compound 7u [PMID: 24775305] [Ligand Id: 8633] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3264590
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
legumain/Legumain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4244] [GtoPdb: 2380] [UniProtKB: Q99538]
ChEMBL Inhibition of recombinant human legumain using Z-Ala-Ala-Asn-AMC fluorogenic substrate B 9.05 pIC50 0.9 nM IC50 Bioorg Med Chem Lett (2014) 24: 2521-2524 [PMID:24775305]
GtoPdb - - 9.05 pIC50 0.9 nM IC50 Bioorg Med Chem Lett (2014) 24: 2521-4 [PMID:24775305]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]