopped flow CO2 hydration assay	B	8.25	pKi	5.6	nM	Ki	Bioorg Med Chem (2014) 22: 6353-6359 [PMID:25438758]
ChEMBL	Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.25	pKi	5.6	nM	Ki	Bioorg Med Chem (2013) 21: 5130-5138 [PMID:23859774]
ChEMBL	Inhibition of human CA12 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.25	pKi	5.6	nM	Ki	Eur J Med Chem (2022) 228: 114008-114008 [PMID:34871842]
ChEMBL	Inhibition of human CA12 incubated for 15 mins by stopped- flow CO2 hydrase assay method	B	8.25	pKi	5.6	nM	Ki	Eur J Med Chem (2020) 201: 112478-112478 [PMID:32659606]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 10 mins by CO2 hydration stopped-flow assay	B	8.25	pKi	5.6	nM	Ki	Bioorg Med Chem (2013) 21: 5228-5232 [PMID:23842519]
ChEMBL	Inhibition of human CA12 after 15 mins by stopped-flow CO2 hydration assay	B	8.25	pKi	5.6	nM	Ki	Eur J Med Chem (2018) 146: 47-59 [PMID:29407972]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-12-mediated CO2 hydration preincubated for 10 mins by stopped-flow assay	B	8.25	pKi	5.6	nM	Ki	Bioorg Med Chem (2013) 21: 1386-1391 [PMID:23352754]
ChEMBL	Inhibition of human recombinant transmembrane tumor associated carbonic anhydrase 12 preincubated for 10 mins prior to testing by stopped-flow CO2 hydration assay	B	8.25	pKi	5.6	nM	Ki	Bioorg Med Chem (2017) 25: 857-863 [PMID:28024887]
ChEMBL	Inhibition of recombinant human catalytic domain of carbonic anhydrase-12 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.25	pKi	5.6	nM	Ki	J Med Chem (2013) 56: 8512-8520 [PMID:24128000]
ChEMBL	Inhibition of human recombinant transmembrane CA12 catalytic domain after 6 hrs by stopped-flow CO2 hydration method	B	8.3	pKi	5	nM	Ki	J Med Chem (2013) 56: 293-300 [PMID:23241068]
ChEMBL	Inhibition of human CAH12 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	8.32	pKi	4.8	nM	Ki	J Med Chem (2021) 64: 1713-1724 [PMID:33523653]
ChEMBL	Inhibition of carbonic anhydrase 12 (unknown origin) preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.52	pKi	3	nM	Ki	J Med Chem (2018) 61: 10860-10874 [PMID:30433782]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 catalytic domain preincubated for 15 mins by CO2 hydration method	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2010) 18: 4873-4878 [PMID:20598552]
ChEMBL	Inhibition of tumor-associated transmembrane human carbonic anhydrase-12 after 15 mins by Stopped-flow CO2 hydrase assay	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2013) 21: 2314-2318 [PMID:23490152]
ChEMBL	Inhibition of human carbonic anhydrase 12 assessed as reduction in CO2 hydration preincubated for 15 mins to 2 hrs by phenol red dye based stopped flow CO2 hydrase assay	B	8.6	pKi	2.5	nM	Ki	ACS Med Chem Lett (2019) 10: 1205-1210 [PMID:31413806]
ChEMBL	Inhibition of human recombinant N-HA--tagged carbonic anhydrase 12 expressed in HEK293T cells using p-nitrophenyl acetate as substrate measured after 30 mins by colorimetric analysis	B	5.81	pIC50	1550	nM	IC50	Bioorg Med Chem (2019) 27: 3889-3901 [PMID:31345748]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 pretreated for 15 mins by stopped flow CO2 hydrase assay	B	7.06	pIC50	88	nM	IC50	Bioorg Med Chem Lett (2014) 24: 2617-2620 [PMID:24813742]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration method	B	7.21	pIC50	61	nM	IC50	Bioorg Med Chem Lett (2014) 24: 1941-1943 [PMID:24650641]
ChEMBL	Inhibition of CA-12 (unknown origin) after 15 mins by CO2 hydration assay	B	7.22	pIC50	60	nM	IC50	Bioorg Med Chem Lett (2014) 24: 3422-3425 [PMID:24948563]
carbonic anhydrase 13/Carbonic anhydrase XIII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3912] [GtoPdb: 2748] [UniProtKB: Q8N1Q1]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 13 expressed in Escherichia coli expression system assessed as observed dissociation constant fluorescent thermal shift assay	B	7.1	pKd	79	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 13 by isothermal titration calorimetry assay	B	7.19	pKd	65	nM	Kd	Bioorg Med Chem (2010) 18: 7413-7421 [PMID:20889345]
ChEMBL	Inhibition of human carbonic anhydrase 13 at pH7 and 37 degC by isothermal titration calorimetry	B	7.22	pKd	60	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 13 by thermal shift assay	B	7.3	pKd	50	nM	Kd	Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428]
ChEMBL	Inhibition of human carbonic anhydrase 13 at pH7 and 37 degC by fluorescent thermal shift assay	B	7.3	pKd	50	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 13 by thermal shift assay	B	7.3	pKd	50	nM	Kd	Bioorg Med Chem (2010) 18: 7413-7421 [PMID:20889345]
