diclofenac [Ligand Id: 2714] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL139 (Voltaren, Voltaren Xr, Cambia, Cataflam, Solaraze, Voltaren Ophthalmic, Zorvolex, Voltaren-XR, Diclofenac, Zorvolex Capsules, Arthrotec)
  • Aldo-keto reductase family 1 member B10 in Human [ChEMBL: CHEMBL5983] [UniProtKB: O60218]
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  • aldo-keto reductase family 1 member B/Aldose reductase in Human [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121]
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  • carbonic anhydrase 1/Carbonic anhydrase I in Human [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
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  • carbonic anhydrase 2/Carbonic anhydrase II in Human [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
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  • carbonic anhydrase 9/Carbonic anhydrase IX in Human [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
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  • fatty acid binding protein 1/Fatty acid-binding protein, liver in Rat [ChEMBL: CHEMBL5738] [GtoPdb: 2531] [UniProtKB: P02692]
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  • CXCR1/Interleukin-8 receptor A in Human [ChEMBL: CHEMBL4029] [GtoPdb: 68] [UniProtKB: P25024]
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  • Organic anion transporter 1/Solute carrier family 22 member 6 in Human [ChEMBL: CHEMBL1641347] [GtoPdb: 1025] [UniProtKB: Q4U2R8]
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  • UDP glucuronosyltransferase family 1 member A1/UDP-glucuronosyltransferase 1-1 in Human [ChEMBL: CHEMBL1287617] [GtoPdb: 2990] [UniProtKB: P22309]
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  • Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Rat [ChEMBL: CHEMBL3762] [GtoPdb: 529] [UniProtKB: P22002]
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  • TRPM3 in Human [GtoPdb: 495] [UniProtKB: Q9HCF6]
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  • Peroxisome proliferator-activated receptor-γ in Human [GtoPdb: 595] [UniProtKB: P37231]
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  • ASIC3 in Human [GtoPdb: 686] [UniProtKB: Q9UHC3]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Aldo-keto reductase family 1 member B10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5983] [UniProtKB: O60218]
ChEMBL Inhibition of wild-type N-terminal 6-His tagged AKR1B10 (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as pyridine-3-aldehyde reduction by spectrophotometry B 5.72 pIC50 1900 nM IC50 J. Med. Chem. (2015) 58: 2047-2067 [PMID:25375908]
aldo-keto reductase family 1 member B/Aldose reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121]
ChEMBL Inhibition of human AR by fluorescence assay B 4 pIC50 >100000 nM IC50 J. Med. Chem. (2015) 58: 2047-2067 [PMID:25375908]
carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
ChEMBL Inhibitory activity against human carbonic anhydrase I was determined B 4 pIC50 >100000 nM IC50 J. Med. Chem. (2004) 47: 550-557 [PMID:14736236]
carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
ChEMBL Inhibitory activity against human carbonic anhydrase II was determined B 4 pIC50 >100000 nM IC50 J. Med. Chem. (2004) 47: 550-557 [PMID:14736236]
Carbonic anhydrase IV in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL281] [UniProtKB: Q95323]
ChEMBL Inhibitory activity against bovine carbonic anhydrase IV was determined B 4 pIC50 >100000 nM IC50 J. Med. Chem. (2004) 47: 550-557 [PMID:14736236]
carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
