quipazine [Ligand Id: 173] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL18772 (Quipazine)
  • β1-adrenoceptor/Beta-1 adrenergic receptor in Human [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
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  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
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  • 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564]
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  • Serotonin 1d (5-HT1d) receptor in Pig [ChEMBL: CHEMBL4105] [UniProtKB: P79400]
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  • 5-HT2A receptor in Human [GtoPdb: 6] [UniProtKB: P28223]
  • Serotonin 2a (5-HT2a) receptor in Bovine [ChEMBL: CHEMBL3446] [UniProtKB: Q75Z89]
  • 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842]
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  • 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
  • 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Rat [ChEMBL: CHEMBL324] [GtoPdb: 8] [UniProtKB: P08909]
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  • 5-HT3A/Serotonin 3a (5-HT3a) receptor in Human [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098]
  • 5-HT3A/Serotonin 3a (5-HT3a) receptor in Rat [ChEMBL: CHEMBL2411] [GtoPdb: 373] [UniProtKB: P35563]
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  • 5-HT4 receptor/Serotonin 4 (5-HT4) receptor in Rat [ChEMBL: CHEMBL4317] [GtoPdb: 9] [UniProtKB: Q62758]
  • Serotonin 4 (5-HT4) receptor in Guinea pig [ChEMBL: CHEMBL5017] [UniProtKB: O70528]
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  • 5-HT5A receptor/Serotonin 5a (5-HT5a) receptor in Mouse [ChEMBL: CHEMBL3597] [GtoPdb: 10] [UniProtKB: P30966]
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  • 5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
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  • 5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
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  • 5-HT2B receptor in Human [GtoPdb: 7] [UniProtKB: P41595]
  • 5-HT2B receptor in Rat [GtoPdb: 7] [UniProtKB: P30994]
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  • 5-HT3AB in Human [GtoPdb: 378]
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  • 5-HT3A in Human [GtoPdb: 379]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
ChEMBL Binding affinity to His-tagged human beta1 adrenergic receptor expressed in HEK293 cell membranes by surface plasmon resonance analysis B 5.25 pKd 5623.41 nM Kd J. Med. Chem. (2013) 56: 3446-3455 [PMID:23517028]
ChEMBL Binding affinity to His-tagged human beta1 adrenergic receptor expressed in HEK293 cell membranes by surface plasmon resonance analysis B 5.25 pKd 5600 nM Kd J. Med. Chem. (2013) 56: 3446-3455 [PMID:23517028]
ChEMBL Displacement of [3H]dihydroalprenolol from human wild type beta1 adrenergic receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analysis B 5.2 pKi 6309.57 nM Ki J. Med. Chem. (2013) 56: 3446-3455 [PMID:23517028]
Neutrophil cytosol factor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1613743] [UniProtKB: P14598]
ChEMBL Binding affinity to immobilized recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constant by SPR assay B 3.38 pKd 420000 nM Kd J Med Chem (2020) 63: 1156-1177 [PMID:31922756]
ChEMBL Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells interaction with Cy5-p22phox149-162 incubated for 10 mins by fluorescence polarization competition assay B 2.85 pKi 1410000 nM Ki J Med Chem (2020) 63: 1156-1177 [PMID:31922756]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL Binding affinity to 5HT1A receptor B 5.7 pKd 1995.26 nM Kd J. Med. Chem. (2009) 52: 6107-6125 [PMID:19754201]
