daunorubicin [Ligand Id: 7063] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL178 (FI-6339, RP-13057, Daunorubicin, Cerubidine, FI 6339, Daunoxome, NSC-83142, RP 13057, Valrubicin impurity, daunorubicin)
  • ABCC2/Canalicular multispecific organic anion transporter 1 in Human [ChEMBL: CHEMBL5748] [GtoPdb: 780] [UniProtKB: Q92887]
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  • MMP2/Matrix metalloproteinase-2 in Human [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253]
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  • ABCC1/Multidrug resistance-associated protein 1 in Human [ChEMBL: CHEMBL3004] [GtoPdb: 779] [UniProtKB: P33527]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
ABCC2/Canalicular multispecific organic anion transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5748] [GtoPdb: 780] [UniProtKB: Q92887]
ChEMBL TP_TRANSPORTER: inhibition of Vinblastine transepithelial transport (basal to apical) in MRP2-expressing MDCK cells F 4.31 pKi 49400 nM Ki Pharm. Res. (2002) 19: 773-779 [PMID:12134946]
MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253]
ChEMBL Inhibitory concentration against Clostridium histolyticum Collagenase B 5.72 pIC50 1900 nM IC50 J. Med. Chem. (1992) 35: 2768-2771 [PMID:1322986]
ABCC1/Multidrug resistance-associated protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3004] [GtoPdb: 779] [UniProtKB: P33527]
ChEMBL TP_TRANSPORTER: inhibition of DNP-SG uptake in membrane vesicles from GLC4/ADR cells F 6.02 pKi 950 nM Ki Biochim. Biophys. Acta (1997) 1326: 12-22 [PMID:9188796]
ChEMBL TP_TRANSPORTER: inhibition of LTC4 uptake in membrane vesicles from SR3A cells F 7.15 pKi 70 nM Ki Biochem. Biophys. Res. Commun. (1998) 247: 859-863 [PMID:9647783]
ChEMBL TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.05 uM) in membrane vesicle from MRP1-expressing HeLa cells F 5.1 pIC50 8000 nM IC50 J. Biol. Chem. (1996) 271: 9683-9689 [PMID:8621644]
ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183]
ChEMBL TP_TRANSPORTER: inhibition of Taxol transepithelial transport (basal to apical) in Caco-2 cells F 5.6 pKi 2500 nM Ki Pharm. Res. (2001) 18: 171-176 [PMID:11405287]
Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653]
ChEMBL HARVARD: Inhibition of liver stage Plasmodium berghei infection in HepG2 cells F 5.52 pIC50 2990 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2012) 109: 8511-8516 [PMID:22586124]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL HARVARD: Inhibition of blood stage Plasmodium falciparum 3D7 infection F 6.47 pIC50 340 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2012) 109: 8511-8516 [PMID:22586124]
ChEMBL HARVARD: Inhibition of blood stage Plasmodium falciparum Dd2 infection F 6.81 pIC50 155 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2012) 109: 8511-8516 [PMID:22586124]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]