ChEMBL ligand: CHEMBL406 (Arifon, Bajaten, Cardide sr, Damide, Ethibide xl, Flubest, Fludex, Fludin, Flupamid, Indaflex, Indamide, Indamol, Indapamide, Indaxa 2.5, Indipam xl, Ipamix, KYD-041, Lorvas, Lozol, Mapemid xl, Natrilix, Natrilix sr, Natrix, Nindaxa 2.5, Noranat, NSC-757075, Opumide 2.5, Rawel xl, S-1520, SE-1520, Tandix, Tensaid xl, Tertensif, Varbim xl, Veroxil)
Arachidonate 15-lipoxygenase in Rabbit [ChEMBL: CHEMBL4358] [UniProtKB: P12530] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 1/Carbonic anhydrase I in Human [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 2/Carbonic anhydrase II in Human [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 4/Carbonic anhydrase IV in Human [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 9/Carbonic anhydrase IX in Human [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 5A/Carbonic anhydrase VA in Human [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase VB in Human [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase VI in Human [ChEMBL: CHEMBL3025] [UniProtKB: P23280] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 7/Carbonic anhydrase VII in Human [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 12/Carbonic anhydrase XII in Human [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 13/Carbonic anhydrase XIII in Human [ChEMBL: CHEMBL3912] [GtoPdb: 2748] [UniProtKB: Q8N1Q1] carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 14/Carbonic anhydrase XIV in Human [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Arachidonate 15-lipoxygenase in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4358] [UniProtKB: P12530]
ChEMBL	DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid)	B	5.53	pIC50	2918	nM	IC50	DrugMatrix in vitro pharmacology data
carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 1 by thermal shift assay	B	5	pKd	10000	nM	Kd	Bioorg Med Chem (2010) 18: 7357-7364 [PMID:20926301]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 1 expressed in Escherichia coli BL21 (DE3) by thermal shift assay	B	5	pKd	10000	nM	Kd	Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428]
ChEMBL	Inhibition of human recombinant full length CA1 by stopped-flow CO2 hydration method	B	4.28	pKi	51900	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 2 by thermal shift assay	B	6.52	pKd	300	nM	Kd	Bioorg Med Chem (2010) 18: 7357-7364 [PMID:20926301]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 2 by thermal shift assay	B	6.52	pKd	300	nM	Kd	Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 2 by isothermal titration calorimetry assay	B	6.7	pKd	200	nM	Kd	Bioorg Med Chem (2010) 18: 7357-7364 [PMID:20926301]
ChEMBL	Inhibition of human recombinant full length CA2 by stopped-flow CO2 hydration method	B	5.6	pKi	2520	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
carbonic anhydrase 4/Carbonic anhydrase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748]
ChEMBL	Inhibition of human recombinant full length CA4 by stopped-flow CO2 hydration method	B	6.67	pKi	213	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
ChEMBL	Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration method	B	7.44	pKi	36	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
carbonic anhydrase 5A/Carbonic anhydrase VA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218]
ChEMBL	Binding affinity to recombinant human full length N-terminal His6-tagged mitochondrial carbonic anhydrase 5A expressed in Escherichia coli BL21 (DE3) in presence of ANS by fluorescent thermal shift assay	B	6.17	pKd	670	nM	Kd	Bioorg Med Chem (2018) 26: 675-687 [PMID:29305297]
ChEMBL	Binding affinity to recombinant human full length N-terminal His6-tagged mitochondrial carbonic anhydrase 5A expressed in Escherichia coli BL21 (DE3) assessed as intrinsic dissociation constant in presence of ANS by fluorescent thermal shift assay	B	8.16	pKd	6.96	nM	Kd	Bioorg Med Chem (2018) 26: 675-687 [PMID:29305297]
ChEMBL	Inhibition of human recombinant full length CA5A by stopped-flow CO2 hydration method	B	6.05	pKi	890	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
Carbonic anhydrase VB in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0]
ChEMBL	Binding affinity to recombinant human full length N-terminal His6-tagged mitochondrial carbonic anhydrase 5B (40 to 317 residues) expressed in Escherichia coli Rosetta 2 (DE3) in presence of ANS by fluorescent thermal shift assay	B	7.23	pKd	59	nM	Kd	Bioorg Med Chem (2018) 26: 675-687 [PMID:29305297]
ChEMBL	Binding affinity to recombinant human full length N-terminal His6-tagged mitochondrial carbonic anhydrase 5B (40 to 317 residues) expressed in Escherichia coli Rosetta 2 (DE3) assessed as intrinsic dissociation constant in presence of ANS by fluorescent thermal shift assay	B	9.34	pKd	0.46	nM	Kd	Bioorg Med Chem (2018) 26: 675-687 [PMID:29305297]
ChEMBL	Inhibition of human recombinant full length CA5B by stopped-flow CO2 hydration method	B	6.56	pKi	274	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
Carbonic anhydrase VI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 6 expressed in Escherichia coli Rosetta2 (DE3) by thermal shift assay	B	6.6	pKd	250	nM	Kd	Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428]
ChEMBL	Inhibition of human recombinant full length CA6 by stopped-flow CO2 hydration method	B	5.79	pKi	1606	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 7 by isothermal titration calorimetry assay	B	5.74	pKd	1800	nM	Kd	Bioorg Med Chem (2010) 18: 7357-7364 [PMID:20926301]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 7 by thermal shift assay	B	6.52	pKd	300	nM	Kd	Bioorg Med Chem (2010) 18: 7357-7364 [PMID:20926301]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 7 by thermal shift assay	B	6.52	pKd	300	nM	Kd	Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428]
ChEMBL	Inhibition of human recombinant full length CA7 by stopped-flow CO2 hydration method	B	9.64	pKi	0.23	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay	B	9.64	pKi	0.23	nM	Ki	Eur J Med Chem (2014) 71: 105-111 [PMID:24287559]
carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 12 by thermal shift assay	B	5.85	pKd	1400	nM	Kd	Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428]
ChEMBL	Inhibition of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration method	B	8	pKi	10	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
carbonic anhydrase 13/Carbonic anhydrase XIII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3912] [GtoPdb: 2748] [UniProtKB: Q8N1Q1]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 13 by isothermal titration calorimetry assay	B	6.7	pKd	200	nM	Kd	Bioorg Med Chem (2010) 18: 7357-7364 [PMID:20926301]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 13 by thermal shift assay	B	7	pKd	100	nM	Kd	Bioorg Med Chem (2010) 18: 7357-7364 [PMID:20926301]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 13 by thermal shift assay	B	7	pKd	100	nM	Kd	Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428]
carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1]
ChEMBL	Inhibition of mouse recombinant full length CA13 by stopped-flow CO2 hydration method	B	7.89	pKi	13	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
carbonic anhydrase 14/Carbonic anhydrase XIV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7]
ChEMBL	Inhibition of human recombinant full length CA14 by stopped-flow CO2 hydration method	B	5.31	pKi	4950	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]