Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	-	17q11.2-q12	ASIC2	acid sensing ion channel subunit 2
Mouse	-	-	11 B5	Asic2	acid-sensing (proton-gated) ion channel 2
Rat	-	-	10q26	Asic2	acid sensing ion channel subunit 2

Previous and Unofficial Names

BNaC1 | BNC1 | ACCN | ACCN1 | ASIC2a | amiloride-sensitive cation channel 1, neuronal | degenerin | acid-sensing ion channel 2 | amiloride-sensitive brain sodium channel 2 | amiloride-sensitive cation channel 1 | BNC1k | brain sodium channel 1 | BNaC1a | acid-sensing (proton-gated) ion channel 2 | acid sensing (proton gated) ion channel 2

Database Links
ChEMBL Target	CHEMBL3232695 (Mm), CHEMBL3562171 (Rn)
Ensembl Gene	ENSG00000108684 (Hs), ENSMUSG00000020704 (Mm), ENSRNOG00000007019 (Rn)
Entrez Gene	40 (Hs), 11418 (Mm), 25364 (Rn)
Human Protein Atlas	ENSG00000108684 (Hs)
KEGG Gene	hsa:40 (Hs), mmu:11418 (Mm), rno:25364 (Rn)
OMIM	601784 (Hs)
Pharos	Q16515 (Hs)
UniProtKB	Q16515 (Hs), Q925H0 (Mm), Q62962 (Rn)
Wikipedia	ASIC2 (Hs)

Functional Characteristics
γ=10.4-13.4 pS PNa/PK =10, PNa/PCa = 20 rapid activation rate, moderate inactivation rate (3.3-5.5 s) @ pH 5

Natural/Endogenous Ligands
H+

Download all structure-activity data for this target as a CSV file

Activators
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Voltage-dependent (mV) Reference Extracellular H+ Hs - ~4.1 – 5.0 pEC50 - no ⤷ pEC50 ~4.1 – 5.0 (EC50 ~8x10-5 – 1x10-5 M) Not voltage dependent

Channel Blockers
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Use-dependent Value Parameter Concentration range (M) Voltage-dependent (mV) Reference diminazene Hs - no ~6.1 pIC50 - no 3 ⤷ pIC50 ~6.1 [3] Not voltage dependent amiloride Hs - no 4.6 pIC50 - no ⤷ pIC50 4.6 (IC50 2.8x10-5 M) Not voltage dependent A-317567 Hs - no ~4.5 pIC50 - no ⤷ pIC50 ~4.5 (IC50 ~3x10-5 M) Not voltage dependent nafamostat Hs - no ~4.2 pIC50 - no ⤷ pIC50 ~4.2 (IC50 ~7x10-5 M) Not voltage dependent Cd2+ Hs - no ~3.0 pIC50 - no ⤷ pIC50 ~3.0 (IC50 ~1x10-3 M) Not voltage dependent

Immunopharmacology Comments

Non-steroidal anti-inflammatory drugs (NSAIDs) are direct inhibitors of ASIC currents (reviewed in [1]). Inflammatory conditions and particular pro-inflammatory mediators such as arachidonic acid induce overexpression of ASIC-encoding genes and enhance ASIC currents [2,4-5]. The sustained current component mediated by ASIC3 is potentiated by hypertonic solutions in a manner that is synergistic with the effect of arachidonic acid [2].