ChEMBL ligand: CHEMBL20 (Acetamox, Acetazolamida, Acetazolamide, Acetazolamidum, Atenezo, Defiltran, Diamox, Diamox sr, Didoc, Diuriwas, Donmox, Edemox, Eytazox, Glaupax, L 579486, Nephramide, NSC-145177, Phonurit)
AGAP002992-PA in Anopheles gambiae [ChEMBL: CHEMBL3399914] [UniProtKB: Q5TU56] There should be some charts here, you may need to enable JavaScript!
Alpha carbonic anhydrase in Stylophora pistillata [ChEMBL: CHEMBL1075028] [UniProtKB: B5SU02] There should be some charts here, you may need to enable JavaScript!
Astrosclerin-3 in Astrosclera willeyana [ChEMBL: CHEMBL1944499] [UniProtKB: A6YCJ1] There should be some charts here, you may need to enable JavaScript!
Beta-carbonic anhydrase 1 in Mycobacterium tuberculosis [ChEMBL: CHEMBL5631] [UniProtKB: P9WPJ7] There should be some charts here, you may need to enable JavaScript!
Carbonate dehydratase in Sulfurihydrogenibium sp. (strain YO3AOP1) [ChEMBL: CHEMBL3745586] [UniProtKB: B2V8E3] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase in Methanosarcina thermophila [ChEMBL: CHEMBL3932] [UniProtKB: P40881] Carbonic anhydrase in Flaveria bidentis [ChEMBL: CHEMBL2401609] [UniProtKB: P46510] Carbonic anhydrase in Dicentrarchus labrax [ChEMBL: CHEMBL1795125] [UniProtKB: Q2PCB5] Carbonic anhydrase in Stylophora pistillata [ChEMBL: CHEMBL1649055] [UniProtKB: C0IX24] Carbonic anhydrase in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) [ChEMBL: CHEMBL4211] [UniProtKB: O24855] Carbonic anhydrase in Methanobacterium thermoautotrophicum [ChEMBL: CHEMBL3926] [UniProtKB: Q50565] Carbonic anhydrase in Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) [ChEMBL: CHEMBL3596083] [UniProtKB: Q9HVB9] Carbonic anhydrase in Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [ChEMBL: CHEMBL5337] [UniProtKB: Q5AJ71] Carbonic anhydrase in Candida glabrata CBS 138 [ChEMBL: CHEMBL6185] [UniProtKB: Q6FTL6] Carbonic anhydrase in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL5931] [UniProtKB: P53615] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase 1 in Drosophila melanogaster [ChEMBL: CHEMBL2331046] [UniProtKB: Q9V396] carbonic anhydrase 1/Carbonic anhydrase 1 in Human [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 12/Carbonic anhydrase 12 in Human [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 13/Carbonic anhydrase 13 in Human [ChEMBL: CHEMBL3912] [GtoPdb: 2748] [UniProtKB: Q8N1Q1] carbonic anhydrase 13/Carbonic anhydrase 13 in Mouse [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 14/Carbonic anhydrase 14 in Human [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase 15 in Mouse [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase 2 in Mycobacterium tuberculosis [ChEMBL: CHEMBL6068] [UniProtKB: P9WPJ9] carbonic anhydrase 2/Carbonic anhydrase 2 in Human [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] Carbonic anhydrase 2 in Bovine [ChEMBL: CHEMBL2283] [UniProtKB: P00921] Carbonic anhydrase 2 in Cryptococcus neoformans var. grubii [ChEMBL: CHEMBL1697676] [UniProtKB: Q3I4V7] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase 2, isoform A in Drosophila melanogaster [ChEMBL: CHEMBL2331045] [UniProtKB: Q9VTU8] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase 3 in Human [ChEMBL: CHEMBL2885] [UniProtKB: P07451] Carbonic anhydrase 3 in Bovine [ChEMBL: CHEMBL1944498] [UniProtKB: Q3SZX4] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 4/Carbonic anhydrase 4 in Human [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748] Carbonic anhydrase 4 in Bovine [ChEMBL: CHEMBL281] [UniProtKB: Q95323] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 5A/Carbonic anhydrase 5A, mitochondrial in Human [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase 5B, mitochondrial in Human [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase 6 in Human [ChEMBL: CHEMBL3025] [UniProtKB: P23280] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 7/Carbonic anhydrase 7 in Human [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166] carbonic anhydrase 7/Carbonic anhydrase 7 in Mouse [ChEMBL: CHEMBL2216] [GtoPdb: 2749] [UniProtKB: Q9ERQ8] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 9/Carbonic anhydrase 9 in Human [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase, alpha family in Thiomicrospira crunogena (strain XCL-2) [ChEMBL: CHEMBL3621035] [UniProtKB: Q31FD6] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase-related protein 11 in Human [ChEMBL: CHEMBL2420] [UniProtKB: O75493] There should be some charts here, you may need to enable JavaScript!
Delta carbonic anhydrase in Thalassiosira weissflogii [ChEMBL: CHEMBL3097982] [UniProtKB: Q5U9J1] There should be some charts here, you may need to enable JavaScript!
Endochitinase in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL1293195] [UniProtKB: P29029] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) in Mycobacterium tuberculosis [ChEMBL: CHEMBL5767] [UniProtKB: P96878] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
AGAP002992-PA in Anopheles gambiae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3399914] [UniProtKB: Q5TU56]
ChEMBL	Inhibition of Anopheles gambiae carbonic anhydrase pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.56	pKi	27.3	nM	Ki	Bioorg Med Chem (2015) 23: 2303-2309 [PMID:25882523]
Alpha carbonic anhydrase in Stylophora pistillata (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075028] [UniProtKB: B5SU02]
ChEMBL	Inhibition of cloned Stylophora pistillata alpha-CA expressed in human HEK293 cells by stopped-flow CO2 assay	B	7.8	pKi	16	nM	Ki	Bioorg Med Chem (2009) 17: 5054-5058 [PMID:19520577]
ChEMBL	Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assay	B	7.8	pKi	16	nM	Ki	Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801]
Astrosclerin-3 in Astrosclera willeyana (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1944499] [UniProtKB: A6YCJ1]
ChEMBL	Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay	B	7.29	pKi	51	nM	Ki	Bioorg Med Chem (2012) 20: 1403-1410 [PMID:22285172]
ChEMBL	Inhibition of Astrosclera willeyana recombinant GST-tagged astrosclerin 3 expressed in Escherichia coli BL21-DE3-RIPL cells preincubated for 15 mins measured for 10 to 100 secs by stopped flow CO2 hydration assay	B	7.29	pKi	51	nM	Ki	Bioorg Med Chem Lett (2012) 22: 1314-1316 [PMID:22227210]
Beta-carbonic anhydrase 1 in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5631] [UniProtKB: P9WPJ7]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase 1 encoded by Rv1284 by stopped flow CO2 hydration assay	B	6.32	pKi	481	nM	Ki	J Med Chem (2009) 52: 3116-3120 [PMID:19338333]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv1284 by stopped flow CO2 hydration assay	B	6.32	pKi	481	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4929-4932 [PMID:19651511]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant beta-carbonic anhydrase Rv1284 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	6.32	pKi	481	nM	Ki	Bioorg Med Chem Lett (2011) 21: 102-105 [PMID:21145236]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv1284 at pH 8.3 by stopped flow CO2 hydration assay	B	6.32	pKi	480	nM	Ki	Bioorg Med Chem (2011) 19: 5023-5030 [PMID:21757360]
ChEMBL	Inhibition of Mycobacterium tuberculosis beta-carbonic anhydrase Rv1284 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.32	pKi	480	nM	Ki	Bioorg Med Chem (2016) 24: 4406-4409 [PMID:27469982]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant Rv1284 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay	B	6.32	pKi	480	nM	Ki	J Med Chem (2011) 54: 1682-1692 [PMID:21332115]
ChEMBL	Inhibition of recombinant Mycobacterium tuberculosis Rv1284 carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay at pH 7.5	B	6.32	pKi	480	nM	Ki	Bioorg Med Chem Lett (2011) 21: 3591-3595 [PMID:21570835]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv1284 by by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2009) 52: 4063-4067 [PMID:19438226]
Carbonate dehydratase in Sulfurihydrogenibium sp. (strain YO3AOP1) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3745586] [UniProtKB: B2V8E3]
ChEMBL	Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assay	B	8.35	pKi	4.5	nM	Ki	Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758]
Carbonic anhydrase in Methanosarcina thermophila (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3932] [UniProtKB: P40881]
ChEMBL	Inhibitory activity against alpha carbonic anhydrase (Co-Cam) from Methanosarcina thermophila	B	5.84	pKi	1430	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717]
ChEMBL	Inhibition of Methanosarcina thermophila recombinant gamma-CA by CO2 hydration assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem Lett (2013) 23: 4067-4071 [PMID:23769640]
ChEMBL	Inhibition of archaeon Methanosarcina thermophila gamma-CA after 15 mins by stopped-flow/Co2 hydration assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem (2015) 23: 4405-4409 [PMID:26145820]
ChEMBL	Inhibition of Methanosarcina thermophila gamma carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem (2016) 24: 3413-3417 [PMID:27283786]
ChEMBL	Inhibition of Methanosarcina thermophila recombinant carbonic anhydrase gamma assessed as inhibition of CO2 hydration preincubated for 15 mins by Lineweaver-burk plot method	B	7.2	pKi	63	nM	Ki	Bioorg Med Chem (2017) 25: 575-580 [PMID:27914949]
ChEMBL	Inhibitory activity against alpha carbonic anhydrase (Zn-Cam) from Methanosarcina thermophila	B	7.22	pKi	60	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717]
Carbonic anhydrase in Flaveria bidentis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2401609] [UniProtKB: P46510]
ChEMBL	Inhibition of Flaveria bidentis recombinant CA by CO2 hydration assay	B	7.57	pKi	27	nM	Ki	Bioorg Med Chem Lett (2013) 23: 4067-4071 [PMID:23769640]
ChEMBL	Inhibition of Flaveria bidentis carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.57	pKi	27	nM	Ki	Bioorg Med Chem Lett (2013) 23: 6706-6710 [PMID:24210500]
ChEMBL	Inhibition of Flaveria bidentis carbonic anhydrase-1 by CO2 hydration reaction based colorimetric stopped-flow method	B	7.57	pKi	27	nM	Ki	Bioorg Med Chem (2015) 23: 4831-4838 [PMID:26068018]
ChEMBL	Inhibition of Flaveria bidentis carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.57	pKi	27	nM	Ki	Bioorg Med Chem (2016) 24: 3413-3417 [PMID:27283786]
Carbonic anhydrase in Dicentrarchus labrax (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795125] [UniProtKB: Q2PCB5]
ChEMBL	Inhibition of Dicentrarchus labrax CA using 4-nitrophenylacetate substrate by esterase assay	B	5.24	pKi	5720	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4259-4262 [PMID:21669522]
Carbonic anhydrase in Stylophora pistillata (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1649055] [UniProtKB: C0IX24]
ChEMBL	Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assay	B	7.13	pKi	74	nM	Ki	Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801]
Carbonic anhydrase in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4211] [UniProtKB: O24855]
ChEMBL	Inhibition of Helicobacter pylori recombinant carbonic anhydrase by stopped-flow CO2 hydrase assay	B	7.68	pKi	21	nM	Ki	J Med Chem (2006) 49: 2117-2126 [PMID:16539401]
ChEMBL	Inhibition of Helicobacter pylori recombinant CA	B	7.7	pKi	20	nM	Ki	Bioorg Med Chem Lett (2006) 16: 2182-2188 [PMID:16459077]
Carbonic anhydrase in Methanobacterium thermoautotrophicum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3926] [UniProtKB: Q50565]
ChEMBL	Inhibitory activity against beta carbonic anhydrase (Cab) from Methanobacterium thermoautotrophicum	B	4.92	pKi	12100	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717]
ChEMBL	Inhibition of Methanobacterium thermoautotrophicum carbonic anhydrase by stopped flow CO2 hydration method	B	4.92	pKi	12100	nM	Ki	J Med Chem (2009) 52: 2226-2232 [PMID:19317447]
ChEMBL	Inhibition of Methanothermobacter thermautotrophicus carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay	B	4.92	pKi	12100	nM	Ki	Bioorg Med Chem (2011) 19: 243-248 [PMID:21163660]
ChEMBL	Inhibition of Methanobacterium thermoautotrophicum beta-carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay	B	4.92	pKi	12100	nM	Ki	Bioorg Med Chem Lett (2013) 23: 6706-6710 [PMID:24210500]
Carbonic anhydrase in Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3596083] [UniProtKB: Q9HVB9]
ChEMBL	Inhibition of Pseudomonas aeruginosa PAO1 type-2 beta-carbonic anhydrase psCA3 expressed in Escherichia coli Tuner BL21 (DE3) cells pre-incubated for 15 mins at pH 8.3 and 293K by CO2 hydration reaction based colorimetric stopped-flow method	B	7.12	pKi	75.9	nM	Ki	Bioorg Med Chem (2015) 23: 4831-4838 [PMID:26068018]
Carbonic anhydrase in Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5337] [UniProtKB: Q5AJ71]
ChEMBL	Inhibition of recombinant Candida albicans beta carbonic anhydrase NCE103 expressed in Escherichia coli preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.88	pKi	132	nM	Ki	Bioorg Med Chem (2016) 24: 1648-1652 [PMID:26951893]
ChEMBL	Inhibition of Candida albicans recombinant Nce103 by stopped-flow CO2 hydration assay	B	6.88	pKi	132	nM	Ki	Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983]
ChEMBL	inhibition of Candida albicans recombinant Nce103 after 15 mins by stopped-flow CO2 hydration assay	B	6.88	pKi	132	nM	Ki	Bioorg Med Chem Lett (2010) 20: 2508-2511 [PMID:20299219]
ChEMBL	Inhibition of Candida albicans recombinant Carbonic anhydrase pre-incubated for 15 mins by CO2 hydration stopped-flow assay	B	6.88	pKi	132	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2642-2645 [PMID:19375309]
ChEMBL	Inhibition of Candida albicans carbonic anhydrase preincubated for 15 mins at pH 8.3 by stopped flow CO2 hydration method	B	6.88	pKi	132	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5210-5213 [PMID:21821413]
ChEMBL	Inhibition of Candida albicans CaNce103 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method	B	6.88	pKi	132	nM	Ki	J Med Chem (2012) 55: 3513-3520 [PMID:22424239]
ChEMBL	Inhibition of Candida albicans recombinant Nce103 beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay	B	6.89	pKi	130	nM	Ki	J Med Chem (2011) 54: 1682-1692 [PMID:21332115]
Carbonic anhydrase in Candida glabrata CBS 138 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6185] [UniProtKB: Q6FTL6]
ChEMBL	Inhibition of Candida glabrata carbonic anhydrase by stopped flow CO2 hydration assay	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4802-4805 [PMID:19574046]
ChEMBL	Inhibition of Candida glabrata CgNce103 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method	B	7.96	pKi	11	nM	Ki	J Med Chem (2012) 55: 3513-3520 [PMID:22424239]
