bempegaldesleukin   

GtoPdb Ligand ID: 10659

Synonyms: NKTR-214 | NKTR214
Comment: Bempegaldesleukin (NKTR-214) is an engineered variant of human interleukin-2 [4] in which Ala1 has been removed and Cys125 is substituted by Ser. The peptide is produced in E. coli and an average of 6 lysine residues are N6 substituted with [(2,7-bis{[methylpoly(oxyethylene)]carbamoyl}-9H-fluoren-9-yl)methoxy]carbonyl (PEG-Lys). In the PEG-bound form the IL-2 is inactive, but In vivo the PEG chains are released slowly which provides a more controlled release of active IL-2 peptide [4] (the IL-2 conjugates with 1 or 2 PEG chains are the most biologically active conjugates [3]). This prodrug strategy mitigates against the severe side effects which limit maximal dosing of parental aldesleukin.
Classification
Compound class Peptide or derivative
International Nonproprietary Names
INN number INN
10593 bempegaldesleukin
Synonyms
NKTR-214 | NKTR214
Database Links
CAS Registry No. 1939126-74-5 (source: WHO INN record)
GtoPdb PubChem SID 404859106
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