ChEMBL ligand: CHEMBL3325507
GlyT2/Glycine transporter 2 in Human [ChEMBL: CHEMBL3060] [GtoPdb: 936] [UniProtKB: Q9Y345] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
GlyT2/Glycine transporter 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3060] [GtoPdb: 936] [UniProtKB: Q9Y345]
ChEMBL	Inhibition of human GlyT2 transfected in HEK293 cells assessed as [3H]glycine uptake after 2 hrs	B	6.98	pIC50	105	nM	IC50	Bioorg Med Chem Lett (2014) 24: 4603-4606 [PMID:25176190]
ChEMBL	Inhibition of human GlyT-2 expressed in HEK293 cells assessed as reduction in [3H]-glycine uptake	B	6.98	pIC50	105	nM	IC50	J Med Chem (2018) 61: 2652-2679 [PMID:28876062]
ChEMBL	Reversible inhibition of recombinant human GlyT2 expressed in HEK293 cells assessed as reduction in [3H]-glycine uptake after 2 hrs by top count assay	B	6.98	pIC50	105	nM	IC50	J Med Chem (2019) 62: 2466-2484 [PMID:30714733]
GtoPdb	-	-	8.8	pIC50	1.6	nM	IC50	J Pharmacol Sci (2015) 127: 377-81 [PMID:25837937]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]