pibrentasvir [Ligand Id: 11268] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3545123 (A-1325912.0, ABT-530, Pibrentasvir)
  • Genome polyprotein in Hepatitis C virus genotype 1b (isolate Con1) (HCV) [ChEMBL: CHEMBL5536] [UniProtKB: Q9WMX2]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Genome polyprotein in Hepatitis C virus genotype 1b (isolate Con1) (HCV) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5536] [UniProtKB: Q9WMX2]
ChEMBL Inhibition of NS5A in HuH7 cell infected HCV genotype 1b Con1 assessed as decrease in viral replication after 3 days in presence of 40% human plasma by luciferase reporter gene assay B 9.7 pEC50 0.2 nM EC50 J Med Chem (2018) 61: 4052-4066 [PMID:29653491]
Nonstructural protein 5A in Hepatitis C virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3307224] [UniProtKB: Q5L478]
ChEMBL Inhibition of NS5A in HuH7 cell infected HCV genotype 1a H77 assessed as decrease in viral replication after 3 days in presence of 40% human plasma by luciferase reporter gene assay B 10.19 pEC50 0.06 nM EC50 J Med Chem (2018) 61: 4052-4066 [PMID:29653491]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]