ChEMBL Inhibitory activity against human carbonic anhydrase IX was determined B 4 pIC50 >100000 nM IC50 J. Med. Chem. (2004) 47: 550-557 [PMID:14736236]
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
ChEMBL Inhibition of COX1 in human platelet microsomes assessed as reduction in formation of oxidized TMPD using arachidonic acid as substrate preincubated for 3 to 5 mins followed by arachidonic acid addition measured for 25 secs by spectrophotometric assay B 4.74 pIC50 18230 nM IC50 ACS Med Chem Lett (2018) 9: 1045-1050 [PMID:30344915]
ChEMBL In vitro inhibitory activity against human whole blood Prostaglandin G/H synthase 1 B 6.82 pIC50 150 nM IC50 Bioorg. Med. Chem. Lett. (1999) 9: 1773-1778 [PMID:10406640]
ChEMBL Inhibition of COX1 B 7.15 pIC50 70 nM IC50 J. Med. Chem. (2007) 50: 1425-1441 [PMID:17341061]
ChEMBL Inhibition of human COX1 expressed in sf9 cells B 7.52 pIC50 30 nM IC50 J. Nat. Prod. (2005) 68: 1514-1518 [PMID:16252917]
ChEMBL Inhibition of human cyclooxygenase 1 B 7.82 pIC50 15 nM IC50 J. Med. Chem. (2008) 51: 4150-4169 [PMID:18588282]
ChEMBL DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) B 7.89 pIC50 13 nM IC50 DrugMatrix in vitro pharmacology data
GtoPdb - - 7.92 pIC50 12 nM IC50 J. Nat. Prod. (2005) 68: 1514-8 [PMID:16252917]
ChEMBL Inhibition of COX1 assessed as inhibition of arachidonic acid conversion to prostaglandin-E2 release B 7.92 pIC50 12 nM IC50 J. Med. Chem. (2009) 52: 1115-1125 [PMID:19191553]
ChEMBL Inhibition of cyclooxygenase 1 B 7.92 pIC50 12 nM IC50 J. Med. Chem. (2008) 51: 6348-6358 [PMID:18811132]
ChEMBL Inhibition of human COX1-mediated conversion of arachidonic acid to prostaglandin-E2 B 7.92 pIC50 12 nM IC50 J. Med. Chem. (2008) 51: 260-270 [PMID:18095641]
ChEMBL Inhibition of COX1 B 8.52 pIC50 3 nM IC50 J. Med. Chem. (2012) 55: 2932-2942 [PMID:22236250]
Cyclooxygenase-1 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2860] [UniProtKB: O62664]
ChEMBL Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLC B 8.52 pIC50 3 nM IC50 Bioorg. Med. Chem. (2009) 17: 558-568 [PMID:19097798]
Cyclooxygenase-1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2949] [UniProtKB: P05979]
ChEMBL Inhibition of ovine COX1 peroxidase activity assessed as reduction of PGG2 to PGH2 by measuring oxidized TMPD level by colorimetric assay B 5.2 pIC50 6250 nM IC50 Bioorg. Med. Chem. (2014) 22: 2855-2866 [PMID:24751552]
ChEMBL Inhibition of ovine COX1 using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 2 mins by enzyme immunoassay B 5.2 pIC50 6240 nM IC50 Eur J Med Chem (2017) 127: 10-21 [PMID:28038322]
ChEMBL Inhibition of ovine COX-1 assessed as PGF2alpha formation using arachidonic acid as substrate pretreated with compound for 20 mins prior to substrate addition by spectrophotometric analysis B 6.21 pIC50 610 nM IC50 Eur. J. Med. Chem. (2015) 97: 104-123 [PMID:25956953]
ChEMBL Inhibition of purified ovine COX1 pre-treated for 1 hr before 10-acetyl-3,7-dihydroxyphenoxazin substrate addition in absence of porcine liver esterase by fluorescence assay B 6.49 pIC50 320 nM IC50 ACS Med. Chem. Lett. (2014) 5: 983-988 [PMID:25221653]
ChEMBL Inhibition of ovine COX1 using arachidonic acid as substrate incubated for 5 mins followed by substrate addition measured after 2 mins by enzyme immunoassay B 6.6 pIC50 250 nM IC50 MedChemComm (2016) 7: 2309-2327
ChEMBL Inhibition of ovine COX1 assessed as inhibition of PGF2alpha production from PGH2 preincubated for 5 mins before arachidonic acid addition measured after 2 mins by enzyme immunoassay B 6.6 pIC50 250 nM IC50 Eur. J. Med. Chem. (2015) 92: 115-123 [PMID:25549551]
ChEMBL Inhibition of ovine COX1 after 2 mins by EIA B 6.74 pIC50 180 nM IC50 Eur. J. Med. Chem. (2014) 80: 167-174 [PMID:24780593]
