indapamide [Ligand Id: 7203] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL406 (Indaxa 2.5, Natrilix sr, Cardide sr, Lozol, Tensaid xl, Indipam xl, Mapemid xl, Indapamide, Nindaxa 2.5, Rawel xl, SE-1520, Opumide 2.5, Varbim xl, Natrilix, S-1520, KYD-041, Ethibide xl)
  • Arachidonate 15-lipoxygenase in Rabbit [ChEMBL: CHEMBL4358] [UniProtKB: P12530]
  • This target only has 0 pki data point
  • 0
1 CHEMBL406_lig_chart_1 Arachidonate 15-lipoxygenase Rabbit
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  • carbonic anhydrase 1/Carbonic anhydrase I in Human [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
  • This target only has 1 pki data point
  • 4.28
2 CHEMBL406_lig_chart_2 Carbonic anhydrase I Human
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  • carbonic anhydrase 2/Carbonic anhydrase II in Human [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
  • This target only has 1 pki data point
  • 5.6
3 CHEMBL406_lig_chart_3 Carbonic anhydrase II Human
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  • carbonic anhydrase 4/Carbonic anhydrase IV in Human [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748]
  • This target only has 1 pki data point
  • 6.67
4 CHEMBL406_lig_chart_4 Carbonic anhydrase IV Human
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  • carbonic anhydrase 9/Carbonic anhydrase IX in Human [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
  • This target only has 1 pki data point
  • 7.44
5 CHEMBL406_lig_chart_5 Carbonic anhydrase IX Human
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  • carbonic anhydrase 5A/Carbonic anhydrase VA in Human [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218]
  • This target only has 1 pki data point
  • 6.05
6 CHEMBL406_lig_chart_6 Carbonic anhydrase VA Human
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  • Carbonic anhydrase VB in Human [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0]
  • This target only has 1 pki data point
  • 6.56
7 CHEMBL406_lig_chart_7 Carbonic anhydrase VB Human
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  • Carbonic anhydrase VI in Human [ChEMBL: CHEMBL3025] [UniProtKB: P23280]
  • This target only has 1 pki data point
  • 5.79
8 CHEMBL406_lig_chart_8 Carbonic anhydrase VI Human
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  • carbonic anhydrase 7/Carbonic anhydrase VII in Human [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166]
  • 9.64
9 CHEMBL406_lig_chart_9 Carbonic anhydrase VII Human
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  • carbonic anhydrase 12/Carbonic anhydrase XII in Human [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
  • This target only has 1 pki data point
  • 8
10 CHEMBL406_lig_chart_10 Carbonic anhydrase XII Human
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  • carbonic anhydrase 13/Carbonic anhydrase XIII in Human [ChEMBL: CHEMBL3912] [GtoPdb: 2748] [UniProtKB: Q8N1Q1]
  • carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1]
  • This target only has 1 pki data point
  • 7.89
11 CHEMBL406_lig_chart_11 Carbonic anhydrase XIII HumanMouse
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  • carbonic anhydrase 14/Carbonic anhydrase XIV in Human [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7]
  • This target only has 1 pki data point
  • 5.31
12 CHEMBL406_lig_chart_12 Carbonic anhydrase XIV Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Arachidonate 15-lipoxygenase in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4358] [UniProtKB: P12530]
ChEMBL DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) B 5.53 pIC50 2918 nM IC50 DrugMatrix in vitro pharmacology data
carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
ChEMBL Binding affinity to human recombinant carbonic anhydrase 1 by thermal shift assay B 5 pKd 10000 nM Kd Bioorg. Med. Chem. (2010) 18: 7357-7364 [PMID:20926301]
ChEMBL Binding affinity to human recombinant carbonic anhydrase 1 expressed in Escherichia coli BL21 (DE3) by thermal shift assay B 5 pKd 10000 nM Kd Bioorg. Med. Chem. (2013) 21: 6937-6947 [PMID:24103428]
ChEMBL Inhibition of human recombinant full length CA1 by stopped-flow CO2 hydration method B 4.28 pKi 51900 nM Ki Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014]
carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
ChEMBL Binding affinity to human recombinant carbonic anhydrase 2 by thermal shift assay B 6.52 pKd 300 nM Kd Bioorg. Med. Chem. (2010) 18: 7357-7364 [PMID:20926301]
ChEMBL Binding affinity to human recombinant carbonic anhydrase 2 by thermal shift assay B 6.52 pKd 300 nM Kd Bioorg. Med. Chem. (2013) 21: 6937-6947 [PMID:24103428]
ChEMBL Binding affinity to human recombinant carbonic anhydrase 2 by isothermal titration calorimetry assay B 6.7 pKd 200 nM Kd Bioorg. Med. Chem. (2010) 18: 7357-7364 [PMID:20926301]
ChEMBL Inhibition of human recombinant full length CA2 by stopped-flow CO2 hydration method B 5.6 pKi 2520 nM Ki Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014]
carbonic anhydrase 4/Carbonic anhydrase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748]
