VPC32183 [Ligand Id: 2908] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL184055
  • LPA1 receptor/Lysophosphatidic acid receptor Edg-2 in Human [ChEMBL: CHEMBL3819] [GtoPdb: 272] [UniProtKB: Q92633]
  • LPA1 receptor in Mouse [GtoPdb: 272] [UniProtKB: P61793]
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  • LPA3 receptor/Lysophosphatidic acid receptor Edg-7 in Human [ChEMBL: CHEMBL3250] [GtoPdb: 274] [UniProtKB: Q9UBY5]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
LPA1 receptor/Lysophosphatidic acid receptor Edg-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3819] [GtoPdb: 272] [UniProtKB: Q92633]
GtoPdb - - 7.75 pKi - - - Bioorg. Med. Chem. Lett. (2004) 14: 2735-40 [PMID:15125924]
ChEMBL Inhibitory concentration against Lysophosphatidic acid 1 (LPA1) receptor B 6 pIC50 992 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 4069-4074 [PMID:15225728]
LPA1 receptor in Mouse [GtoPdb: 272] [UniProtKB: P61793]
GtoPdb - - 6.96 pIC50 109 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 2735-40 [PMID:15125924]
LPA3 receptor/Lysophosphatidic acid receptor Edg-7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3250] [GtoPdb: 274] [UniProtKB: Q9UBY5]
ChEMBL Binding affinity towards Lysophosphatidic acid 3 (LPA3) receptor B 5.77 pKi 1688 nM Ki Bioorg. Med. Chem. Lett. (2004) 14: 4069-4074 [PMID:15225728]
GtoPdb - - 6.76 pIC50 175 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 2735-40 [PMID:15125924]
GtoPdb - - 6.76 pIC50 - - - Bioorg. Med. Chem. Lett. (2004) 14: 2735-40 [PMID:15125924]

ChEMBL data shown on this page come from version 26:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]