PD168,077 [Ligand Id: 975] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL45244 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 5-HT1A receptor/5-hydroxytryptamine receptor 1A in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3737] [GtoPdb: 1] [UniProtKB: Q64264] | ||||||||
| ChEMBL | Binding affinity at 5-hydroxytryptamine 1A receptor | B | 6.41 | pKi | 385 | nM | Ki | J Med Chem (1997) 40: 1771-1772 [PMID:9191952] |
| 5-HT2A receptor/5-hydroxytryptamine receptor 2A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
| ChEMBL | Binding affinity at 5-hydroxytryptamine 2A receptor | B | 5.4 | pKi | 4010 | nM | Ki | J Med Chem (1997) 40: 1771-1772 [PMID:9191952] |
| A2B receptor/Adenosine receptor A2b in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2592] [GtoPdb: 20] [UniProtKB: P29276] | ||||||||
| ChEMBL | Binding affinity at Alpha-2 adrenergic receptor | B | 6.75 | pKi | 177 | nM | Ki | J Med Chem (1997) 40: 1771-1772 [PMID:9191952] |
| α2A-adrenoceptor/Alpha-2A adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL327] [GtoPdb: 25] [UniProtKB: P22909] | ||||||||
| ChEMBL | Binding affinity at alpha-1 adrenergic receptor | B | 6.77 | pKi | 168 | nM | Ki | J Med Chem (1997) 40: 1771-1772 [PMID:9191952] |
| D(1A) dopamine receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2967] [UniProtKB: Q95136] | ||||||||
| ChEMBL | Affinity for Dopamine receptor D1 using [3H]SCH-23390 was carried out on bovine retinal membrane preparations | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2003) 46: 161-168 [PMID:12502370] |
| D2 receptor/D(2) dopamine receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
| ChEMBL | Displacement of 3H-N-Methylspiperone from DRD2 in human HEK293T cells membrane assessed as inhibition constant incubated for 2 hrs by radioligand competition assay | B | 5.19 | pKi | 6480 | nM | Ki | Science (2017) 358: 381-386 [PMID:29051383] |
| ChEMBL | Displacement of 3H-N-Methylspiperone from DRD2 in human HEK293T cells membrane assessed as inhibition constant incubated for 2 hrs by radioligand competition assay | B | 5.2 | pKi | 6309.57 | nM | Ki | Science (2017) 358: 381-386 [PMID:29051383] |
| ChEMBL | Binding affinity towards cloned human Dopamine receptor D2 | B | 5.43 | pKi | 3740 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 223-226 [PMID:11206464] |
| ChEMBL | Binding affinity for human Dopamine receptor D2 expressed in CHO K1 transfected cells using [3H]spiperone as radioligand | B | 5.43 | pKi | 3740 | nM | Ki | J Med Chem (1997) 40: 1771-1772 [PMID:9191952] |
| ChEMBL | Binding affinity towards human dopamine receptor D2 was determined by using [3H]spiperone as radioligand | B | 5.55 | pKi | 2818.38 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 2149-2157 [PMID:15808487] |
| ChEMBL | Displacement of [3H] Spiperone from human D2L receptor expressed in CHO cells by competitive radioligand binding assay | B | 5.64 | pKi | 2300 | nM | Ki | J Med Chem (2019) 62: 9658-9679 [PMID:31613617] |
| ChEMBL | Displacement of [3H] Spiperone from human D2S receptor expressed in CHO cells by competitive radioligand binding assay | B | 5.96 | pKi | 1100 | nM | Ki | J Med Chem (2019) 62: 9658-9679 [PMID:31613617] |
| ChEMBL | Antagonist activity at human recombinant D2 receptor expressed in HEK293 cells by FLIPR assay | F | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2006) 49: 5093-5109 [PMID:16913699] |
| ChEMBL | Agonist activity at human recombinant D2 receptor expressed in HEK293 cells by FLIPR assay | F | 5 | pEC50 | >10000 | nM | EC50 | J Med Chem (2006) 49: 5093-5109 [PMID:16913699] |
| D(2) dopamine receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3998] [UniProtKB: P20288] | ||||||||
| ChEMBL | Affinity for Dopamine receptor D2 using [3H]-YM-09151-2 was carried out on bovine striatal membrane preparations | B | 4.74 | pKi | 18300 | nM | Ki | J Med Chem (2003) 46: 161-168 [PMID:12502370] |
