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ChEMBL ligand: CHEMBL502642 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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furin, paired basic amino acid cleaving enzyme/Furin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2611] [GtoPdb: 2366] [UniProtKB: P09958] | ||||||||
ChEMBL | Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavage | B | 7.64 | pKi | 23 | nM | Ki | J Biol Chem (2007) 282: 20847-20853 [PMID:17537721] |
GtoPdb | - | - | 7.64 | pKi | 23 | nM | Ki | J Biol Chem (2007) 282: 20847-53 [PMID:17537721] |
proprotein convertase subtilisin/kexin type 6 in Human [GtoPdb: 2386] [UniProtKB: P29122] | ||||||||
GtoPdb | - | - | 6.79 | pKi | 162 | nM | Ki | J Biol Chem (2007) 282: 20847-53 [PMID:17537721] |
proprotein convertase subtilisin/kexin type 6/Proprotein convertase subtilisin/kexin type 6 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5507] [GtoPdb: 2386] [UniProtKB: Q63415] | ||||||||
ChEMBL | Inhibition of rat PACE4 assessed as fluorescent Pyr-RTKR-AMC substrate cleavage | B | 6.79 | pKi | 162 | nM | Ki | J Biol Chem (2007) 282: 20847-20853 [PMID:17537721] |
proprotein convertase subtilisin/kexin type 4/Subtilisin/kexin type 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4861] [GtoPdb: 2384] [UniProtKB: Q6UW60] | ||||||||
ChEMBL | Inhibition of human recombinant PC4 assessed as fluorescent Pyr-RTKR-AMC substrate cleavage | B | 6.36 | pKi | 441 | nM | Ki | J Biol Chem (2007) 282: 20847-20853 [PMID:17537721] |
GtoPdb | - | - | 6.36 | pKi | 441 | nM | Ki | J Biol Chem (2007) 282: 20847-53 [PMID:17537721] |
proprotein convertase subtilisin/kexin type 5/Subtilisin/kexin type 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2826] [GtoPdb: 2385] [UniProtKB: Q92824] | ||||||||
GtoPdb | - | - | 6.63 | pKi | 232 | nM | Ki | J Biol Chem (2007) 282: 20847-53 [PMID:17537721] |
ChEMBL | Inhibition of human recombinant PC5/6 assessed as fluorescent Pyr-RTKR-AMC substrate cleavage | B | 6.63 | pKi | 232 | nM | Ki | J Biol Chem (2007) 282: 20847-20853 [PMID:17537721] |
proprotein convertase subtilisin/kexin type 7/Subtilisin/kexin type 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2232] [GtoPdb: 2387] [UniProtKB: Q16549] | ||||||||
GtoPdb | - | - | 6.82 | pKi | 152 | nM | Ki | J Biol Chem (2007) 282: 20847-53 [PMID:17537721] |
ChEMBL | Inhibition of human recombinant PC7 assessed as fluorescent Pyr-RTKR-AMC substrate cleavage | B | 6.87 | pKi | 135 | nM | Ki | J Biol Chem (2007) 282: 20847-20853 [PMID:17537721] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]