ChEMBL	Inhibition of recombinant full length Candida glabrata NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem Lett (2013) 23: 2647-2652 [PMID:23511020]
ChEMBL	Inhibition of recombinant Candida glabrata beta carbonic anhydrase NCE103 expressed in Escherichia coli preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem (2016) 24: 1648-1652 [PMID:26951893]
ChEMBL	Inhibition of Candida glabrata Nce103 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	7.96	pKi	11	nM	Ki	ACS Med Chem Lett (2017) 8: 1194-1198 [PMID:29152053]
Carbonic anhydrase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5931] [UniProtKB: P53615]
ChEMBL	Inhibition of Saccharomyces cerevisiae carbonic anhydrase by oxygen-18 isotope exchange assay	B	4.8	pKi	16000	nM	Ki	Bioorg Med Chem Lett (2008) 18: 6327-6331 [PMID:18993072]
ChEMBL	Inhibition of Saccharomyces cerevisiae recombinant CA expressed in Escherichia coli by stopped-flow CO2 hydrase assay	B	7.08	pKi	82.6	nM	Ki	Bioorg Med Chem (2009) 17: 1158-1163 [PMID:19124253]
ChEMBL	Inhibition of Saccharomyces cerevisiae beta-carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.09	pKi	82	nM	Ki	Bioorg Med Chem Lett (2013) 23: 1626-1630 [PMID:23414801]
ChEMBL	Inhibition of Saccharomyces cerevisiae carbonic anhydrase SceCA preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.09	pKi	82	nM	Ki	Bioorg Med Chem Lett (2013) 23: 6706-6710 [PMID:24210500]
ChEMBL	Inhibition of Saccharomyces cerevisiae carbonic anhydrase by CO2 hydration reaction based colorimetric stopped-flow method	B	7.09	pKi	82	nM	Ki	Bioorg Med Chem (2015) 23: 4831-4838 [PMID:26068018]
Carbonic anhydrase 1 in Drosophila melanogaster (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2331046] [UniProtKB: Q9V396]
ChEMBL	Inhibition of Drosophila melanogaster recombinant carbonic anhydrase-1 expressed in Escherichia coli BL21 (DE3) preincubated for 15 mins by CO2 hydration stopped-flow assay	B	6.97	pKi	106	nM	Ki	Bioorg Med Chem (2013) 21: 1516-1521 [PMID:22989910]
carbonic anhydrase 1/Carbonic anhydrase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 1 expressed in Escherichia coli expression system assessed as observed dissociation constant fluorescent thermal shift assay	B	5.62	pKd	2400	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Binding affinity to human recombinant CA1 at 37 degC and pH 7.0 by thermal shift assay	B	5.85	pKd	1400	nM	Kd	Bioorg Med Chem (2013) 21: 2093-2106 [PMID:23394791]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 1 expressed in Escherichia coli BL21 (DE3) by thermal shift assay	B	5.85	pKd	1400	nM	Kd	Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 1 by thermal shift assay	B	5.85	pKd	1400	nM	Kd	Bioorg Med Chem (2010) 18: 7413-7421 [PMID:20889345]
ChEMBL	Inhibition of human carbonic anhydrase 1 at pH7 and 37 degC by fluorescent thermal shift assay	B	5.85	pKd	1400	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 1 expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	B	5.96	pKd	1100	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Inhibition of human carbonic anhydrase 1 at pH7 and 37 degC by isothermal titration calorimetry	B	6.09	pKd	810	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 1 by isothermal titration calorimetry assay	B	6.11	pKd	780	nM	Kd	Bioorg Med Chem (2010) 18: 7413-7421 [PMID:20889345]
ChEMBL	Inhibition of human carbonic anhydrase 1 at pH7 and 25 degC by stopped-flow kinetic inhibition assay	B	6.54	pKd	290	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 assessed as inhibition constant incubated for 1 hr prior to testing by phenol red based stopped-flow CO2 hydration assay	B	3.6	pKi	250000	nM	Ki	Bioorg Med Chem (2022) 67: 116805-116805 [PMID:35635929]
ChEMBL	Inhibition of human carbonic anhydrase 1 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis	B	4.44	pKi	36200	nM	Ki	Eur J Med Chem (2012) 49: 68-73 [PMID:22245047]
ChEMBL	Inhibition of human erythrocytes esterase activity of carbonic anhydrase-1 using 4-nitrophenylacetate as substrate after 3 mins by Lineweaver-Burk plot analysis	B	4.44	pKi	36200	nM	Ki	Bioorg Med Chem (2013) 21: 1379-1385 [PMID:23394864]
ChEMBL	Inhibition of human erythrocyte CA1 esterase activity using 4-nitrophenyl acetate substrate	B	4.44	pKi	36200	nM	Ki	Bioorg Med Chem (2009) 17: 3207-3211 [PMID:19231207]
ChEMBL	Inhibition of human carbonic anhydrase 1 esterase activity using 4-nitrophenylacetate as substrate	B	4.44	pKi	36200	nM	Ki	Bioorg Med Chem Lett (2012) 22: 1352-1357 [PMID:22230050]
ChEMBL	Inhibition of human erythrocytes CA1 using 4-nitrophenylacetate as substrate by esterase assay	B	4.44	pKi	36200	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3261-3263 [PMID:26073005]
ChEMBL	Inhibition of human carbonic anhydrase 1 by Lineweaver-Burke plot analysis	B	5.2	pKi	6300	nM	Ki	Eur J Med Chem (2010) 45: 4769-4773 [PMID:20724038]
ChEMBL	Inhibition of human carbonic anhydrase 1 by Lineweaver-Burke plot	B	5.46	pKi	3500	nM	Ki	Bioorg Med Chem (2009) 17: 3295-3301 [PMID:19362844]
ChEMBL	Inhibition of human carbonic anhydrase 1 using 4-NPA as substrate measured for 3 mins by spectrophotometry	B	5.81	pKi	1532.01	nM	Ki	Bioorg Med Chem Lett (2020) 30: 126874-126874 [PMID:31859159]
ChEMBL	Inhibition of human carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2004) 14: 225-229 [PMID:14684332]
ChEMBL	Inhibitory activity against human carbonic anhydrase I.	B	6.05	pKi	900	nM	Ki	J Med Chem (2003) 46: 5471-5477 [PMID:14640555]
ChEMBL	Inhibitory activity against human carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2004) 14: 2351-2356 [PMID:15081039]
ChEMBL	Binding affinity towards human cloned carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5775-5780 [PMID:15501039]
ChEMBL	In vitro inhibitory activity against human carbonic anhydrase I (hCAI)	B	6.05	pKi	900	nM	Ki	J Med Chem (2004) 47: 2796-2804 [PMID:15139757]
ChEMBL	Inhibitory activity against human cloned Carbonic anhydrase I by the CO2 hydration method	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4872-4876 [PMID:16165351]
ChEMBL	Inhibitory activity against Human carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	J Med Chem (2002) 45: 1466-1476 [PMID:11906288]
ChEMBL	Inhibition against human carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2004) 14: 231-234 [PMID:14684333]
ChEMBL	Inhibition of human carbonic anhydrase 1 after 6 hrs by Lineweaver-Burk plot analysis	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2011) 21: 2515-2520 [PMID:21420862]
ChEMBL	Inhibition of human recombinant carbonic anhydrase I (CA1)	B	6.05	pKi	900	nM	Ki	J Med Chem (2000) 43: 4542-4551 [PMID:11087579]
ChEMBL	Inhibitory activity against human cloned isoenzyme carbonic anhydrase I (hCA I), by esterase method.	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2003) 13: 837-840 [PMID:12617903]
ChEMBL	Binding affinity towards human cloned carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5781-5786 [PMID:15501040]
ChEMBL	Inhibition of human CA1	B	6.05	pKi	900	nM	Ki	J Med Chem (2006) 49: 2743-2749 [PMID:16640335]
ChEMBL	Inhibitory activity against cytosolic human carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2005) 15: 579-584 [PMID:15664816]
ChEMBL	Inhibition of human cloned CA1 by CO2 hydration assay	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2006) 16: 4846-4851 [PMID:16809036]
ChEMBL	Inhibition of human cloned CA1 by CO2 hydration method	B	6.05	pKi	900	nM	Ki	J Med Chem (2006) 49: 6539-6548 [PMID:17064072]
ChEMBL	Inhibition of cloned isozyme, human carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2001) 11: 575-582 [PMID:11229775]
ChEMBL	Inhibitory potency against human cloned Carbonic anhydrase I expressed in Escherichia coli strain BL21	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2005) 15: 367-372 [PMID:15603956]
ChEMBL	Inhibitory effect on human carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	J Med Chem (2002) 45: 312-320 [PMID:11784136]
ChEMBL	Inhibition of human recombinant isozyme CA1 by CO2 hydration method	B	6.05	pKi	900	nM	Ki	J Med Chem (2007) 50: 1651-1657 [PMID:17343373]
ChEMBL	Inhibitory activity against human recombinant carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	J Med Chem (2000) 43: 4884-4892 [PMID:11123998]
ChEMBL	Inhibitory activity against human recombinant carbonic anhydrase I (CA1)	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2002) 12: 1551-1557 [PMID:12039560]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by CO2 hydration stopped-flow assay	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2008) 18: 3475-3480 [PMID:18513964]
ChEMBL	Inhibition constant against human (cloned) isozyme (hCA I) by the CO2 hydration method	B	6.05	pKi	900	nM	Ki	J Med Chem (2005) 48: 4834-4841 [PMID:16033263]
ChEMBL	Inhibition of human recombinant CA1 by stopped flow CO2 hydration assay	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem (2009) 17: 553-557 [PMID:19097911]
ChEMBL	Inhibition of human recombinant CA1 by stopped flow CO2 hydration assay	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2273-2276 [PMID:19286378]
ChEMBL	Inhibitory activity against human Carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	J Med Chem (2004) 47: 5224-5229 [PMID:15456265]
ChEMBL	Inhibition of human recombinant carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	J Med Chem (2003) 46: 2197-2204 [PMID:12747791]
ChEMBL	Inhibitory constant against human Carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	Bioorg Med Chem Lett (2005) 15: 2359-2364 [PMID:15837325]
ChEMBL	Inhibition of cloned human cytosolic isozyme Carbonic anhydrase I	B	6.05	pKi	900	nM	Ki	J Med Chem (2004) 47: 1272-1279 [PMID:14971907]
ChEMBL	Inhibition of human recombinant CA1 by stopped flow CO2 hydration assay	B	6.32	pKi	481	nM	Ki	J Med Chem (2009) 52: 4063-4067 [PMID:19438226]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 using 4-nitrophenyl acetate as substrate assessed as inhibition constant by spectrophotometric analysis	B	6.35	pKi	451.8	nM	Ki	Bioorg Med Chem (2023) 77: 117111-117111 [PMID:36463726]
ChEMBL	Binding affinity to carbonic anhydrase 1 (unknown origin) assessed as inhibition constant	B	6.36	pKi	436.2	nM	Ki	Eur J Med Chem (2022) 233: 114242-114242 [PMID:35276424]
ChEMBL	Binding affinity to human CA1 assessed as inhibition constant using 4-nitrophenylacetate as substrate by spectrophotometry based esterase assay	B	6.36	pKi	434.55	nM	Ki	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of esterase activity of human carbonic anhydrase 2 by Lineweaver-Burke plot analysis	B	6.43	pKi	370	nM	Ki	Bioorg Med Chem (2010) 18: 4468-4474 [PMID:20554206]
ChEMBL	Inhibition of human CA1 using 4-nitrophenylacetate as substrate preincubated for 10 mins by spectrophotometric esterase assay	B	6.47	pKi	342	nM	Ki	J Med Chem (2012) 55: 6776-6783 [PMID:22775345]
ChEMBL	Inhibition of human cloned carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.51	pKi	310	nM	Ki	Eur J Med Chem (2011) 46: 4403-4410 [PMID:21820216]
ChEMBL	Inhibition of human cloned CA1 after 15 mins by stopped-flow CO2 hydration assay	B	6.51	pKi	310	nM	Ki	Eur J Med Chem (2010) 45: 3656-3661 [PMID:20554082]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by CO2 hydration method	B	6.51	pKi	310	nM	Ki	Bioorg Med Chem (2007) 15: 2298-2311 [PMID:17276072]
ChEMBL	Inhibition of human cloned carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.51	pKi	310	nM	Ki	Eur J Med Chem (2010) 45: 2396-2404 [PMID:20202722]
ChEMBL	Inhibition of human erythrocyte CA1 b using 4-nitrophenyl acetate as substrate by Lineweaver-Burk plot analysis	B	6.54	pKi	289	nM	Ki	Eur J Med Chem (2020) 198: 112392-112392 [PMID:32388113]
ChEMBL	Binding affinity to human CA1 assessed as inhibition constant using p-Nitrophenylacetate as substrate by SDS-PAGE analysis	B	6.55	pKi	282.1	nM	Ki	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of human CA1	B	6.55	pKi	278.8	nM	Ki	Eur J Med Chem (2020) 205: 112666-112666 [PMID:32795767]
ChEMBL	Inhibition of human CA1	B	6.55	pKi	278.76	nM	Ki	Eur J Med Chem (2020) 205: 112666-112666 [PMID:32795767]
ChEMBL	Inhibition of cytosolic carbonic anhydrase 1 (unknown origin) preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	252.2	nM	Ki	Eur J Med Chem (2013) 66: 372-379 [PMID:23827177]
GtoPdb	-	-	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6 [PMID:15546717]; Bioorg Med Chem Lett (2005) 15: 963-9 [PMID:15686894]; Bioorg Med Chem Lett (2010) 20: 4376-81 [PMID:20605094]
ChEMBL	Inhibition of human carbonic anhydrase 1 pre-incubated for 15 mins by stopped flow carbon dioxide hydrase assay	B	6.6	pKi	250.2	nM	Ki	J Med Chem (2016) 59: 10692-10704 [PMID:27933963]
ChEMBL	Inhibition of human cloned CA1 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2009) 52: 6421-6432 [PMID:19827837]
ChEMBL	Inhibition of human recombinant CA1 by stopped-flow hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2009) 19: 6649-6654 [PMID:19846301]
ChEMBL	Inhibition of human recombinant CA1 by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2010) 53: 850-854 [PMID:20028100]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 expressed in Escherichia coli by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2009) 19: 5825-5828 [PMID:19751975]
ChEMBL	Inhibition of human CA1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318]
ChEMBL	Inhibition of human recombinant carbonic anhydrase1 after 15 mins by stopped flow carbon dioxide hydrase assay method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2010) 20: 2178-2182 [PMID:20211561]
ChEMBL	Inhibition of human recombinant CA1 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2010) 53: 2913-2926 [PMID:20201556]
ChEMBL	Inhibition of full length human carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human carbonic anhydrase 1	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3623-3627 [PMID:20478708]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2010) 18: 4873-4878 [PMID:20598552]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 after 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
ChEMBL	Inhibition of wild type human recombinant carbonic anhydrase 1 expressed in Escherichia coli BL21 (DE3) after 15 mins by CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2010) 18: 5498-5503 [PMID:20624682]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2010) 18: 5081-5089 [PMID:20580561]
ChEMBL	Inhibition of human recombinant CA1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801]
ChEMBL	Inhibition of human carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2011) 19: 243-248 [PMID:21163660]
ChEMBL	Inhibition of human carbonic anhydrase I by spectrophotometry at pH 7.5	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2011) 19: 1172-1178 [PMID:21251841]
