VPC32183 [Ligand Id: 2908] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL184055
  • LPA1 receptor/Lysophosphatidic acid receptor Edg-2 in Human [ChEMBL: CHEMBL3819] [GtoPdb: 272] [UniProtKB: Q92633]
  • LPA1 receptor in Mouse [GtoPdb: 272] [UniProtKB: P61793]
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  • LPA3 receptor/Lysophosphatidic acid receptor Edg-7 in Human [ChEMBL: CHEMBL3250] [GtoPdb: 274] [UniProtKB: Q9UBY5]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
LPA1 receptor/Lysophosphatidic acid receptor Edg-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3819] [GtoPdb: 272] [UniProtKB: Q92633]
GtoPdb - - 7.75 pKi - - - Bioorg Med Chem Lett (2004) 14: 2735-40 [PMID:15125924]
ChEMBL Inhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptor B 6 pIC50 992 nM IC50 Bioorg Med Chem Lett (2004) 14: 4069-4074 [PMID:15225728]
LPA1 receptor in Mouse [GtoPdb: 272] [UniProtKB: P61793]
GtoPdb - - 6.96 pIC50 109 nM IC50 Bioorg Med Chem Lett (2004) 14: 2735-40 [PMID:15125924]
LPA3 receptor/Lysophosphatidic acid receptor Edg-7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3250] [GtoPdb: 274] [UniProtKB: Q9UBY5]
ChEMBL Binding affinity towards Lysophosphatidic acid 3 (LPA3) receptor B 5.77 pKi 1688 nM Ki Bioorg Med Chem Lett (2004) 14: 4069-4074 [PMID:15225728]
GtoPdb - - 6.76 pIC50 175 nM IC50 Bioorg Med Chem Lett (2004) 14: 2735-40 [PMID:15125924]
GtoPdb - - 6.76 pIC50 - - - Bioorg Med Chem Lett (2004) 14: 2735-40 [PMID:15125924]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]