ChEMBL	Binding affinity to human recombinant CA13 at 37 degC and pH 7.0 by thermal shift assay	B	7.3	pKd	50	nM	Kd	Bioorg Med Chem (2013) 21: 2093-2106 [PMID:23394791]
ChEMBL	Binding affinity to human N-terminal full length His-tagged CA13 (1 to 262 residues) expressed in Escherichia coli BL21(DE3) assessed as thermodynamic equilibrium constant at pH 7 by SPR assay	B	7.44	pKd	36.5	nM	Kd	J Med Chem (2018) 61: 2292-2302 [PMID:29466001]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 13 expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	B	7.46	pKd	35	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Binding affinity to human N-terminal full length His-tagged CA13 (1 to 262 residues) expressed in Escherichia coli BL21(DE3) assessed as intrinsic thermodynamic equilibrium constant at pH 7 by SPR assay	B	8	pKd	10	nM	Kd	J Med Chem (2018) 61: 2292-2302 [PMID:29466001]
ChEMBL	Inhibition of human carbonic anhydrase 13 at pH7 and 25 degC by stopped-flow kinetic inhibition assay	B	8	pKd	<10	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Inhibition of human CAH13 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	7.68	pKi	21.1	nM	Ki	J Med Chem (2021) 64: 1713-1724 [PMID:33523653]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 13 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.74	pKi	18	nM	Ki	Bioorg Med Chem (2014) 22: 6768-6775 [PMID:25468040]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 13 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem (2011) 19: 3732-3738 [PMID:21620713]
ChEMBL	Inhibition of human carbonic anhydrase 13 preincubated for 15 mins at pH 7.5 by stopped flow CO2 hydration method	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5210-5213 [PMID:21821413]
ChEMBL	Inhibition of human carbonic anhydrase13 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem (2013) 21: 7210-7215 [PMID:24090602]
ChEMBL	Inhibition of human CA13 preincubated for 15 mins by stopped-flow CO2 hydration method	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem (2014) 22: 334-340 [PMID:24300919]
ChEMBL	Inhibition of human recombinant CA13 by stopped flow CO2 hydrase assay	B	7.77	pKi	17	nM	Ki	J Med Chem (2010) 53: 850-854 [PMID:20028100]
ChEMBL	Inhibition of carbonic anhydrase-13 (unknown origin)	B	7.77	pKi	17	nM	Ki	J Med Chem (2015) 58: 7580-7590 [PMID:26347950]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 13 after 15 mins by stopped-flow CO2 hydration assay	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 13 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	7.77	pKi	17	nM	Ki	ACS Med Chem Lett (2020) 11: 727-731 [PMID:32435377]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 13 by stopped flow CO2 hydrase assay	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem Lett (2021) 37: 127856-127856 [PMID:33609663]
ChEMBL	Inhibition of human CA13 by stopped-flow CO2 hydrase assay	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280]
ChEMBL	Inhibition of recombinant human CA13 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	7.77	pKi	17	nM	Ki	ACS Med Chem Lett (2018) 9: 1035-1038 [PMID:30344913]
ChEMBL	Inhibition of human carbonic anhydrase 13 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	7.77	pKi	17	nM	Ki	Eur J Med Chem (2019) 177: 188-197 [PMID:31136893]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 13 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay	B	7.79	pKi	16.4	nM	Ki	J Med Chem (2016) 59: 5462-5470 [PMID:27172398]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 13 preincubated for 15 mins by CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2011) 19: 3105-3119 [PMID:21515057]
carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1]
ChEMBL	Inhibitory activity against murine carbonic anhydrase XIII (mCA XIII) by using CO2 hydrase assay method	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem Lett (2004) 14: 3757-3762 [PMID:15203157]
ChEMBL	Ki value against mouse carbonic anhydrase XIII	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem Lett (2005) 15: 971-976 [PMID:15686895]
ChEMBL	Ki value against mouse carbonic anhydrase XIII	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem Lett (2005) 15: 971-976 [PMID:15686895]
