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CYP11A1

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Target not currently curated in GtoImmuPdb

Target id: 1358

Nomenclature: CYP11A1

Family: CYP11, CYP17, CYP19, CYP20 and CYP21 families

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 521 15q24.1 CYP11A1 cytochrome P450 family 11 subfamily A member 1
Mouse - 526 9 31.63 cM Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1
Rat - 526 8q24 Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1
Previous and Unofficial Names Click here for help
cholesterol desmolase | cholesterol monooxygenase (side-chain-cleaving) | cytochrome P450 11A1 | cytochrome P450, family 11, subfamily a, polypeptide 1 | cytochrome P450, family 11, subfamily A, polypeptide 1 | cytochrome P450
Database Links Click here for help
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 1.14.15.6

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
aminoglutethimide Small molecule or natural product Approved drug Ma Inhibition 4.5 pIC50 1
pIC50 4.5 (IC50 3x10-5 M) [1]
Description: Measuring inhibition of progesterone synthesis in hamster ovarian slices as an indicatior of CYP11A1 activity.
mitotane Small molecule or natural product Approved drug Click here for species-specific activity table Hs Inhibition - - 2-3
[2-3]
View species-specific inhibitor tables
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 2 GO processes
GO:0071347 cellular response to interleukin-1 IEP
GO:0071356 cellular response to tumor necrosis factor IEP
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Adrenal insufficiency, congenital, with 46,XY sex reversal, partial or complete
Synonyms: 46,XY disorder of sex development - adrenal insufficiency due to CYP11A1 deficiency [Orphanet: ORPHA168558]
Congenital adrenal insufficiency [Disease Ontology: DOID:0050546]
Disease Ontology: DOID:0050546
OMIM: 613743
Orphanet: ORPHA168558
Disease:  Inherited isolated adrenal insufficiency due to CYP11A1 deficiency
Orphanet: ORPHA289548

References

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1. Browne LJ, Gude C, Rodriguez H, Steele RE, Bhatnager A. (1991) Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease. J. Med. Chem., 34 (2): 725-36. [PMID:1825337]

2. Lehmann TP, Wrzesiński T, Jagodziński PP. (2013) The effect of mitotane on viability, steroidogenesis and gene expression in NCI‑H295R adrenocortical cells. Mol Med Rep, 7 (3): 893-900. [PMID:23254310]

3. Libè R, Fratticci A, Bertherat J. (2007) Adrenocortical cancer: pathophysiology and clinical management. Endocr. Relat. Cancer, 14 (1): 13-28. [PMID:17395972]

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