ChEMBL ligand: CHEMBL49302 (LY-223982, LY-333982)
BLT1 receptor/Leukotriene B4 receptor 1 in Human [ChEMBL: CHEMBL3911] [GtoPdb: 267] [UniProtKB: Q15722] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
BLT1 receptor/Leukotriene B4 receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3911] [GtoPdb: 267] [UniProtKB: Q15722]
GtoPdb	-	-	7.9	pKd	13	nM	Kd	J Pharmacol Exp Ther (1992) 262: 80-9 [PMID:1320692]
ChEMBL	Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4	B	6.44	pKi	360	nM	Ki	J. Med. Chem. (1993) 36: 3333-3340 [PMID:8230123]
ChEMBL	Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes	B	8.11	pKi	7.8	nM	Ki	Bioorg. Med. Chem. Lett. (1993) 3: 1981-1984
ChEMBL	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	F	6	pIC50	1000	nM	IC50	J. Med. Chem. (1992) 35: 4315-4324 [PMID:1333012]
ChEMBL	Inhibition of specific binding of [3H]LTB4 ( 0.1 nM) to LTB4 receptor on intact human neutrophils	B	7.88	pIC50	13.2	nM	IC50	J. Med. Chem. (1993) 36: 1726-1734 [PMID:8389876]
ChEMBL	Inhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophils	B	7.88	pIC50	13.2	nM	IC50	J. Med. Chem. (1990) 33: 2807-2813 [PMID:2170648]
ChEMBL	Compound was tested for inhibitory activity against human neutrophil LTB4 receptor binding	F	7.89	pIC50	13	nM	IC50	J. Med. Chem. (1996) 39: 2629-2654 [PMID:8709092]
ChEMBL	In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils	B	7.89	pIC50	13	nM	IC50	Bioorg. Med. Chem. Lett. (1993) 3: 1981-1984
ChEMBL	Antagonistic activity against human polymorphonuclear (PMN) LTB4 receptor	F	7.92	pIC50	12	nM	IC50	J. Med. Chem. (1992) 35: 4253-4255 [PMID:1331462]
ChEMBL	Binding affinity to leukotriene B4 receptor on intact human PMNs by displacing radioligand [3H]LTB4	B	7.92	pIC50	12	nM	IC50	J. Med. Chem. (1994) 37: 3327-3336 [PMID:7932560]
ChEMBL	Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)	B	7.92	pIC50	12	nM	IC50	J. Med. Chem. (1993) 36: 2703-2705 [PMID:8410983]
ChEMBL	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	B	8.46	pIC50	3.5	nM	IC50	J. Med. Chem. (1992) 35: 4315-4324 [PMID:1333012]
ChEMBL	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes	B	8.46	pIC50	3.5	nM	IC50	J. Med. Chem. (1992) 35: 4306-4314 [PMID:1333011]
ChEMBL	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	B	8.7	pIC50	2	nM	IC50	J. Med. Chem. (1992) 35: 4306-4314 [PMID:1333011]
ChEMBL	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	B	8.7	pIC50	2	nM	IC50	J. Med. Chem. (1992) 35: 4315-4324 [PMID:1333012]
ChEMBL	Inhibition of binding of [3H]LTB4 to receptor on nonradioactive LTB4	B	8.72	pIC50	1.9	nM	IC50	J. Med. Chem. (1993) 36: 1726-1734 [PMID:8389876]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]