ChEMBL Inhibition of human recombinant full length CA4 by stopped-flow CO2 hydration method B 6.67 pKi 213 nM Ki Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014]
carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
ChEMBL Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration method B 7.44 pKi 36 nM Ki Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014]
carbonic anhydrase 5A/Carbonic anhydrase VA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218]
ChEMBL Binding affinity to recombinant human full length N-terminal His6-tagged mitochondrial carbonic anhydrase 5A expressed in Escherichia coli BL21 (DE3) in presence of ANS by fluorescent thermal shift assay B 6.17 pKd 670 nM Kd Bioorg Med Chem (2018) 26: 675-687 [PMID:29305297]
ChEMBL Binding affinity to recombinant human full length N-terminal His6-tagged mitochondrial carbonic anhydrase 5A expressed in Escherichia coli BL21 (DE3) assessed as intrinsic dissociation constant in presence of ANS by fluorescent thermal shift assay B 8.16 pKd 6.96 nM Kd Bioorg Med Chem (2018) 26: 675-687 [PMID:29305297]
ChEMBL Inhibition of human recombinant full length CA5A by stopped-flow CO2 hydration method B 6.05 pKi 890 nM Ki Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014]
Carbonic anhydrase VB in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0]
ChEMBL Binding affinity to recombinant human full length N-terminal His6-tagged mitochondrial carbonic anhydrase 5B (40 to 317 residues) expressed in Escherichia coli Rosetta 2 (DE3) in presence of ANS by fluorescent thermal shift assay B 7.23 pKd 59 nM Kd Bioorg Med Chem (2018) 26: 675-687 [PMID:29305297]
ChEMBL Binding affinity to recombinant human full length N-terminal His6-tagged mitochondrial carbonic anhydrase 5B (40 to 317 residues) expressed in Escherichia coli Rosetta 2 (DE3) assessed as intrinsic dissociation constant in presence of ANS by fluorescent thermal shift assay B 9.34 pKd 0.46 nM Kd Bioorg Med Chem (2018) 26: 675-687 [PMID:29305297]
ChEMBL Inhibition of human recombinant full length CA5B by stopped-flow CO2 hydration method B 6.56 pKi 274 nM Ki Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014]
Carbonic anhydrase VI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280]
ChEMBL Binding affinity to human recombinant carbonic anhydrase 6 expressed in Escherichia coli Rosetta2 (DE3) by thermal shift assay B 6.6 pKd 250 nM Kd Bioorg. Med. Chem. (2013) 21: 6937-6947 [PMID:24103428]
ChEMBL Inhibition of human recombinant full length CA6 by stopped-flow CO2 hydration method B 5.79 pKi 1606 nM Ki Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014]
carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166]
ChEMBL Binding affinity to human recombinant carbonic anhydrase 7 by isothermal titration calorimetry assay B 5.74 pKd 1800 nM Kd Bioorg. Med. Chem. (2010) 18: 7357-7364 [PMID:20926301]
ChEMBL Binding affinity to human recombinant carbonic anhydrase 7 by thermal shift assay B 6.52 pKd 300 nM Kd Bioorg. Med. Chem. (2010) 18: 7357-7364 [PMID:20926301]
ChEMBL Binding affinity to human recombinant carbonic anhydrase 7 by thermal shift assay B 6.52 pKd 300 nM Kd Bioorg. Med. Chem. (2013) 21: 6937-6947 [PMID:24103428]
ChEMBL Inhibition of human recombinant full length CA7 by stopped-flow CO2 hydration method B 9.64 pKi 0.23 nM Ki Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay B 9.64 pKi 0.23 nM Ki Eur. J. Med. Chem. (2014) 71: 105-111 [PMID:24287559]
carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
ChEMBL Binding affinity to human recombinant carbonic anhydrase 12 by thermal shift assay B 5.85 pKd 1400 nM Kd Bioorg. Med. Chem. (2013) 21: 6937-6947 [PMID:24103428]
ChEMBL Inhibition of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration method B 8 pKi 10 nM Ki Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014]
carbonic anhydrase 13/Carbonic anhydrase XIII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3912] [GtoPdb: 2748] [UniProtKB: Q8N1Q1]
ChEMBL Binding affinity to human recombinant carbonic anhydrase 13 by isothermal titration calorimetry assay B 6.7 pKd 200 nM Kd Bioorg. Med. Chem. (2010) 18: 7357-7364 [PMID:20926301]
ChEMBL Binding affinity to human recombinant carbonic anhydrase 13 by thermal shift assay B 7 pKd 100 nM Kd Bioorg. Med. Chem. (2010) 18: 7357-7364 [PMID:20926301]
ChEMBL Binding affinity to human recombinant carbonic anhydrase 13 by thermal shift assay B 7 pKd 100 nM Kd Bioorg. Med. Chem. (2013) 21: 6937-6947 [PMID:24103428]
carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1]
ChEMBL Inhibition of mouse recombinant full length CA13 by stopped-flow CO2 hydration method B 7.89 pKi 13 nM Ki Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014]
carbonic anhydrase 14/Carbonic anhydrase XIV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7]
ChEMBL Inhibition of human recombinant full length CA14 by stopped-flow CO2 hydration method B 5.31 pKi 4950 nM Ki Bioorg. Med. Chem. (2009) 17: 1214-1221 [PMID:19119014]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]