Abbott 14c [Ligand Id: 5871] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL212761
  • dihydrofolate reductase/Dihydrofolate reductase in Human [ChEMBL: CHEMBL202] [GtoPdb: 2603] [UniProtKB: P00374]
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  • ghrelin receptor/Ghrelin receptor in Human [ChEMBL: CHEMBL4616] [GtoPdb: 246] [UniProtKB: Q92847]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
dihydrofolate reductase/Dihydrofolate reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL202] [GtoPdb: 2603] [UniProtKB: P00374]
ChEMBL Inhibition of human recombinant DHFR assessed as rate of depletion of NADPH B 4 pIC50 >100000 nM IC50 J. Med. Chem. (2006) 49: 4459-4469 [PMID:16854051]
ghrelin receptor/Ghrelin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4616] [GtoPdb: 246] [UniProtKB: Q92847]
GtoPdb - - 8.15 pIC50 7 nM IC50 J Med Chem (2006) 49: 4459-69 [PMID:16854051]
ChEMBL Activity at GHS receptor by calcium flux assay in CHO-K cells F 8.15 pIC50 7 nM IC50 J. Med. Chem. (2006) 49: 4459-4469 [PMID:16854051]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]