ChEMBL	Inhibition of human recombinant CA1 cytosolic isoform by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2011) 21: 1334-1337 [PMID:21300547]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 min by CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2011) 54: 1896-1902 [PMID:21361354]
ChEMBL	Inhibition of human carbonic anhydrase 1 after 15 mins by Lineweaver-Burk plot	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2011) 19: 1847-1851 [PMID:21377369]
ChEMBL	Inhibition of human carbonic anhydrase 1 after 15 mins by CO2 hydrase assay at pH 7.5	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2011) 19: 1847-1851 [PMID:21377369]
ChEMBL	Inhibition of human recombinant alpha-carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2011) 54: 1682-1692 [PMID:21332115]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2011) 21: 2521-2526 [PMID:21402476]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay at pH 8.3	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2011) 21: 3591-3595 [PMID:21570835]
ChEMBL	Inhibition of human CA1 by CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2011) 21: 3216-3221 [PMID:21549597]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2009) 19: 3170-3173 [PMID:19435663]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated with compound for 15 mins by carbon dioxide hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2011) 54: 3977-3981 [PMID:21506569]
ChEMBL	Inhibition of human full length cytosolic isoform of carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2011) 21: 2975-2979 [PMID:21470859]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2011) 19: 3732-3738 [PMID:21620713]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2011) 19: 3105-3119 [PMID:21515057]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 at pH 7.5 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2011) 19: 5023-5030 [PMID:21757360]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins at pH 7.5 by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5210-5213 [PMID:21821413]
ChEMBL	Inhibition of human recombinant CA1 by CO2 hydration based stopped flow assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2011) 54: 6905-6918 [PMID:21851094]
ChEMBL	Inhibition of human carbonic anhydrase 1-catalyzed CO2 hydration activity by stopped flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5892-5896 [PMID:21852133]
ChEMBL	Inhibition of human cloned carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2012) 20: 2392-2404 [PMID:22370338]
ChEMBL	Inhibition of human CA1 pre-incubated for 15 mins by stopped-flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	J Med Chem (2012) 55: 1721-1730 [PMID:22276570]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method	B	6.6	pKi	250	nM	Ki	J Med Chem (2012) 55: 3513-3520 [PMID:22424239]
ChEMBL	Inhibition of human recombinant full length CA1-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2012) 55: 3891-3899 [PMID:22443141]
ChEMBL	Inhibition of human CA1 using CO2 as substrate incubated for 6 hrs prior to substrate addition measured for 10 to 100 secs by stopped flow technique	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2012) 22: 5801-5806 [PMID:22901388]
ChEMBL	Inhibition of full length human CA1 cytosolic isoform preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2012) 55: 6776-6783 [PMID:22775345]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2012) 22: 7142-7145 [PMID:23072866]
ChEMBL	Inhibition of human recombinant wild type CA1 by stopped-flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2013) 23: 256-260 [PMID:23200251]
ChEMBL	Inhibition of full length human recombinant CA1 cytosolic isoform after 6 hrs by stopped-flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	J Med Chem (2013) 56: 293-300 [PMID:23241068]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2013) 56: 1761-1771 [PMID:23391336]
ChEMBL	Inhibition of human CA1 by stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2013) 23: 715-719 [PMID:23265898]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-1-mediated CO2 hydration preincubated for 10 mins by stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 1386-1391 [PMID:23352754]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 10 mins by CO2 hydration stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 1451-1464 [PMID:23168081]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase-1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2013) 23: 1626-1630 [PMID:23414801]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 1396-1403 [PMID:23290254]
ChEMBL	Inhibition of human carbonic anhydrase-1 cytosolic isoform after 15 mins by Stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 2314-2318 [PMID:23490152]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 1534-1538 [PMID:22883029]
ChEMBL	Inhibition of recombinant human CA1 cytosolic isoform preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2013) 56: 4691-4700 [PMID:23647428]
ChEMBL	Inhibition of human carbonic anhydrase-1 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 2925-2931 [PMID:23623256]
ChEMBL	Inhibition of human recombinant CA1 by CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2013) 23: 4067-4071 [PMID:23769640]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins to 6 hrs by CO2 hydration stopped-flow assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2013) 56: 5773-5781 [PMID:23815159]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 3949-3957 [PMID:23706268]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 after 6 hrs by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 4502-4510 [PMID:23769167]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 10 mins by CO2 hydration stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 5228-5232 [PMID:23842519]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 5130-5138 [PMID:23859774]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 5168-5174 [PMID:23867389]
ChEMBL	Inhibition of recombinant human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 5799-5805 [PMID:23910989]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175]
ChEMBL	Inhibition of full length human cytosolic carbonic anhydrase-1 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2013) 56: 8512-8520 [PMID:24128000]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2013) 23: 6706-6710 [PMID:24210500]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2013) 23: 6759-6763 [PMID:24189056]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2013) 56: 9623-9634 [PMID:24200125]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2014) 71: 105-111 [PMID:24287559]
ChEMBL	Inhibition of human CA1 cytosolic isoform preincubated for 15 mins by stopped-flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 334-340 [PMID:24300919]
ChEMBL	Inhibition of human carbonic anhydrase 1 cytosolic isoform preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 141-147 [PMID:24332658]
ChEMBL	Inhibition of human CA1 cytosolic isoform after 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2014) 71: 135-147 [PMID:24291567]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1127-1132 [PMID:24461298]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 1 after 6 hrs by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 1522-1528 [PMID:24513186]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 1873-1882 [PMID:24560737]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1310-1314 [PMID:24507918]
ChEMBL	Inhibition of human carbonic anhydrase 1-mediated CO2 hydration preincubated for 10 mins by stopped-flow assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2014) 76: 284-290 [PMID:24589484]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 1821-1831 [PMID:24560739]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1-mediated CO2 hydration after 6 hrs by stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1256-1260 [PMID:24518190]
ChEMBL	Inhibition of human recombinant cytosolic human carbonic anhydrase-1 incubated for 15 mins prior to testing by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1776-1779 [PMID:24589511]
ChEMBL	Inhibition of human carbonic anhydrase 1-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 2643-2647 [PMID:24713308]
ChEMBL	Inhibition of human carbonic anhydrase-1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 2939-2946 [PMID:24792813]
ChEMBL	Inhibition of human cloned cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2014) 82: 47-55 [PMID:24871996]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 3684-3695 [PMID:24878360]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 6768-6775 [PMID:25468040]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped flow CO2 hydrase assay method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 6945-6952 [PMID:25456084]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2014) 24: 4006-4010 [PMID:25011913]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 3982-3988 [PMID:25027802]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2014) 5: 793-796 [PMID:25050167]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2014) 5: 826-830 [PMID:25050173]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2014) 84: 240-246 [PMID:25019479]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydrase Assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2014) 5: 927-930 [PMID:25147616]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2014) 24: 5185-5189 [PMID:25442309]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	J Med Chem (2014) 57: 9152-9167 [PMID:25310626]
ChEMBL	Inhibition of human CA-1 by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2014) 57: 9673-9686 [PMID:25358036]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2014) 24: 4389-4396 [PMID:25168745]
ChEMBL	Inhibition of human full length CA1 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 6353-6359 [PMID:25438758]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2014) 24: 4402-4406 [PMID:25168748]
ChEMBL	Inhibition of human recombinant Carbonic anhydrase 1 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 4537-4543 [PMID:25129169]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2014) 87: 186-196 [PMID:25255434]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 5133-5140 [PMID:25194929]
ChEMBL	Inhibition of human CA-1 after 15 mins by stopped-flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2014) 22: 5883-5890 [PMID:25267005]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 526-531 [PMID:25533402]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 1728-1734 [PMID:25773015]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 1430-1436 [PMID:25753329]
ChEMBL	Inhibition of human carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 2303-2309 [PMID:25882523]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 1421-1429 [PMID:25757603]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 expressed in Escherichia coli pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 2368-2376 [PMID:25846066]
ChEMBL	Inhibition of human recombinant CA-1 after 15 mins by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 1828-1840 [PMID:25766630]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 by CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2015) 58: 1494-1501 [PMID:25581127]
ChEMBL	Inhibition of human cytosolic form of carbonic anhydrase-1 assessed as CO2 hydration activity incubated for 15 mins prior to testing by stopped flow method	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2015) 96: 425-435 [PMID:25912674]
ChEMBL	Inhibition of human recombinant carbonic anhdydrase-1 expressed in Escherichia coli pre-incubated for 6 hrs by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2015) 58: 3975-3983 [PMID:25875209]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 2975-2981 [PMID:26007302]
ChEMBL	Inhibition of human carbonic anhydrase-1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay based Lineweaver-Burk plot method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 3674-3680 [PMID:25921266]
ChEMBL	Inhibition of human CA1 after 15 mins by stopped-flow/Co2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 4405-4409 [PMID:26145820]
ChEMBL	Inhibition of human carbonic anhydrase 1 by by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 4989-4999 [PMID:26048024]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 expressed in Escherichia coli preincubated for 15 mins by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 4649-4659 [PMID:26088336]
ChEMBL	Inhibition of human carbonic anhydrase-1 by CO2 hydration reaction based colorimetric stopped-flow method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 4831-4838 [PMID:26068018]
ChEMBL	Inhibition of human carbonic anhydrase-1 incubated for 10 mins prior to testing by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3208-3212 [PMID:26105196]
ChEMBL	Inhibition of human recombinant CA1 expressed in Escherichia coli by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2015) 58: 6630-6638 [PMID:26203869]
ChEMBL	Inhibition of human carbonic anhydrase-1	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3281-3284 [PMID:26073006]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 5619-5625 [PMID:26233796]
ChEMBL	Inhibition of human carbonic anhydrase-1 incubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 5311-5318 [PMID:26264840]
ChEMBL	Inhibition of human carbonic anhydrase-1 by CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3550-3555 [PMID:26174556]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3850-3853 [PMID:26233435]
ChEMBL	Inhibition of full length human carbonic anhydrase-1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2015) 6: 819-821 [PMID:26191373]
ChEMBL	Inhibition of carbonic anhydrase-1 (unknown origin)	B	6.6	pKi	250	nM	Ki	J Med Chem (2015) 58: 7580-7590 [PMID:26347950]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 expressed in Escherichia coli incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 6573-6580 [PMID:26422787]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 6 hrs by stopped flow carbon-di-oxide hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 6955-6966 [PMID:26432607]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2015) 23: 7219-7225 [PMID:26498393]
