(2S,4S)-ketoconazole [Ligand Id: 8871] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL319160 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CYP11A1 in Human [GtoPdb: 1358] [UniProtKB: P05108] | ||||||||
| GtoPdb | - | - | 5.9 | pIC50 | - | - | - | J Med Chem (1992) 35: 2818-25 [PMID:1495014] |
| CYP11A1/Cytochrome P450 11A1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5246] [GtoPdb: 1358] [UniProtKB: P14137] | ||||||||
| ChEMBL | Inhibition of cholesterol side chain cleavage cytochrome P450 | B | 5.53 | pIC50 | 2950 | nM | IC50 | J Med Chem (1992) 35: 2818-2825 [PMID:1495014] |
| Cytochrome P450 11B1 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2927] [UniProtKB: P15150] | ||||||||
| ChEMBL | Inhibition of Corticoid 11-beta-hydroxylase cytochrome P450 | B | 6.61 | pIC50 | 247 | nM | IC50 | J Med Chem (1992) 35: 2818-2825 [PMID:1495014] |
| CYP19A1/Cytochrome P450 19A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511] | ||||||||
| GtoPdb | - | - | 5.4 | pIC50 | - | - | - | J Med Chem (1992) 35: 2818-25 [PMID:1495014] |
| ChEMBL | Inhibition of cytochrome P450 19A1 involved in steroid biosynthesis | B | 5.4 | pIC50 | 3980 | nM | IC50 | J Med Chem (1992) 35: 2818-2825 [PMID:1495014] |
| CYP21A2/Cytochrome P450 21 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2759] [GtoPdb: 1364] [UniProtKB: P08686] | ||||||||
| ChEMBL | Inhibition of Progesterone 21-hydroxylase cytochrome P450 21 | B | 5.35 | pIC50 | 4460 | nM | IC50 | J Med Chem (1992) 35: 2818-2825 [PMID:1495014] |
| CYP21A2 in Rat [GtoPdb: 1364] | ||||||||
| GtoPdb | - | - | 5.4 | pIC50 | 4460 | nM | IC50 | J Med Chem (1992) 35: 2818-25 [PMID:1495014] |
| CYP51A1/Cytochrome P450 51 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4981] [GtoPdb: 1374] [UniProtKB: Q64654] | ||||||||
| ChEMBL | Inhibition of lanosterol 14 alpha-demethylase cytochrome P450 51A | B | 5.8 | pIC50 | 1600 | nM | IC50 | J Med Chem (1992) 35: 2818-2825 [PMID:1495014] |
| CYP7A1 in Human [GtoPdb: 1354] [UniProtKB: P22680] | ||||||||
| GtoPdb | - | - | 9.7 | pIC50 | - | - | - | J Med Chem (1992) 35: 2818-25 [PMID:1495014] |
| CYP7A1/Cytochrome P450 7A1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2339] [GtoPdb: 1354] [UniProtKB: P18125] | ||||||||
| ChEMBL | Inhibition of cytochrome P450 Cholesterol 7-alpha-hydroxylase | B | 6.26 | pIC50 | 546 | nM | IC50 | J Med Chem (1992) 35: 2818-2825 [PMID:1495014] |
| CYP11B1 in Human [GtoPdb: 1359] [UniProtKB: P15538] | ||||||||
| GtoPdb | - | - | 6.9 | pIC50 | - | - | - | J Med Chem (1992) 35: 2818-25 [PMID:1495014] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