| ChEMBL | Affinity for Dopamine receptor D2 using [3H]YM-09151-2 was carried out on bovine retinal membrane preparations (low-affinity) | B | 5.2 | pKi | 6300 | nM | Ki | J Med Chem (2003) 46: 161-168 [PMID:12502370] |
| ChEMBL | Affinity for Dopamine receptor D2 using [3H]YM-09151-2 was carried out on bovine retinal membrane preparations (high-affinity) | B | 7.6 | pKi | 25 | nM | Ki | J Med Chem (2003) 46: 161-168 [PMID:12502370] |
| D3 receptor/D(3) dopamine receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462] | ||||||||
| ChEMBL | Displacement of [3H] Spiperone from human D3 receptor expressed in CHO cells by competitive radioligand binding assay | B | 5.33 | pKi | 4700 | nM | Ki | J Med Chem (2019) 62: 9658-9679 [PMID:31613617] |
| ChEMBL | Binding affinity for human Dopamine receptor D3 expressed in CHO K1 transfected cells using [3H]spiperone as radioligand | B | 5.55 | pKi | 2810 | nM | Ki | J Med Chem (1997) 40: 1771-1772 [PMID:9191952] |
| D4 receptor/D(4) dopamine receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917] | ||||||||
| ChEMBL | Displacement of 3H-N-Methylspiperone from DRD4 in human HEK293T cells membrane assessed as inhibition constant incubated for 2 hrs by radioligand competition assay | B | 7.47 | pKi | 34.1 | nM | Ki | Science (2017) 358: 381-386 [PMID:29051383] |
| ChEMBL | Displacement of 3H-N-Methylspiperone from DRD4 in human HEK293T cells membrane assessed as inhibition constant incubated for 2 hrs by radioligand competition assay | B | 7.47 | pKi | 33.88 | nM | Ki | Science (2017) 358: 381-386 [PMID:29051383] |
| ChEMBL | Binding affinity towards human dopamine receptor D4 expressed in CHO cells was determined by using [3H]thymidine as radioligand | B | 7.77 | pKi | 16.98 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 2149-2157 [PMID:15808487] |
| ChEMBL | Displacement of [3H]-spiperone from human D4 receptor assessed as inhibition constant | B | 7.8 | pKi | 16 | nM | Ki | Eur J Med Chem (2021) 212: 113141-113141 [PMID:33422983] |
| ChEMBL | Binding affinity towards cloned human Dopamine receptor D4 | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 223-226 [PMID:11206464] |
| ChEMBL | Binding affinity of compound towards human dopamine receptor D4 was determined | B | 8.06 | pKi | 8.71 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 2149-2157 [PMID:15808487] |
| ChEMBL | Binding affinity for human Dopamine receptor D4 expressed in CHO K1 transfected cells using [3H]spiperone as radioligand | B | 8.06 | pKi | 8.7 | nM | Ki | J Med Chem (1997) 40: 1771-1772 [PMID:9191952] |
| ChEMBL | Displacement of [3H] Spiperone from human D4.4 receptor expressed in CHO cells by competitive radioligand binding assay | B | 8.64 | pKi | 2.3 | nM | Ki | J Med Chem (2019) 62: 9658-9679 [PMID:31613617] |
| ChEMBL | Agonist activation of human dopamine receptor stimulating mitogenesis in Dopamine receptor D4-transfected CHO pro-5 cells using [3H]thymidine as radioligand | F | 7.77 | pEC50 | 17 | nM | EC50 | J Med Chem (1997) 40: 1771-1772 [PMID:9191952] |
| ChEMBL | Activity at human recombinant D4.4 receptor expressed in HEK293 cells by FLIPR assay | F | 8.08 | pEC50 | 8.3 | nM | EC50 | J Med Chem (2006) 49: 5093-5109 [PMID:16913699] |
| ChEMBL | Agonist activity at human D4.4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR | F | 8.08 | pEC50 | 8.3 | nM | EC50 | J Med Chem (2006) 49: 7450-7465 [PMID:17149874] |
| ChEMBL | Agonist activity at human D4R expressed in HEK293 cells by calcium flux assay | B | 8.16 | pEC50 | 6.9 | nM | EC50 | Eur J Med Chem (2021) 212: 113141-113141 [PMID:33422983] |
| D4 receptor in Rat [GtoPdb: 217] [UniProtKB: P30729] | ||||||||
| GtoPdb | - | - | 8.8 | pKi | 1.58 | nM | Ki | Mol Pharmacol (2004) 66: 1491-9 [PMID:15448188] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
