ChEMBL ligand: CHEMBL1548353
15-LOX-1/Arachidonate 15-lipoxygenase in Human [ChEMBL: CHEMBL2903] [GtoPdb: 1388] [UniProtKB: P16050] There should be some charts here, you may need to enable JavaScript!
15-LOX-2/Arachidonate 15-lipoxygenase, type II in Human [ChEMBL: CHEMBL2457] [GtoPdb: 1389] [UniProtKB: O15296] There should be some charts here, you may need to enable JavaScript!
5-LOX/Arachidonate 5-lipoxygenase in Human [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
15-LOX-1/Arachidonate 15-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2903] [GtoPdb: 1388] [UniProtKB: P16050]
ChEMBL	Inhibition of recombinant N-terminal His6-tagged human reticulocyte 12/15-lipoxygenase using arachidonic acid as substrate assessed as equilibrium constant of dissociation from secondary site measured 15-HpETE formation by UV-vis spectrometric analysis	B	5.92	pKi	1200	nM	Ki	J Med Chem (2014) 57: 4035-4048 [PMID:24684213]
ChEMBL	Inhibition of recombinant N-terminal His6-tagged human reticulocyte 12/15-lipoxygenase using arachidonic acid as substrate assessed as equilibrium constant of dissociation from catalytic site measured 15-HpETE formation by UV-vis spectrometric analysis	B	7	pKi	100	nM	Ki	J Med Chem (2014) 57: 4035-4048 [PMID:24684213]
ChEMBL	Inhibition of N-terminal His6-tagged human platelet 12-lipoxygenase using arachidonic acid as substrate by UV-vis spectrometric analysis	B	4.3	pIC50	>50000	nM	IC50	J Med Chem (2014) 57: 4035-4048 [PMID:24684213]
ChEMBL	Inhibition of human N-terminal His6-tagged 15-LOX-1 F414I mutant expressed in sf9 cells using arachidonic acid or linoleic acid as substrate by UV-Visible spectrophotometric analysis	B	5.39	pIC50	4100	nM	IC50	Bioorg Med Chem (2016) 24: 5380-5387 [PMID:27647374]
ChEMBL	Inhibition of human N-terminal His6-tagged 15-LOX-1 E356Q mutant expressed in sf9 cells using arachidonic acid as substrate by UV-Visible spectrophotometric analysis	B	6.06	pIC50	870	nM	IC50	Bioorg Med Chem (2016) 24: 5380-5387 [PMID:27647374]
ChEMBL	Inhibition of human N-terminal His6-tagged 15-LOX-1 F414W mutant expressed in sf9 cells using arachidonic acid as substrate by UV-Visible spectrophotometric analysis	B	6.11	pIC50	770	nM	IC50	Bioorg Med Chem (2016) 24: 5380-5387 [PMID:27647374]
ChEMBL	Inhibition of human N-terminal His6-tagged 15-LOX-1 L407A mutant expressed in sf9 cells using arachidonic acid as substrate by UV-Visible spectrophotometric analysis	B	6.41	pIC50	390	nM	IC50	Bioorg Med Chem (2016) 24: 5380-5387 [PMID:27647374]
ChEMBL	Inhibition of wild type human N-terminal His6-tagged 15-LOX-1 expressed in sf9 cells using arachidonic acid or linoleic acid as substrate by UV-Visible spectrophotometric analysis	B	6.48	pIC50	330	nM	IC50	Bioorg Med Chem (2016) 24: 5380-5387 [PMID:27647374]
ChEMBL	Inhibition of human N-terminal His6-tagged 15-LOX-1 Q547L mutant expressed in sf9 cells using arachidonic acid as substrate by UV-Visible spectrophotometric analysis	B	6.52	pIC50	300	nM	IC50	Bioorg Med Chem (2016) 24: 5380-5387 [PMID:27647374]
ChEMBL	Inhibition of human N-terminal His6-tagged 15-LOX-1 R404L mutant expressed in sf9 cells using arachidonic acid or linoleic acid as substrate by UV-Visible spectrophotometric analysis	B	6.59	pIC50	260	nM	IC50	Bioorg Med Chem (2016) 24: 5380-5387 [PMID:27647374]
ChEMBL	Inhibition of recombinant N-terminal His6-tagged human reticulocyte 12/15-lipoxygenase using arachidonic acid as substrate by UV-vis spectrometric analysis	B	6.7	pIC50	200	nM	IC50	J Med Chem (2014) 57: 4035-4048 [PMID:24684213]
ChEMBL	Inhibition of N-terminal His6-tagged human 12/15-LOX using arachidonic acid as substrate by UV-visible spectrophotometric analysis	B	6.7	pIC50	200	nM	IC50	Bioorg Med Chem (2016) 24: 1183-1190 [PMID:26899595]
GtoPdb	-	-	6.7	pIC50	200	nM	IC50	Probe Reports from the NIH Molecular Libraries Program (2010) : [PMID:24672829]
ChEMBL	Inhibition of human N-terminal His6-tagged 15-LOX-1 I417A mutant expressed in sf9 cells using arachidonic acid or linoleic acid as substrate by UV-Visible spectrophotometric analysis	B	6.74	pIC50	180	nM	IC50	Bioorg Med Chem (2016) 24: 5380-5387 [PMID:27647374]
ChEMBL	Inhibition of human N-terminal His6-tagged 15-LOX-1 R402L mutant expressed in sf9 cells using arachidonic acid or linoleic acid as substrate by UV-Visible spectrophotometric analysis	B	6.92	pIC50	120	nM	IC50	Bioorg Med Chem (2016) 24: 5380-5387 [PMID:27647374]
15-LOX-2/Arachidonate 15-lipoxygenase, type II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2457] [GtoPdb: 1389] [UniProtKB: O15296]
ChEMBL	Inhibition of N-terminal His6-tagged human epithelial 15-lipoxygenase-2 using arachidonic acid as substrate by UV-vis spectrometric analysis	B	4.3	pIC50	>50000	nM	IC50	J Med Chem (2014) 57: 4035-4048 [PMID:24684213]
5-LOX/Arachidonate 5-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917]
ChEMBL	Inhibition of human 5-lipoxygenase using arachidonic acid as substrate by UV-vis spectrometric analysis	B	4.3	pIC50	>50000	nM	IC50	J Med Chem (2014) 57: 4035-4048 [PMID:24684213]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]