ChEMBL	Inhibition of human carbonic anhydrase-1 assessed as CO2 hydration activity by stopped-flow method	B	6.6	pKi	250	nM	Ki	J Med Chem (2015) 58: 8564-8572 [PMID:26497049]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2015) 25: 5636-5641 [PMID:26520662]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 expressed in Escherichia coli preincubated for 6 hrs by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2015) 103: 583-593 [PMID:26408817]
ChEMBL	Inhibition of human CA1 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2015) 25: 5485-5489 [PMID:26525863]
ChEMBL	Inhibition of human carbonic anhydrase-1 preincubated for 15 mins by stopped flow CO2 dehydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 20-25 [PMID:26678172]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-1 by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 921-927 [PMID:26796953]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 894-901 [PMID:26795114]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 982-988 [PMID:26803577]
ChEMBL	Inhibition of human carbonic anhydrase-1 using p-nitrophenyl acetate as substrate by esterase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2016) 26: 1337-1341 [PMID:26804228]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 1095-1105 [PMID:26810710]
ChEMBL	Inhibition of human carbonic anhydrase 1 for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 976-981 [PMID:26810836]
ChEMBL	Inhibition of human Carbonic anhydrase1 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 1115-1120 [PMID:26850377]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 15 mins prior to testing by CO2 hydration-based stopped flow assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2016) 59: 721-732 [PMID:26741028]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 1402-1407 [PMID:26875933]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2016) 26: 1253-1259 [PMID:26832216]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped flow carbon dioxide hydrase assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2016) 110: 259-266 [PMID:26840366]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2016) 26: 1821-1826 [PMID:26920803]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 expressed in Escherichia coli preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 1648-1652 [PMID:26951893]
ChEMBL	Inhibition of human carbonic anhydrase 1 using saturated CO2 as substrate incubated for 10 mins prior to testing by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 2882-2886 [PMID:27137360]
ChEMBL	Inhibition of human recombinant CA1 preincubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 3043-3051 [PMID:27234893]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated for 15 min to 72 hrs by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 2907-2913 [PMID:27166574]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 3413-3417 [PMID:27283786]
ChEMBL	Inhibition of human recombinant CA1 expressed in Escherichia coli preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 3548-3555 [PMID:27298005]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 6 hrs at 4 degC measured for 10 to 100 secs by stopped-flow carbon dioxide hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 3643-3648 [PMID:27316543]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2016) 59: 5462-5470 [PMID:27172398]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2016) 59: 5077-5088 [PMID:27144971]
ChEMBL	Inhibition of human carbonic anhydrase-1 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 4406-4409 [PMID:27469982]
ChEMBL	Inhibition of human CA1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2016) 24: 4100-4107 [PMID:27396930]
ChEMBL	Inhibition of human full length carbonic anhydrase 1	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2016) 26: 5867-5870 [PMID:27884694]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 expressed in Escherichia coli assessed as reduction in CO2 hydration preincubated for 15 mins prior to testing measured for 10 to 100 secs by stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2017) 27: 86-89 [PMID:27876475]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-1 preincubated for 6 hrs by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 677-683 [PMID:27939347]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 1 preincubated for 10 mins prior to testing by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 857-863 [PMID:28024887]
ChEMBL	Inhibition of human erythrocyte carbonic anhydrase 1 preincubated for 15 mins prior to testing by bromothymol blue-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 1260-1265 [PMID:28057408]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-1 using CO2 as substrate preincubated for 10 mins by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 539-544 [PMID:27919611]
ChEMBL	Inhibition of recombinant human erythrocyte cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 1286-1293 [PMID:28065499]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 assessed as reduction in CO2 hydration preincubated for 15 mins by stopped flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 1456-1464 [PMID:28111158]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 1 after 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2017) 127: 691-702 [PMID:27823879]
ChEMBL	Inhibition of recombinant human CA1 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2017) 60: 1159-1170 [PMID:28075587]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2017) 127: 521-530 [PMID:28109946]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-1 assessed as reduction in enzyme-catalyzed hydration activity using CO2 as substrate preincubated for 15 mins followed substrate addition measured after 10 to 100 sec by phenol red dye based stopped flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 1914-1925 [PMID:28237553]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 assessed as inhibition of CO2 hydration incubated for 15 mins prior to testing by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 2010-2015 [PMID:28238511]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2017) 27: 490-495 [PMID:28025002]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 10 mins prior to testing by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 1666-1671 [PMID:28161252]
ChEMBL	Inhibition of recombinant human cytosolic carbonic anhydrase 1 assessed as inhibition of CO2 hydration preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 2210-2217 [PMID:28256371]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2017) 60: 2456-2469 [PMID:28253618]
ChEMBL	Inhibition of recombinant human Carbonic anhydrase 1 assessed as reduction in CO2 hydration preincubated for 15 mins prior to testing measured for 10 to 100 secs by stopped-flow assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2017) 60: 3154-3164 [PMID:28272885]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 2577-2582 [PMID:28343756]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 2569-2576 [PMID:28347633]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-1 assessed as reduction in CO2 hydration preincubated for 10 mins measured for 5 to 10 secs by stopped flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 3583-3589 [PMID:28416101]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 2782-2788 [PMID:28389112]
ChEMBL	Inhibition of recombinant human cytosolic carbonic anhydrase 1 pretreated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 2518-2523 [PMID:28302505]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 10 mins by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 3093-3097 [PMID:28400084]
ChEMBL	Inhibition of human carbonic anhydrase-1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 3555-3561 [PMID:28511911]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 3567-3573 [PMID:28522267]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 2524-2529 [PMID:28318894]
ChEMBL	Inhibition of human CA1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280]
ChEMBL	Inhibition of human CA1 incubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 4800-4804 [PMID:28754318]
ChEMBL	Inhibition of human CA1 pre-incubated for 10 mins by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 5373-5379 [PMID:28789908]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-1 preincubated for 10 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 5726-5732 [PMID:28887000]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 assessed as reduction in CO2 hydration pretreated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2017) 8: 792-796 [PMID:28835790]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2017) 8: 1105-1109 [PMID:29057059]
ChEMBL	Inhibition of human carbonic anhydrase-1 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2017) 8: 1194-1198 [PMID:29152053]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2017) 8: 1213-1217 [PMID:29259736]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2017) 8: 1314-1319 [PMID:29259754]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2018) 61: 5380-5394 [PMID:29851481]
ChEMBL	Inhibition of human carbonic anhydrase 1 after 15 mins by stopped flow carbon dioxide hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2018) 9: 462-467 [PMID:29795760]
ChEMBL	Inhibition of recombinant human cytosolic CA1 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2018) 61: 5765-5770 [PMID:29912561]
ChEMBL	Binding affinity to human carbonic anhydrase 1 by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2018) 9: 725-729 [PMID:30034608]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 assessed as inhibition of CO2 hydration preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2018) 151: 363-375 [PMID:29635168]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 assessed as inhibition of CO2 hydration preincubated for 15 mins prior to testing by phenol red based stopped-flow assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2018) 152: 1-9 [PMID:29684705]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2018) 154: 210-219 [PMID:29803994]
ChEMBL	Binding affinity to human carbonic anhydrase 1 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2018) 155: 545-551 [PMID:29909339]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-1 incubated for 15 mins by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2018) 61: 4961-4977 [PMID:29746127]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2017) 139: 250-262 [PMID:28802125]
ChEMBL	Inhibition of recombinant human full-length carbonic anhydrase 1 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2017) 8: 941-946 [PMID:28947941]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2017) 8: 963-968 [PMID:28947945]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated 15 mins prior to testing by CO2 hydration based stopped-flow assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2018) 9: 947-951 [PMID:30258546]
ChEMBL	Inhibition of cytosolic human carbonic anhydrase 1 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2018) 150: 678-686 [PMID:29571155]
ChEMBL	Inhibition of human CA1 assessed as enzyme inhibitor complex formation preincubated for 15 mins and measured for 10 to 100 secs by phenol red dye based stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2018) 61: 6328-6338 [PMID:29962205]
ChEMBL	Inhibition of recombinant human CA1 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2018) 9: 1035-1038 [PMID:30344913]
ChEMBL	Inhibition of human CA1 by Lineweaver-Burk plot analysis	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2018) 9: 1045-1050 [PMID:30344915]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 assessed as CO2 hydration preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red dye-based stopped-flow assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2018) 156: 430-443 [PMID:30015076]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2018) 157: 28-36 [PMID:30071407]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2018) 157: 1214-1222 [PMID:30193219]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as reduction in CO2 hydration incubated for 1 hr by phenol red staining-based stopped flow assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 183: 111698-111698 [PMID:31539777]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 10 mins prior to testing measured for 5 to 10 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 183: 111702-111702 [PMID:31542715]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 184: 111768-111768 [PMID:31629164]
ChEMBL	Inhibition of recombinant full length human carbonic anhydrase-1 assessed as reduction in CO2 hydration after 15 mins by phenol red dye based stopped flow assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 163: 443-452 [PMID:30530195]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2019) 62: 4174-4192 [PMID:30925064]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 177: 188-197 [PMID:31136893]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2020) 63: 2470-2488 [PMID:31972093]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2019) 62: 7233-7249 [PMID:31287314]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 181: 111565-111565 [PMID:31387062]
ChEMBL	Inhibition of recombinant human CA1 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 181: 111573-111573 [PMID:31394463]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 181: 111586-111586 [PMID:31401537]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as inhibitory constant incubated for 15 mins by phenol red dye based stopped flow assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 182: 111638-111638 [PMID:31472471]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 182: 111642-111642 [PMID:31476557]
ChEMBL	Inhibition of recombinant human CA1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 182: 111600-111600 [PMID:31419777]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 15 mins by phenol red staining-based stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2019) 27: 115086-115086 [PMID:31515057]
ChEMBL	Inhibition of recombinant human carbonic anhydrase1 preincubated for 10 mins followed by CO2 solution addition by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2019) 27: 115090-115090 [PMID:31515058]
ChEMBL	Inhibitory activity against human carbonic anhydrase I (hCA I) by using esterase assay method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2004) 14: 3757-3762 [PMID:15203157]
