ChEMBL ligand: CHEMBL189753 (XCT790)
Estrogen-related receptor-α/Estrogen-related receptor alpha in Human [ChEMBL: CHEMBL3429] [GtoPdb: 622] [UniProtKB: P11474] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Estrogen-related receptor-α/Estrogen-related receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3429] [GtoPdb: 622] [UniProtKB: P11474]
ChEMBL	Inhibition of estrogen-related receptor alpha Gal4 activity	B	6.43	pIC50	370	nM	IC50	J Med Chem (2004) 47: 5593-5596 [PMID:15509154]
ChEMBL	Antagonist activity at ERRalpha LBD expressed in HEK293 cells assessed as Gal4-SRC2 interaction by two hybrid luciferase reporter gene assay	F	6.43	pIC50	370	nM	IC50	J Med Chem (2011) 54: 788-808 [PMID:21218783]
ChEMBL	Inverse agonist activity at GAL4-fused ERRalpha (unknown origin) transfected in african green monkey CV1 cells after 24 hrs by luciferase reporter gene assay	B	6.43	pIC50	370	nM	IC50	J Med Chem (2013) 56: 4631-4640 [PMID:23656512]
ChEMBL	Inverse agonist activity at CMX-gal4-fused ERRgamma (unknown origin) transfected in (African Green monkey CV1 cells incubated for 20 hrs by luciferase reporter gene assay	B	6.43	pIC50	370	nM	IC50	ACS Med Chem Lett (2019) 10: 767-772 [PMID:31097997]
GtoPdb	-	-	6.5	pIC50	-	-	IC50	Proc Natl Acad Sci USA (2004) 101: 8912-7 [PMID:15184675]
ChEMBL	Inverse agonist activity at GAL4-DNA binding domain-fused human ERRalpha ligand binding domain expressed in HEK293 cells assessed as inhibition of transcriptional activity after 48 hrs by luciferase reporter gene assay	B	6.57	pIC50	270	nM	IC50	Eur J Med Chem (2017) 136: 457-467 [PMID:28525844]
ChEMBL	Binding affinity to GST-tagged ERRalpha-LBD (unknown origin) using fluorescein-conjugated coactivator PGC-1alpha incubated for 1 hr by TR-FRET assay	B	7.21	pIC50	61.33	nM	IC50	ACS Med Chem Lett (2019) 10: 767-772 [PMID:31097997]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]