revaprazan   Click here for help

GtoPdb Ligand ID: 12007

Synonyms: Revanex® | YH-1885 | YH1885
Approved drug
revaprazan is an approved drug (S Korea (2007))
Compound class: Synthetic organic
Comment: Revaprazan (YH-1885) is a K+-competitive acid blocker (P-CAB)/proton pump inhibitor [1-2]. First in human data demonstrating the on-target effect of revaprazan were reported in 2010 [3].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 41.05
Molecular weight 362.19
XLogP 5.51
No. Lipinski's rules broken 1
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Canonical SMILES Fc1ccc(cc1)Nc1nc(c(c(n1)C)C)N1CCc2c(C1C)cccc2
Isomeric SMILES CC1c2ccccc2CCN1c1nc(nc(c1C)C)Nc1ccc(cc1)F
InChI InChI=1S/C22H23FN4/c1-14-15(2)24-22(25-19-10-8-18(23)9-11-19)26-21(14)27-13-12-17-6-4-5-7-20(17)16(27)3/h4-11,16H,12-13H2,1-3H3,(H,24,25,26)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (S Korea (2007))
International Nonproprietary Names Click here for help
INN number INN
8415 revaprazan
Synonyms Click here for help
Revanex® | YH-1885 | YH1885
Database Links Click here for help
CAS Registry No. 199463-33-7 (source: WHO INN record)
ChEMBL Ligand CHEMBL1618279
GtoPdb PubChem SID 464244148
PubChem CID 204104
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