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proprotein convertase subtilisin/kexin type 4

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Target not currently curated in GtoImmuPdb

Target id: 2384

Nomenclature: proprotein convertase subtilisin/kexin type 4

Family: S8: Subtilisin

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 755 19p13.3 PCSK4 proprotein convertase subtilisin/kexin type 4
Mouse - 655 10 39.72 cM Pcsk4 proprotein convertase subtilisin/kexin type 4
Rat - 678 7q11 Pcsk4 proprotein convertase subtilisin/kexin type 4
Previous and Unofficial Names Click here for help
NEC 3 | neuroendocrine convertase 3 | PC4 | prohormone convertase 3 | SPC5
Database Links Click here for help
Specialist databases
MEROPS S08.074 (Hs)
Other databases
Alphafold Q6UW60 (Hs), P29121 (Mm), Q78EH2 (Rn)
BRENDA 3.4.21.-
CATH/Gene3D 2.60.120.260, 3.40.50.200
ChEMBL Target CHEMBL4861 (Hs)
Ensembl Gene ENSG00000115257 (Hs), ENSMUSG00000020131 (Mm), ENSRNOG00000016405 (Rn)
Entrez Gene 54760 (Hs), 18551 (Mm), 171085 (Rn)
Human Protein Atlas ENSG00000115257 (Hs)
KEGG Enzyme 3.4.21.-
KEGG Gene hsa:54760 (Hs), mmu:18551 (Mm), rno:171085 (Rn)
OMIM 600487 (Hs)
Pharos Q6UW60 (Hs)
RefSeq Nucleotide NM_017573 (Hs), NM_008793 (Mm), NM_133559 (Rn)
RefSeq Protein NP_060043 (Hs), NP_032819 (Mm), NP_598243 (Rn)
UniProtKB Q6UW60 (Hs), P29121 (Mm), Q78EH2 (Rn)
Wikipedia PCSK4 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.21.-

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
furin inhibitor peptide Peptide Click here for species-specific activity table Hs Inhibition 6.4 pKi 1
⤷ pKi 6.4 (Ki 4.41x10-7 M) [1]

References

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1. Shiryaev SA, Remacle AG, Ratnikov BI, Nelson NA, Savinov AY, Wei G, Bottini M, Rega MF, Parent A, Desjardins R et al.. (2007) Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens. J Biol Chem, 282 (29): 20847-53. [PMID:17537721]

How to cite this page

S8: Subtilisin: proprotein convertase subtilisin/kexin type 4. Last modified on 28/07/2015. Accessed on 18/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2384.