ChEMBL ligand: CHEMBL303984 (Clorobiocin)
DNA gyrase subunit A/DNA gyrase subunit B/DNA gyrase in Escherichia coli [ChEMBL: CHEMBL2094139] [GtoPdb: 3217, 3218] [UniProtKB: P0AES4, P0AES6] DNA gyrase in S.aureus [ChEMBL: CHEMBL3038482] [UniProtKB: P0A0K8, P20831] There should be some charts here, you may need to enable JavaScript!
DNA gyrase subunit B in Escherichia coli [ChEMBL: CHEMBL1826] [GtoPdb: 3218] [UniProtKB: P0AES6] There should be some charts here, you may need to enable JavaScript!
Topoisomerase IV in S.aureus [ChEMBL: CHEMBL3038508] [UniProtKB: P0C1S7, P0C1U9] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
DNA gyrase subunit A/DNA gyrase subunit B/DNA gyrase in Escherichia coli (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094139] [GtoPdb: 3217, 3218] [UniProtKB: P0AES4, P0AES6]
ChEMBL	Inhibition of Escherichia coli DNA gyrase supercoiling activity	B	7.52	pIC50	30	nM	IC50	Bioorg Med Chem (2016) 24: 6291-6297 [PMID:27143131]
DNA gyrase in S.aureus (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038482] [UniProtKB: P0A0K8, P20831]
ChEMBL	Inhibition of Staphylococcus aureus DNA gyrase assessed as reduction in relaxation of pBR322 DNA by SDS-PAGE analysis	B	8.07	pIC50	8.5	nM	IC50	Bioorg Med Chem (2018) 26: 3438-3452 [PMID:29803359]
ChEMBL	Inhibition of Staphylococcus aureus DNA gyrase supercoiling activity	B	8.22	pIC50	6	nM	IC50	Bioorg Med Chem (2016) 24: 6291-6297 [PMID:27143131]
DNA gyrase subunit B in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1826] [GtoPdb: 3218] [UniProtKB: P0AES6]
ChEMBL	Binding affinity to Escherichia coli GyrB	B	8.92	pKd	1.2	nM	Kd	J Med Chem (2011) 54: 915-929 [PMID:21235241]
ChEMBL	Inhibition of Escherichia coli JM109 DNA gyrase subunit B assessed as ATP hydrolysis by ATPase assay	B	7.14	pIC50	73	nM	IC50	Antimicrob Agents Chemother (2008) 52: 1982-1990 [PMID:18347114]
ChEMBL	Inhibition of Escherichia coli JM109 DNA gyrase subunit B assessed as DNA triple helix formation by supercoiling assay	B	8.3	pIC50	<5	nM	IC50	Antimicrob Agents Chemother (2008) 52: 1982-1990 [PMID:18347114]
Topoisomerase IV in S.aureus (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038508] [UniProtKB: P0C1S7, P0C1U9]
ChEMBL	Inhibition of Staphylococcus aureus DNA topoisomerase 4 decatenation activity	B	5	pIC50	10000	nM	IC50	Bioorg Med Chem (2016) 24: 6291-6297 [PMID:27143131]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]