ChEMBL	Inhibition of murine CA13 by stopped-flow CO2 hydration method	B	7.77	pKi	17	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibition of mouse carbonic anhydrase 13	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of mouse full length carbonic anhydrase 13 by stopped flow CO2 hydrase assay	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of mouse recombinant full length CA13 by stopped flow CO2 hydration assay	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of mouse recombinant full length CA13 by stopped-flow CO2 hydration method	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of mouse CA13 by stopped-flow CO2 hydration method	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem Lett (2008) 18: 4282-4286 [PMID:18640037]
ChEMBL	Inhibition of mouse carbonic anhydrase 13 by stopped-flow CO2 hydration assay	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL	Inhibition of mouse carbonic anhydrase 13 by stopped flow CO2 hydration assay	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4102-4106 [PMID:19527930]
ChEMBL	Inhibition of mouse full length cytosolic carbonic anhydrase 13 after 15 mins by stopped-flow CO2 hydration assay	B	7.77	pKi	17	nM	Ki	J Med Chem (2009) 52: 5990-5998 [PMID:19731956]
ChEMBL	Inhibition of mouse CA13 by stopped-flow CO2 hydration assay	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318]
ChEMBL	Inhibition of full length mouse carbonic anhydrase 13 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.77	pKi	17	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of mouse carbonic anhydrase 13 by stopped flow CO2 hydration method	B	7.77	pKi	17	nM	Ki	J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
GtoPdb	-	-	7.77	pKi	17	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-81 [PMID:20605094]
ChEMBL	Inhibition of mouse carbonic anhydrase 13 assessed as 4-nitrophenyl phosphate hydrolysis	B	5.98	pIC50	1050	nM	IC50	Bioorg Med Chem Lett (2008) 18: 2267-2271 [PMID:18353640]
ChEMBL	Inhibition of mouse carbonic anhydrase 13 assessed as 4-nitrophenyl acetate hydrolysis	B	6.31	pIC50	490	nM	IC50	Bioorg Med Chem Lett (2008) 18: 2267-2271 [PMID:18353640]
carbonic anhydrase 14/Carbonic anhydrase XIV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 14 expressed in Escherichia coli expression system assessed as observed dissociation constant fluorescent thermal shift assay	B	7.2	pKd	63	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 14 expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	B	7.92	pKd	12	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Inhibition of human carbonic anhydrase 14 at pH7 and 37 degC by fluorescent thermal shift assay	B	7.96	pKd	11	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Inhibition of human CAH14 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	6.71	pKi	194.4	nM	Ki	J Med Chem (2021) 64: 1713-1724 [PMID:33523653]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 14 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay	B	7.38	pKi	41.3	nM	Ki	J Med Chem (2016) 59: 5462-5470 [PMID:27172398]
ChEMBL	Inhibition of human recombinant CA14 by CO2 hydration assay	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem Lett (2007) 17: 987-992 [PMID:17157501]
ChEMBL	Inhibition of human recombinant CA14 after 15 mins by CO2 hydration stopped flow assay	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem Lett (2007) 17: 2685-2691 [PMID:17376683]
ChEMBL	Inhibition of human carbonic anhydrase 14	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human full length carbonic anhydrase 14 by stopped flow CO2 hydrase assay	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human recombinant full length CA14 by stopped flow CO2 hydration assay	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human recombinant full length CA14 by stopped-flow CO2 hydration method	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of human cloned CA14 by stopped-flow CO2 hydration method	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem Lett (2008) 18: 4282-4286 [PMID:18640037]
ChEMBL	Inhibition of human carbonic anhydrase 14 by stopped-flow CO2 hydration assay	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL	Inhibition of human carbonic anhydrase 14 by CO2 hydration assay	B	7.39	pKi	41	nM	Ki	Eur J Med Chem (2008) 43: 2853-2860 [PMID:18406497]
ChEMBL	Inhibition of human carbonic anhydrase 14 by stopped flow CO2 hydration assay	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4102-4106 [PMID:19527930]
ChEMBL	Inhibition of human full length membrane-bound carbonic anhydrase 14 after 15 mins by stopped-flow CO2 hydration assay	B	7.39	pKi	41	nM	Ki	J Med Chem (2009) 52: 5990-5998 [PMID:19731956]