ChEMBL Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 mins B 6.64 pKi 230 nM Ki Eur. J. Med. Chem. (2012) 49: 200-210 [PMID:22309909]
ChEMBL Binding affinity for 5-hydroxytryptamine 1A receptor B 5.84 pIC50 1445.44 nM IC50 J. Med. Chem. (1996) 39: 2068-2080 [PMID:8642566]
ChEMBL Binding affinity against 5-hydroxytryptamine 1A receptor was measured using [3H]8-OH-DPAT as radioligand B 5.84 pIC50 1445.44 nM IC50 J. Med. Chem. (1997) 40: 1808-1819 [PMID:9191957]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
ChEMBL Ability to displace [3H]- -OH-DPAT bound to 5-hydroxytryptamine 1A receptor in rat hippocampus B 5.44 pKi 3600 nM Ki J. Med. Chem. (1998) 41: 728-741 [PMID:9513601]
ChEMBL Binding affinity against 5-hydroxytryptamine 1A receptor of rat hippocampus tissue. B 5.44 pKi 3600 nM Ki J. Med. Chem. (1999) 42: 1556-1575 [PMID:10229626]
ChEMBL Evaluated for the binding affinity to hippocampus striatal membranes at 5-hydroxytryptamine 1A receptor binding site by using [3H]-8-OH- DPAT as a radioligand. B 5.48 pKi 3300 nM Ki J. Med. Chem. (1987) 30: 1-12 [PMID:3543362]
ChEMBL The compound was tested for the binding affinity against 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand. B 5.8 pKi 1584.89 nM Ki J. Med. Chem. (1999) 42: 4362-4379 [PMID:10543880]
ChEMBL Displacement of [3H]8-OHDPAT from 5HT1A receptor in rat hippocampus B 5.8 pKi 1584 nM Ki J. Med. Chem. (2009) 52: 6946-6950 [PMID:19831400]
ChEMBL Displacement of [3H]8-OHDPAT from 5HT1A receptor in rat hippocampus B 5.8 pKi 1584 nM Ki J. Med. Chem. (2009) 52: 3548-3562 [PMID:19425598]
ChEMBL The compound was tested for their binding affinity towards 5-hydroxytryptamine 1A receptor from rat hippocampus using [3H]-8-OH-DPAT as radioligand B 5.82 pKi 1500 nM Ki J. Med. Chem. (1995) 38: 2692-2704 [PMID:7629808]
ChEMBL Inhibition of radiolabeled [3H]-8-OH-DPAT ligand binding to 5-hydroxytryptamine 1A receptor B 5.57 pIC50 2700 nM IC50 J. Med. Chem. (1997) 40: 3670-3678 [PMID:9357534]
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564]
ChEMBL Binding affinity (Ki) to rat cortical membranes at 5-HT1B binding site by using [125 I] ICYP as a radioligand. B 6.49 pKi 320 nM Ki J. Med. Chem. (1987) 30: 1-12 [PMID:3543362]
ChEMBL Ability to displace [3H]5-HT bound to 5-hydroxytryptamine 1B receptor in rat striatum B 6.51 pKi 310 nM Ki J. Med. Chem. (1998) 41: 728-741 [PMID:9513601]
ChEMBL Binding affinity against 5-hydroxytryptamine 1B receptor of rat striatum. B 6.51 pKi 310 nM Ki J. Med. Chem. (1999) 42: 1556-1575 [PMID:10229626]
ChEMBL The compound was tested for their binding affinity towards 5-hydroxytryptamine 1B receptor from rat striatum using [3H]5-HT as radioligand B 6.68 pKi 208 nM Ki J. Med. Chem. (1995) 38: 2692-2704 [PMID:7629808]
ChEMBL The compound was tested for the binding affinity against 5-hydroxytryptamine 1B receptor using [3H]5-HT as radioligand. B 6.7 pKi 199.53 nM Ki J. Med. Chem. (1999) 42: 4362-4379 [PMID:10543880]
ChEMBL Binding affinity for 5-hydroxytryptamine 1B receptor B 5.15 pIC50 7079.46 nM IC50 J. Med. Chem. (1996) 39: 2068-2080 [PMID:8642566]
ChEMBL Binding affinity towards 5-hydroxytryptamine 1B receptor was measured using [3H]5-HT as radioligand B 5.15 pIC50 7079.46 nM IC50 J. Med. Chem. (1997) 40: 1808-1819 [PMID:9191957]
ChEMBL Inhibition of radiolabeled [3H]-5-HT ligand binding to 5-hydroxytryptamine 1B receptor B 6.42 pIC50 380 nM IC50 J. Med. Chem. (1997) 40: 3670-3678 [PMID:9357534]
Serotonin 1d (5-HT1d) receptor in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105] [UniProtKB: P79400]
ChEMBL Binding affinity for 5-hydroxytryptamine 1D receptor B 5.43 pIC50 3715.35 nM IC50 J. Med. Chem. (1996) 39: 2068-2080 [PMID:8642566]
