indapamide [Ligand Id: 7203] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL406 (Arifon, Bajaten, Cardide sr, Damide, Ethibide xl, Flubest, Fludex, Fludin, Flupamid, Indaflex, Indamide, Indamol, Indapamida, Indapamide, Indapamide component of br-1015, Indaxa 2.5, Indipam xl, Ipamix, KYD-041, Lorvas, Lozol, Mapemid xl, Natrilix, Natrilix sr, Natrix, Nindaxa 2.5, Noranat, NSC-757075, Opumide 2.5, Rawel xl, S-1520, SE-1520, Tandix, Tensaid xl, Tertensif, Varbim xl, Veroxil) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| carbonic anhydrase 1/Carbonic anhydrase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] | ||||||||
| ChEMBL | Binding affinity to human recombinant carbonic anhydrase 1 by thermal shift assay | B | 5 | pKd | 10000 | nM | Kd | Bioorg Med Chem (2010) 18: 7357-7364 [PMID:20926301] |
| ChEMBL | Binding affinity to human recombinant carbonic anhydrase 1 expressed in Escherichia coli BL21 (DE3) by thermal shift assay | B | 5 | pKd | 10000 | nM | Kd | Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428] |
| ChEMBL | Inhibition of human recombinant full length CA1 by stopped-flow CO2 hydration method | B | 4.28 | pKi | 51900 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014] |
| carbonic anhydrase 12/Carbonic anhydrase 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570] | ||||||||
| ChEMBL | Binding affinity to human recombinant carbonic anhydrase 12 by thermal shift assay | B | 5.85 | pKd | 1400 | nM | Kd | Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428] |
| ChEMBL | Inhibition of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration method | B | 8 | pKi | 10 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014] |
| carbonic anhydrase 13/Carbonic anhydrase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3912] [GtoPdb: 2748] [UniProtKB: Q8N1Q1] | ||||||||
| ChEMBL | Binding affinity to human recombinant carbonic anhydrase 13 by isothermal titration calorimetry assay | B | 6.7 | pKd | 200 | nM | Kd | Bioorg Med Chem (2010) 18: 7357-7364 [PMID:20926301] |
| ChEMBL | Binding affinity to human recombinant carbonic anhydrase 13 by thermal shift assay | B | 7 | pKd | 100 | nM | Kd | Bioorg Med Chem (2010) 18: 7357-7364 [PMID:20926301] |
| ChEMBL | Binding affinity to human recombinant carbonic anhydrase 13 by thermal shift assay | B | 7 | pKd | 100 | nM | Kd | Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428] |
| carbonic anhydrase 13/Carbonic anhydrase 13 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1] | ||||||||
| ChEMBL | Inhibition of mouse recombinant full length CA13 by stopped-flow CO2 hydration method | B | 7.89 | pKi | 13 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014] |
| carbonic anhydrase 14/Carbonic anhydrase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7] | ||||||||
| ChEMBL | Inhibition of human recombinant full length CA14 by stopped-flow CO2 hydration method | B | 5.31 | pKi | 4950 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014] |
| carbonic anhydrase 2/Carbonic anhydrase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] | ||||||||
| ChEMBL | Displacement of dansylamide from human recombinant CA II expressed in Escherichia coli BL21 DE3 assessed as dissociation constant by fluorescence microplate reader | B | 5.85 | pKd | 1420 | nM | Kd | J Med Chem (2024) 67: 15862-15872 [PMID:39161321] |
| ChEMBL | Binding affinity to human recombinant carbonic anhydrase 2 by thermal shift assay | B | 6.52 | pKd | 300 | nM | Kd | Bioorg Med Chem (2010) 18: 7357-7364 [PMID:20926301] |
| ChEMBL | Binding affinity to human recombinant carbonic anhydrase 2 by thermal shift assay | B | 6.52 | pKd | 300 | nM | Kd | Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428] |
| ChEMBL | Binding affinity to human recombinant carbonic anhydrase 2 by isothermal titration calorimetry assay | B | 6.7 | pKd | 200 | nM | Kd | Bioorg Med Chem (2010) 18: 7357-7364 [PMID:20926301] |
| ChEMBL | Binding affinity to human recombinant CA II assessed as dissociation constant | B | 6.89 | pKd | 130 | nM | Kd | J Med Chem (2024) 67: 15862-15872 [PMID:39161321] |
| ChEMBL | Inhibition of human recombinant full length CA2 by stopped-flow CO2 hydration method | B | 5.6 | pKi | 2520 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014] |
| Carbonic anhydrase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2885] [UniProtKB: P07451] | ||||||||
| ChEMBL | Binding affinity to human recombinant CA III assessed as dissociation constant | B | 4.96 | pKd | 11000 | nM | Kd | J Med Chem (2024) 67: 15862-15872 [PMID:39161321] |
