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ChEMBL ligand: CHEMBL3127326 (ABT-267, Ombitasvir) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Genome polyprotein in Hepatitis C virus genotype 1b (isolate Con1) (HCV) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5536] [UniProtKB: Q9WMX2] | ||||||||
ChEMBL | Inhibition of HCV genotype 1b Con1 NS5A expressed in HuH7 cell infected HCV genotype 6a assessed as decrease in viral replication after 3 days by luciferase reporter gene assay | B | 9.44 | pEC50 | 0.37 | nM | EC50 | J Med Chem (2018) 61: 4052-4066 [PMID:29653491] |
ChEMBL | Inhibition of NS5A in HuH7 cell infected HCV genotype 1b Con1 assessed as decrease in viral replication after 3 days in presence of 40% human plasma by luciferase reporter gene assay | B | 10.25 | pEC50 | 0.06 | nM | EC50 | J Med Chem (2018) 61: 4052-4066 [PMID:29653491] |
ChEMBL | Inhibition of HCV genotype 1b Con1 NS5A expressed in HuH7 cell infected HCV genotype 3a assessed as decrease in viral replication after 3 days by luciferase reporter gene assay | B | 10.72 | pEC50 | 0.02 | nM | EC50 | J Med Chem (2018) 61: 4052-4066 [PMID:29653491] |
ChEMBL | Inhibition of HCV genotype 1b Con1 NS5A expressed in HuH7 cell infected HCV genotype 2a assessed as decrease in viral replication after 3 days by luciferase reporter gene assay | B | 10.92 | pEC50 | 0.01 | nM | EC50 | J Med Chem (2018) 61: 4052-4066 [PMID:29653491] |
Nonstructural protein 5A in Hepatitis C virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3307224] [UniProtKB: Q5L478] | ||||||||
ChEMBL | Inhibition of NS5A in HCV genotype 6a infected in human HuH7 replicon cells expressing HCV genotype 1b chimeric replicon assessed as reduction in viral replication after 3 days by luciferase reporter gene assay | B | 8.47 | pEC50 | 3.39 | nM | EC50 | Eur J Med Chem (2018) 148: 95-105 [PMID:29454920] |
ChEMBL | Inhibition of NS5A in HuH7 cell infected HCV genotype 1a H77 assessed as decrease in viral replication after 3 days in presence of 40% human plasma by luciferase reporter gene assay | B | 9.73 | pEC50 | 0.19 | nM | EC50 | J Med Chem (2018) 61: 4052-4066 [PMID:29653491] |
ChEMBL | Inhibition of NS5A in HCV genotype 3a infected in human HuH7 replicon cells expressing HCV genotype 1b chimeric replicon assessed as reduction in viral replication after 3 days by luciferase reporter gene assay | B | 10.07 | pEC50 | 0.09 | nM | EC50 | Eur J Med Chem (2018) 148: 95-105 [PMID:29454920] |
ChEMBL | Inhibition of NS5A in HCV genotype 6a | B | 10.26 | pEC50 | 0.06 | nM | EC50 | Eur J Med Chem (2018) 148: 95-105 [PMID:29454920] |
ChEMBL | Inhibition of NS5A in HCV genotype 1a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase reporter gene assay | B | 10.52 | pEC50 | 0.03 | nM | EC50 | Eur J Med Chem (2018) 148: 95-105 [PMID:29454920] |
ChEMBL | Inhibition of NS5A in HuH7 cell infected HCV genotype 1a H77 assessed as decrease in viral replication after 3 days by luciferase reporter gene assay | B | 10.85 | pEC50 | 0.01 | nM | EC50 | J Med Chem (2018) 61: 4052-4066 [PMID:29653491] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]