ChEMBL	Inhibition of human recombinant CA14 by stopped flow CO2 hydrase assay	B	7.39	pKi	41	nM	Ki	J Med Chem (2010) 53: 850-854 [PMID:20028100]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 14 expressed in Escherichia coli by stopped-flow CO2 hydration assay	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem Lett (2009) 19: 5825-5828 [PMID:19751975]
ChEMBL	Inhibition of human CA14 by stopped-flow CO2 hydration assay	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318]
ChEMBL	Inhibition of full length human carbonic anhydrase 14 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human full length carbonic anhydrase 14 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.39	pKi	41	nM	Ki	Eur J Med Chem (2010) 45: 2396-2404 [PMID:20202722]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 14 after 15 mins by stopped-flow CO2 hydration assay	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of human carbonic anhydrase 14 by stopped flow CO2 hydration method	B	7.39	pKi	41	nM	Ki	J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
ChEMBL	Inhibition of human carbonic anhydrase 14 preincubated with compound for 15 mins by carbon dioxide hydration assay	B	7.39	pKi	41	nM	Ki	J Med Chem (2011) 54: 3977-3981 [PMID:21506569]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 14 preincubated for 15 mins by CO2 hydration method	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem (2011) 19: 3105-3119 [PMID:21515057]
ChEMBL	Inhibition of human cloned full length carbonic anhydrase 14 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.39	pKi	41	nM	Ki	Eur J Med Chem (2011) 46: 4403-4410 [PMID:21820216]
ChEMBL	Inhibition of human carbonic anhydrase 14 preincubated for 15 mins at pH 7.5 by stopped flow CO2 hydration method	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5210-5213 [PMID:21821413]
ChEMBL	Inhibition of human full length cloned transmembrane carbonic anhydrase 14 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem (2012) 20: 2392-2404 [PMID:22370338]
ChEMBL	Inhibition of human recombinant full length CA14-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay	B	7.39	pKi	41	nM	Ki	J Med Chem (2012) 55: 3891-3899 [PMID:22443141]
ChEMBL	Inhibition of human carbonic anhydrase-14 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem (2013) 21: 2925-2931 [PMID:23623256]
ChEMBL	Inhibition of human carbonic anhydrase14 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem (2013) 21: 7210-7215 [PMID:24090602]
ChEMBL	Inhibition of human carbonic anhydrase 14 by stopped-flow CO2 hydration assay	B	7.39	pKi	41	nM	Ki	J Med Chem (2013) 56: 9623-9634 [PMID:24200125]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 14 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.39	pKi	41	nM	Ki	Eur J Med Chem (2014) 71: 105-111 [PMID:24287559]
ChEMBL	Inhibition of human CA14 preincubated for 15 mins by stopped-flow CO2 hydration method	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem (2014) 22: 334-340 [PMID:24300919]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 14 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem (2014) 22: 6768-6775 [PMID:25468040]
ChEMBL	Inhibition of carbonic anhydrase-14 (unknown origin)	B	7.39	pKi	41	nM	Ki	J Med Chem (2015) 58: 7580-7590 [PMID:26347950]
ChEMBL	Inhibition of human carbonic anhydrase-14 assessed as CO2 hydration activity by stopped-flow method	B	7.39	pKi	41	nM	Ki	J Med Chem (2015) 58: 8564-8572 [PMID:26497049]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 14 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem (2016) 24: 894-901 [PMID:26795114]
ChEMBL	Inhibitory constant against human carbonic anhydrase XIV in CO2 hydrase assay	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3828-3833 [PMID:16039848]
ChEMBL	Inhibition of human CA14 by stopped-flow CO2 hydrase assay	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280]
ChEMBL	Inhibition of recombinant human CA14 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	7.39	pKi	41	nM	Ki	ACS Med Chem Lett (2018) 9: 1035-1038 [PMID:30344913]
ChEMBL	Inhibition of human carbonic anhydrase-14 catalytic domain assessed as reduction in CO2 hydration after 15 mins by phenol red dye based stopped flow assay	B	7.39	pKi	41	nM	Ki	Eur J Med Chem (2019) 163: 443-452 [PMID:30530195]
ChEMBL	Inhibition of human CA14 preincubated for 15 mins by stopped-flow carbon dioxide hydration assay	B	7.39	pKi	41	nM	Ki	ACS Med Chem Lett (2020) 11: 1000-1005 [PMID:32435417]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 14 preincubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	7.39	pKi	41	nM	Ki	J Med Chem (2016) 59: 5077-5088 [PMID:27144971]