ChEMBL Binding affinity against 5-hydroxytryptamine 1D receptor was measured using [3H]5-HT as radioligand B 5.43 pIC50 3715.35 nM IC50 J. Med. Chem. (1997) 40: 1808-1819 [PMID:9191957]
5-HT2A receptor in Human [GtoPdb: 6] [UniProtKB: P28223]
GtoPdb - - 6.9 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733]
Serotonin 2a (5-HT2a) receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3446] [UniProtKB: Q75Z89]
ChEMBL Binding affinity towards 5-hydroxytryptamine 2A receptor B 5.46 pIC50 3467.37 nM IC50 J. Med. Chem. (1996) 39: 2068-2080 [PMID:8642566]
ChEMBL Binding affinity against 5-hydroxytryptamine 2A receptor was measured using [3H]ketanserin as radioligand B 5.46 pIC50 3467.37 nM IC50 J. Med. Chem. (1997) 40: 1808-1819 [PMID:9191957]
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842]
ChEMBL Ability to displace [3H]- ketanserin bound to 5-hydroxytryptamine 2A receptor in rat pre-frontal cortex B 5.74 pKi 1800 nM Ki J. Med. Chem. (1998) 41: 728-741 [PMID:9513601]
ChEMBL Binding affinity against 5-hydroxytryptamine 2A receptor of rat pre-frontal cortex. B 5.74 pKi 1800 nM Ki J. Med. Chem. (1999) 42: 1556-1575 [PMID:10229626]
ChEMBL The compound was tested for the binding affinity against 5-hydroxytryptamine 2A receptor using [3H]ketanserin as radioligand. B 6.1 pKi 794.33 nM Ki J. Med. Chem. (1999) 42: 4362-4379 [PMID:10543880]
ChEMBL Displacement of [3H]ketanserin from 5HT2A receptor in rat cortex B 6.1 pKi 794 nM Ki J. Med. Chem. (2009) 52: 3548-3562 [PMID:19425598]
ChEMBL Displacement of [3H]ketanserin from 5HT2A receptor in rat cortex B 6.1 pKi 794 nM Ki J. Med. Chem. (2009) 52: 6946-6950 [PMID:19831400]
ChEMBL Binding affinity to 5-hydroxytryptamine 2A receptor from rat cortex assayed using [3H]ketanserin as radioligand. B 6.89 pKi 130 nM Ki J. Med. Chem. (1995) 38: 2692-2704 [PMID:7629808]
ChEMBL Inhibition of radiolabeled [3H]-Ketanserin ligand binding to 5-hydroxytryptamine 2A receptor B 5.85 pIC50 1400 nM IC50 J. Med. Chem. (1997) 40: 3670-3678 [PMID:9357534]
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
ChEMBL Evaluated for the binding affinity to porcine choroid plexus at 5-hydroxytryptamine 2C receptor binding site by using [3H]-MES as a radioligand. B 6.7 pKi 200 nM Ki J. Med. Chem. (1987) 30: 1-12 [PMID:3543362]
GtoPdb - - 7.3 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733];
J Neurochem (1999) 72: 2127-34 [PMID:10217294];
Synapse (2000) 35: 144-150 [PMID:10611640]
ChEMBL Binding affinity towards 5-hydroxytryptamine 2C receptor B 7.21 pIC50 61.66 nM IC50 J. Med. Chem. (1996) 39: 2068-2080 [PMID:8642566]
ChEMBL Binding affinity against 5-Hydroxytryptamine 2C Receptor was measured using [3H]N-methyl-mesulergine as radioligand B 7.21 pIC50 61.66 nM IC50 J. Med. Chem. (1997) 40: 1808-1819 [PMID:9191957]
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL324] [GtoPdb: 8] [UniProtKB: P08909]
ChEMBL The compound was tested for the binding affinity against 5-hydroxytryptamine 2C receptor using [3H]Mesulergine as radioligand. B 6.5 pKi 316.23 nM Ki J. Med. Chem. (1999) 42: 4362-4379 [PMID:10543880]
ChEMBL Ability to displace [3H]mesulergine bound to 5-hydroxytryptamine 2C receptor in rat cortex B 6.72 pKi 190 nM Ki J. Med. Chem. (1998) 41: 728-741 [PMID:9513601]
ChEMBL Binding affinity against 5-hydroxytryptamine 2C receptor of rat cortex. B 6.72 pKi 190 nM Ki J. Med. Chem. (1999) 42: 1556-1575 [PMID:10229626]
ChEMBL Inhibition of radiolabeled [3H]mesulergine ligand binding to 5-hydroxytryptamine 2C receptor B 6.33 pIC50 470 nM IC50 J. Med. Chem. (1997) 40: 3670-3678 [PMID:9357534]
5-HT3E/5-HT3B/5-HT3A/5-HT3D/5-HT3C/Serotonin 3 (5-HT3) receptor in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094132] [GtoPdb: 377374373376375] [UniProtKB: A5X5Y0O95264P46098Q70Z44Q8WXA8]
