quipazine [Ligand Id: 173] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL18772 (Quipazine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588] | ||||||||
| ChEMBL | Binding affinity to His-tagged human beta1 adrenergic receptor expressed in HEK293 cell membranes by surface plasmon resonance analysis | B | 5.25 | pKd | 5623.41 | nM | Kd | J Med Chem (2013) 56: 3446-3455 [PMID:23517028] |
| ChEMBL | Binding affinity to His-tagged human beta1 adrenergic receptor expressed in HEK293 cell membranes by surface plasmon resonance analysis | B | 5.25 | pKd | 5600 | nM | Kd | J Med Chem (2013) 56: 3446-3455 [PMID:23517028] |
| ChEMBL | Displacement of [3H]dihydroalprenolol from human wild type beta1 adrenergic receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analysis | B | 5.2 | pKi | 6309.57 | nM | Ki | J Med Chem (2013) 56: 3446-3455 [PMID:23517028] |
| Neutrophil cytosol factor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1613743] [UniProtKB: P14598] | ||||||||
| ChEMBL | Binding affinity to immobilized recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constant by SPR assay | B | 3.38 | pKd | 420000 | nM | Kd | J Med Chem (2020) 63: 1156-1177 [PMID:31922756] |
| ChEMBL | Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells interaction with Cy5-p22phox149-162 incubated for 10 mins by fluorescence polarization competition assay | B | 2.85 | pKi | 1410000 | nM | Ki | J Med Chem (2020) 63: 1156-1177 [PMID:31922756] |
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
| ChEMBL | Binding affinity to 5HT1A receptor | B | 5.7 | pKd | 1995.26 | nM | Kd | J Med Chem (2009) 52: 6107-6125 [PMID:19754201] |
| ChEMBL | Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 mins | B | 6.64 | pKi | 230 | nM | Ki | Eur J Med Chem (2012) 49: 200-210 [PMID:22309909] |
| ChEMBL | Binding affinity for 5-hydroxytryptamine 1A receptor | B | 5.84 | pIC50 | 1445.44 | nM | IC50 | J Med Chem (1996) 39: 2068-2080 [PMID:8642566] |
| ChEMBL | Binding affinity against 5-hydroxytryptamine 1A receptor was measured using [3H]8-OH-DPAT as radioligand | B | 5.84 | pIC50 | 1445.44 | nM | IC50 | J Med Chem (1997) 40: 1808-1819 [PMID:9191957] |
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327] | ||||||||
| ChEMBL | Ability to displace [3H]- -OH-DPAT bound to 5-hydroxytryptamine 1A receptor in rat hippocampus | B | 5.44 | pKi | 3600 | nM | Ki | J Med Chem (1998) 41: 728-741 [PMID:9513601] |
| ChEMBL | Binding affinity against 5-hydroxytryptamine 1A receptor of rat hippocampus tissue. | B | 5.44 | pKi | 3600 | nM | Ki | J Med Chem (1999) 42: 1556-1575 [PMID:10229626] |
| ChEMBL | Evaluated for the binding affinity to hippocampus striatal membranes at 5-hydroxytryptamine 1A receptor binding site by using [3H]-8-OH- DPAT as a radioligand. | B | 5.48 | pKi | 3300 | nM | Ki | J Med Chem (1987) 30: 1-12 [PMID:3543362] |
| ChEMBL | The compound was tested for the binding affinity against 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand. | B | 5.8 | pKi | 1584.89 | nM | Ki | J Med Chem (1999) 42: 4362-4379 [PMID:10543880] |
| ChEMBL | Displacement of [3H]8-OHDPAT from 5HT1A receptor in rat hippocampus | B | 5.8 | pKi | 1584 | nM | Ki | J Med Chem (2009) 52: 6946-6950 [PMID:19831400] |
| ChEMBL | Displacement of [3H]8-OHDPAT from 5HT1A receptor in rat hippocampus | B | 5.8 | pKi | 1584 | nM | Ki | J Med Chem (2009) 52: 3548-3562 [PMID:19425598] |
| ChEMBL | The compound was tested for their binding affinity towards 5-hydroxytryptamine 1A receptor from rat hippocampus using [3H]-8-OH-DPAT as radioligand | B | 5.82 | pKi | 1500 | nM | Ki | J Med Chem (1995) 38: 2692-2704 [PMID:7629808] |
