XD1 [Ligand Id: 7525] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL142588
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  • bromodomain containing 4 in Human [GtoPdb: 1945] [UniProtKB: O60885]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Tubulin beta-1 chain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1915] [UniProtKB: Q9H4B7]
ChEMBL Inhibitory concentration against tubulin assembly B 5.54 pIC50 2900 nM IC50 Bioorg Med Chem Lett (2005) 15: 235-238 [PMID:15582446]
bromodomain containing 4 in Human [GtoPdb: 1945] [UniProtKB: O60885]
GtoPdb - - 4.34 pKd 46000 nM Kd Angew Chem Int Ed Engl (2013) 52: 14055-9 [PMID:24272870]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]