ChEMBL Compound was tested for the inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor expressed in NG 108-15 cells B 8.7 pKi 2 nM Ki J. Med. Chem. (1996) 39: 4017-4026 [PMID:8831767]
ChEMBL Binding affinity towards 5-hydroxytryptamine 3 receptor B 8.74 pKi 1.8 nM Ki Bioorg. Med. Chem. Lett. (2002) 12: 2743-2747 [PMID:12217367]
ChEMBL Binding affinity against 5-hydroxytryptamine 3 receptor was measured using [3H]granisetron as radioligand B 9.35 pIC50 0.45 nM IC50 J. Med. Chem. (1997) 40: 1808-1819 [PMID:9191957]
ChEMBL Effective concentration against 5-Hydroxytryptamine 3 receptor by measuring [14C]guanidinium uptake on NG108-15 cells. F 9 pEC50 1 nM EC50 J. Med. Chem. (1999) 42: 4362-4379 [PMID:10543880]
5-HT3A/5-HT3B/Serotonin 3 (5-HT3) receptor in Rat (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094116] [GtoPdb: 373374] [UniProtKB: P35563Q9JJ16]
ChEMBL The compound was tested for the binding affinity against 5-hydroxytryptamine 3 receptor using [3H]zacopride as radioligand. B 8.2 pKi 6.31 nM Ki J. Med. Chem. (1999) 42: 4362-4379 [PMID:10543880]
ChEMBL Inhibitory activity against 5-hydroxytryptamine 3 receptor in rat cortical membranes using [3H]- 1-Methyl-1H-indazole-3-carboxylic acid (8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-amide as a radioligand B 8.52 pKi 3.04 nM Ki J. Med. Chem. (1990) 33: 3176-3181 [PMID:2258903]
ChEMBL pKi value for inhibition of [3H]LY-278584 binding to 5-hydroxytryptamine 3 receptor B 8.52 pKi 3.02 nM Ki J. Med. Chem. (1990) 33: 3176-3181 [PMID:2258903]
ChEMBL Binding affinity at 5-hydroxytryptamine 3 receptor in rat cortical membrane by [3H]graniestron displacement. B 8.74 pKi 1.82 nM Ki J. Med. Chem. (1998) 41: 728-741 [PMID:9513601]
ChEMBL Inhibition of [3H]granisetron binding to 5-hydroxytryptamine 3 receptor of rat cortical membrane B 8.74 pKi 1.8 nM Ki J. Med. Chem. (1999) 42: 1556-1575 [PMID:10229626]
ChEMBL Ability to displace [3H]granisetron specifically bound to 5-hydroxytryptamine 3 receptor in rat cortical membrane B 8.74 pKi 1.8 nM Ki J. Med. Chem. (1998) 41: 728-741 [PMID:9513601]
ChEMBL Binding affinity to 5-hydroxytryptamine 3 receptor using [3H]GR-65630 as radioligand in rat cortex B 8.85 pKi 1.41 nM Ki J. Med. Chem. (1990) 33: 1594-1600 [PMID:2342053]
ChEMBL Compound was evaluated for its binding affinity for 5-hydroxytryptamine 3 receptor by measuring displacement [3H]GR-65630 in rat cerebral cortex B 8.85 pKi 1.4 nM Ki J. Med. Chem. (1998) 41: 311-317 [PMID:9464362]
ChEMBL Binding affinity for 5-hydroxytryptamine 3 receptor from rat cortex using [3H]BRL-43694 as radioligand B 8.92 pKi 1.2 nM Ki J. Med. Chem. (1995) 38: 2692-2704 [PMID:7629808]
ChEMBL Binding affinity to 5-hydroxytryptamine 3 receptor using [3H]quipazine as radioligand in rat cortex B 9 pKi 1 nM Ki J. Med. Chem. (1990) 33: 1594-1600 [PMID:2342053]
ChEMBL Inhibition of [3H]BRL-43694 binding to 5-hydroxytryptamine 3 receptor of rat cortical homogenate. B 8.21 pIC50 6.2 nM IC50 J. Med. Chem. (1997) 40: 3670-3678 [PMID:9357534]
ChEMBL Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]zacopride as radioligand B 8.42 pIC50 3.8 nM IC50 J. Med. Chem. (1999) 42: 4362-4379 [PMID:10543880]
ChEMBL Binding affinity towards 5-hydroxytryptamine 3 receptor B 9.35 pIC50 0.45 nM IC50 J. Med. Chem. (1996) 39: 2068-2080 [PMID:8642566]
5-HT3A/Serotonin 3a (5-HT3a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098]
ChEMBL Displacement of [3H]GR65630 from human 5HT3A receptor in HEK293 cells B 8.4 pKi 3.98 nM Ki J. Med. Chem. (2007) 50: 4616-4629 [PMID:17722904]
ChEMBL Displacement of [3H]GR65630 from human 5HT3A receptor in HEK293 cells B 8.43 pKi 3.7 nM Ki J. Med. Chem. (2007) 50: 4616-4629 [PMID:17722904]
