ZAK inhibitor 6p [Ligand Id: 10402] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ABL proto-oncogene 1, non-receptor tyrosine kinase in Human [GtoPdb: 1923] [UniProtKB: P00519] | ||||||||
| GtoPdb | - | - | 7.82 | pKd | 15 | nM | Kd | J Med Chem (2020) 63: 2114-2130 [PMID:31244114] |
| GtoPdb | Inhibition of enzymatic activity determined in a ADP-GloTM assay. | - | 8.4 | pIC50 | 4 | nM | IC50 | J Med Chem (2020) 63: 2114-2130 [PMID:31244114] |
| BLK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 1940] [UniProtKB: P51451] | ||||||||
| GtoPdb | - | - | 6.72 | pKd | 190 | nM | Kd | J Med Chem (2020) 63: 2114-2130 [PMID:31244114] |
| LCK proto-oncogene, Src family tyrosine kinase in Human [GtoPdb: 2053] [UniProtKB: P06239] | ||||||||
| GtoPdb | - | - | 6.8 | pKd | 160 | nM | Kd | J Med Chem (2020) 63: 2114-2130 [PMID:31244114] |
| LIM domain kinase 1 in Human [GtoPdb: 2054] [UniProtKB: P53667] | ||||||||
| GtoPdb | - | - | 7.64 | pKd | 23 | nM | Kd | J Med Chem (2020) 63: 2114-2130 [PMID:31244114] |
| LIM domain kinase 2 in Human [GtoPdb: 2055] [UniProtKB: P53671] | ||||||||
| GtoPdb | - | - | 7.2 | pKd | 63 | nM | Kd | J Med Chem (2020) 63: 2114-2130 [PMID:31244114] |
| receptor interacting serine/threonine kinase 2 in Human [GtoPdb: 2190] [UniProtKB: O43353] | ||||||||
| GtoPdb | - | - | 7.24 | pKd | 57 | nM | Kd | J Med Chem (2020) 63: 2114-2130 [PMID:31244114] |
| ZAK sterile alpha motif and leucine zipper containing kinase AZK in Human [GtoPdb: 2289] [UniProtKB: Q9NYL2] | ||||||||
| GtoPdb | Binding affinity determined using an active site-dependent competition binding assay. | - | 8.1 | pKd | 8 | nM | Kd | J Med Chem (2020) 63: 2114-2130 [PMID:31244114] |
| GtoPdb | Inhibition of enzymatic activity determined in a ADP-GloTM assay. | - | 8.4 | pIC50 | 4 | nM | IC50 | J Med Chem (2020) 63: 2114-2130 [PMID:31244114] |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
