spermine [Ligand Id: 710] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL23194 (4,9-diazadodecamethylenediamine, Actilip sp-91, Gerotine, Musculamine, Neuridine, NSC-268508, Spermine) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Carbonic anhydrase 15 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23] | ||||||||
| ChEMBL | Inhibition of mouse carbonic anhydrase 15 by stopped flow CO2 hydration method | B | 4.13 | pKi | 74000 | nM | Ki | J Med Chem (2010) 53: 5511-5522 [PMID:20590092] |
| carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 2 by stopped flow CO2 hydration method | B | 4.08 | pKi | 84000 | nM | Ki | J Med Chem (2010) 53: 5511-5522 [PMID:20590092] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay | B | 4.08 | pKi | 84000 | nM | Ki | Bioorg Med Chem (2011) 19: 1381-1389 [PMID:21282059] |
| carbonic anhydrase 4/Carbonic anhydrase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 4 by stopped flow CO2 hydration method | B | 8 | pKi | 10 | nM | Ki | J Med Chem (2010) 53: 5511-5522 [PMID:20590092] |
| carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 9 by stopped flow CO2 hydration method | B | 4.88 | pKi | 13300 | nM | Ki | J Med Chem (2010) 53: 5511-5522 [PMID:20590092] |
| ChEMBL | Inhibition of human carbonic anhydrase 9 preincubated for 15 mins by CO2 hydration stopped-flow assay | B | 4.88 | pKi | 13300 | nM | Ki | Bioorg Med Chem (2011) 19: 1381-1389 [PMID:21282059] |
| carbonic anhydrase 5A/Carbonic anhydrase VA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 5A by stopped flow CO2 hydration method | B | 6.08 | pKi | 840 | nM | Ki | J Med Chem (2010) 53: 5511-5522 [PMID:20590092] |
| Carbonic anhydrase VB in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 5B by stopped flow CO2 hydration method | B | 6.08 | pKi | 830 | nM | Ki | J Med Chem (2010) 53: 5511-5522 [PMID:20590092] |
| Carbonic anhydrase VI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 6 by stopped flow CO2 hydration method | B | 6 | pKi | 990 | nM | Ki | J Med Chem (2010) 53: 5511-5522 [PMID:20590092] |
| carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 7 by stopped flow CO2 hydration method | B | 6.15 | pKi | 710 | nM | Ki | J Med Chem (2010) 53: 5511-5522 [PMID:20590092] |
| carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 12 by stopped flow CO2 hydration method | B | 4.56 | pKi | 27600 | nM | Ki | J Med Chem (2010) 53: 5511-5522 [PMID:20590092] |
| ChEMBL | Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration stopped-flow assay | B | 4.56 | pKi | 27600 | nM | Ki | Bioorg Med Chem (2011) 19: 1381-1389 [PMID:21282059] |
| carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1] | ||||||||
| ChEMBL | Inhibition of mouse carbonic anhydrase 13 by stopped flow CO2 hydration method | B | 4.65 | pKi | 22600 | nM | Ki | J Med Chem (2010) 53: 5511-5522 [PMID:20590092] |
| carbonic anhydrase 14/Carbonic anhydrase XIV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 14 by stopped flow CO2 hydration method | B | 6.07 | pKi | 860 | nM | Ki | J Med Chem (2010) 53: 5511-5522 [PMID:20590092] |
| Caspase 2/Caspase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4884] [GtoPdb: 1618] [UniProtKB: P42575] | ||||||||
| ChEMBL | Activation of procaspase 2 after 24 hrs | B | 5.07 | pEC50 | 8500 | nM | EC50 | J Med Chem (2008) 51: 2346-2349 [PMID:18366176] |
| Coagulation factor XIII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4530] [UniProtKB: P00488] | ||||||||
| ChEMBL | Inhibition of human coagulation factor XIIIa assessed as inhibition of factor 13a mediated crosslinking of fibronectin-collagen incubated for 2 hrs by SDS-PAGE analysis | B | 4 | pIC50 | 100000 | nM | IC50 | Eur J Med Chem (2020) 200: 112442-112442 [PMID:32502864] |
| GluN1/GluN2A/GluN2B/GluN2C/GluN2D/GluN3B/GluN3A/Glutamate NMDA receptor in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL1907608] [GtoPdb: 455, 456, 457, 458, 459, 461, 460] [UniProtKB: P35439, Q00959, Q00960, Q00961, Q62645, Q8VHN2, Q9R1M7] | ||||||||
| ChEMBL | Ability to enhance [3H]MK-801 binding to NMDA receptors in rat forebrain membranes was calculated with respect to spermine | B | 5.28 | pEC50 | 5200 | nM | EC50 | J Med Chem (1995) 38: 4891-4896 [PMID:8523402] |
| GluN1/GluN2B/Glutamate NMDA receptor; Grin1/Grin2b in Rat (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2096666] [GtoPdb: 455, 457] [UniProtKB: P35439, Q00960] | ||||||||
| ChEMBL | Positive allosteric modulation of recombinant rat GluN1/GluN2B receptor expressed in xenopus laevis oocyte assessed as potentiation of glycine-induced current response by whole cell voltage clamp method | B | 4 | pEC50 | 100000 | nM | EC50 | J Med Chem (2017) 60: 5556-5585 [PMID:28586221] |
| GluN2B/Glutamate [NMDA] receptor subunit epsilon 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL311] [GtoPdb: 457] [UniProtKB: Q00960] | ||||||||
| ChEMBL | Positive allosteric modulation of GluN2B receptor in rat spinal cord neurons assessed as increase in glycine-induced channel current by two electrode voltage clamp method | B | 4.09 | pEC50 | 81000 | nM | EC50 | J Med Chem (2018) 62: 3-23 [PMID:29446949] |
| CaS receptor in Human [GtoPdb: 54] [UniProtKB: P41180] | ||||||||
| GtoPdb | - | - | 3.5 | pKd | - | - | - | Am J Physiol (1997) 273: C1315-23 [PMID:9357776] |
| Kir2.1 in Mouse [GtoPdb: 430] [UniProtKB: P35561] | ||||||||
| GtoPdb | - | - | 9.1 | pKd | - | - | - |
Neuron (1995) 14: 1047-54 [PMID:7748552]; J Physiol (Lond.) (1996) 491 ( Pt 2): 367-81 [PMID:8866861] |
| TRPM4 in Human [GtoPdb: 496] [UniProtKB: Q8TD43] | ||||||||
| GtoPdb | - | - | 4.2 | pIC50 | 61000 | nM | IC50 | Pflugers Arch (2004) 448: 70-5 [PMID:14758478] |
| TRPM4 in Mouse [GtoPdb: 496] [UniProtKB: Q7TN37] | ||||||||
| GtoPdb | - | - | 4.5 | pIC50 | - | - | - | Cell Calcium (2005) 37: 267-78 [PMID:15670874] |
| TRPM5 in Human [GtoPdb: 497] [UniProtKB: Q9NZQ8] | ||||||||
| GtoPdb | - | - | 4.43 | pIC50 | 37000 | nM | IC50 | |
| TRPM7 in Rat [GtoPdb: 499] [UniProtKB: Q925B3] | ||||||||
| GtoPdb | - | - | 5.64 | pKi | 2300 | nM | Ki | J Gen Physiol (2002) 120: 221-35 [PMID:12149283] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