| carbonic anhydrase 4/Carbonic anhydrase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748] | ||||||||
| ChEMBL | Inhibition of human recombinant full length CA4 by stopped-flow CO2 hydration method | B | 6.67 | pKi | 213 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014] |
| carbonic anhydrase 5A/Carbonic anhydrase 5A, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218] | ||||||||
| ChEMBL | Binding affinity to recombinant human full length N-terminal His6-tagged mitochondrial carbonic anhydrase 5A expressed in Escherichia coli BL21 (DE3) in presence of ANS by fluorescent thermal shift assay | B | 6.17 | pKd | 670 | nM | Kd | Bioorg Med Chem (2018) 26: 675-687 [PMID:29305297] |
| ChEMBL | Binding affinity to recombinant human full length N-terminal His6-tagged mitochondrial carbonic anhydrase 5A expressed in Escherichia coli BL21 (DE3) assessed as intrinsic dissociation constant in presence of ANS by fluorescent thermal shift assay | B | 8.16 | pKd | 6.96 | nM | Kd | Bioorg Med Chem (2018) 26: 675-687 [PMID:29305297] |
| ChEMBL | Inhibition of human recombinant full length CA5A by stopped-flow CO2 hydration method | B | 6.05 | pKi | 890 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014] |
| Carbonic anhydrase 5B, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0] | ||||||||
| ChEMBL | Binding affinity to recombinant human full length N-terminal His6-tagged mitochondrial carbonic anhydrase 5B (40 to 317 residues) expressed in Escherichia coli Rosetta 2 (DE3) in presence of ANS by fluorescent thermal shift assay | B | 7.23 | pKd | 59 | nM | Kd | Bioorg Med Chem (2018) 26: 675-687 [PMID:29305297] |
| ChEMBL | Binding affinity to recombinant human full length N-terminal His6-tagged mitochondrial carbonic anhydrase 5B (40 to 317 residues) expressed in Escherichia coli Rosetta 2 (DE3) assessed as intrinsic dissociation constant in presence of ANS by fluorescent thermal shift assay | B | 9.34 | pKd | 0.46 | nM | Kd | Bioorg Med Chem (2018) 26: 675-687 [PMID:29305297] |
| ChEMBL | Inhibition of human recombinant full length CA5B by stopped-flow CO2 hydration method | B | 6.56 | pKi | 274 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014] |
| Carbonic anhydrase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280] | ||||||||
| ChEMBL | Binding affinity to human recombinant carbonic anhydrase 6 expressed in Escherichia coli Rosetta2 (DE3) by thermal shift assay | B | 6.6 | pKd | 250 | nM | Kd | Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428] |
| ChEMBL | Inhibition of human recombinant full length CA6 by stopped-flow CO2 hydration method | B | 5.79 | pKi | 1606 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014] |
| carbonic anhydrase 7/Carbonic anhydrase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166] | ||||||||
| ChEMBL | Binding affinity to human recombinant carbonic anhydrase 7 by isothermal titration calorimetry assay | B | 5.74 | pKd | 1800 | nM | Kd | Bioorg Med Chem (2010) 18: 7357-7364 [PMID:20926301] |
| ChEMBL | Binding affinity to human recombinant carbonic anhydrase 7 by thermal shift assay | B | 6.52 | pKd | 300 | nM | Kd | Bioorg Med Chem (2010) 18: 7357-7364 [PMID:20926301] |
| ChEMBL | Binding affinity to human recombinant carbonic anhydrase 7 by thermal shift assay | B | 6.52 | pKd | 300 | nM | Kd | Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428] |
| ChEMBL | Inhibition of human recombinant full length CA7 by stopped-flow CO2 hydration method | B | 9.64 | pKi | 0.23 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 9.64 | pKi | 0.23 | nM | Ki | Eur J Med Chem (2014) 71: 105-111 [PMID:24287559] |
| carbonic anhydrase 9/Carbonic anhydrase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] | ||||||||
| ChEMBL | Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration method | B | 7.44 | pKi | 36 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014] |
| Polyunsaturated fatty acid lipoxygenase ALOX15 in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4358] [UniProtKB: P12530] | ||||||||
| ChEMBL | DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) | B | 5.53 | pIC50 | 2918 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| N-Acylphosphatidylethanolamine-phospholipase D in Human [GtoPdb: 1398] [UniProtKB: Q6IQ20] | ||||||||
| GtoPdb | Equilibrium dissociation constant determined in the presence of DCA | - | 6.24 | pKd | 570 | nM | Kd | Cell Chem Biol (2025) 32: 449-462.e5 [PMID:39999832] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
