quinaprilat [Ligand Id: 6352] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1733 (CI-928, NSC-759825, Quinaprilat, Quinapril diacid, Quinapril related compound b)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Angiotensin-converting enzyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1808] [GtoPdb: 1613] [UniProtKB: P12821]
ChEMBL In vitro inhibitory activity against Angiotensin I converting enzyme from unpurified guinea pig serum B 6.55 pIC50 280 nM IC50 J. Med. Chem. (1985) 28: 1291-1295 [PMID:2993618]
GtoPdb - - 8.5 pIC50 2.9 nM IC50 J Med Chem (1991) 34: 511-7 [PMID:1995872]
ChEMBL Compound was tested for its inhibitory potency against angiotensin I converting enzyme B 8.54 pIC50 2.9 nM IC50 J. Med. Chem. (1991) 34: 511-517 [PMID:1995872]
ChEMBL Inhibition of guinea pig angiotensin I converting enzyme B 8.55 pIC50 2.8 nM IC50 J. Med. Chem. (1986) 29: 1953-1961 [PMID:3020249]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]