| ChEMBL | Inhibition of radiolabeled [3H]-8-OH-DPAT ligand binding to 5-hydroxytryptamine 1A receptor | B | 5.57 | pIC50 | 2700 | nM | IC50 | J Med Chem (1997) 40: 3670-3678 [PMID:9357534] |
| 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564] | ||||||||
| ChEMBL | Binding affinity (Ki) to rat cortical membranes at 5-HT1B binding site by using [125 I] ICYP as a radioligand. | B | 6.49 | pKi | 320 | nM | Ki | J Med Chem (1987) 30: 1-12 [PMID:3543362] |
| ChEMBL | Ability to displace [3H]5-HT bound to 5-hydroxytryptamine 1B receptor in rat striatum | B | 6.51 | pKi | 310 | nM | Ki | J Med Chem (1998) 41: 728-741 [PMID:9513601] |
| ChEMBL | Binding affinity against 5-hydroxytryptamine 1B receptor of rat striatum. | B | 6.51 | pKi | 310 | nM | Ki | J Med Chem (1999) 42: 1556-1575 [PMID:10229626] |
| ChEMBL | The compound was tested for their binding affinity towards 5-hydroxytryptamine 1B receptor from rat striatum using [3H]5-HT as radioligand | B | 6.68 | pKi | 208 | nM | Ki | J Med Chem (1995) 38: 2692-2704 [PMID:7629808] |
| ChEMBL | The compound was tested for the binding affinity against 5-hydroxytryptamine 1B receptor using [3H]5-HT as radioligand. | B | 6.7 | pKi | 199.53 | nM | Ki | J Med Chem (1999) 42: 4362-4379 [PMID:10543880] |
| ChEMBL | Binding affinity for 5-hydroxytryptamine 1B receptor | B | 5.15 | pIC50 | 7079.46 | nM | IC50 | J Med Chem (1996) 39: 2068-2080 [PMID:8642566] |
| ChEMBL | Binding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligand | B | 5.15 | pIC50 | 7079.46 | nM | IC50 | J Med Chem (1997) 40: 1808-1819 [PMID:9191957] |
| ChEMBL | Inhibition of radiolabeled [3H]-5-HT ligand binding to 5-hydroxytryptamine 1B receptor | B | 6.42 | pIC50 | 380 | nM | IC50 | J Med Chem (1997) 40: 3670-3678 [PMID:9357534] |
| Serotonin 1d (5-HT1d) receptor in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105] [UniProtKB: P79400] | ||||||||
| ChEMBL | Binding affinity for 5-hydroxytryptamine 1D receptor | B | 5.43 | pIC50 | 3715.35 | nM | IC50 | J Med Chem (1996) 39: 2068-2080 [PMID:8642566] |
| ChEMBL | Binding affinity against 5-hydroxytryptamine 1D receptor was measured using [3H]5-HT as radioligand | B | 5.43 | pIC50 | 3715.35 | nM | IC50 | J Med Chem (1997) 40: 1808-1819 [PMID:9191957] |
| 5-HT2A receptor in Human [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
| GtoPdb | - | - | 6.9 | pKi | - | - | - | Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733] |
| Serotonin 2a (5-HT2a) receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3446] [UniProtKB: Q75Z89] | ||||||||
| ChEMBL | Binding affinity towards 5-hydroxytryptamine 2A receptor | B | 5.46 | pIC50 | 3467.37 | nM | IC50 | J Med Chem (1996) 39: 2068-2080 [PMID:8642566] |
| ChEMBL | Binding affinity against 5-hydroxytryptamine 2A receptor was measured using [3H]ketanserin as radioligand | B | 5.46 | pIC50 | 3467.37 | nM | IC50 | J Med Chem (1997) 40: 1808-1819 [PMID:9191957] |
| 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842] | ||||||||
| ChEMBL | Ability to displace [3H]- ketanserin bound to 5-hydroxytryptamine 2A receptor in rat pre-frontal cortex | B | 5.74 | pKi | 1800 | nM | Ki | J Med Chem (1998) 41: 728-741 [PMID:9513601] |
| ChEMBL | Binding affinity against 5-hydroxytryptamine 2A receptor of rat pre-frontal cortex. | B | 5.74 | pKi | 1800 | nM | Ki | J Med Chem (1999) 42: 1556-1575 [PMID:10229626] |
| ChEMBL | The compound was tested for the binding affinity against 5-hydroxytryptamine 2A receptor using [3H]ketanserin as radioligand. | B | 6.1 | pKi | 794.33 | nM | Ki | J Med Chem (1999) 42: 4362-4379 [PMID:10543880] |
