(+)-MCPG [Ligand Id: 1373] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL257626
  • mGlu1 receptor/Metabotropic glutamate receptor 1 in Human [ChEMBL: CHEMBL3772] [GtoPdb: 289] [UniProtKB: Q13255]
  • mGlu1 receptor in Rat [GtoPdb: 289] [UniProtKB: P23385]
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  • mGlu2 receptor/Metabotropic glutamate receptor 2 in Human [ChEMBL: CHEMBL5137] [GtoPdb: 290] [UniProtKB: Q14416]
  • mGlu2 receptor in Rat [GtoPdb: 290] [UniProtKB: P31421]
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  • mGlu3 receptor in Human [GtoPdb: 291] [UniProtKB: Q14832]
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  • mGlu5 receptor in Rat [GtoPdb: 293] [UniProtKB: P31424]
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  • mGlu7 receptor in Human [GtoPdb: 295] [UniProtKB: Q14831]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mGlu1 receptor/Metabotropic glutamate receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3772] [GtoPdb: 289] [UniProtKB: Q13255]
ChEMBL Antagonist activity at mGlu1 receptor F 5.37 pIC50 4300 nM IC50 J. Med. Chem. (2007) 50: 2563-2568 [PMID:17489573]
mGlu1 receptor in Rat [GtoPdb: 289] [UniProtKB: P23385]
GtoPdb - - 3.8 pKi - - - Mol Pharmacol (2003) 63: 1082-93 [PMID:12695537]
mGlu2 receptor/Metabotropic glutamate receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5137] [GtoPdb: 290] [UniProtKB: Q14416]
GtoPdb - - 3.8 pKi - - - Neuropharmacology (1999) 38: 1519-29 [PMID:10530814]
ChEMBL Antagonist activity at mGlu2 receptor F 5.37 pIC50 4300 nM IC50 J. Med. Chem. (2007) 50: 2563-2568 [PMID:17489573]
mGlu2 receptor in Rat [GtoPdb: 290] [UniProtKB: P31421]
GtoPdb - - 4.6 pKi - - - Br J Pharmacol (1998) 123: 497-504 [PMID:9504391]
mGlu3 receptor in Human [GtoPdb: 291] [UniProtKB: Q14832]
GtoPdb - - 3.8 pKi - - - Neuropharmacology (1999) 38: 1519-29 [PMID:10530814]
mGlu5 receptor in Rat [GtoPdb: 293] [UniProtKB: P31424]
GtoPdb - - 3.7 pIC50 - - - J Neurochem (2000) 75: 2590-601 [PMID:11080213]
mGlu7 receptor in Human [GtoPdb: 295] [UniProtKB: Q14831]
GtoPdb - - 3.2 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (2000) 362: 546-54 [PMID:11138847]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]