ChEMBL	Inhibition of full length human CA 1	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 168: 301-314 [PMID:30826507]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as inhibitory constant preincubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 175: 40-48 [PMID:31071549]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing measured for 5 to 10 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2019) 27: 1588-1594 [PMID:30846402]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as reduction in CO2 hydration after 15 mins by phenol red staining-based stopped flow assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2019) 164: 92-105 [PMID:30594030]
ChEMBL	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2016) 59: 5857-5867 [PMID:27253845]
ChEMBL	Inhibition of full length human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stop flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2016) 26: 4184-4190 [PMID:27485387]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2016) 26: 3892-3895 [PMID:27423482]
ChEMBL	Inhibition of recombinant human CA1 incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2020) 185: 111811-111811 [PMID:31693947]
ChEMBL	Compound was evaluated for inhibition against human carbonic anhydrase I	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2004) 14: 217-223 [PMID:14684331]
ChEMBL	Inhibition constant determined against human cloned carbonic anhydrase I	B	6.6	pKi	250	nM	Ki	J Med Chem (2003) 46: 2187-2196 [PMID:12747790]
ChEMBL	Inhibitory activity against human carbonic anhydrase I	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2004) 14: 869-873 [PMID:15012984]
ChEMBL	Inhibitory activity against human cloned carbonic anhydrase I (hCA I)	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2003) 13: 841-845 [PMID:12617904]
ChEMBL	Inhibitory activity against human cloned carbonic anhydrase isozyme I by esterase assay method.	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2003) 13: 1005-1009 [PMID:12643899]
ChEMBL	Inhibition constant evaluated for the inhibition of human CA I (Carbonic anhydrase I)	B	6.6	pKi	250	nM	Ki	J Med Chem (2004) 47: 2337-2347 [PMID:15084132]
ChEMBL	Inhibitory activity against Carbonic anhydrase I	B	6.6	pKi	250	nM	Ki	J Med Chem (2005) 48: 2121-2125 [PMID:15771455]
ChEMBL	Inhibitory constant against cytosolic human Carbonic anhydrase I using CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3828-3833 [PMID:16039848]
ChEMBL	Inhibitory activity against human carbonic anhydrase I	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3821-3827 [PMID:16039853]
ChEMBL	Ki value against carbonic anhydrase I	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 971-976 [PMID:15686895]
ChEMBL	Ki value against human carbonic anhydrase I	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 971-976 [PMID:15686895]
ChEMBL	Ki value against human carbonic anhydrase I (hCA I)	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 963-969 [PMID:15686894]
ChEMBL	Inhibitory activity against human carbonic anhydrase I (hCAI)	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1149-1154 [PMID:15686931]
ChEMBL	Inhibitory activity against human carbonic anhydrase I expressed in Escherichia coli BL21	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5427-5433 [PMID:15454239]
ChEMBL	Inhibitory activity against human carbonic anhydrase I at 0.09 uM	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717]
ChEMBL	Inhibitory constant against human Carbonic anhydrase I	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3102-3108 [PMID:15905091]
ChEMBL	Inhibition constant against human recombinant carbonic anhydrase I	F	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3302-3306 [PMID:15908201]
ChEMBL	Inhibitory constant against human Carbonic anhydrase I	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 2347-2352 [PMID:15837323]
ChEMBL	Inhibition constant against human carbonic anhydrase I	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3096-3101 [PMID:15908204]
ChEMBL	Inhibitory activity against human Carbonic anhydrase I (hCA I)	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4862-4866 [PMID:16168653]
ChEMBL	Inhibition of recombinant human cytosolic isozyme CA I	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2005) 15: 5192-5196 [PMID:16203142]
ChEMBL	Inhibitory activity against cloned human CA1	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2006) 16: 437-442 [PMID:16290146]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2006) 49: 2117-2126 [PMID:16539401]
ChEMBL	Inhibition of human recombinant CA1	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2006) 16: 2182-2188 [PMID:16459077]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2006) 49: 5544-5551 [PMID:16942027]
ChEMBL	Inhibition of human cloned CA1 by stopped-flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibition of human recombinant cytosolic isozyme CA I by stopped-flow CO2 hydrase method	B	6.6	pKi	250	nM	Ki	J Med Chem (2007) 50: 381-388 [PMID:17228881]
ChEMBL	Inhibition of human recombinant CA1 after 15 mins by CO2 hydration stopped flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2007) 17: 2685-2691 [PMID:17376683]
ChEMBL	Inhibition of human cloned CA1 by CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2007) 17: 5032-5035 [PMID:17681760]
ChEMBL	Inhibition of human cloned carbonic anhydrase1 by CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2007) 15: 6975-6984 [PMID:17822907]
ChEMBL	Inhibition of human recombinant CA 1 assessed as CO2 hydration by stopped flow kinetic assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2007) 15: 7229-7236 [PMID:17826101]
ChEMBL	Inhibition of human carbonic anhydrase 1	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human recombinant CA1 by CO2 hydration stopped flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2008) 18: 836-841 [PMID:18042384]
ChEMBL	Inhibition of human cloned CA1 by CO2 hydration method	B	6.6	pKi	250	nM	Ki	J Med Chem (2008) 51: 1945-1953 [PMID:18307288]
ChEMBL	Inhibition of human full length carbonic anhydrase 1 by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2008) 18: 3593-3596 [PMID:18501600]
ChEMBL	Inhibition of human recombinant full length CA1 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	J Med Chem (2009) 52: 2226-2232 [PMID:19317447]
ChEMBL	Inhibition of human recombinant full length CA1 by stopped-flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of human carbonic anhydrase 1 measured by CO2 hydration reaction assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2009) 19: 650-653 [PMID:19121582]
ChEMBL	Inhibition of human recombinant CA1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2009) 17: 1158-1163 [PMID:19124253]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2009) 52: 646-654 [PMID:19193158]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2008) 18: 6332-6335 [PMID:18990571]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2009) 52: 3116-3120 [PMID:19338333]
ChEMBL	Inhibition of human cloned CA1 by stopped-flow CO2 hydration method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2008) 18: 4282-4286 [PMID:18640037]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL	Inhibition of human recombinant CA1 by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2008) 51: 7968-7979 [PMID:19053764]
ChEMBL	Inhibition of human erythrocytes carbonic anhydrase 1 by CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2009) 52: 4853-4859 [PMID:19580287]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2642-2645 [PMID:19375309]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4102-4106 [PMID:19527930]
ChEMBL	Inhibition of human recombinant CA1 by stopped-flow CO2 assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2009) 17: 5054-5058 [PMID:19520577]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2009) 17: 4894-4899 [PMID:19539481]
ChEMBL	Inhibition of human full length cytosolic carbonic anhydrase 1 after 15 mins by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2009) 52: 5990-5998 [PMID:19731956]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as inhibition constant preincubated for 15 mins and measured by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2023) 94: 117467-117467 [PMID:37722299]
ChEMBL	Binding affinity to human CA1 assessed as inhibition constant by stopped flow kinetic assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2023) 250: 115180-115180 [PMID:36796297]
ChEMBL	Binding affinity to human recombinant CA1 assessed as inhibition constant incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2023) 66: 14824-14842 [PMID:37902628]
ChEMBL	Binding affinity to human carbonic anhydrase 1 assessed as inhibition constant incubated for 15 mins by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2024) 271: 116434-116434 [PMID:38653067]
ChEMBL	Inhibition of human CA1 preincubated for 6 hrs by phenol red staining based stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2024) 67: 7406-7430 [PMID:38642371]
ChEMBL	Inhibition of human CA1 (alpha) catalytic activity assessed as inhibition constant by CO2 hydration - stopped-flow kinetic assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2024) 67: 9613-9627 [PMID:38776401]
ChEMBL	Inhibition of human CA1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2024) 67: 3066-3089 [PMID:38266245]
ChEMBL	Inhibition of human recombinant CA1 assessed as inhibition constant incubated for 45 mins by phenol red dye based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2024) 67: 4170-4193 [PMID:38436571]
ChEMBL	Inhibition of recombinant human CA1 incubated for 15 mins by phenol red dye based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2024) 15: 972-978 [PMID:38894925]
ChEMBL	Inhibition of human recombinant CA I assessed as inhibition constant incubated for 15 min by stopped-flow CO2 hydrase assay method	B	6.6	pKi	250	nM	Ki	J Med Chem (2024) 67: 1611-1623 [PMID:38207099]
ChEMBL	Inhibition of human carbonic anhydrase I assessed as inhibition constant incubated for 15 mins by phenol red dye based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	RSC Med Chem (2024) 15: 1929-1941 [PMID:38911163]
ChEMBL	Inhibition of human CA1 assessed as inhibition constant preincubated for 15 mins by phenol red dye based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2024) 274: 116527-116527 [PMID:38810335]
ChEMBL	Inhibition of human recombinant CA1 by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2024) 67: 15892-15907 [PMID:39207927]
ChEMBL	Inhibition of human CA1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2024) 15: 1559-1565 [PMID:39291024]
ChEMBL	Binding affinity to human CA1 assessed as inhibition constant incubated for 6 hrs by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2023) 258: 115538-115538 [PMID:37321108]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as inhibition constant preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2023) 259: 115707-115707 [PMID:37556946]
ChEMBL	Inhibition of recombinant human CA-I incubated for 15 mins by stop-flow method	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2023) 260: 115783-115783 [PMID:37678143]
ChEMBL	Inhibition of human CA1 preincubated for 15 mins by stopped-flow carbon dioxide hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2020) 11: 1000-1005 [PMID:32435417]
ChEMBL	Inhibition of human CA1 pre-incubated for 15 mins by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2020) 63: 7392-7409 [PMID:32463228]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated with enzyme for 10 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2020) 11: 633-637 [PMID:32435363]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2020) 11: 727-731 [PMID:32435377]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 6 hrs prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2020) 11: 852-856 [PMID:32435395]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2020) 11: 1022-1027 [PMID:32435420]
ChEMBL	Inhibition of human CA1 preincubated for 15 mins by stopped-flow CO2 hydration kinetic assay based Cheng-Prusoff equation analysis	B	6.6	pKi	250	nM	Ki	J Med Chem (2020) 63: 7422-7444 [PMID:32519851]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as inhibitory constant incubated for 6 hrs by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2020) 28: 115496-115496 [PMID:32327349]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red dye based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2020) 28: 115329-115329 [PMID:32007388]
ChEMBL	Inhibition of recombinant human CA1 expressed in Escherichia coli BL21 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2020) 63: 13064-13075 [PMID:33085484]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2018) 61: 3151-3165 [PMID:29566486]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2020) 188: 112021-112021 [PMID:31901743]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 6 hrs prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2020) 200: 112300-112300 [PMID:32460112]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2020) 200: 112449-112449 [PMID:32485534]
ChEMBL	Inhibition of human CA1 incubated for 15 mins by stopped- flow CO2 hydrase assay method	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2020) 201: 112478-112478 [PMID:32659606]
ChEMBL	Inhibition of human CA1 preincubated for 15 mins prior to testing by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2020) 207: 112745-112745 [PMID:32877804]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 212: 113035-113035 [PMID:33303238]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2021) 37: 127856-127856 [PMID:33609663]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 assessed as inhibition constant preincubated with enzyme for 10 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2020) 28: 115586-115586 [PMID:32631564]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 209: 112875-112875 [PMID:33059188]
ChEMBL	Inhibition of human CA1 incubated for 15 mins by stopped-flow CO2 hydration kinetic assay based Cheng-Prusoff equation analysis	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 214: 113260-113260 [PMID:33581552]
ChEMBL	Inhibition of recombinant human CA1 pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2020) 190: 112112-112112 [PMID:32044580]
ChEMBL	Inhibition of human CA1 by stopped-flow carbon dioxide hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2020) 200: 112439-112439 [PMID:32485532]
ChEMBL	Inhibition of human CA1 measured by stopped flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2021) 48: 128249-128249 [PMID:34237441]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2021) 49: 128309-128309 [PMID:34371130]
ChEMBL	Inhibition of recombinant human CA1 pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 218: 113360-113360 [PMID:33773285]