5-HT3A/Serotonin 3a (5-HT3a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2411] [GtoPdb: 373] [UniProtKB: P35563]
ChEMBL Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenate B 9.02 pKi 0.96 nM Ki J. Med. Chem. (2009) 52: 3548-3562 [PMID:19425598]
ChEMBL Displacement of [3H]LY278584 from 5HT3 receptor in rat cortical homogenate B 9.02 pKi 0.96 nM Ki J. Med. Chem. (2009) 52: 6946-6950 [PMID:19831400]
5-HT4 receptor/Serotonin 4 (5-HT4) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4317] [GtoPdb: 9] [UniProtKB: Q62758]
ChEMBL Inhibition of radiolabeled [3H]GR-113808 ligand binding to 5-hydroxytryptamine 4 receptor B 5 pIC50 >10000 nM IC50 J. Med. Chem. (1997) 40: 3670-3678 [PMID:9357534]
Serotonin 4 (5-HT4) receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5017] [UniProtKB: O70528]
ChEMBL The compound was tested for the binding affinity against 5-hydroxytryptamine 4 receptor using [3H]GR-113808 as radioligand. B 5 pKi <10000 nM Ki J. Med. Chem. (1999) 42: 4362-4379 [PMID:10543880]
ChEMBL Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatum B 5 pKi >10000 nM Ki J. Med. Chem. (2009) 52: 3548-3562 [PMID:19425598]
ChEMBL Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatum B 5 pKi >10000 nM Ki J. Med. Chem. (2009) 52: 6946-6950 [PMID:19831400]
5-HT5A receptor/Serotonin 5a (5-HT5a) receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3597] [GtoPdb: 10] [UniProtKB: P30966]
ChEMBL Binding affinity towards murine 5-hydroxytryptamine 5A receptor B 5 pKi >10000 nM Ki J. Med. Chem. (2003) 46: 2795-2812 [PMID:12825922]
ChEMBL Binding affinity towards mouse 5-hydroxytryptamine 5A receptor was evaluated using [3H]LSD as radioligand B 5 pKi >10000 nM Ki J. Med. Chem. (2003) 46: 2795-2812 [PMID:12825922]
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
ChEMBL Binding affinity towards human 5-hydroxytryptamine 6 receptor was evaluated using [3H]-LSD as radioligand B 5.44 pKi 3600 nM Ki J. Med. Chem. (2003) 46: 2795-2812 [PMID:12825922]
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
ChEMBL Binding affinity of compound towards rodent 5-hydroxytryptamine 7 receptor B 5.52 pKi 3033 nM Ki J. Med. Chem. (2003) 46: 2795-2812 [PMID:12825922]
SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
ChEMBL Displacement of [3H]-5HT from human SERT B 7.52 pKi 30 nM Ki Eur. J. Med. Chem. (2012) 49: 200-210 [PMID:22309909]
SERT/Serotonin transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652]
ChEMBL Inhibition of [3H]citalopram binding to Serotonin transporter of rat cerebral cortex B 7.2 pKi 63 nM Ki Bioorg. Med. Chem. Lett. (2000) 10: 1559-1562 [PMID:10915050]
ChEMBL Effect of compound on Serotonin transporter uptake from rat cortex using [3H]citalopram as radioligand B 7.37 pKi 43 nM Ki J. Med. Chem. (1995) 38: 2692-2704 [PMID:7629808]
ChEMBL Ability to displace [3H]paroxetine bound to Serotonin transporter receptor in rat forebrain B 7.51 pKi 31 nM Ki J. Med. Chem. (1998) 41: 728-741 [PMID:9513601]
ChEMBL Binding affinity towards Serotonin transporter was determined in rat forebrain membrane B 7.51 pKi 31 nM Ki J. Med. Chem. (1999) 42: 1556-1575 [PMID:10229626]
5-HT2B receptor in Human [GtoPdb: 7] [UniProtKB: P41595]
GtoPdb - - 7.1 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (2004) 370: 114-23 [PMID:15322733]
5-HT2B receptor in Rat [GtoPdb: 7] [UniProtKB: P30994]
GtoPdb - - 6.9 pKi - - - Mol Pharmacol (1993) 43: 419-26 [PMID:8450835]
5-HT3AB in Human [GtoPdb: 378]
GtoPdb - - 9 pKi - - - Neuropharmacology (2001) 41: 282-4 [PMID:11489465]
5-HT3A in Human [GtoPdb: 379]
GtoPdb - - 9.5 pKi - - - Neuropharmacology (2001) 41: 282-4 [PMID:11489465]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]