CXCL12γ   Click here for help

GtoPdb Ligand ID: 8530

Immunopharmacology Ligand
Comment: CXCL12-γ is produced by alternative splicing of the CXCL12 gene and it is almost twice as large as CXCL12α and CXCL12β. It is a low affinity CXCR4 agonist and has limited signal transduction capacity. Expression of this γ isoform is mainly restricted to regions of adult brain and heart in humans and rats. In the mouse heart, CXCL12-γ localises to the nucleus via canonical nuclear localization signals and to the nucleolus via a specific nucleolar localization signal (NoLS) in its unique C-terminal region [3]. This suggests an intracellular signalling function for this isoform, which would make it unique amongst all of the known chemokines.
Species: Human
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Chemokines
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
CXCL12 C-X-C motif chemokine ligand 12 Human chemokine (C-X-C motif) ligand 12 chemokine (C-X-C motif) ligand 12, PBSF, SCYB12, SDF1, SDF-1a, SDF1A, SDF-1b, SDF1B, stromal cell-derived factor 1, TLSF-a, TLSF-b, TPAR1
Database Links Click here for help
Specialist databases
GPCRdb Ligand CXCL12gamma
Other databases
Ensembl Gene ENSG00000107562 (Hs)
Entrez Gene 6387 (Hs)
GtoPdb PubChem SID 252166732
Human Protein Atlas ENSG00000107562 (Hs)
UniProtKB P48061 (Hs)
Wikipedia Stromal_cell-derived_factor-1