bempegaldesleukin   Click here for help

GtoPdb Ligand ID: 10659

Synonyms: NKTR-214 | NKTR214
Immunopharmacology Ligand
Comment: Bempegaldesleukin (NKTR-214) is an engineered variant of human interleukin-2 [4] in which Ala1 has been removed and Cys125 is substituted by Ser. The peptide is produced in E. coli and an average of 6 lysine residues are N6 substituted with [(2,7-bis{[methylpoly(oxyethylene)]carbamoyl}-9H-fluoren-9-yl)methoxy]carbonyl (PEG-Lys). In the PEG-bound form the IL-2 is inactive, but In vivo the PEG chains are released slowly which provides a more controlled release of active IL-2 peptide [4] (the IL-2 conjugates with 1 or 2 PEG chains are the most biologically active conjugates [3]). This prodrug strategy mitigates against the severe side effects which limit maximal dosing of parental aldesleukin.
Click here for help
Classification Click here for help
Compound class Peptide or derivative
International Nonproprietary Names Click here for help
INN number INN
10593 bempegaldesleukin
Synonyms Click here for help
NKTR-214 | NKTR214
Database Links Click here for help
CAS Registry No. 1939126-74-5 (source: WHO INN record)
GtoPdb PubChem SID 404859106
Search PubMed clinical trials bempegaldesleukin
Search PubMed titles bempegaldesleukin
Search PubMed titles/abstracts bempegaldesleukin