Syk inhibitor II [Ligand Id: 6047] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL471901
  • Lysyl-tRNA synthetase in Human [ChEMBL: CHEMBL5575] [UniProtKB: Q15046]
  • This target only has 0 pki data point
1 CHEMBL471901_lig_chart_1 Lysyl-tRNA synthetase Human
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  • spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405]
  • This target only has 0 pki data point
2 CHEMBL471901_lig_chart_2 Tyrosine-protein kinase SYK Human
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  • zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403]
  • This target only has 0 pki data point
3 CHEMBL471901_lig_chart_3 Tyrosine-protein kinase ZAP-70 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Lysyl-tRNA synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5575] [UniProtKB: Q15046]
ChEMBL Inhibition of human Syk B 7.39 pIC50 41 nM IC50 Bioorg. Med. Chem. (2008) 16: 7347-7357 [PMID:18585046]
spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405]
ChEMBL Inhibition of SYK B 7.39 pIC50 41 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 6231-6235 [PMID:18938080]
ChEMBL Inhibition of recombinant Syk B 7.39 pIC50 41 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 1944-1949 [PMID:19254842]
ChEMBL Inhibition of spleen tyrosine kinase (unknown origin) B 7.39 pIC50 41 nM IC50 Eur. J. Med. Chem. (2013) 67: 434-446 [PMID:23917087]
GtoPdb - - 7.39 pIC50 41 nM IC50 Bioorg. Med. Chem. (2005) 13: 4936-51 [PMID:15990316]
zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403]
GtoPdb - - 4.95 pIC50 11200 nM IC50 Bioorg. Med. Chem. (2005) 13: 4936-51 [PMID:15990316]
ChEMBL Inhibition of human ZAP70 B 4.95 pIC50 11200 nM IC50 Bioorg. Med. Chem. (2008) 16: 7347-7357 [PMID:18585046]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]