LIT-001 [Ligand Id: 10444] activity data from GtoPdb

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  • V1A receptor in Human [GtoPdb: 366] [UniProtKB: P37288]
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  • V2 receptor in Human [GtoPdb: 368] [UniProtKB: P30518]
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  • OT receptor in Human [GtoPdb: 369] [UniProtKB: P30559]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
V1A receptor in Human [GtoPdb: 366] [UniProtKB: P37288]
GtoPdb Binding affinity determined by a TR-FRET binding assay on HEK cells expressing SNAP-tagged V1a receptors using 20 nM fluorescent DY647 and increasing concentration of competitor. - 5.9 pKi 1253 nM Ki J Med Chem (2018) 61: 8670-8692 [PMID:30199637]
V2 receptor in Human [GtoPdb: 368] [UniProtKB: P30518]
GtoPdb Binding affinity determined by a TR-FRET binding assay on HEK cells expressing SNAP-tagged V2 receptors using 20 nM fluorescent DY647 and increasing concentration of competitor. - 5.78 pKi 1666 nM Ki J Med Chem (2018) 61: 8670-8692 [PMID:30199637]
OT receptor in Human [GtoPdb: 369] [UniProtKB: P30559]
GtoPdb Binding affinity determined by a TR-FRET binding assay on HEK cells expressing SNAP-tagged OT receptors using 20 nM fluorescent DY647 and increasing concentration of competitor. - 6.65 pKi 226 nM Ki J Med Chem (2018) 61: 8670-8692 [PMID:30199637]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.