ChEMBL Inhibition of ovine COX-1 preincubated for 5 mins followed by arachidonic acid substrate addition by colorimetric enzyme immunoassay B 6.82 pIC50 150 nM IC50 Bioorg Med Chem (2017) 25: 4424-4432 [PMID:28669741]
ChEMBL Inhibition of ovine COX1 assessed as reduction in PGH2-derived PGF2alpha using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 2 mins by enzyme immunoassay B 7.15 pIC50 70 nM IC50 J. Med. Chem. (2016) 59: 3920-3934 [PMID:27019010]
ChEMBL Inhibition of ovine COX1 using arachidonic acid as substrate incubated for 10 mins prior to substrate addition measured after 2 mins by spectrophotometry B 7.15 pIC50 70 nM IC50 Bioorg. Med. Chem. Lett. (2014) 24: 77-82 [PMID:24332492]
ChEMBL Inhibition of ovine COX1 for 17 mins pre-incubated before addition of [1-14C]arachidonic acid B 7.17 pIC50 67 nM IC50 J. Biol. Chem. (2007) 282: 16379-16390 [PMID:17434872]
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354]
ChEMBL Inhibition of human COX2 expressed in baculovirus infected sf21 cells assessed as reduction in formation of oxidized TMPD using arachidonic acid as substrate preincubated for 3 to 5 mins followed by arachidonic acid addition measured for 25 secs by spectrophotometric assay B 4.63 pIC50 23620 nM IC50 ACS Med Chem Lett (2018) 9: 1045-1050 [PMID:30344915]
ChEMBL Inhibition of human recombinant COX2 expressed in baculovirus infected SF21 cell B 4.63 pIC50 23620 nM IC50 Eur. J. Med. Chem. (2010) 45: 6135-6138 [PMID:20974503]
ChEMBL Inhibition of human recombinant COX2 pre-treated for 1 hr before 10-acetyl-3,7-dihydroxyphenoxazin substrate addition in absence of porcine liver esterase by fluorescence assay B 4.77 pIC50 16900 nM IC50 ACS Med. Chem. Lett. (2014) 5: 983-988 [PMID:25221653]
ChEMBL Inhibition of human COX2 using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 2 mins by enzyme immunoassay B 5.53 pIC50 2940 nM IC50 Eur J Med Chem (2017) 127: 10-21 [PMID:28038322]
ChEMBL Inhibition of human recombinant COX2 after 2 mins by EIA B 5.57 pIC50 2700 nM IC50 Eur. J. Med. Chem. (2014) 80: 167-174 [PMID:24780593]
ChEMBL Inhibition of human recombinant COX-2 assessed as PGF2 alpha formation using arachidonic acid as substrate pretreated with compound for 20 mins prior to substrate addition by spectrophotometric analysis B 6.2 pIC50 630 nM IC50 Eur. J. Med. Chem. (2015) 97: 104-123 [PMID:25956953]
ChEMBL Inhibition of human COX2 expressed in sf9 cells B 7.15 pIC50 70 nM IC50 J. Nat. Prod. (2005) 68: 1514-1518 [PMID:16252917]
ChEMBL In vitro inhibitory activity against human whole blood Prostaglandin G/H synthase 2 B 7.3 pIC50 50 nM IC50 Bioorg. Med. Chem. Lett. (1999) 9: 1773-1778 [PMID:10406640]
ChEMBL Inhibition of human COX-2 preincubated for 5 mins followed by arachidonic acid substrate addition by colorimetric enzyme immunoassay B 7.3 pIC50 50 nM IC50 Bioorg Med Chem (2017) 25: 4424-4432 [PMID:28669741]
ChEMBL DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid) B 7.43 pIC50 37 nM IC50 DrugMatrix in vitro pharmacology data
ChEMBL Inhibition of human COX2 for 17 mins pre-incubated before addition of [1-14C]arachidonic acid B 7.55 pIC50 28 nM IC50 J. Biol. Chem. (2007) 282: 16379-16390 [PMID:17434872]
ChEMBL Inhibitory concentration against COX-2; (valus obtained by Kato et al.) B 7.59 pIC50 26 nM IC50 J. Med. Chem. (2005) 48: 6997-7004 [PMID:16250658]
ChEMBL Inhibition of COX2 B 7.7 pIC50 20 nM IC50 J. Med. Chem. (2007) 50: 1425-1441 [PMID:17341061]
ChEMBL Inhibition of human recombinant COX2 using arachidonic acid as substrate incubated for 10 mins prior to substrate addition measured after 2 mins by spectrophotometry B 7.7 pIC50 20 nM IC50 Bioorg. Med. Chem. Lett. (2014) 24: 77-82 [PMID:24332492]
