ChEMBL ligand: CHEMBL127686 (L-365209)
OT receptor in Human [GtoPdb: 369] [UniProtKB: P30559] OT receptor/Oxytocin receptor in Rat [ChEMBL: CHEMBL3996] [GtoPdb: 369] [UniProtKB: P70536] There should be some charts here, you may need to enable JavaScript!
V1A receptor/Vasopressin V1a receptor in Rat [ChEMBL: CHEMBL2868] [GtoPdb: 366] [UniProtKB: P30560] There should be some charts here, you may need to enable JavaScript!
V2 receptor/Vasopressin V2 receptor in Rat [ChEMBL: CHEMBL3766] [GtoPdb: 368] [UniProtKB: Q00788] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
OT receptor in Human [GtoPdb: 369] [UniProtKB: P30559]
GtoPdb	-	-	8.5	pKi	-	-	-	Life Sci (1995) 57: 2253-61 [PMID:7475979]
OT receptor/Oxytocin receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3996] [GtoPdb: 369] [UniProtKB: P70536]
ChEMBL	Binding affinity towards rat uterine receptor was determined using [3H]oxytocin as radioligand	B	8.14	pKi	7.3	nM	Ki	J Med Chem (1992) 35: 3905-3918 [PMID:1331448]
ChEMBL	Inhibition of [3H]- oxytocin binding to rat uterine Oxytocin receptor	B	8.14	pKi	7.3	nM	Ki	J Med Chem (1990) 33: 1843-1845 [PMID:2163451]
ChEMBL	Concentration required to displace 50% of [3H]oxytocin from rat uterine receptor.	B	7.74	pIC50	18	nM	IC50	J Med Chem (1992) 35: 3905-3918 [PMID:1331448]
V1A receptor/Vasopressin V1a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2868] [GtoPdb: 366] [UniProtKB: P30560]
ChEMBL	Binding affinity towards rat liver V1a receptor was determined using [3H]arginine vasopressin as radioligand	B	6.43	pKi	370	nM	Ki	J Med Chem (1992) 35: 3905-3918 [PMID:1331448]
ChEMBL	Concentration required to displace 50% of [3H]arginine vasopressin from rat liver arginine vasopressin 1A (AVP-V1a) site.	B	5.89	pIC50	1300	nM	IC50	J Med Chem (1992) 35: 3905-3918 [PMID:1331448]
V2 receptor/Vasopressin V2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3766] [GtoPdb: 368] [UniProtKB: Q00788]
ChEMBL	Binding affinity towards rat kidney V2 receptor was determined using [3H]arginine vasopressin as radioligand	B	6.09	pKi	820	nM	Ki	J Med Chem (1992) 35: 3905-3918 [PMID:1331448]
ChEMBL	Inhibition of [3H]arginine vasopressin binding to rat kidney medulla Vasopressin V2 receptor	B	6.27	pKi	540	nM	Ki	J Med Chem (1990) 33: 1843-1845 [PMID:2163451]
ChEMBL	Inhibition of [3H]arginine vasopressin binding to AVP-V2 site in rat kidney medulla.	B	5.64	pIC50	2300	nM	IC50	J Med Chem (1992) 35: 3905-3918 [PMID:1331448]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]