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ChEMBL ligand: CHEMBL471901 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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calcium/calmodulin dependent protein kinase ID/CaM kinase I delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5073] [GtoPdb: 1953] [UniProtKB: Q8IU85] | ||||||||
ChEMBL | Inhibition of human CAMK1D using KKALRRQETVDAL as substrate in presence of [gamma-33P]-ATP by hotspot kinase assay | B | 6.34 | pIC50 | 456 | nM | IC50 | J Med Chem (2020) 63: 6784-6801 [PMID:32433887] |
ChEMBL | Inhibition of recombinant human full-length His-tagged CAMK1D expressed in baculovirus expression system using autocamtide-2 as substrate preincubated for 15 mins followed by ATP addition and measured after 2 hrs by ADP-glo luminescence assay | B | 6.36 | pIC50 | 432 | nM | IC50 | J Med Chem (2020) 63: 6784-6801 [PMID:32433887] |
Lysyl-tRNA synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5575] [UniProtKB: Q15046] | ||||||||
ChEMBL | Inhibition of human Syk | B | 7.39 | pIC50 | 41 | nM | IC50 | Bioorg Med Chem (2008) 16: 7347-7357 [PMID:18585046] |
spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405] | ||||||||
ChEMBL | Inhibition of SYK | B | 7.39 | pIC50 | 41 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 6231-6235 [PMID:18938080] |
ChEMBL | Inhibition of recombinant Syk | B | 7.39 | pIC50 | 41 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 1944-1949 [PMID:19254842] |
ChEMBL | Inhibition of spleen tyrosine kinase (unknown origin) | B | 7.39 | pIC50 | 41 | nM | IC50 | Eur J Med Chem (2013) 67: 434-446 [PMID:23917087] |
GtoPdb | - | - | 7.39 | pIC50 | 41 | nM | IC50 | Bioorg Med Chem (2005) 13: 4936-51 [PMID:15990316] |
ChEMBL | Inhibition of human SYK using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-33P]-ATP by hotspot kinase assay | B | 8.15 | pIC50 | 7 | nM | IC50 | J Med Chem (2020) 63: 6784-6801 [PMID:32433887] |
zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403] | ||||||||
GtoPdb | - | - | 4.95 | pIC50 | 11200 | nM | IC50 | Bioorg Med Chem (2005) 13: 4936-51 [PMID:15990316] |
ChEMBL | Inhibition of human ZAP70 | B | 4.95 | pIC50 | 11200 | nM | IC50 | Bioorg Med Chem (2008) 16: 7347-7357 [PMID:18585046] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]