ChEMBL Inhibition of human recombinant COX2 assessed as reduction in PGH2-derived PGF2alpha using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 2 mins by enzyme immunoassay B 7.7 pIC50 20 nM IC50 J. Med. Chem. (2016) 59: 3920-3934 [PMID:27019010]
GtoPdb - - 7.7 pIC50 20 nM IC50 J. Med. Chem. (2007) 50: 1425-41 [PMID:17341061]
ChEMBL Inhibition of COX2 in LPS-stimulated human blood B 8 pIC50 10 nM IC50 Bioorg. Med. Chem. (2009) 17: 558-568 [PMID:19097798]
ChEMBL Inhibition of COX2 B 8.3 pIC50 5 nM IC50 J. Med. Chem. (2012) 55: 2932-2942 [PMID:22236250]
ChEMBL Inhibitory concentration against COX-2 upon incubation for 15 minutes at 37 degree C B 8.3 pIC50 5 nM IC50 J. Med. Chem. (2005) 48: 6997-7004 [PMID:16250658]
Cyclooxygenase-2 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4102] [UniProtKB: P79208]
ChEMBL Inhibition of ovine COX2 peroxidase activity assessed as reduction of PGG2 to PGH2 by measuring oxidized TMPD level by colorimetric assay B 4.82 pIC50 15000 nM IC50 Bioorg. Med. Chem. (2014) 22: 2855-2866 [PMID:24751552]
ChEMBL Inhibition of ovine COX2 assessed as inhibition of PGF2alpha production from PGH2 preincubated for 5 mins before arachidonic acid addition measured after 2 mins by enzyme immunoassay B 5.38 pIC50 4200 nM IC50 Eur. J. Med. Chem. (2015) 92: 115-123 [PMID:25549551]
ChEMBL Inhibition of ovine COX2 using arachidonic acid as substrate incubated for 5 mins followed by substrate addition measured after 2 mins by enzyme immunoassay B 6.59 pIC50 260 nM IC50 MedChemComm (2016) 7: 2309-2327
ChEMBL Inhibition of sheep placental cotyledons COX2 B 7.22 pIC50 60 nM IC50 J. Med. Chem. (2011) 54: 8555-8562 [PMID:22091869]
COX-2 /Cyclooxygenase-2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4321] [GtoPdb: 1376] [UniProtKB: Q05769]
ChEMBL Inhibition of purified mouse COX-2 assessed as inhibition of PGE2/PGD2 formation preincubated for 15 mins before arachidonic acid substrate addition measured after 30 seconds by LC-MS-MS method B 7 pIC50 100 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 5860-5864 [PMID:24060487]
ChEMBL Inhibition of mouse wild type COX2 B 7.11 pIC50 77 nM IC50 J. Med. Chem. (2007) 50: 1425-1441 [PMID:17341061]
ChEMBL Inhibition of purified mouse COX-2 assessed as inhibition of PGE2-G/PGD2-G formation preincubated for 15 mins before 2-AG substrate addition measured after 30 seconds by LC-MS-MS method B 7.52 pIC50 30 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 5860-5864 [PMID:24060487]
ChEMBL Inhibition of mouse COX2 for 17 mins pre-incubated before addition of [1-14C]arachidonic acid B 7.66 pIC50 22 nM IC50 J. Biol. Chem. (2007) 282: 16379-16390 [PMID:17434872]
ChEMBL Inhibition of mouse COX2 for 20 mins pre-incubated before addition of [1-14C]arachidonic acid B 7.66 pIC50 22 nM IC50 J. Biol. Chem. (2007) 282: 16379-16390 [PMID:17434872]
fatty acid binding protein 1/Fatty acid-binding protein, liver in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5738] [GtoPdb: 2531] [UniProtKB: P02692]
ChEMBL Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP low binding affinity site expressed in Escherichia coli BL21 by competitive fluorescence displacement assay B 4.45 pKi 35400 nM Ki J. Med. Chem. (2008) 51: 3755-3764 [PMID:18533710]
ChEMBL Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP high binding affinity site expressed in Escherichia coli BL21 by competitive fluorescence displacement assay B 5.49 pKi 3220 nM Ki J. Med. Chem. (2008) 51: 3755-3764 [PMID:18533710]
Interleukin-8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2157] [UniProtKB: P10145]
