indapamide [Ligand Id: 7203] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL406 (Arifon, Bajaten, Cardide sr, Damide, Ethibide xl, Flubest, Fludex, Fludin, Flupamid, Indaflex, Indamide, Indamol, Indapamide, Indaxa 2.5, Indipam xl, Ipamix, KYD-041, Lorvas, Lozol, Mapemid xl, Natrilix, Natrilix sr, Natrix, Nindaxa 2.5, Noranat, NSC-757075, Opumide 2.5, Rawel xl, S-1520, SE-1520, Tandix, Tensaid xl, Tertensif, Varbim xl, Veroxil) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Arachidonate 15-lipoxygenase in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4358] [UniProtKB: P12530] | ||||||||
| ChEMBL | DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) | B | 5.53 | pIC50 | 2918 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] | ||||||||
| ChEMBL | Binding affinity to human recombinant carbonic anhydrase 1 by thermal shift assay | B | 5 | pKd | 10000 | nM | Kd | Bioorg Med Chem (2010) 18: 7357-7364 [PMID:20926301] |
| ChEMBL | Binding affinity to human recombinant carbonic anhydrase 1 expressed in Escherichia coli BL21 (DE3) by thermal shift assay | B | 5 | pKd | 10000 | nM | Kd | Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428] |
| ChEMBL | Inhibition of human recombinant full length CA1 by stopped-flow CO2 hydration method | B | 4.28 | pKi | 51900 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014] |
| carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] | ||||||||
| ChEMBL | Binding affinity to human recombinant carbonic anhydrase 2 by thermal shift assay | B | 6.52 | pKd | 300 | nM | Kd | Bioorg Med Chem (2010) 18: 7357-7364 [PMID:20926301] |
| ChEMBL | Binding affinity to human recombinant carbonic anhydrase 2 by thermal shift assay | B | 6.52 | pKd | 300 | nM | Kd | Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428] |
| ChEMBL | Binding affinity to human recombinant carbonic anhydrase 2 by isothermal titration calorimetry assay | B | 6.7 | pKd | 200 | nM | Kd | Bioorg Med Chem (2010) 18: 7357-7364 [PMID:20926301] |
| ChEMBL | Inhibition of human recombinant full length CA2 by stopped-flow CO2 hydration method | B | 5.6 | pKi | 2520 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014] |
| carbonic anhydrase 4/Carbonic anhydrase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748] | ||||||||
| ChEMBL | Inhibition of human recombinant full length CA4 by stopped-flow CO2 hydration method | B | 6.67 | pKi | 213 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014] |
| carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] | ||||||||
| ChEMBL | Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration method | B | 7.44 | pKi | 36 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014] |
| carbonic anhydrase 5A/Carbonic anhydrase VA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218] | ||||||||
| ChEMBL | Binding affinity to recombinant human full length N-terminal His6-tagged mitochondrial carbonic anhydrase 5A expressed in Escherichia coli BL21 (DE3) in presence of ANS by fluorescent thermal shift assay | B | 6.17 | pKd | 670 | nM | Kd | Bioorg Med Chem (2018) 26: 675-687 [PMID:29305297] |
| ChEMBL | Binding affinity to recombinant human full length N-terminal His6-tagged mitochondrial carbonic anhydrase 5A expressed in Escherichia coli BL21 (DE3) assessed as intrinsic dissociation constant in presence of ANS by fluorescent thermal shift assay | B | 8.16 | pKd | 6.96 | nM | Kd | Bioorg Med Chem (2018) 26: 675-687 [PMID:29305297] |
| ChEMBL | Inhibition of human recombinant full length CA5A by stopped-flow CO2 hydration method | B | 6.05 | pKi | 890 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014] |
| Carbonic anhydrase VB in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0] | ||||||||
