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ChEMBL ligand: CHEMBL55267 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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protein kinase C alpha/Protein kinase C alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252] | ||||||||
ChEMBL | Displacement of [3H]PDBu from human recombinant PKCalpha expressed in Sf9 cells by liquid scintillation counting | B | 7.4 | pKi | 40.1 | nM | Ki | J Med Chem (2009) 52: 3969-3981 [PMID:19438240] |
ChEMBL | Displacement of [20-3H] phorbol 12,13-dibutyrate from protein kinase C alpha | B | 7.48 | pKi | 33 | nM | Ki | Bioorg Med Chem Lett (2000) 10: 653-655 [PMID:10762046] |
Protein kinase C alpha in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2213] [UniProtKB: P04409] | ||||||||
ChEMBL | Ability to displace bound [20-3H]-PDBU from a recombinant single isozyme (PKCalpha) in the presence of phosphatidylserine | B | 7.48 | pKi | 33 | nM | Ki | J Med Chem (2001) 44: 1892-1904 [PMID:11384235] |
protein kinase C delta/Protein kinase C delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655] | ||||||||
ChEMBL | Binding affinity to GST-tagged PKCdelta expressed in Escherichia coli BL21(DE3) by fluorescence quenching | B | 4.79 | pEC50 | 16150 | nM | EC50 | Bioorg Med Chem (2010) 18: 1591-1598 [PMID:20100661] |
protein kinase C epsilon/Protein kinase C epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156] | ||||||||
ChEMBL | Binding affinity to GST-tagged PKCepsilon expressed in Escherichia coli BL21(DE3) by fluorescence quenching | B | 5.09 | pEC50 | 8190 | nM | EC50 | Bioorg Med Chem (2010) 18: 1591-1598 [PMID:20100661] |
protein kinase C theta/Protein kinase C theta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3920] [GtoPdb: 1488] [UniProtKB: Q04759] | ||||||||
ChEMBL | Binding affinity to GST-tagged PKCtheta expressed in Escherichia coli BL21(DE3) by fluorescence quenching | B | 5.28 | pEC50 | 5240 | nM | EC50 | Bioorg Med Chem (2010) 18: 1591-1598 [PMID:20100661] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]