| ChEMBL | Displacement of [3H]ketanserin from 5HT2A receptor in rat cortex | B | 6.1 | pKi | 794 | nM | Ki | J Med Chem (2009) 52: 3548-3562 [PMID:19425598] |
| ChEMBL | Displacement of [3H]ketanserin from 5HT2A receptor in rat cortex | B | 6.1 | pKi | 794 | nM | Ki | J Med Chem (2009) 52: 6946-6950 [PMID:19831400] |
| ChEMBL | Binding affinity to 5-hydroxytryptamine 2A receptor from rat cortex assayed using [3H]ketanserin as radioligand. | B | 6.89 | pKi | 130 | nM | Ki | J Med Chem (1995) 38: 2692-2704 [PMID:7629808] |
| ChEMBL | Inhibition of radiolabeled [3H]-Ketanserin ligand binding to 5-hydroxytryptamine 2A receptor | B | 5.85 | pIC50 | 1400 | nM | IC50 | J Med Chem (1997) 40: 3670-3678 [PMID:9357534] |
| 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
| ChEMBL | Evaluated for the binding affinity to porcine choroid plexus at 5-hydroxytryptamine 2C receptor binding site by using [3H]-MES as a radioligand. | B | 6.7 | pKi | 200 | nM | Ki | J Med Chem (1987) 30: 1-12 [PMID:3543362] |
| GtoPdb | - | - | 7.3 | pKi | - | - | - |
Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733]; J Neurochem (1999) 72: 2127-34 [PMID:10217294]; Synapse (2000) 35: 144-150 [PMID:10611640] |
| ChEMBL | Binding affinity towards 5-hydroxytryptamine 2C receptor | B | 7.21 | pIC50 | 61.66 | nM | IC50 | J Med Chem (1996) 39: 2068-2080 [PMID:8642566] |
| ChEMBL | Binding affinity against 5-Hydroxytryptamine 2C Receptor was measured using [3H]N-methyl-mesulergine as radioligand | B | 7.21 | pIC50 | 61.66 | nM | IC50 | J Med Chem (1997) 40: 1808-1819 [PMID:9191957] |
| 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL324] [GtoPdb: 8] [UniProtKB: P08909] | ||||||||
| ChEMBL | The compound was tested for the binding affinity against 5-hydroxytryptamine 2C receptor using [3H]Mesulergine as radioligand. | B | 6.5 | pKi | 316.23 | nM | Ki | J Med Chem (1999) 42: 4362-4379 [PMID:10543880] |
| ChEMBL | Ability to displace [3H]mesulergine bound to 5-hydroxytryptamine 2C receptor in rat cortex | B | 6.72 | pKi | 190 | nM | Ki | J Med Chem (1998) 41: 728-741 [PMID:9513601] |
| ChEMBL | Binding affinity against 5-hydroxytryptamine 2C receptor of rat cortex. | B | 6.72 | pKi | 190 | nM | Ki | J Med Chem (1999) 42: 1556-1575 [PMID:10229626] |
| ChEMBL | Inhibition of radiolabeled [3H]mesulergine ligand binding to 5-hydroxytryptamine 2C receptor | B | 6.33 | pIC50 | 470 | nM | IC50 | J Med Chem (1997) 40: 3670-3678 [PMID:9357534] |
| 5-HT3E/5-HT3B/5-HT3A/5-HT3D/5-HT3C/Serotonin 3 (5-HT3) receptor in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094132] [GtoPdb: 377, 374, 373, 376, 375] [UniProtKB: A5X5Y0, O95264, P46098, Q70Z44, Q8WXA8] | ||||||||
| ChEMBL | Compound was tested for the inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor expressed in NG 108-15 cells | B | 8.7 | pKi | 2 | nM | Ki | J Med Chem (1996) 39: 4017-4026 [PMID:8831767] |
| ChEMBL | Binding affinity towards 5-hydroxytryptamine 3 receptor | B | 8.74 | pKi | 1.8 | nM | Ki | Bioorg Med Chem Lett (2002) 12: 2743-2747 [PMID:12217367] |
| ChEMBL | Binding affinity against 5-hydroxytryptamine 3 receptor was measured using [3H]granisetron as radioligand | B | 9.35 | pIC50 | 0.45 | nM | IC50 | J Med Chem (1997) 40: 1808-1819 [PMID:9191957] |
| ChEMBL | Effective concentration against 5-Hydroxytryptamine 3 receptor by measuring [14C]guanidinium uptake on NG108-15 cells. | F | 9 | pEC50 | 1 | nM | EC50 | J Med Chem (1999) 42: 4362-4379 [PMID:10543880] |
| 5-HT3A/5-HT3B/Serotonin 3 (5-HT3) receptor in Rat (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094116] [GtoPdb: 373, 374] [UniProtKB: P35563, Q9JJ16] | ||||||||