ChEMBL	Inhibition of recombinant human CA1 pre-incubated for 15 mins prior to testing by phenol red-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 218: 113352-113352 [PMID:33774343]
ChEMBL	Inhibition of recombinant human CA 1 preincubated for 15 mins by measured for 10 to 100 secs by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2021) 45: 128147-128147 [PMID:34052322]
ChEMBL	Inhibition of recombinant human CA1 incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2021) 44: 116279-116279 [PMID:34216985]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 210: 112994-112994 [PMID:33234343]
ChEMBL	Inhibition of human CA1 by stopped- flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 216: 113283-113283 [PMID:33667848]
ChEMBL	Inhibition of human CA1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 217: 113351-113351 [PMID:33744685]
ChEMBL	Inhibition of recombinant human CA1 pre-incubated for 15 mins measured by stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2021) 64: 3100-3114 [PMID:33721499]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 222: 113589-113589 [PMID:34147910]
ChEMBL	Inhibition of recombinant human CA1 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 220: 113490-113490 [PMID:33975138]
ChEMBL	Inhibition of recombinant human CA1 pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 225: 113793-113793 [PMID:34507012]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 221: 113486-113486 [PMID:33965860]
ChEMBL	Inhibition of human CA1 measured after 15 mins by stopped flow carbon dioxide anhydrase assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 225: 113800-113800 [PMID:34482273]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2021) 64: 11432-11444 [PMID:34283610]
ChEMBL	Inhibition of human CA1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2022) 228: 114004-114004 [PMID:34847409]
ChEMBL	Inhibition of human CA1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2022) 228: 114008-114008 [PMID:34871842]
ChEMBL	Inhibition of human CA1 incubated for 15 mins prior to testing by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2022) 228: 114026-114026 [PMID:34920169]
ChEMBL	Inhibition of human CA1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2022) 65: 824-837 [PMID:34958217]
ChEMBL	Inhibition of human CA1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2022) 228: 113997-113997 [PMID:34902732]
ChEMBL	Binding affinity to human CA1 assessed as inhibition constant by stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Binding affinity to human recombinant CA1 assessed as inhibition constant incubated for 10 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of recombinant human CA1 pre-incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2022) 65: 13143-13157 [PMID:36121705]
ChEMBL	Inhibition of human recombinant CA1 assessed as inhibition constant pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2022) 65: 13946-13966 [PMID:36201615]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2022) 238: 114412-114412 [PMID:35551035]
ChEMBL	Inhibition of human carbonic anhydrase 1 by stopped flow CO2 assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2022) 70: 128809-128809 [PMID:35605838]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2022) 59: 128581-128581 [PMID:35066141]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 assessed as inhibition constant incubated for 10 mins by phenol red dye based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2022) 234: 114247-114247 [PMID:35305463]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 assessed as inhibition constant preincubated for 15 mins by measured for 10 to 100 secs by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2022) 227: 113956-113956 [PMID:34731762]
ChEMBL	Inhibition of recombinant human CA 1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2022) 232: 114190-114190 [PMID:35182815]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 preincubated for 10 mins and measured by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2022) 65: 14655-14672 [PMID:36269278]
ChEMBL	Binding affinity to human CA1 assessed as inhibition constant	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2020) 28: 115813-115813 [PMID:33069128]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 assessed as inhibition constant preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2023) 14: 810-819 [PMID:37312840]
ChEMBL	Inhibition of human CA1	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2020) 205: 112666-112666 [PMID:32795767]
ChEMBL	Inhibition of human CA1	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2020) 205: 112666-112666 [PMID:32795767]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as inhibition constant	B	6.6	pKi	250	nM	Ki	RSC Med Chem (2023) 14: 144-153 [PMID:36760748]
ChEMBL	Inhibition of human CA1 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2023) 66: 1616-1633 [PMID:36626645]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 1 assessed as inhibition constant incubated for 15 mins by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2023) 66: 10010-10026 [PMID:37436184]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as inhibition constant incubated for 15 mins by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2024) 67: 3018-3038 [PMID:38301036]
ChEMBL	Inhibition of human carbonic anhydrase I assessed as inhibition constant incubated for 15 min by stopped-flow CO2 hydrase assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2024) 15: 470-477 [PMID:38628786]
ChEMBL	Inhibition of recombinant human CA1 assessed as inhibition constant preincubated for 15 mins by phenol red dye based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2023) 66: 5703-5718 [PMID:37022308]
ChEMBL	Inhibition of recombinant human carbonic anhydrase I assessed as inhibition constant incubated for 15 mins by phenol red dye based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2023) 66: 8118-8129 [PMID:37283561]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	J Med Chem (2023) 66: 10558-10578 [PMID:37501287]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as inhibition constant preincubated for 15 mins and measured for 10 to 100 sec by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2022) 243: 114793-114793 [PMID:36201858]
ChEMBL	Binding affinity to human CA1 assessed as inhibition constant incubated for 6 hrs by phenol red dye based stopped flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	Eur J Med Chem (2023) 246: 115011-115011 [PMID:36516582]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as inhibition constant incubated for 1 hr prior to testing by phenol red based stopped-flow CO2 hydration assay	B	6.6	pKi	250	nM	Ki	ACS Med Chem Lett (2023) 14: 1067-1072 [PMID:37583824]
ChEMBL	Inhibition of human CA I assessed as inhibition constant by stopped-flow CO2 hydrase assay method	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem Lett (2023) 95: 129479-129479 [PMID:37704010]
ChEMBL	Inhibition of human carbonic anhydrase 1 using 4-nitrophenylacetate as substrate by Lineweaver-Burk plot analysis	B	6.69	pKi	204.03	nM	Ki	Bioorg Med Chem (2016) 24: 2318-2329 [PMID:27068142]
ChEMBL	Inhibitory activity against human carbonic anhydrase I (hCA I)	B	6.7	pKi	200	nM	Ki	Bioorg Med Chem Lett (2003) 13: 2867-2873 [PMID:14611846]
ChEMBL	Inhibition of human carbonic anhydrase 1 by Stopped-Flow CO2 Hydrase assay	B	6.7	pKi	200	nM	Ki	J Med Chem (2016) 59: 462-473 [PMID:26688270]
ChEMBL	Inhibition of human CA-1 using p-nitro-phenylacetate as substrate by Lineweaver-Burk plot analysis	B	6.73	pKi	184.3	nM	Ki	Bioorg Med Chem (2015) 23: 2598-2605 [PMID:25863492]
ChEMBL	Inhibition of human CA1 using para-nitrophenylacetate as substrate measured over 3 mins by UV-vis spectrophotometric method	B	6.73	pKi	184.3	nM	Ki	J Med Chem (2015) 58: 640-650 [PMID:25432060]
ChEMBL	Inhibition of human CA1 by stopped-flow assay	B	6.74	pKi	182.09	nM	Ki	Bioorg Med Chem (2021) 39: 116140-116140 [PMID:33905966]
ChEMBL	Inhibition of human CA1	B	6.74	pKi	182	nM	Ki	Eur J Med Chem (2020) 205: 112666-112666 [PMID:32795767]
ChEMBL	Binding affinity to human CA1 assessed as inhibition constant by SDS-PAGE analysis	B	6.78	pKi	164.7	nM	Ki	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of human CA1 by UV spectrophotometric analysis	B	6.78	pKi	164.7	nM	Ki	Eur J Med Chem (2020) 205: 112666-112666 [PMID:32795767]
ChEMBL	Inhibition of esterase activity of carbonic anhydrase 1 in human erythrocytes using PNF as substrate by spectrophotometer analysis	B	7.21	pKi	61.1	nM	Ki	Bioorg Med Chem (2015) 23: 3592-3602 [PMID:25921269]
ChEMBL	Binding affinity to human CA1 assessed as inhibition constant by esterase activity assay	B	7.29	pKi	51.17	nM	Ki	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Binding affinity to human recombinant CA1 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	7.59	pKi	25.8	nM	Ki	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of human carbonic anhydrase 1-catalyzed CO2 hydration preincubated for 10 mins by stopped-flow assay	B	7.92	pKi	12	nM	Ki	Bioorg Med Chem (2014) 22: 2867-2874 [PMID:24746465]
ChEMBL	Inhibition of carbonic anhydrase-1 in human erythrocyte membranes assessed as reduction in H+ release using CO2 as substrate by bromine thymol blue indicator based assay	B	8.05	pKi	8.89	nM	Ki	Bioorg Med Chem (2017) 25: 3547-3554 [PMID:28511907]
ChEMBL	Inhibition of human CAH1 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	8.36	pKi	4.4	nM	Ki	J Med Chem (2021) 64: 1713-1724 [PMID:33523653]
ChEMBL	Binding affinity to human CA1 assessed as inhibition constant using 4-nitrophenylacetate as substrate by spectrophotometrical analysis	B	9.13	pKi	0.75	nM	Ki	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of human carbonic anhydrase-1 preincubated for 15 mins by stopped flow CO2 dehydration method	B	9.6	pKi	0.25	nM	Ki	Bioorg Med Chem (2016) 24: 104-112 [PMID:26682703]
ChEMBL	Inhibition of esterase-activity of CA1 from human erythrocytes by spectrophotometry	B	5.21	pIC50	6100	nM	IC50	Bioorg Med Chem (2010) 18: 930-938 [PMID:20006931]
ChEMBL	Inhibition of CA1 from human erythrocytes by Lineweaver-Burke analysis	B	5.28	pIC50	5200	nM	IC50	Bioorg Med Chem (2010) 18: 930-938 [PMID:20006931]
ChEMBL	Inhibition of human carbonic anhydrase 1 esterase activity by spectrophotometry	B	5.42	pIC50	3800	nM	IC50	Eur J Med Chem (2010) 45: 4769-4773 [PMID:20724038]
ChEMBL	Inhibition of CO2-hydratase activity of human carbonic anhydrase 1 by CO2 hydration method	B	5.43	pIC50	3750	nM	IC50	Bioorg Med Chem (2009) 17: 3295-3301 [PMID:19362844]
ChEMBL	Inhibition of hydratase-activity of CA1 from human erythrocytes by CO2-hydration method	B	5.44	pIC50	3600	nM	IC50	Bioorg Med Chem (2010) 18: 930-938 [PMID:20006931]
ChEMBL	Inhibition of human carbonic anhydrase 1 hydratase activity by spectrophotometry	B	5.51	pIC50	3100	nM	IC50	Eur J Med Chem (2010) 45: 4769-4773 [PMID:20724038]
ChEMBL	Inhibition of esterase activity of human carbonic anhydrase 1 by CO2 hydration method	B	5.54	pIC50	2900	nM	IC50	Bioorg Med Chem (2009) 17: 3295-3301 [PMID:19362844]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as 4-nitrophenyl acetate hydrolysis	B	5.92	pIC50	1210	nM	IC50	Bioorg Med Chem Lett (2008) 18: 2267-2271 [PMID:18353640]
ChEMBL	Inhibition of carbonic anhydrase 1 (unknown origin)	B	6.05	pIC50	900	nM	IC50	Bioorg Med Chem Lett (2022) 57: 128520-128520 [PMID:34965467]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay	B	6.29	pIC50	509.6	nM	IC50	Eur J Med Chem (2013) 62: 597-604 [PMID:23429054]
ChEMBL	Inhibition of human erythrocyte CA1 using 4-nitrophenyl acetate as substrate by spectrophotometry	B	6.44	pIC50	361	nM	IC50	Eur J Med Chem (2020) 198: 112392-112392 [PMID:32388113]
ChEMBL	Inhibition of human carbonic anhydrase 1 assessed as 4-nitrophenyl phosphate hydrolysis	B	6.48	pIC50	330	nM	IC50	Bioorg Med Chem Lett (2008) 18: 2267-2271 [PMID:18353640]
ChEMBL	Inhibition of human CA-1 using p-nitro-phenylacetate as substrate after 3 mins by UV-Vis spectrophotometry	B	6.5	pIC50	315.5	nM	IC50	Bioorg Med Chem (2015) 23: 2598-2605 [PMID:25863492]
ChEMBL	Inhibition of recombinant human CA1 using 4-nitrophenylacetate as substrate by esterase assay	B	6.52	pIC50	300	nM	IC50	Bioorg Med Chem Lett (2021) 53: 128420-128420 [PMID:34728369]
ChEMBL	Inhibition of human CA1 using 4-nitrophenylacetate as substrate incubated for 10 mins prior to testing by spectrophotometry based esterase assay	B	6.52	pIC50	300	nM	IC50	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 using 4-nitrophenylacetate as substrate	B	6.52	pIC50	300	nM	IC50	Bioorg Med Chem Lett (2021) 51: 128291-128291 [PMID:34324968]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 pretreated for 15 mins by stopped flow CO2 hydrase assay	B	6.52	pIC50	299	nM	IC50	Bioorg Med Chem Lett (2014) 24: 2617-2620 [PMID:24813742]
ChEMBL	Inhibition of CA-1 (unknown origin) after 15 mins by CO2 hydration assay	B	6.53	pIC50	295	nM	IC50	Bioorg Med Chem Lett (2014) 24: 3422-3425 [PMID:24948563]
ChEMBL	Inhibitory activity against human carbonic anhydrase I was determined	B	6.6	pIC50	250	nM	IC50	J Med Chem (2004) 47: 550-557 [PMID:14736236]
ChEMBL	Inhibitory activity of compound against human carbonic anhydrase I	F	6.6	pIC50	250	nM	IC50	Bioorg Med Chem Lett (2004) 14: 337-341 [PMID:14698154]
ChEMBL	Inhibition of human recombinant CA1 incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	6.6	pIC50	250	nM	IC50	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of human carbonic anhydrase 1 using 4-nitrophenylacetate as substrate by spectrophotometric analysis	B	6.68	pIC50	210.11	nM	IC50	Bioorg Med Chem (2016) 24: 2318-2329 [PMID:27068142]
ChEMBL	Inhibition of human CA1 by stopped-flow assay	B	6.71	pIC50	197.1	nM	IC50	Bioorg Med Chem (2021) 39: 116140-116140 [PMID:33905966]
ChEMBL	Inhibition of human CA1	B	6.71	pIC50	197	nM	IC50	Eur J Med Chem (2020) 205: 112666-112666 [PMID:32795767]
ChEMBL	Inhibition of full length carbonic anhydrase-1 in human erythrocytes	B	6.79	pIC50	161.11	nM	IC50	Bioorg Med Chem Lett (2013) 23: 3496-3499 [PMID:23664215]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration method	B	7.32	pIC50	48	nM	IC50	Bioorg Med Chem Lett (2014) 24: 1941-1943 [PMID:24650641]
