azelaprag   Click here for help

GtoPdb Ligand ID: 10061

Synonyms: AMG 986 | AMG-986 | AMG986 | example 263 [WO2016187308A1]
Compound class: Synthetic organic
Comment: Azelaprag (AMG 986) is an apelin receptor agonist that is claimed in Amgen's patent WO2016187308A1 (as example 263) [2]. The chemical structure is identical to that submitted to the WHO for the INN azelaprag. Apelin receptor agonists are being pursued for their clinical inotropic potential in the treatment of heart failure.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 8
Hydrogen bond donors 1
Rotatable bonds 9
Topological polar surface area 141.87
Molecular weight 523.2
XLogP 3.82
No. Lipinski's rules broken 0
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Canonical SMILES COc1cccc(c1n1c(nnc1c1cncc(c1)C)NS(=O)(=O)C(C(c1ncc(cn1)C)C)C)OC
Isomeric SMILES COc1cccc(c1n1c(nnc1c1cncc(c1)C)NS(=O)(=O)[C@H]([C@@H](c1ncc(cn1)C)C)C)OC
InChI InChI=1S/C25H29N7O4S/c1-15-10-19(14-26-11-15)24-29-30-25(32(24)22-20(35-5)8-7-9-21(22)36-6)31-37(33,34)18(4)17(3)23-27-12-16(2)13-28-23/h7-14,17-18H,1-6H3,(H,30,31)/t17-,18-/m0/s1
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
10870 azelaprag
Synonyms Click here for help
AMG 986 | AMG-986 | AMG986 | example 263 [WO2016187308A1]
Database Links Click here for help
Specialist databases
GPCRdb Ligand azelaprag
Other databases
GtoPdb PubChem SID 375973249
PubChem CID 122702529
Search Google for chemical match using the InChIKey DOMQFIFVDIAOOT-ROUUACIJSA-N
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UniChem Compound Search for chemical match using the InChIKey DOMQFIFVDIAOOT-ROUUACIJSA-N
UniChem Connectivity Search for chemical match using the InChIKey DOMQFIFVDIAOOT-ROUUACIJSA-N