pibrentasvir [Ligand Id: 11268] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3545123 (Pibrentasvir, ABT-530, A-1325912.0)
  • Genome polyprotein in Hepatitis C virus genotype 1b (isolate Con1) (HCV) [ChEMBL: CHEMBL5536] [UniProtKB: Q9WMX2]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Genome polyprotein in Hepatitis C virus genotype 1b (isolate Con1) (HCV) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5536] [UniProtKB: Q9WMX2]
ChEMBL Inhibition of NS5A in HuH7 cell infected HCV genotype 1b Con1 assessed as decrease in viral replication after 3 days in presence of 40% human plasma by luciferase reporter gene assay B 9.7 pEC50 0.2 nM EC50 J Med Chem (2018) 61: 4052-4066 [PMID:29653491]
Nonstructural protein 5A in Hepatitis C virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3307224] [UniProtKB: Q5L478]
ChEMBL Inhibition of NS5A in HuH7 cell infected HCV genotype 1a H77 assessed as decrease in viral replication after 3 days in presence of 40% human plasma by luciferase reporter gene assay B 10.19 pEC50 0.06 nM EC50 J Med Chem (2018) 61: 4052-4066 [PMID:29653491]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]