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ChEMBL ligand: CHEMBL3545123 (Pibrentasvir, ABT-530, A-1325912.0) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Genome polyprotein in Hepatitis C virus genotype 1b (isolate Con1) (HCV) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5536] [UniProtKB: Q9WMX2] | ||||||||
ChEMBL | Inhibition of NS5A in HuH7 cell infected HCV genotype 1b Con1 assessed as decrease in viral replication after 3 days in presence of 40% human plasma by luciferase reporter gene assay | B | 9.7 | pEC50 | 0.2 | nM | EC50 | J Med Chem (2018) 61: 4052-4066 [PMID:29653491] |
Nonstructural protein 5A in Hepatitis C virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3307224] [UniProtKB: Q5L478] | ||||||||
ChEMBL | Inhibition of NS5A in HuH7 cell infected HCV genotype 1a H77 assessed as decrease in viral replication after 3 days in presence of 40% human plasma by luciferase reporter gene assay | B | 10.19 | pEC50 | 0.06 | nM | EC50 | J Med Chem (2018) 61: 4052-4066 [PMID:29653491] |
ChEMBL data shown on this page come from version 28:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]