ChEMBL	Inhibition of human cloned CA14 by stopped-flow CO2 hydration method	B	7.39	pKi	41	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
GtoPdb	-	-	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5427-33 [PMID:15454239]; Bioorg Med Chem Lett (2010) 20: 4376-81 [PMID:20605094]
ChEMBL	Inhibition of human carbonic anhydrase-14 preincubated for 15 mins by stopped flow CO2 dehydration method	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2016) 24: 104-112 [PMID:26682703]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 14 pretreated for 15 mins by stopped flow CO2 hydrase assay	B	6.65	pIC50	224	nM	IC50	Bioorg Med Chem Lett (2014) 24: 2617-2620 [PMID:24813742]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 14 preincubated for 15 mins by stopped flow CO2 hydration method	B	7.32	pIC50	48	nM	IC50	Bioorg Med Chem Lett (2014) 24: 1941-1943 [PMID:24650641]
Delta carbonic anhydrase in Thalassiosira weissflogii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3097982] [UniProtKB: Q5U9J1]
ChEMBL	Inhibition of Thalassiosira weissflogii delta carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.08	pKi	83	nM	Ki	Bioorg Med Chem Lett (2014) 24: 275-279 [PMID:24314394]
Endochitinase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293195] [UniProtKB: P29029]
ChEMBL	Inhibition of Saccharomyces cerevisiae CTS1	B	4.68	pKi	21000	nM	Ki	Bioorg Med Chem (2010) 18: 8334-8340 [PMID:21044846]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Ex vivo inhibition of Plasmodium falciparum growth in cultured cells after 48hrs as [3H]hypoxanthine uptake	F	4.7	pIC50	20000	nM	IC50	Bioorg Med Chem Lett (2008) 18: 5466-5471 [PMID:18805693]
PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5767] [UniProtKB: P96878]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv3273 by stopped flow CO2 hydration assay	B	6.98	pKi	104	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4929-4932 [PMID:19651511]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant beta-carbonic anhydrase Rv3273 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	6.98	pKi	104	nM	Ki	Bioorg Med Chem Lett (2011) 21: 102-105 [PMID:21145236]
ChEMBL	Inhibition of recombinant Mycobacterium tuberculosis Rv3273 carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay at pH 7.5	B	6.98	pKi	104	nM	Ki	Bioorg Med Chem Lett (2011) 21: 3591-3595 [PMID:21570835]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv3273 at pH 8.3 by stopped flow CO2 hydration assay	B	6.98	pKi	104	nM	Ki	Bioorg Med Chem (2011) 19: 5023-5030 [PMID:21757360]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant Rv3273 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay	B	7	pKi	100	nM	Ki	J Med Chem (2011) 54: 1682-1692 [PMID:21332115]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv3273 by by stopped flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	J Med Chem (2009) 52: 4063-4067 [PMID:19438226]
Uncharacterized protein Rv1284/MT1322 in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5631] [UniProtKB: P9WPJ7]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase 1 encoded by Rv1284 by stopped flow CO2 hydration assay	B	6.32	pKi	481	nM	Ki	J Med Chem (2009) 52: 3116-3120 [PMID:19338333]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv1284 by stopped flow CO2 hydration assay	B	6.32	pKi	481	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4929-4932 [PMID:19651511]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant beta-carbonic anhydrase Rv1284 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	6.32	pKi	481	nM	Ki	Bioorg Med Chem Lett (2011) 21: 102-105 [PMID:21145236]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv1284 at pH 8.3 by stopped flow CO2 hydration assay	B	6.32	pKi	480	nM	Ki	Bioorg Med Chem (2011) 19: 5023-5030 [PMID:21757360]
ChEMBL	Inhibition of Mycobacterium tuberculosis beta-carbonic anhydrase Rv1284 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.32	pKi	480	nM	Ki	Bioorg Med Chem (2016) 24: 4406-4409 [PMID:27469982]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant Rv1284 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay	B	6.32	pKi	480	nM	Ki	J Med Chem (2011) 54: 1682-1692 [PMID:21332115]
ChEMBL	Inhibition of recombinant Mycobacterium tuberculosis Rv1284 carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay at pH 7.5	B	6.32	pKi	480	nM	Ki	Bioorg Med Chem Lett (2011) 21: 3591-3595 [PMID:21570835]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv1284 by by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2009) 52: 4063-4067 [PMID:19438226]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]