ChEMBL ligand: CHEMBL455 (Bleph-10, Bleph-30, Cetamide, FML-S, Klaron, NSC-63871, Ocusulf-10, Ocusulf-30, SULF-10, SULF-15, Sulfacel-15, Sulfacetamida, Sulfacetamide, Sulfacetamide (triple sulfa), Sulfacetamidum, Sulfair-15, Sulphacetamide, Sulster, Sulten-10, Triple sulfa (sulfacetamide), Urosulfon)
dihydrofolate reductase/Dihydrofolate reductase in Human [ChEMBL: CHEMBL202] [GtoPdb: 2603] [UniProtKB: P00374] Dihydrofolate reductase in Bovine [ChEMBL: CHEMBL1075051] [UniProtKB: P00376] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
dihydrofolate reductase/Dihydrofolate reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL202] [GtoPdb: 2603] [UniProtKB: P00374]
ChEMBL	Inhibition of human DHFR after 2 mins	B	4.74	pIC50	18000	nM	IC50	Bioorg Med Chem (2010) 18: 2849-2863 [PMID:20350811]
Dihydrofolate reductase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075051] [UniProtKB: P00376]
ChEMBL	Inhibition of bovine DHFR after 2 mins	B	4.66	pIC50	22000	nM	IC50	Bioorg Med Chem (2010) 18: 2849-2863 [PMID:20350811]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]