ChEMBL	Inhibition of human CA1 using 4-nitrophenylacetate as substrate by spectrophotometrical analysis	B	7.5	pIC50	31.8	nM	IC50	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Known Inhibitors of Carbonic Anhydrase: Compounds which are CAIs are well known in the art, see for example, Pastorekova et al, Journal of Enzyme Inhibition and Medicinal Chemistry, 19(3), 199-229, 2004. Methods for determining the carbonic anhydrase inhibitory activity of a compound, i.e. whether a compound can be classified as a CAI, are known in the art and may usefully identify further compounds which may be suitable for use in the present invention. Exemplary methods and levels of activity required for consideration as CAIs are described in US 20020022245 and the references cited therein, the contents of which are incorporated herein by reference, in particular Supuran et al, European Journal of Medicinal Chemistry, 1998, 33, 577-594 and Scozzafava et al, Journal of Medicinal Chemistry, 1999, 42 25, 3690-3700).	B	7.92	pIC50	12	nM	IC50	US-10172837-B2. Insulin sensitisers and methods of treatment (2019)
ChEMBL	Inhibition of carbonic anhydrase-1 in human erythrocyte membranes assessed as reduction in H+ release using CO2 as substrate by bromine thymol blue indicator based assay	B	8.24	pIC50	5.8	nM	IC50	Bioorg Med Chem (2017) 25: 3547-3554 [PMID:28511907]
ChEMBL	Inhibition of human erythrocyte carbonic anhydrase-1	B	8.24	pIC50	5.8	nM	IC50	Eur J Med Chem (2017) 125: 190-196 [PMID:27657811]
carbonic anhydrase 12/Carbonic anhydrase 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
ChEMBL	Inhibition of chimeric carbonic anhydrase 12 (unknown origin) expressing with full length CA2 (1 to 260) at pH7 and 37 degC by fluorescent thermal shift assay	B	6.48	pKd	330	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 12 by thermal shift assay	B	6.88	pKd	133	nM	Kd	Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428]
ChEMBL	Binding affinity to human recombinant CA12 at 37 degC and pH 7.0 by thermal shift assay	B	6.88	pKd	133	nM	Kd	Bioorg Med Chem (2013) 21: 2093-2106 [PMID:23394791]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 12 expressed in Escherichia coli expression system assessed as observed dissociation constant fluorescent thermal shift assay	B	6.89	pKd	130	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Inhibition of human carbonic anhydrase 12 at pH7 and 37 degC by fluorescent thermal shift assay	B	6.89	pKd	130	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Inhibition of human carbonic anhydrase 12 at pH7 and 37 degC by isothermal titration calorimetry	B	6.89	pKd	130	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Inhibition of human carbonic anhydrase 12 at pH7 and 25 degC by stopped-flow kinetic inhibition assay	B	7.6	pKd	25	nM	Kd	J Med Chem (2014) 57: 9435-9446 [PMID:25358084]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 12 expressed in Escherichia coli expression system assessed as kinetic dissociation constant fluorescent thermal shift assay	B	7.62	pKd	24	nM	Kd	Eur J Med Chem (2020) 185: 111825-111825 [PMID:31740053]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 assessed as inhibition constant incubated for 1 hr prior to testing by phenol red based stopped-flow CO2 hydration assay	B	5.24	pKi	5700	nM	Ki	Bioorg Med Chem (2022) 67: 116805-116805 [PMID:35635929]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 12 using 4-nitrophenyl acetate as substrate assessed as inhibition constant by spectrophotometric analysis	B	6.47	pKi	338.9	nM	Ki	Bioorg Med Chem (2023) 77: 117111-117111 [PMID:36463726]
ChEMBL	Inhibition of human CA12	B	6.6	pKi	250	nM	Ki	Bioorg Med Chem (2017) 25: 4560-4565 [PMID:28728897]
ChEMBL	Inhibition of human carbonic anhydrase-12 preincubated for 15 mins by stopped flow CO2 dehydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2016) 24: 104-112 [PMID:26682703]
ChEMBL	Inhibition of recombinant human CA12 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay	B	7.92	pKi	12	nM	Ki	Eur J Med Chem (2019) 181: 111573-111573 [PMID:31394463]
ChEMBL	Inhibition of human CA12 by Lineweaver-Burk plot analysis	B	8.22	pKi	6	nM	Ki	ACS Med Chem Lett (2018) 9: 1045-1050 [PMID:30344915]
ChEMBL	Inhibition of human CA12 using CO2 as substrate incubated for 6 hrs prior to substrate addition measured for 10 to 100 secs by stopped flow technique	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem Lett (2012) 22: 5801-5806 [PMID:22901388]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem (2016) 24: 982-988 [PMID:26803577]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem (2016) 24: 1095-1105 [PMID:26810710]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 catalytic domain preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	ACS Med Chem Lett (2017) 8: 941-946 [PMID:28947941]
ChEMBL	Inhibition of human carbonic anhydrase 12 catalytic domain by Stopped-Flow CO2 Hydrase assay	B	8.22	pKi	6	nM	Ki	J Med Chem (2016) 59: 462-473 [PMID:26688270]
ChEMBL	Inhibition of recombinant human transmembrane, tumor-associated form of carbonic anhydrase-12 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem Lett (2015) 25: 2377-2381 [PMID:25913118]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 6 hrs prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	Eur J Med Chem (2020) 200: 112300-112300 [PMID:32460112]
ChEMBL	Inhibition of human CA12 by stopped-flow CO2 hydrase assay	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem (2017) 25: 5064-5067 [PMID:28277280]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 catalytic domain expressed in Escherichia coli incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem (2015) 23: 6573-6580 [PMID:26422787]
ChEMBL	Inhibition of recombinant human carbonic anhydrase12 preincubated for 10 mins followed by CO2 solution addition by phenol red dye based stopped flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem (2019) 27: 115090-115090 [PMID:31515058]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem Lett (2013) 23: 6759-6763 [PMID:24189056]
ChEMBL	Inhibition of human carbonic anhydrase-12 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem (2013) 21: 2925-2931 [PMID:23623256]
ChEMBL	Inhibition of human recombinant CA12 expressed in Escherichia coli by stopped flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	J Med Chem (2015) 58: 6630-6638 [PMID:26203869]
ChEMBL	Inhibition of human carbonic anhydrase 12 by stopped flow CO2 assay	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem Lett (2022) 70: 128809-128809 [PMID:35605838]
ChEMBL	Inhibition of human carbonic anhydrase 12 by stopped-flow CO2 hydrase assay	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem (2014) 22: 1821-1831 [PMID:24560739]
ChEMBL	Inhibition of human CA12 by stopped-flow CO2 hydration method	B	8.22	pKi	6	nM	Ki	J Med Chem (2015) 58: 640-650 [PMID:25432060]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-12 catalytic domain by stopped-flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	ACS Med Chem Lett (2015) 6: 819-821 [PMID:26191373]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 preincubated with enzyme for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	ACS Med Chem Lett (2020) 11: 1022-1027 [PMID:32435420]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 expressed in Escherichia coli preincubated for 15 mins by stopped flow CO2 hydration method	B	8.22	pKi	6	nM	Ki	Bioorg Med Chem (2015) 23: 4649-4659 [PMID:26088336]
ChEMBL	Inhibition of human CA12 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.22	pKi	6	nM	Ki	ACS Med Chem Lett (2024) 15: 1559-1565 [PMID:39291024]
ChEMBL	Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.24	pKi	5.8	nM	Ki	ACS Med Chem Lett (2014) 5: 793-796 [PMID:25050167]
ChEMBL	Inhibition of human carbonic anhydrase-12 pre-incubated for 15 mins by stopped-flow CO2 hydration assay based Lineweaver-Burk plot method	B	8.24	pKi	5.8	nM	Ki	Bioorg Med Chem (2015) 23: 3674-3680 [PMID:25921266]
ChEMBL	Inhibition of human carbonic anhydrase 12 by by stopped flow CO2 hydration method	B	8.24	pKi	5.8	nM	Ki	Bioorg Med Chem (2015) 23: 4989-4999 [PMID:26048024]
ChEMBL	Inhibition of human carbonic anhydrase 12-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay	B	8.24	pKi	5.8	nM	Ki	Bioorg Med Chem (2014) 22: 2643-2647 [PMID:24713308]
ChEMBL	Inhibition of human CA12 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.24	pKi	5.8	nM	Ki	J Med Chem (2022) 65: 824-837 [PMID:34958217]
ChEMBL	Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration assay	B	8.24	pKi	5.8	nM	Ki	Bioorg Med Chem (2015) 23: 1421-1429 [PMID:25757603]
GtoPdb	-	-	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2005) 15: 963-9 [PMID:15686894]; Bioorg Med Chem Lett (2010) 20: 4376-81 [PMID:20605094]
ChEMBL	Inhibition of human carbonic anhydrase XII by spectrophotometry at pH 7.5	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2011) 19: 1172-1178 [PMID:21251841]
ChEMBL	Inhibition of tumor-associated human carbonic anhydrase 12 preincubated for 15 min by CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2011) 54: 1896-1902 [PMID:21361354]
ChEMBL	Inhibition of human recombinant CA12 catalytic domain by CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2011) 21: 3216-3221 [PMID:21549597]
ChEMBL	Inhibition of human recombinant catalytic domain of carbonic anhydrase 12 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2011) 21: 2975-2979 [PMID:21470859]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2011) 19: 3105-3119 [PMID:21515057]
ChEMBL	Inhibition of human cloned carbonic anhydrase 12 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2011) 46: 4403-4410 [PMID:21820216]
ChEMBL	Inhibition of human carbonic anhydrase 12 preincubated for 15 mins at pH 7.5 by stopped flow CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5210-5213 [PMID:21821413]
ChEMBL	Inhibition of human recombinant CA12 by CO2 hydration based stopped flow assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2011) 54: 6905-6918 [PMID:21851094]
ChEMBL	Inhibition of human carbonic anhydrase 12-catalyzed CO2 hydration activity by stopped flow assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5892-5896 [PMID:21852133]
ChEMBL	Inhibition of human carbonic anhydrase 12 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2012) 20: 2392-2404 [PMID:22370338]
ChEMBL	Inhibition of human CA12 pre-incubated for 15 mins by stopped-flow CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2012) 55: 1721-1730 [PMID:22276570]
ChEMBL	Inhibition of human recombinant CA12 catalytic domain preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2012) 55: 6776-6783 [PMID:22775345]
ChEMBL	Inhibition of human CA12 by stopped-flow assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2013) 23: 715-719 [PMID:23265898]
ChEMBL	Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2013) 21: 1396-1403 [PMID:23290254]
ChEMBL	Inhibition of recombinant human CA12 transmembrane isoform preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2013) 56: 4691-4700 [PMID:23647428]
ChEMBL	Inhibition of human carbonic anhydrase 12 by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2013) 21: 3949-3957 [PMID:23706268]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 12 after 6 hrs by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2013) 21: 4502-4510 [PMID:23769167]
ChEMBL	Inhibition of human membrane bound carbonic anhydrase 12 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175]
ChEMBL	Inhibition of human carbonic anhydrase-12 by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2013) 23: 5646-5649 [PMID:23993330]
ChEMBL	Inhibition of human carbonic anhydrase12 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2013) 21: 7210-7215 [PMID:24090602]
ChEMBL	Inhibition of human carbonic anhydrase 12 by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2013) 56: 9623-9634 [PMID:24200125]
ChEMBL	Inhibition of human CA12 preincubated for 15 mins by stopped-flow CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2014) 22: 334-340 [PMID:24300919]
ChEMBL	Inhibition of human CA12 after 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2014) 71: 135-147 [PMID:24291567]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 12 by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184]
ChEMBL	Inhibition of human recombinant transmembrane carbonic anhydrase 12 after 6 hrs by stopped flow CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2014) 22: 1522-1528 [PMID:24513186]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 12 by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2014) 22: 1873-1882 [PMID:24560737]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1310-1314 [PMID:24507918]
ChEMBL	Inhibition of human carbonic anhydrase 12-mediated CO2 hydration preincubated for 10 mins by stopped-flow assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2014) 76: 284-290 [PMID:24589484]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12-mediated CO2 hydration after 6 hrs by stopped-flow assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1256-1260 [PMID:24518190]
ChEMBL	Inhibition of human recombinant transmembrane tumor associated carbonic anhydrase-12 incubated for 15 mins prior to testing by stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1776-1779 [PMID:24589511]
ChEMBL	Inhibition of human cloned transmembrane tumor-associated catalytic domain of carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2014) 82: 47-55 [PMID:24871996]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2014) 22: 3684-3695 [PMID:24878360]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2014) 22: 6768-6775 [PMID:25468040]
ChEMBL	Inhibition of human carbonic anhydrase 12 by stopped flow CO2 hydrase assay method	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2014) 22: 6945-6952 [PMID:25456084]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 after 15 mins by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2014) 22: 3982-3988 [PMID:25027802]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 by stopped flow CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2014) 84: 240-246 [PMID:25019479]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 preincubated for 15 mins by stopped-flow CO2 hydrase Assay	B	8.24	pKi	5.7	nM	Ki	ACS Med Chem Lett (2014) 5: 927-930 [PMID:25147616]
ChEMBL	Inhibition of human carbonic anhydrase 12 by stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2014) 24: 5185-5189 [PMID:25442309]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2014) 57: 9152-9167 [PMID:25310626]
ChEMBL	Inhibition of human CA-12 by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2014) 57: 9673-9686 [PMID:25358036]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2014) 87: 186-196 [PMID:25255434]
ChEMBL	Inhibition of human CA-12 after 15 mins by stopped-flow CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2014) 22: 5883-5890 [PMID:25267005]
