ChEMBL ligand: CHEMBL185515 (A-317567)
ASIC1/Acid-sensing ion channel 1 in Rat [ChEMBL: CHEMBL3562170] [GtoPdb: 684] [UniProtKB: P55926] There should be some charts here, you may need to enable JavaScript!
ASIC3 in Human [GtoPdb: 686] [UniProtKB: Q9UHC3] ASIC3/Amiloride-sensitive cation channel 3 in Rat [ChEMBL: CHEMBL5757] [GtoPdb: 686] [UniProtKB: O35240] There should be some charts here, you may need to enable JavaScript!
kallikrein 1/Kallikrein 1 in Human [ChEMBL: CHEMBL2319] [GtoPdb: 2865] [UniProtKB: P06870] There should be some charts here, you may need to enable JavaScript!
plasminogen/Plasminogen in Human [ChEMBL: CHEMBL1801] [GtoPdb: 2394] [UniProtKB: P00747] There should be some charts here, you may need to enable JavaScript!
plasminogen activator, tissue type/Tissue-type plasminogen activator in Human [ChEMBL: CHEMBL1873] [GtoPdb: 2392] [UniProtKB: P00750] There should be some charts here, you may need to enable JavaScript!
Trypsin in Pig [ChEMBL: CHEMBL2366] [UniProtKB: P00761] There should be some charts here, you may need to enable JavaScript!
plasminogen activator, urokinase/Urokinase-type plasminogen activator in Human [ChEMBL: CHEMBL3286] [GtoPdb: 2393] [UniProtKB: P00749] There should be some charts here, you may need to enable JavaScript!
ASIC2 in Human [GtoPdb: 685] [UniProtKB: Q16515] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
ASIC1/Acid-sensing ion channel 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3562170] [GtoPdb: 684] [UniProtKB: P55926]
ChEMBL	Inhibition of ASIC1a in rat dorsal root ganglion neurons assessed as reduction in peak current preincubated for 120 secs followed by acid medium stimulation at pH 5.5 for 3 secs by automated patch clamp electrophysiology assay	B	5.7	pIC50	2000	nM	IC50	Bioorg Med Chem (2018) 26: 3158-3165 [PMID:29699911]
GtoPdb	-	-	5.7	pIC50	~2000	nM	IC50	Pain (2005) 117: 88-96 [PMID:16061325]
ASIC3 in Human [GtoPdb: 686] [UniProtKB: Q9UHC3]
GtoPdb	Human ASIC3 expressed in HEK293 cells	-	5.99	pIC50	1025	nM	IC50	ACS Chem Neurosci (2010) 1: 19-24 [PMID:22778804]
ASIC3/Amiloride-sensitive cation channel 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5757] [GtoPdb: 686] [UniProtKB: O35240]
ChEMBL	Inhibition of ASIC3 in rat DRG neurons	B	5.02	pIC50	9500	nM	IC50	J. Med. Chem. (2013) 56: 593-624 [PMID:23121096]
kallikrein 1/Kallikrein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2319] [GtoPdb: 2865] [UniProtKB: P06870]
ChEMBL	Binding affinity value against kallikrein	B	6.24	pKi	576	nM	Ki	Bioorg. Med. Chem. Lett. (2005) 15: 93-98 [PMID:15582418]
plasminogen/Plasminogen in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1801] [GtoPdb: 2394] [UniProtKB: P00747]
ChEMBL	Binding affinity value against plasmin	B	5.89	pKi	1302	nM	Ki	Bioorg. Med. Chem. Lett. (2005) 15: 93-98 [PMID:15582418]
plasminogen activator, tissue type/Tissue-type plasminogen activator in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1873] [GtoPdb: 2392] [UniProtKB: P00750]
ChEMBL	Binding affinity value against Tissue plasminogen activator	B	5.21	pKi	6230	nM	Ki	Bioorg. Med. Chem. Lett. (2005) 15: 93-98 [PMID:15582418]
Trypsin in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366] [UniProtKB: P00761]
ChEMBL	Binding affinity value against trypsin	B	7.05	pKi	90	nM	Ki	Bioorg. Med. Chem. Lett. (2005) 15: 93-98 [PMID:15582418]
plasminogen activator, urokinase/Urokinase-type plasminogen activator in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3286] [GtoPdb: 2393] [UniProtKB: P00749]
ChEMBL	Inhibition of urokinase	B	7.3	pKi	50.12	nM	Ki	J. Med. Chem. (2009) 52: 3159-3165 [PMID:19385614]
ChEMBL	Binding affinity value against urokinase plasminogen activator	B	7.33	pKi	47	nM	Ki	Bioorg. Med. Chem. Lett. (2005) 15: 93-98 [PMID:15582418]
ASIC2 in Human [GtoPdb: 685] [UniProtKB: Q16515]
GtoPdb	-	-	4.5	pIC50	~30000	nM	IC50	Pain (2005) 117: 88-96 [PMID:16061325]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]