veliparib   Click here for help

GtoPdb Ligand ID: 7417

Synonyms: ABT-888
PDB Ligand
Compound class: Synthetic organic
Comment: Veliparib is an investigational poly ADP ribose polymerase (PARP) inhibitor. PARP inhibitors have potential for treating many diseases, including cancer.

veliparib is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 83.8
Molecular weight 244.13
XLogP 0.45
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES NC(=O)c1cccc2c1nc([nH]2)C1(C)CCCN1
Isomeric SMILES NC(=O)c1cccc2c1nc([nH]2)[C@@]1(C)CCCN1
InChI InChI=1S/C13H16N4O/c1-13(6-3-7-15-13)12-16-9-5-2-4-8(11(14)18)10(9)17-12/h2,4-5,15H,3,6-7H2,1H3,(H2,14,18)(H,16,17)/t13-/m1/s1
InChI Key JNAHVYVRKWKWKQ-CYBMUJFWSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide
International Nonproprietary Names Click here for help
INN number INN
9211 veliparib
Synonyms Click here for help
ABT-888
Database Links Click here for help
CAS Registry No. 912444-00-9
ChEMBL Ligand CHEMBL506871
DrugBank Ligand DB07232
GtoPdb PubChem SID 178103989
PubChem CID 11960529
RCSB PDB Ligand 78P
Search Google for chemical match using the InChIKey JNAHVYVRKWKWKQ-CYBMUJFWSA-N
Search Google for chemicals with the same backbone JNAHVYVRKWKWKQ
Search PubMed clinical trials veliparib
Search PubMed titles veliparib
Search PubMed titles/abstracts veliparib
UniChem Compound Search for chemical match using the InChIKey JNAHVYVRKWKWKQ-CYBMUJFWSA-N
UniChem Connectivity Search for chemical match using the InChIKey JNAHVYVRKWKWKQ-CYBMUJFWSA-N
Wikipedia Veliparib

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MedChemExpress
Veliparib (links to external site)
Cat. No. HY-10129