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ChEMBL ligand: CHEMBL127686 (L-365209) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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OT receptor in Human [GtoPdb: 369] [UniProtKB: P30559] | ||||||||
GtoPdb | - | - | 8.5 | pKi | - | - | - | Life Sci (1995) 57: 2253-61 [PMID:7475979] |
OT receptor/Oxytocin receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3996] [GtoPdb: 369] [UniProtKB: P70536] | ||||||||
ChEMBL | Binding affinity towards rat uterine receptor was determined using [3H]oxytocin as radioligand | B | 8.14 | pKi | 7.3 | nM | Ki | J Med Chem (1992) 35: 3905-3918 [PMID:1331448] |
ChEMBL | Inhibition of [3H]- oxytocin binding to rat uterine Oxytocin receptor | B | 8.14 | pKi | 7.3 | nM | Ki | J Med Chem (1990) 33: 1843-1845 [PMID:2163451] |
ChEMBL | Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor. | B | 7.74 | pIC50 | 18 | nM | IC50 | J Med Chem (1992) 35: 3905-3918 [PMID:1331448] |
V1A receptor/Vasopressin V1a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2868] [GtoPdb: 366] [UniProtKB: P30560] | ||||||||
ChEMBL | Binding affinity towards rat liver V1a receptor was determined using [3H]arginine vasopressin as radioligand | B | 6.43 | pKi | 370 | nM | Ki | J Med Chem (1992) 35: 3905-3918 [PMID:1331448] |
ChEMBL | Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site. | B | 5.89 | pIC50 | 1300 | nM | IC50 | J Med Chem (1992) 35: 3905-3918 [PMID:1331448] |
V2 receptor/Vasopressin V2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3766] [GtoPdb: 368] [UniProtKB: Q00788] | ||||||||
ChEMBL | Binding affinity towards rat kidney V2 receptor was determined using [3H]arginine vasopressin as radioligand | B | 6.09 | pKi | 820 | nM | Ki | J Med Chem (1992) 35: 3905-3918 [PMID:1331448] |
ChEMBL | Inhibition of [3H]arginine vasopressin binding to rat kidney medulla Vasopressin V2 receptor | B | 6.27 | pKi | 540 | nM | Ki | J Med Chem (1990) 33: 1843-1845 [PMID:2163451] |
ChEMBL | Inhibition of [3H]arginine vasopressin binding to AVP-V2 site in rat kidney medulla. | B | 5.64 | pIC50 | 2300 | nM | IC50 | J Med Chem (1992) 35: 3905-3918 [PMID:1331448] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]