| ChEMBL | Binding affinity to recombinant human full length N-terminal His6-tagged mitochondrial carbonic anhydrase 5B (40 to 317 residues) expressed in Escherichia coli Rosetta 2 (DE3) in presence of ANS by fluorescent thermal shift assay | B | 7.23 | pKd | 59 | nM | Kd | Bioorg Med Chem (2018) 26: 675-687 [PMID:29305297] |
| ChEMBL | Binding affinity to recombinant human full length N-terminal His6-tagged mitochondrial carbonic anhydrase 5B (40 to 317 residues) expressed in Escherichia coli Rosetta 2 (DE3) assessed as intrinsic dissociation constant in presence of ANS by fluorescent thermal shift assay | B | 9.34 | pKd | 0.46 | nM | Kd | Bioorg Med Chem (2018) 26: 675-687 [PMID:29305297] |
| ChEMBL | Inhibition of human recombinant full length CA5B by stopped-flow CO2 hydration method | B | 6.56 | pKi | 274 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014] |
| Carbonic anhydrase VI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280] | ||||||||
| ChEMBL | Binding affinity to human recombinant carbonic anhydrase 6 expressed in Escherichia coli Rosetta2 (DE3) by thermal shift assay | B | 6.6 | pKd | 250 | nM | Kd | Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428] |
| ChEMBL | Inhibition of human recombinant full length CA6 by stopped-flow CO2 hydration method | B | 5.79 | pKi | 1606 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014] |
| carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166] | ||||||||
| ChEMBL | Binding affinity to human recombinant carbonic anhydrase 7 by isothermal titration calorimetry assay | B | 5.74 | pKd | 1800 | nM | Kd | Bioorg Med Chem (2010) 18: 7357-7364 [PMID:20926301] |
| ChEMBL | Binding affinity to human recombinant carbonic anhydrase 7 by thermal shift assay | B | 6.52 | pKd | 300 | nM | Kd | Bioorg Med Chem (2010) 18: 7357-7364 [PMID:20926301] |
| ChEMBL | Binding affinity to human recombinant carbonic anhydrase 7 by thermal shift assay | B | 6.52 | pKd | 300 | nM | Kd | Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428] |
| ChEMBL | Inhibition of human recombinant full length CA7 by stopped-flow CO2 hydration method | B | 9.64 | pKi | 0.23 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 9.64 | pKi | 0.23 | nM | Ki | Eur J Med Chem (2014) 71: 105-111 [PMID:24287559] |
| carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570] | ||||||||
| ChEMBL | Binding affinity to human recombinant carbonic anhydrase 12 by thermal shift assay | B | 5.85 | pKd | 1400 | nM | Kd | Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428] |
| ChEMBL | Inhibition of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration method | B | 8 | pKi | 10 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014] |
| carbonic anhydrase 13/Carbonic anhydrase XIII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3912] [GtoPdb: 2748] [UniProtKB: Q8N1Q1] | ||||||||
| ChEMBL | Binding affinity to human recombinant carbonic anhydrase 13 by isothermal titration calorimetry assay | B | 6.7 | pKd | 200 | nM | Kd | Bioorg Med Chem (2010) 18: 7357-7364 [PMID:20926301] |
| ChEMBL | Binding affinity to human recombinant carbonic anhydrase 13 by thermal shift assay | B | 7 | pKd | 100 | nM | Kd | Bioorg Med Chem (2010) 18: 7357-7364 [PMID:20926301] |
| ChEMBL | Binding affinity to human recombinant carbonic anhydrase 13 by thermal shift assay | B | 7 | pKd | 100 | nM | Kd | Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428] |
| carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1] | ||||||||
| ChEMBL | Inhibition of mouse recombinant full length CA13 by stopped-flow CO2 hydration method | B | 7.89 | pKi | 13 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014] |
| carbonic anhydrase 14/Carbonic anhydrase XIV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7] | ||||||||
| ChEMBL | Inhibition of human recombinant full length CA14 by stopped-flow CO2 hydration method | B | 5.31 | pKi | 4950 | nM | Ki | Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
