daunorubicin [Ligand Id: 7063] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL178 (Cerubidine, Daunomycin, Daunorubicin, Daunorubicina, Daunorubicine, Daunoxome, Epirubicin hydrochloride impurity, daunorubicin-, FI 6339, FI-6339, NSC-83142, RP 13057, RP-13057, Valrubicin impurity, daunorubicin)
  • ABCC2/Canalicular multispecific organic anion transporter 1 in Human [ChEMBL: CHEMBL5748] [GtoPdb: 780] [UniProtKB: Q92887]
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  • histone deacetylase 1/Histone deacetylase 1 in Human [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547]
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  • histone deacetylase 6/Histone deacetylase 6 in Human [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7]
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  • histone deacetylase 8/Histone deacetylase 8 in Human [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41]
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  • MMP2/Matrix metalloproteinase-2 in Human [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253]
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  • ABCC1/Multidrug resistance-associated protein 1 in Human [ChEMBL: CHEMBL3004] [GtoPdb: 779] [UniProtKB: P33527]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
ABCC2/Canalicular multispecific organic anion transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5748] [GtoPdb: 780] [UniProtKB: Q92887]
ChEMBL TP_TRANSPORTER: inhibition of Vinblastine transepithelial transport (basal to apical) in MRP2-expressing MDCK cells F 4.31 pKi 49400 nM Ki Pharm Res (2002) 19: 773-779 [PMID:12134946]
DNA topoisomerase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1806] [GtoPdb: 2637] [UniProtKB: P11388]
ChEMBL Inhibition of Topo IIalpha (unknown origin) B 8 pIC50 10 nM IC50 Bioorg Med Chem (2023) 95: 117486-117486 [PMID:37847948]
histone deacetylase 1/Histone deacetylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547]
ChEMBL Inhibition of HDAC1 (unknown origin) B 7.33 pIC50 47 nM IC50 Eur J Med Chem (2021) 209: 112844-112844 [PMID:33143937]
histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7]
ChEMBL Inhibition of HDAC6 (unknown origin) B 7.7 pIC50 20 nM IC50 Eur J Med Chem (2021) 209: 112844-112844 [PMID:33143937]
histone deacetylase 8/Histone deacetylase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41]
ChEMBL Inhibition of HDAC8 (unknown origin) B 6.66 pIC50 220 nM IC50 Eur J Med Chem (2021) 209: 112844-112844 [PMID:33143937]
MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253]
ChEMBL Inhibitory concentration against Clostridium histolyticum Collagenase B 5.72 pIC50 1900 nM IC50 J Med Chem (1992) 35: 2768-2771 [PMID:1322986]
ABCC1/Multidrug resistance-associated protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3004] [GtoPdb: 779] [UniProtKB: P33527]
ChEMBL TP_TRANSPORTER: inhibition of DNP-SG uptake in membrane vesicles from GLC4/ADR cells F 6.02 pKi 950 nM Ki Biochim Biophys Acta (1997) 1326: 12-22 [PMID:9188796]
ChEMBL TP_TRANSPORTER: inhibition of LTC4 uptake in membrane vesicles from SR3A cells F 7.15 pKi 70 nM Ki Biochem Biophys Res Commun (1998) 247: 859-863 [PMID:9647783]
ChEMBL TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.05 uM) in membrane vesicle from MRP1-expressing HeLa cells F 5.1 pIC50 8000 nM IC50 J Biol Chem (1996) 271: 9683-9689 [PMID:8621644]
ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183]
ChEMBL TP_TRANSPORTER: inhibition of Taxol transepithelial transport (basal to apical) in Caco-2 cells F 5.6 pKi 2500 nM Ki Pharm Res (2001) 18: 171-176 [PMID:11405287]
Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653]
ChEMBL HARVARD: Inhibition of liver stage Plasmodium berghei infection in HepG2 cells F 5.52 pIC50 2990 nM IC50 Proc Natl Acad Sci U S A (2012) 109: 8511-8516 [PMID:22586124]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL HARVARD: Inhibition of blood stage Plasmodium falciparum 3D7 infection F 6.47 pIC50 340 nM IC50 Proc Natl Acad Sci U S A (2012) 109: 8511-8516 [PMID:22586124]
ChEMBL HARVARD: Inhibition of blood stage Plasmodium falciparum Dd2 infection F 6.81 pIC50 155 nM IC50 Proc Natl Acad Sci U S A (2012) 109: 8511-8516 [PMID:22586124]
transthyretin/Transthyretin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3194] [GtoPdb: 2851] [UniProtKB: P02766]
ChEMBL Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by protein dilution in acetate buffer and further incubated for 96 hrs at pH 4.6 by thioflavin-T fluorescence assay B 4 pIC50 >100000 nM IC50 Bioorg Med Chem (2021) 44: 116292-116292 [PMID:34225167]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]