Top ▲

Caspase 2

Click here for help

Target not currently curated in GtoImmuPdb

Target id: 1618

Nomenclature: Caspase 2

Family: C14: Caspase

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 452 7q34 CASP2 caspase 2
Mouse - 452 6 20.54 cM Casp2 caspase 2
Rat - 452 4q24 Casp2 caspase 2
Previous and Unofficial Names Click here for help
protein phosphatase 1, regulatory subunit 57 | protease ICH-1 | ICH1 | NEDD2 | neural precursor cell expressed developmentally down-regulated protein 2 | PPP1R57 | caspase 2, apoptosis-related cysteine peptidase
Database Links Click here for help
Specialist databases
MEROPS C14.006 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.22.55

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 4 [PMID: 12408711] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 6.0 pKi 1
pKi 6.0 (Ki 9.6x10-7 M) [1]
Z-VDVAD-FMK Peptide Hs Inhibition - - 2
[2]

References

Show »

1. Choong IC, Lew W, Lee D, Pham P, Burdett MT, Lam JW, Wiesmann C, Luong TN, Fahr B, DeLano WL et al.. (2002) Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design. J Med Chem, 45 (23): 5005-22. [PMID:12408711]

2. Gamen S, Anel A, Pérez-Galán P, Lasierra P, Johnson D, Piñeiro A, Naval J. (2000) Doxorubicin treatment activates a Z-VAD-sensitive caspase, which causes deltapsim loss, caspase-9 activity, and apoptosis in Jurkat cells. Exp Cell Res, 258 (1): 223-35. [PMID:10912804]

How to cite this page

C14: Caspase: Caspase 2. Last modified on 22/07/2015. Accessed on 18/06/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1618.