compound 32 [PMID: 20471253] [Ligand Id: 8184] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1082821
  • Cell division control protein 42 homolog in Human [ChEMBL: CHEMBL6088] [UniProtKB: P60953]
There should be some charts here, you may need to enable JavaScript!
  • Protein kinase G (PKG) 2/cGMP-dependent protein kinase 2 in Human [ChEMBL: CHEMBL2896] [GtoPdb: 1493] [UniProtKB: Q13237]
There should be some charts here, you may need to enable JavaScript!
  • protein kinase C epsilon/Protein kinase C epsilon in Human [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156]
There should be some charts here, you may need to enable JavaScript!
  • protein kinase N2/Protein kinase N2 in Human [ChEMBL: CHEMBL3032] [GtoPdb: 1521] [UniProtKB: Q16513]
There should be some charts here, you may need to enable JavaScript!
  • Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Cell division control protein 42 homolog in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6088] [UniProtKB: P60953]
ChEMBL Inhibition of CDC42 B 7.27 pIC50 54 nM IC50 Bioorg Med Chem Lett (2010) 20: 3746-3749 [PMID:20471253]
Protein kinase G (PKG) 2/cGMP-dependent protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2896] [GtoPdb: 1493] [UniProtKB: Q13237]
ChEMBL Inhibition of PRKG2 B 7.62 pIC50 24 nM IC50 Bioorg Med Chem Lett (2010) 20: 3746-3749 [PMID:20471253]
GtoPdb - - 7.62 pIC50 24 nM IC50 Bioorg Med Chem Lett (2010) 20: 3746-9 [PMID:20471253]
protein kinase C epsilon/Protein kinase C epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156]
ChEMBL Inhibition of PRKCE B 6 pIC50 1000 nM IC50 Bioorg Med Chem Lett (2010) 20: 3746-3749 [PMID:20471253]
protein kinase N2/Protein kinase N2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3032] [GtoPdb: 1521] [UniProtKB: Q16513]
GtoPdb - - 7.85 pIC50 14 nM IC50 Bioorg Med Chem Lett (2010) 20: 3746-9 [PMID:20471253]
ChEMBL Inhibition of PRKCL2 B 7.85 pIC50 14 nM IC50 Bioorg Med Chem Lett (2010) 20: 3746-3749 [PMID:20471253]
Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116]
ChEMBL Inhibition of ROCK2 by luciferase based ATP detection assay B 8.4 pIC50 4 nM IC50 Bioorg Med Chem Lett (2010) 20: 3746-3749 [PMID:20471253]
GtoPdb - - 8.4 pIC50 4 nM IC50 Bioorg Med Chem Lett (2010) 20: 3746-9 [PMID:20471253]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]