volociximab   Click here for help

GtoPdb Ligand ID: 10236

Synonyms: M200
Compound class: Antibody
Comment: Volociximab is a chimeric human IgG4 anti-integrin α5 subunit monoclonal antibody [5]. It blocks the interaction between α5β1 and fibronectin and inhibits the complex's functional activity [4], and was originally developed for anti-angiogenic, anti-tumour potential [1-2]. Volociximab does not cross-react with murine α5β1 so is unsuitable for use in standard xenograft models [2]. A rat anti-mouse function-blocking α5β1 designed for murine experiments has been reported (339.1, Kd 0.59 nM), and like volociximab it inhibits angiogenesis and slows tumour growth in vivo[3].
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Classification Click here for help
Compound class Antibody
International Nonproprietary Names Click here for help
INN number INN
8600 volociximab
Synonyms Click here for help
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 256
Other databases
GtoPdb PubChem SID 381744918
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