ChEMBL ligand: CHEMBL1548353
15-LOX-1/Arachidonate 15-lipoxygenase in Human [ChEMBL: CHEMBL2903] [GtoPdb: 1388] [UniProtKB: P16050] There should be some charts here, you may need to enable JavaScript!
15-LOX-2/Arachidonate 15-lipoxygenase, type II in Human [ChEMBL: CHEMBL2457] [GtoPdb: 1389] [UniProtKB: O15296] There should be some charts here, you may need to enable JavaScript!
5-LOX/Arachidonate 5-lipoxygenase in Human [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
15-LOX-1/Arachidonate 15-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2903] [GtoPdb: 1388] [UniProtKB: P16050]
ChEMBL	Inhibition of recombinant N-terminal His6-tagged human reticulocyte 12/15-lipoxygenase using arachidonic acid as substrate assessed as equilibrium constant of dissociation from secondary site measured 15-HpETE formation by UV-vis spectrometric analysis	B	5.92	pKi	1200	nM	Ki	J Med Chem (2014) 57: 4035-4048 [PMID:24684213]
ChEMBL	Inhibition of recombinant N-terminal His6-tagged human reticulocyte 12/15-lipoxygenase using arachidonic acid as substrate assessed as equilibrium constant of dissociation from catalytic site measured 15-HpETE formation by UV-vis spectrometric analysis	B	7	pKi	100	nM	Ki	J Med Chem (2014) 57: 4035-4048 [PMID:24684213]
ChEMBL	Inhibition of N-terminal His6-tagged human platelet 12-lipoxygenase using arachidonic acid as substrate by UV-vis spectrometric analysis	B	4.3	pIC50	>50000	nM	IC50	J Med Chem (2014) 57: 4035-4048 [PMID:24684213]
ChEMBL	Inhibition of human N-terminal His6-tagged 15-LOX-1 F414I mutant expressed in sf9 cells using arachidonic acid or linoleic acid as substrate by UV-Visible spectrophotometric analysis	B	5.39	pIC50	4100	nM	IC50	Bioorg Med Chem (2016) 24: 5380-5387 [PMID:27647374]
ChEMBL	Inhibition of human N-terminal His6-tagged 15-LOX-1 E356Q mutant expressed in sf9 cells using arachidonic acid as substrate by UV-Visible spectrophotometric analysis	B	6.06	pIC50	870	nM	IC50	Bioorg Med Chem (2016) 24: 5380-5387 [PMID:27647374]
ChEMBL	Inhibition of human N-terminal His6-tagged 15-LOX-1 F414W mutant expressed in sf9 cells using arachidonic acid as substrate by UV-Visible spectrophotometric analysis	B	6.11	pIC50	770	nM	IC50	Bioorg Med Chem (2016) 24: 5380-5387 [PMID:27647374]
ChEMBL	Inhibition of human N-terminal His6-tagged 15-LOX-1 L407A mutant expressed in sf9 cells using arachidonic acid as substrate by UV-Visible spectrophotometric analysis	B	6.41	pIC50	390	nM	IC50	Bioorg Med Chem (2016) 24: 5380-5387 [PMID:27647374]
ChEMBL	Inhibition of wild type human N-terminal His6-tagged 15-LOX-1 expressed in sf9 cells using arachidonic acid or linoleic acid as substrate by UV-Visible spectrophotometric analysis	B	6.48	pIC50	330	nM	IC50	Bioorg Med Chem (2016) 24: 5380-5387 [PMID:27647374]
ChEMBL	Inhibition of human N-terminal His6-tagged 15-LOX-1 Q547L mutant expressed in sf9 cells using arachidonic acid as substrate by UV-Visible spectrophotometric analysis	B	6.52	pIC50	300	nM	IC50	Bioorg Med Chem (2016) 24: 5380-5387 [PMID:27647374]
ChEMBL	Inhibition of human N-terminal His6-tagged 15-LOX-1 R404L mutant expressed in sf9 cells using arachidonic acid or linoleic acid as substrate by UV-Visible spectrophotometric analysis	B	6.59	pIC50	260	nM	IC50	Bioorg Med Chem (2016) 24: 5380-5387 [PMID:27647374]
ChEMBL	Inhibition of recombinant N-terminal His6-tagged human reticulocyte 12/15-lipoxygenase using arachidonic acid as substrate by UV-vis spectrometric analysis	B	6.7	pIC50	200	nM	IC50	J Med Chem (2014) 57: 4035-4048 [PMID:24684213]
ChEMBL	Inhibition of N-terminal His6-tagged human 12/15-LOX using arachidonic acid as substrate by UV-visible spectrophotometric analysis	B	6.7	pIC50	200	nM	IC50	Bioorg Med Chem (2016) 24: 1183-1190 [PMID:26899595]
GtoPdb	-	-	6.7	pIC50	200	nM	IC50	Probe Reports from the NIH Molecular Libraries Program (2010) : [PMID:24672829]
ChEMBL	Inhibition of human N-terminal His6-tagged 15-LOX-1 I417A mutant expressed in sf9 cells using arachidonic acid or linoleic acid as substrate by UV-Visible spectrophotometric analysis	B	6.74	pIC50	180	nM	IC50	Bioorg Med Chem (2016) 24: 5380-5387 [PMID:27647374]
ChEMBL	Inhibition of human N-terminal His6-tagged 15-LOX-1 R402L mutant expressed in sf9 cells using arachidonic acid or linoleic acid as substrate by UV-Visible spectrophotometric analysis	B	6.92	pIC50	120	nM	IC50	Bioorg Med Chem (2016) 24: 5380-5387 [PMID:27647374]
15-LOX-2/Arachidonate 15-lipoxygenase, type II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2457] [GtoPdb: 1389] [UniProtKB: O15296]
ChEMBL	Inhibition of N-terminal His6-tagged human epithelial 15-lipoxygenase-2 using arachidonic acid as substrate by UV-vis spectrometric analysis	B	4.3	pIC50	>50000	nM	IC50	J Med Chem (2014) 57: 4035-4048 [PMID:24684213]
5-LOX/Arachidonate 5-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917]
ChEMBL	Inhibition of human 5-lipoxygenase using arachidonic acid as substrate by UV-vis spectrometric analysis	B	4.3	pIC50	>50000	nM	IC50	J Med Chem (2014) 57: 4035-4048 [PMID:24684213]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]