ChEMBL	Inhibition of human tumor-associated carbonic anhydrase 12 by stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2015) 23: 1430-1436 [PMID:25753329]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 expressed in Escherichia coli pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2015) 23: 2368-2376 [PMID:25846066]
ChEMBL	Inhibition of human recombinant CA-12 after 15 mins by stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2015) 23: 1828-1840 [PMID:25766630]
ChEMBL	Inhibition of human membrane associated form of carbonic anhydrase-12 assessed as CO2 hydration activity incubated for 15 mins prior to testing by stopped flow method	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2015) 96: 425-435 [PMID:25912674]
ChEMBL	Inhibition of human recombinant carbonic anhdydrase-12 expressed in Escherichia coli pre-incubated for 6 hrs by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2015) 58: 3975-3983 [PMID:25875209]
ChEMBL	Inhibition of human carbonic anhydrase 12 by stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2015) 23: 2975-2981 [PMID:26007302]
ChEMBL	Inhibition of human carbonic anhydrase-12 incubated for 10 mins prior to testing by stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3208-3212 [PMID:26105196]
ChEMBL	Inhibition of human carbonic anhydrase-12	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3281-3284 [PMID:26073006]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-12 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2015) 23: 5619-5625 [PMID:26233796]
ChEMBL	Inhibition of human carbonic anhydrase-12 incubated for 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2015) 23: 5311-5318 [PMID:26264840]
ChEMBL	Inhibition of carbonic anhydrase-12 (unknown origin)	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2015) 58: 7580-7590 [PMID:26347950]
ChEMBL	Inhibition of human carbonic anhydrase 12 incubated for 6 hrs by stopped flow carbon-di-oxide hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2015) 23: 6955-6966 [PMID:26432607]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2015) 23: 7219-7225 [PMID:26498393]
ChEMBL	Inhibition of human carbonic anhydrase-12 assessed as CO2 hydration activity by stopped-flow method	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2015) 58: 8564-8572 [PMID:26497049]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 expressed in Escherichia coli preincubated for 6 hrs by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2015) 103: 583-593 [PMID:26408817]
ChEMBL	Inhibition of human carbonic anhydrase-12 preincubated for 15 mins by stopped flow CO2 dehydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2016) 24: 20-25 [PMID:26678172]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2016) 24: 894-901 [PMID:26795114]
ChEMBL	Inhibition of human carbonic anhydrase 12 incubated for 15 mins prior to testing by CO2 hydration-based stopped flow assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2016) 59: 721-732 [PMID:26741028]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2016) 24: 1402-1407 [PMID:26875933]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow carbon dioxide hydrase assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2016) 110: 259-266 [PMID:26840366]
ChEMBL	Inhibition of human carbonic anhydrase 12 using saturated CO2 as substrate incubated for 10 mins prior to testing by stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2016) 24: 2882-2886 [PMID:27137360]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 preincubated for 15 min to 72 hrs by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2016) 24: 2907-2913 [PMID:27166574]
ChEMBL	Inhibition of human carbonic anhydrase 12 preincubated for 6 hrs at 4 degC measured for 10 to 100 secs by stopped-flow carbon dioxide hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2016) 24: 3643-3648 [PMID:27316543]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2016) 59: 5462-5470 [PMID:27172398]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2016) 59: 5077-5088 [PMID:27144971]
ChEMBL	Inhibition of human CA12 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2016) 24: 4100-4107 [PMID:27396930]
ChEMBL	Inhibition of human carbonic anhydrase 12 pre-incubated for 15 mins by stopped flow carbon dioxide hydrase assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2016) 59: 10692-10704 [PMID:27933963]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-12 preincubated for 6 hrs by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2017) 25: 677-683 [PMID:27939347]
ChEMBL	Inhibition of recombinant human membrane bound carbonic anhydrase 12 by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2017) 25: 1286-1293 [PMID:28065499]
ChEMBL	Binding affinity to recombinant human carbonic anhydrase 12 after 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2017) 127: 691-702 [PMID:27823879]
ChEMBL	Inhibition of recombinant human CA12 preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2017) 60: 1159-1170 [PMID:28075587]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2017) 60: 2456-2469 [PMID:28253618]
ChEMBL	Inhibition of recombinant human CA-XII incubated for 15 mins by stop-flow method	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2023) 260: 115783-115783 [PMID:37678143]
ChEMBL	Inhibitory activity against catalytic domain of human carbonic anhydrase XII	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3821-3827 [PMID:16039853]
ChEMBL	Ki value against human carbonic anhydrase XII (hCA XII)	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2005) 15: 963-969 [PMID:15686894]
ChEMBL	Inhibition constant against human carbonic anhydrase XII	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3096-3101 [PMID:15908204]
ChEMBL	Inhibitory activity against human Carbonic anhydrase XII (hCA XII)	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4862-4866 [PMID:16168653]
ChEMBL	Inhibitory activity against cloned human CA12	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2006) 16: 437-442 [PMID:16290146]
ChEMBL	Inhibition of human cloned CA12 catalytic domain by CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2006) 16: 4846-4851 [PMID:16809036]
ChEMBL	Inhibition of catalytic domain of human cloned CA12 by stopped-flow CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibition of catalytic domain of human CA XII	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2007) 50: 381-388 [PMID:17228881]
ChEMBL	Inhibition of human recombinant CA12 by CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2007) 17: 987-992 [PMID:17157501]
ChEMBL	Inhibition of human carbonic anhydrase 12	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human recombinant CA12 by CO2 hydration stopped flow assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2008) 18: 836-841 [PMID:18042384]
ChEMBL	Inhibition of human catalytic domain carbonic anhydrase 12 by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human recombinant CA12 catalytic domain by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human recombinant CA12 by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2273-2276 [PMID:19286378]
ChEMBL	Inhibition of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of human cloned CA12 catalytic domain by stopped-flow CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2008) 18: 4282-4286 [PMID:18640037]
ChEMBL	Inhibition of human carbonic anhydrase 12 catalytic domain by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL	Inhibition of human carbonic anhydrase 12 by CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2008) 43: 2853-2860 [PMID:18406497]
ChEMBL	Inhibition of human carbonic anhydrase 12 by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4102-4106 [PMID:19527930]
ChEMBL	Inhibition of human membrane-bound carbonic anhydrase 12 catalytic domain after 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2009) 52: 5990-5998 [PMID:19731956]
ChEMBL	Inhibition of human cloned CA12 catalytic domain by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2009) 52: 6421-6432 [PMID:19827837]
ChEMBL	Inhibition of human recombinant CA12 by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2010) 53: 850-854 [PMID:20028100]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 expressed in Escherichia coli by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2009) 19: 5825-5828 [PMID:19751975]
ChEMBL	Inhibition of human recombinant CA12 catalytic domain expressed in Sf9 cells by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2009) 17: 7093-7099 [PMID:19773173]
ChEMBL	Inhibition of human CA12 by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318]
ChEMBL	Inhibition of human recombinant CA12 by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2010) 53: 2913-2926 [PMID:20201556]
ChEMBL	Inhibition of human carbonic anhydrase 12 catalytic domain preincubated for 15 mins by CO2 hydration stopped-flow assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human cloned carbonic anhydrase 12 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2010) 45: 2396-2404 [PMID:20202722]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 after 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of human carbonic anhydrase 12 by stopped flow CO2 hydration method	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2010) 53: 5511-5522 [PMID:20590092]
ChEMBL	Inhibition of human cloned catalytic domain of CA12 after 15 mins by stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2010) 45: 3656-3661 [PMID:20554082]
ChEMBL	Inhibition of recombinant human CA 12 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2022) 232: 114190-114190 [PMID:35182815]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 preincubated for 10 mins and measured by phenol red based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2022) 65: 14655-14672 [PMID:36269278]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 assessed as inhibition constant preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	ACS Med Chem Lett (2023) 14: 810-819 [PMID:37312840]
ChEMBL	Inhibition of human CA12	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2020) 205: 112666-112666 [PMID:32795767]
ChEMBL	Inhibition of human carbonic anhydrase 12 assessed as inhibition constant	B	8.24	pKi	5.7	nM	Ki	RSC Med Chem (2023) 14: 144-153 [PMID:36760748]
ChEMBL	Inhibition of human CA12 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2023) 66: 1616-1633 [PMID:36626645]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 12 assessed as inhibition constant incubated for 15 mins by phenol red based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2023) 66: 10010-10026 [PMID:37436184]
ChEMBL	Inhibition of human carbonic anhydrase 12 assessed as inhibition constant incubated for 15 mins by phenol red based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2024) 67: 3018-3038 [PMID:38301036]
ChEMBL	Inhibition of human human carbonic anhydrase XII assessed as inhibition constant incubated for 15 min by stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	ACS Med Chem Lett (2024) 15: 470-477 [PMID:38628786]
ChEMBL	Inhibition of recombinant human CA XII (30 to 291 residues) expressed in escherichia coli BL21 assessed as inhibition constant preincubated for 15 mins by phenol red dye based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2023) 66: 5703-5718 [PMID:37022308]
ChEMBL	Binding affinity to human CA12 assessed as inhibition constant incubated for 6 hrs by phenol red dye based stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2023) 246: 115011-115011 [PMID:36516582]
ChEMBL	Inhibition of human carbonic anhydrase 12 assessed as inhibition constant incubated for 1 hr prior to testing by phenol red based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	ACS Med Chem Lett (2023) 14: 1067-1072 [PMID:37583824]
ChEMBL	Inhibition of human CA XII assessed as inhibition constant by stopped-flow CO2 hydrase assay method	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2023) 95: 129479-129479 [PMID:37704010]
ChEMBL	Inhibition of human carbonic anhydrase 12 assessed as inhibition constant preincubated for 15 mins and measured by phenol red based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2023) 94: 117467-117467 [PMID:37722299]
ChEMBL	Binding affinity to human CA12 assessed as inhibition constant by stopped flow kinetic assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2023) 250: 115180-115180 [PMID:36796297]
ChEMBL	Binding affinity to human recombinant CA12 assessed as inhibition constant incubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2023) 66: 14824-14842 [PMID:37902628]
ChEMBL	Binding affinity to human carbonic anhydrase 12 assessed as inhibition constant incubated for 15 mins by phenol red based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2024) 271: 116434-116434 [PMID:38653067]
ChEMBL	Inhibition of human CA12 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2024) 67: 3066-3089 [PMID:38266245]
ChEMBL	Inhibition of human recombinant CA12 assessed as inhibition constant incubated for 45 mins by phenol red dye based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2024) 67: 4170-4193 [PMID:38436571]
ChEMBL	Inhibition of recombinant human CA12 incubated for 15 mins by phenol red dye based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	ACS Med Chem Lett (2024) 15: 972-978 [PMID:38894925]
ChEMBL	Inhibition of recombinant human carbonic anhydrase XII assessed as inhibition constant incubated for 15 mins by phenol red dye based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	RSC Med Chem (2024) 15: 1929-1941 [PMID:38911163]
ChEMBL	Inhibition of human CA12 assessed as inhibition constant preincubated for 15 mins by phenol red dye based stopped-flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2024) 274: 116527-116527 [PMID:38810335]
ChEMBL	Inhibition of human recombinant CA12 by phenol red dye based stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2024) 67: 15892-15907 [PMID:39207927]
ChEMBL	Inhibition of human carbonic anhydrase 12 assessed as inhibition constant preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Eur J Med Chem (2023) 259: 115707-115707 [PMID:37556946]
ChEMBL	Inhibitory constant against catalytic domain of human carbonic anhydrase XII	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3828-3833 [PMID:16039848]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2017) 25: 2782-2788 [PMID:28389112]
ChEMBL	Inhibition of human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	J Med Chem (2017) 60: 9003-9011 [PMID:29048889]
ChEMBL	Inhibition of human CA12 pre-incubated for 10 mins by stopped-flow CO2 hydrase assay	B	8.24	pKi	5.7	nM	Ki	Bioorg Med Chem (2017) 25: 5373-5379 [PMID:28789908]
ChEMBL