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Target not currently curated in GtoImmuPdb

Target id: 1358

Nomenclature: CYP11A1

Abbreviated Name: Cholesterol side-chain cleavage enzyme

Family: CYP11, CYP17, CYP19, CYP20 and CYP21 families

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 521 15q24.1 CYP11A1 cytochrome P450 family 11 subfamily A member 1
Mouse - 526 9 31.63 cM Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1
Rat - 526 8q24 Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1
Previous and Unofficial Names Click here for help
cholesterol desmolase | cholesterol monooxygenase (side-chain-cleaving) | cytochrome P450 11A1 | cytochrome P450, family 11, subfamily a, polypeptide 1 | cytochrome P450, family 11, subfamily A, polypeptide 1 | cytochrome P450
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
Enzyme Reaction Click here for help
EC Number:

Download all structure-activity data for this target as a CSV file go icon to follow link

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
(2S,4S)-ketoconazole Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 5.9 pIC50 4
pIC50 5.9 [4]
aminoglutethimide Small molecule or natural product Approved drug Ma Inhibition 4.5 pIC50 1
pIC50 4.5 (IC50 3x10-5 M) [1]
Description: Measuring inhibition of progesterone synthesis in hamster ovarian slices as an indicatior of CYP11A1 activity.
mitotane Small molecule or natural product Approved drug Hs Inhibition - - 2-3
View species-specific inhibitor tables
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Adrenal insufficiency, congenital, with 46,XY sex reversal, partial or complete
Synonyms: 46,XY disorder of sex development - adrenal insufficiency due to CYP11A1 deficiency [Orphanet: ORPHA168558]
Congenital adrenal insufficiency [Disease Ontology: DOID:0050546]
Disease Ontology: DOID:0050546
OMIM: 613743
Orphanet: ORPHA168558
Disease:  Inherited isolated adrenal insufficiency due to CYP11A1 deficiency
Orphanet: ORPHA289548


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1. Browne LJ, Gude C, Rodriguez H, Steele RE, Bhatnager A. (1991) Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease. J Med Chem, 34 (2): 725-36. [PMID:1825337]

2. Lehmann TP, Wrzesiński T, Jagodziński PP. (2013) The effect of mitotane on viability, steroidogenesis and gene expression in NCI‑H295R adrenocortical cells. Mol Med Rep, 7 (3): 893-900. [PMID:23254310]

3. Libè R, Fratticci A, Bertherat J. (2007) Adrenocortical cancer: pathophysiology and clinical management. Endocr Relat Cancer, 14 (1): 13-28. [PMID:17395972]

4. Rotstein DM, Kertesz DJ, Walker KA, Swinney DC. (1992) Stereoisomers of ketoconazole: preparation and biological activity. J Med Chem, 35 (15): 2818-25. [PMID:1495014]

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