| ChEMBL | The compound was tested for the binding affinity against 5-hydroxytryptamine 3 receptor using [3H]zacopride as radioligand. | B | 8.2 | pKi | 6.31 | nM | Ki | J Med Chem (1999) 42: 4362-4379 [PMID:10543880] |
| ChEMBL | Inhibitory activity against 5-hydroxytryptamine 3 receptor in rat cortical membranes using [3H]- 1-Methyl-1H-indazole-3-carboxylic acid (8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-amide as a radioligand | B | 8.52 | pKi | 3.04 | nM | Ki | J Med Chem (1990) 33: 3176-3181 [PMID:2258903] |
| ChEMBL | pKi value for inhibition of [3H]LY-278584 binding to 5-hydroxytryptamine 3 receptor | B | 8.52 | pKi | 3.02 | nM | Ki | J Med Chem (1990) 33: 3176-3181 [PMID:2258903] |
| ChEMBL | Binding affinity at 5-hydroxytryptamine 3 receptor in rat cortical membrane by [3H]graniestron displacement. | B | 8.74 | pKi | 1.82 | nM | Ki | J Med Chem (1998) 41: 728-741 [PMID:9513601] |
| ChEMBL | Inhibition of [3H]granisetron binding to 5-hydroxytryptamine 3 receptor of rat cortical membrane | B | 8.74 | pKi | 1.8 | nM | Ki | J Med Chem (1999) 42: 1556-1575 [PMID:10229626] |
| ChEMBL | Ability to displace [3H]granisetron specifically bound to 5-hydroxytryptamine 3 receptor in rat cortical membrane | B | 8.74 | pKi | 1.8 | nM | Ki | J Med Chem (1998) 41: 728-741 [PMID:9513601] |
| ChEMBL | Binding affinity to 5-hydroxytryptamine 3 receptor using [3H]GR-65630 as radioligand in rat cortex | B | 8.85 | pKi | 1.41 | nM | Ki | J Med Chem (1990) 33: 1594-1600 [PMID:2342053] |
| ChEMBL | Compound was evaluated for its binding affinity for 5-hydroxytryptamine 3 receptor by measuring displacement [3H]GR-65630 in rat cerebral cortex | B | 8.85 | pKi | 1.4 | nM | Ki | J Med Chem (1998) 41: 311-317 [PMID:9464362] |
| ChEMBL | Binding affinity for 5-hydroxytryptamine 3 receptor from rat cortex using [3H]BRL-43694 as radioligand | B | 8.92 | pKi | 1.2 | nM | Ki | J Med Chem (1995) 38: 2692-2704 [PMID:7629808] |
| ChEMBL | Binding affinity to 5-hydroxytryptamine 3 receptor using [3H]quipazine as radioligand in rat cortex | B | 9 | pKi | 1 | nM | Ki | J Med Chem (1990) 33: 1594-1600 [PMID:2342053] |
| ChEMBL | Inhibition of [3H]BRL-43694 binding to 5-hydroxytryptamine 3 receptor of rat cortical homogenate. | B | 8.21 | pIC50 | 6.2 | nM | IC50 | J Med Chem (1997) 40: 3670-3678 [PMID:9357534] |
| ChEMBL | Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]zacopride as radioligand | B | 8.42 | pIC50 | 3.8 | nM | IC50 | J Med Chem (1999) 42: 4362-4379 [PMID:10543880] |
| ChEMBL | Binding affinity towards 5-hydroxytryptamine 3 receptor | B | 9.35 | pIC50 | 0.45 | nM | IC50 | J Med Chem (1996) 39: 2068-2080 [PMID:8642566] |
| 5-HT3A/Serotonin 3a (5-HT3a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098] | ||||||||
| ChEMBL | Displacement of [3H]GR65630 from human 5HT3A receptor in HEK293 cells | B | 8.4 | pKi | 3.98 | nM | Ki | J Med Chem (2007) 50: 4616-4629 [PMID:17722904] |
| ChEMBL | Displacement of [3H]GR65630 from human 5HT3A receptor in HEK293 cells | B | 8.43 | pKi | 3.7 | nM | Ki | J Med Chem (2007) 50: 4616-4629 [PMID:17722904] |
| 5-HT3A/Serotonin 3a (5-HT3a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2411] [GtoPdb: 373] [UniProtKB: P35563] | ||||||||
| ChEMBL | Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenate | B | 9.02 | pKi | 0.96 | nM | Ki | J Med Chem (2009) 52: 3548-3562 [PMID:19425598] |
| ChEMBL | Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenate | B | 9.02 | pKi | 0.96 | nM | Ki | J Med Chem (2009) 52: 6946-6950 [PMID:19831400] |
| 5-HT4 receptor/Serotonin 4 (5-HT4) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4317] [GtoPdb: 9] [UniProtKB: Q62758] | ||||||||
