aplaviroc [Ligand Id: 805] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1255794 (Aplaviroc)
  • CCR5/C-C chemokine receptor type 5 in Human [ChEMBL: CHEMBL274] [GtoPdb: 62] [UniProtKB: P51681]
  • CCR5/C-C chemokine receptor type 5 in Mouse [ChEMBL: CHEMBL3676] [GtoPdb: 62] [UniProtKB: P51682]
  • This target only has 1 pki data point
  • 0
1 CHEMBL1255794_lig_chart_1 C-C chemokine receptor type 5 HumanMouse
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CCR5/C-C chemokine receptor type 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL274] [GtoPdb: 62] [UniProtKB: P51681]
ChEMBL Binding affinity to CCR5 B 8.52 pKd 3 nM Kd J. Med. Chem. (2012) 55: 9363-9392 [PMID:22931505]
GtoPdb - - 8.5 pKi 3.16 nM Ki J Biol Chem (2006) 281: 12688-12698 [PMID:16476734]
CCR5/C-C chemokine receptor type 5 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3676] [GtoPdb: 62] [UniProtKB: P51682]
ChEMBL Displacement of [125I]-RANTES from CCR5 in mouse NIH/3T3 cells after 1 hr B 9.4 pIC50 0.4 nM IC50 Eur J Med Chem (2018) 147: 115-129 [PMID:29425816]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]