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CYP11A1

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Target not currently curated in GtoImmuPdb

Target id: 1358

Nomenclature: CYP11A1

Abbreviated Name: Cholesterol side-chain cleavage enzyme

Family: CYP11, CYP17, CYP19, CYP20 and CYP21 families

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 521 15q24.1 CYP11A1 cytochrome P450 family 11 subfamily A member 1
Mouse - 526 9 31.63 cM Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1
Rat - 526 8q24 Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1
Previous and Unofficial Names Click here for help
cholesterol desmolase | cholesterol monooxygenase (side-chain-cleaving) | cytochrome P450 11A1 | cytochrome P450, family 11, subfamily a, polypeptide 1 | cytochrome P450, family 11, subfamily A, polypeptide 1 | cytochrome P450
Database Links Click here for help
Alphafold P05108 (Hs), Q9QZ82 (Mm), P14137 (Rn)
BRENDA 1.14.15.6
ChEMBL Target CHEMBL2033 (Hs), CHEMBL5246 (Rn)
Ensembl Gene ENSG00000140459 (Hs), ENSMUSG00000032323 (Mm), ENSRNOG00000008074 (Rn)
Entrez Gene 1583 (Hs), 13070 (Mm), 29680 (Rn)
Human Protein Atlas ENSG00000140459 (Hs)
KEGG Enzyme 1.14.15.6
KEGG Gene hsa:1583 (Hs), mmu:13070 (Mm), rno:29680 (Rn)
OMIM 118485 (Hs)
Pharos P05108 (Hs)
UniProtKB P05108 (Hs), Q9QZ82 (Mm), P14137 (Rn)
Wikipedia CYP11A1 (Hs)
Enzyme Reaction Click here for help
EC Number: 1.14.15.6

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
(2S,4S)-ketoconazole Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 5.9 pIC50 4
⤷ pIC50 5.9 [4]
aminoglutethimide Small molecule or natural product Approved drug Ma Inhibition 4.5 pIC50 1
⤷ pIC50 4.5 (IC50 3x10-5 M) [1]
Description: Measuring inhibition of progesterone synthesis in hamster ovarian slices as an indicatior of CYP11A1 activity.
mitotane Small molecule or natural product Approved drug Hs Inhibition - - 2-3
⤷ [2-3]
View species-specific inhibitor tables
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Adrenal insufficiency, congenital, with 46,XY sex reversal, partial or complete
Synonyms: 46,XY disorder of sex development - adrenal insufficiency due to CYP11A1 deficiency [Orphanet: ORPHA168558]
Congenital adrenal insufficiency [Disease Ontology: DOID:0050546]
Disease Ontology: DOID:0050546
OMIM: 613743
Orphanet: ORPHA168558
Disease:  Inherited isolated adrenal insufficiency due to CYP11A1 deficiency
Orphanet: ORPHA289548

References

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1. Browne LJ, Gude C, Rodriguez H, Steele RE, Bhatnager A. (1991) Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease. J Med Chem, 34 (2): 725-36. [PMID:1825337]

2. Lehmann TP, Wrzesiński T, Jagodziński PP. (2013) The effect of mitotane on viability, steroidogenesis and gene expression in NCI‑H295R adrenocortical cells. Mol Med Rep, 7 (3): 893-900. [PMID:23254310]

3. Libè R, Fratticci A, Bertherat J. (2007) Adrenocortical cancer: pathophysiology and clinical management. Endocr Relat Cancer, 14 (1): 13-28. [PMID:17395972]

4. Rotstein DM, Kertesz DJ, Walker KA, Swinney DC. (1992) Stereoisomers of ketoconazole: preparation and biological activity. J Med Chem, 35 (15): 2818-25. [PMID:1495014]

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