| ChEMBL | Inhibition of radiolabeled [3H]GR-113808 ligand binding to 5-hydroxytryptamine 4 receptor | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (1997) 40: 3670-3678 [PMID:9357534] |
| Serotonin 4 (5-HT4) receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5017] [UniProtKB: O70528] | ||||||||
| ChEMBL | The compound was tested for the binding affinity against 5-hydroxytryptamine 4 receptor using [3H]GR-113808 as radioligand. | B | 5 | pKi | <10000 | nM | Ki | J Med Chem (1999) 42: 4362-4379 [PMID:10543880] |
| ChEMBL | Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatum | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2009) 52: 3548-3562 [PMID:19425598] |
| ChEMBL | Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatum | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2009) 52: 6946-6950 [PMID:19831400] |
| 5-HT5A receptor/Serotonin 5a (5-HT5a) receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3597] [GtoPdb: 10] [UniProtKB: P30966] | ||||||||
| ChEMBL | Binding affinity towards murine 5-hydroxytryptamine 5A receptor | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2003) 46: 2795-2812 [PMID:12825922] |
| ChEMBL | Binding affinity towards mouse 5-hydroxytryptamine 5A receptor was evaluated using [3H]LSD as radioligand | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2003) 46: 2795-2812 [PMID:12825922] |
| 5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406] | ||||||||
| ChEMBL | Binding affinity towards human 5-hydroxytryptamine 6 receptor was evaluated using [3H]-LSD as radioligand | B | 5.44 | pKi | 3600 | nM | Ki | J Med Chem (2003) 46: 2795-2812 [PMID:12825922] |
| 5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969] | ||||||||
| ChEMBL | Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor | B | 5.52 | pKi | 3033 | nM | Ki | J Med Chem (2003) 46: 2795-2812 [PMID:12825922] |
| SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645] | ||||||||
| ChEMBL | Displacement of [3H]-5HT from human SERT | B | 7.52 | pKi | 30 | nM | Ki | Eur J Med Chem (2012) 49: 200-210 [PMID:22309909] |
| SERT/Serotonin transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652] | ||||||||
| ChEMBL | Inhibition of [3H]citalopram binding to Serotonin transporter of rat cerebral cortex | B | 7.2 | pKi | 63 | nM | Ki | Bioorg Med Chem Lett (2000) 10: 1559-1562 [PMID:10915050] |
| ChEMBL | Effect of compound on Serotonin transporter uptake from rat cortex using [3H]citalopram as radioligand | B | 7.37 | pKi | 43 | nM | Ki | J Med Chem (1995) 38: 2692-2704 [PMID:7629808] |
| ChEMBL | Ability to displace [3H]paroxetine bound to Serotonin transporter receptor in rat forebrain | B | 7.51 | pKi | 31 | nM | Ki | J Med Chem (1998) 41: 728-741 [PMID:9513601] |
| ChEMBL | Binding affinity towards Serotonin transporter was determined in rat forebrain membrane | B | 7.51 | pKi | 31 | nM | Ki | J Med Chem (1999) 42: 1556-1575 [PMID:10229626] |
| 5-HT2B receptor in Human [GtoPdb: 7] [UniProtKB: P41595] | ||||||||
| GtoPdb | - | - | 7.1 | pKi | - | - | - | Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733] |
| 5-HT2B receptor in Rat [GtoPdb: 7] [UniProtKB: P30994] | ||||||||
| GtoPdb | - | - | 6.9 | pKi | - | - | - | Mol Pharmacol (1993) 43: 419-26 [PMID:8450835] |
| 5-HT3AB in Human [GtoPdb: 378] | ||||||||
| GtoPdb | - | - | 9 | pKi | - | - | - | Neuropharmacology (2001) 41: 282-4 [PMID:11489465] |
| 5-HT3A in Human [GtoPdb: 379] | ||||||||
| GtoPdb | - | - | 9.5 | pKi | - | - | - | Neuropharmacology (2001) 41: 282-4 [PMID:11489465] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