ChEMBL Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay B 8.1 pIC50 8 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 4026-4030 [PMID:19560921]
CXCR1/Interleukin-8 receptor A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4029] [GtoPdb: 68] [UniProtKB: P25024]
ChEMBL Inhibition of CXCR1 Lys99Ala mutant transfected in mouse L1.2 cells assessed as inhibition of CXCL8-induced cell migration pretreated for 15 mins measured after 4 hrs B 5 pIC50 >10000 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 4026-4030 [PMID:19560921]
ChEMBL Inhibition of wild type CXCR1 transfected in mouse L1.2 cells assessed as inhibition of CXCL8-induced cell migration pretreated for 15 mins measured after 4 hrs B 7.92 pIC50 12 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 4026-4030 [PMID:19560921]
Organic anion transporter 1/Solute carrier family 22 member 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641347] [GtoPdb: 1025] [UniProtKB: Q4U2R8]
ChEMBL TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cells F 5.4 pIC50 4000 nM IC50 J. Pharmacol. Exp. Ther. (2000) 295: 10-15 [PMID:10991954]
transthyretin/Transthyretin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3194] [GtoPdb: 2851] [UniProtKB: P02766]
ChEMBL Binding affinity to TTR (unknown origin) by isothermal titration calorimetric analysis B 6 pKd 1000 nM Kd J. Med. Chem. (2015) 58: 6507-6515 [PMID:26214366]
UDP glucuronosyltransferase family 1 member A1/UDP-glucuronosyltransferase 1-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1287617] [GtoPdb: 2990] [UniProtKB: P22309]
ChEMBL Inhibition of 4-methylumbelliferone glucuronidation by human recombinant UGT1A1 B 4.28 pKi 52000 nM Ki Pharmacology and Therapeutics (2005) 106: 97-132 [PMID:15781124]
UDP-glucuronosyltransferase 1-10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743320] [UniProtKB: Q9HAW8]
ChEMBL Inhibition of 4-methylumbelliferone glucuronidation by human recombinant UGT1A10 B 4.55 pKi 28000 nM Ki Pharmacology and Therapeutics (2005) 106: 97-132 [PMID:15781124]
UDP-glucuronosyltransferase 1-6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743316] [UniProtKB: P19224]
ChEMBL Inhibition of 4-methylumbelliferone glucuronidation by human recombinant UGT1A6 B 4.64 pKi 23000 nM Ki Pharmacology and Therapeutics (2005) 106: 97-132 [PMID:15781124]
UDP-glucuronosyltransferase 1-7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743317] [UniProtKB: Q9HAW7]
ChEMBL Inhibition of 4-methylumbelliferone glucuronidation by human recombinant UGT1A7 B 4.72 pKi 19000 nM Ki Pharmacology and Therapeutics (2005) 106: 97-132 [PMID:15781124]
UDP-glucuronosyltransferase 1-9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743319] [UniProtKB: O60656]
ChEMBL Inhibition of 4-methylumbelliferone glucuronidation by human recombinant UGT1A9 B 4.96 pKi 11000 nM Ki Pharmacology and Therapeutics (2005) 106: 97-132 [PMID:15781124]
Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3762] [GtoPdb: 529] [UniProtKB: P22002]
ChEMBL Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytes F 4.89 pIC50 12890 nM IC50 Journal of Applied Toxicology (2012) 32: 858-866 [PMID:22761000]
TRPM3 in Human [GtoPdb: 495] [UniProtKB: Q9HCF6]
GtoPdb - - 5.2 pIC50 - - - Pharmacol Res Perspect (2016) 4: e00232 [PMID:27433342]
Peroxisome proliferator-activated receptor-γ in Human [GtoPdb: 595] [UniProtKB: P37231]
GtoPdb - - 6.2 pKi - - - Mol. Pharmacol. (2002) 61: 7-12 [PMID:11752200]
ASIC3 in Human [GtoPdb: 686] [UniProtKB: Q9UHC3]
GtoPdb - - 4 pIC50 92000 nM IC50

ChEMBL data shown on this page come from version 26:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]