EMD-386088 [Ligand Id: 8428] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL364005
  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
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  • 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222]
  • 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564]
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  • 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
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  • 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
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  • 5-HT3A/Serotonin 3a (5-HT3a) receptor in Human [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098]
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  • Serotonin 4 (5-HT4) receptor in Guinea pig [ChEMBL: CHEMBL5017] [UniProtKB: O70528]
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  • 5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
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  • 5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
ChEMBL Inhibitory activity against 5-hydroxytryptamine 1A receptor in rat B 6.18 pIC50 660 nM IC50 Bioorg Med Chem Lett (2005) 15: 3230-4234 [PMID:16055331]
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222]
ChEMBL Inhibitory activity against 5-hydroxytryptamine 1B receptor in calf B 6.96 pIC50 110 nM IC50 Bioorg Med Chem Lett (2005) 15: 3230-4234 [PMID:16055331]
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564]
ChEMBL Inhibitory activity against 5-hydroxytryptamine 1B receptor in rat B 6.74 pIC50 180 nM IC50 Bioorg Med Chem Lett (2005) 15: 3230-4234 [PMID:16055331]
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
ChEMBL Inhibitory activity against 5-hydroxytryptamine 2A receptor in human B 6.62 pIC50 240 nM IC50 Bioorg Med Chem Lett (2005) 15: 3230-4234 [PMID:16055331]
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
ChEMBL Inhibitory activity against 5-hydroxytryptamine 2C receptor in human B 6.35 pIC50 450 nM IC50 Bioorg Med Chem Lett (2005) 15: 3230-4234 [PMID:16055331]
5-HT3A/Serotonin 3a (5-HT3a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098]
ChEMBL Inhibitory activity against 5-hydroxytryptamine 3 receptor expressed in NG 108 cells B 7.47 pIC50 34 nM IC50 Bioorg Med Chem Lett (2005) 15: 3230-4234 [PMID:16055331]
Serotonin 4 (5-HT4) receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5017] [UniProtKB: O70528]
ChEMBL Inhibitory activity against 5-hydroxytryptamine 4 receptor in guinea pig B 6.21 pIC50 620 nM IC50 Bioorg Med Chem Lett (2005) 15: 3230-4234 [PMID:16055331]
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
GtoPdb - - 8.13 pIC50 7.4 nM IC50 Bioorg Med Chem Lett (2005) 15: 4230-4 [PMID:16055331]
ChEMBL Displacement of [3H]LSD binding to cloned human 5-hydroxytryptamine 6 receptor expressed in HEK cells B 8.13 pIC50 7.4 nM IC50 Bioorg Med Chem Lett (2005) 15: 3230-4234 [PMID:16055331]
ChEMBL Inhibitory activity against 5-hydroxytryptamine 6 receptor in human B 8.13 pIC50 7.4 nM IC50 Bioorg Med Chem Lett (2005) 15: 3230-4234 [PMID:16055331]
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
ChEMBL Inhibitory activity against 5-hydroxytryptamine 7 receptor in human B 5.52 pIC50 3000 nM IC50 Bioorg Med Chem Lett (2005) 15: 3230-4234 [PMID:16055331]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]