(2S,4S)-ketoconazole [Ligand Id: 8871] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL319160 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CYP11A1 in Human [GtoPdb: 1358] [UniProtKB: P05108] | ||||||||
| GtoPdb | - | - | 5.9 | pIC50 | - | - | - | J Med Chem (1992) 35: 2818-25 [PMID:1495014] |
| CYP11A1/Cytochrome P450 11A1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5246] [GtoPdb: 1358] [UniProtKB: P14137] | ||||||||
| ChEMBL | Inhibition of cholesterol side chain cleavage cytochrome P450 | B | 5.53 | pIC50 | 2950 | nM | IC50 | J Med Chem (1992) 35: 2818-2825 [PMID:1495014] |
| Cytochrome P450 11B1 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2927] [UniProtKB: P15150] | ||||||||
| ChEMBL | Inhibition of Corticoid 11-beta-hydroxylase cytochrome P450 | B | 6.61 | pIC50 | 247 | nM | IC50 | J Med Chem (1992) 35: 2818-2825 [PMID:1495014] |
| CYP19A1/Cytochrome P450 19A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511] | ||||||||
| GtoPdb | - | - | 5.4 | pIC50 | - | - | - | J Med Chem (1992) 35: 2818-25 [PMID:1495014] |
| ChEMBL | Inhibition of cytochrome P450 19A1 involved in steroid biosynthesis | B | 5.4 | pIC50 | 3980 | nM | IC50 | J Med Chem (1992) 35: 2818-2825 [PMID:1495014] |
| CYP21A2/Cytochrome P450 21 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2759] [GtoPdb: 1364] [UniProtKB: P08686] | ||||||||
| ChEMBL | Inhibition of Progesterone 21-hydroxylase cytochrome P450 21 | B | 5.35 | pIC50 | 4460 | nM | IC50 | J Med Chem (1992) 35: 2818-2825 [PMID:1495014] |
| CYP21A2 in Rat [GtoPdb: 1364] | ||||||||
| GtoPdb | - | - | 5.4 | pIC50 | 4460 | nM | IC50 | J Med Chem (1992) 35: 2818-25 [PMID:1495014] |
| CYP51A1/Cytochrome P450 51 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4981] [GtoPdb: 1374] [UniProtKB: Q64654] | ||||||||
| ChEMBL | Inhibition of lanosterol 14 alpha-demethylase cytochrome P450 51A | B | 5.8 | pIC50 | 1600 | nM | IC50 | J Med Chem (1992) 35: 2818-2825 [PMID:1495014] |
| CYP7A1 in Human [GtoPdb: 1354] [UniProtKB: P22680] | ||||||||
| GtoPdb | - | - | 9.7 | pIC50 | - | - | - | J Med Chem (1992) 35: 2818-25 [PMID:1495014] |
| CYP7A1/Cytochrome P450 7A1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2339] [GtoPdb: 1354] [UniProtKB: P18125] | ||||||||
| ChEMBL | Inhibition of cytochrome P450 Cholesterol 7-alpha-hydroxylase | B | 6.26 | pIC50 | 546 | nM | IC50 | J Med Chem (1992) 35: 2818-2825 [PMID:1495014] |
| CYP11B1 in Human [GtoPdb: 1359] [UniProtKB: P15538] | ||||||||
| GtoPdb | - | - | 6.9 | pIC50 | - | - | - | J Med Chem (1992) 35: 2818-25 [PMID:1495014] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
