Synonyms: (E)-3-tosylacrylonitrile | BAY-117082 | BAY117082
Compound class:
Synthetic organic
Comment: BAY 11-7082 has long been reported as a NF-κB inhibitor, which inhibits TNFα-induced IκBα phosphorylation (IC50 10μM) [4]. However, an alternative report suggests that BAY 11-7082 reduces the activation of IκB kinases by targeting components of the ubiquitin system, and that this is responsible for its anti-inflammatory effects and induction of B-cell lymphoma and leukaemic T-cell death
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
(2E)-3-[(4-methylbenzene)sulfonyl]prop-2-enenitrile |
Synonyms ![]() |
(E)-3-tosylacrylonitrile | BAY-117082 | BAY117082 |
Database Links ![]() |
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CAS Registry No. | 19542-67-7 |
ChEMBL Ligand | CHEMBL403183 |
GtoPdb PubChem SID | 178102557 |
PubChem CID | 5353431 |
Search Google for chemical match using the InChIKey | DOEWDSDBFRHVAP-KRXBUXKQSA-N |
Search Google for chemicals with the same backbone | DOEWDSDBFRHVAP |
UniChem Compound Search for chemical match using the InChIKey | DOEWDSDBFRHVAP-KRXBUXKQSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | DOEWDSDBFRHVAP-KRXBUXKQSA-N |