asapiprant [Ligand Id: 11951] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3545043 (Asapiprant, Bge 175, Bge-175, BGE175, S-555739) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| DP1 receptor/Prostanoid DP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4427] [GtoPdb: 338] [UniProtKB: Q13258] | ||||||||
| ChEMBL | Displacement of [3H]-PGD2 from PGD2 receptor in human platelet membranes after 2 hrs by micro beta scintillation counting analysis | B | 6.62 | pKi | 240 | nM | Ki | US-8153793-B2. Sulfonamide derivative having PGD2 receptor antagonistic activity (2012) |
| GtoPdb | Displacement of [3H]-PGD2 from DP receptor in human platelet membranes | - | 6.62 | pKi | 240 | nM | Ki | US8153793B2. Sulfonamide derivative having PGD2 receptor antagonistic activity (2012) |
| ChEMBL | Antagonist activity at PGD2 receptor in human platelets assessed as inhibition of PGD2-mediated cAMP accumulation preincubated for 5 mins followed by PGD2 addition measured after 2 mins by HTRF assay | F | 6.28 | pIC50 | 520 | nM | IC50 | US-8153793-B2. Sulfonamide derivative having PGD2 receptor antagonistic activity (2012) |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
