compound 32 [PMID: 20471253] [Ligand Id: 8184] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1082821
  • Cell division control protein 42 homolog in Human [ChEMBL: CHEMBL6088] [UniProtKB: P60953]
  • This target only has 0 pki data point
  • 0
1 CHEMBL1082821_lig_chart_1 Cell division control protein 42 homolog Human
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  • Protein kinase G (PKG) 2/cGMP-dependent protein kinase 2 in Human [ChEMBL: CHEMBL2896] [GtoPdb: 1493] [UniProtKB: Q13237]
  • This target only has 0 pki data point
  • 0
2 CHEMBL1082821_lig_chart_2 cGMP-dependent protein kinase 2 Human
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  • protein kinase C epsilon/Protein kinase C epsilon in Human [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156]
  • This target only has 0 pki data point
  • 0
3 CHEMBL1082821_lig_chart_3 Protein kinase C epsilon Human
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  • protein kinase N2/Protein kinase N2 in Human [ChEMBL: CHEMBL3032] [GtoPdb: 1521] [UniProtKB: Q16513]
  • This target only has 0 pki data point
  • 0
4 CHEMBL1082821_lig_chart_4 Protein kinase N2 Human
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  • Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116]
  • This target only has 0 pki data point
  • 0
5 CHEMBL1082821_lig_chart_5 Rho-associated protein kinase 2 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Cell division control protein 42 homolog in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6088] [UniProtKB: P60953]
ChEMBL Inhibition of CDC42 B 7.27 pIC50 54 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 3746-3749 [PMID:20471253]
Protein kinase G (PKG) 2/cGMP-dependent protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2896] [GtoPdb: 1493] [UniProtKB: Q13237]
ChEMBL Inhibition of PRKG2 B 7.62 pIC50 24 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 3746-3749 [PMID:20471253]
GtoPdb - - 7.62 pIC50 24 nM IC50 Bioorg Med Chem Lett (2010) 20: 3746-9 [PMID:20471253]
protein kinase C epsilon/Protein kinase C epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156]
ChEMBL Inhibition of PRKCE B 6 pIC50 1000 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 3746-3749 [PMID:20471253]
protein kinase N2/Protein kinase N2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3032] [GtoPdb: 1521] [UniProtKB: Q16513]
GtoPdb - - 7.85 pIC50 14 nM IC50 Bioorg Med Chem Lett (2010) 20: 3746-9 [PMID:20471253]
ChEMBL Inhibition of PRKCL2 B 7.85 pIC50 14 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 3746-3749 [PMID:20471253]
Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116]
ChEMBL Inhibition of ROCK2 by luciferase based ATP detection assay B 8.4 pIC50 4 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 3746-3749 [PMID:20471253]
GtoPdb - - 8.4 pIC50 4 nM IC50 Bioorg Med Chem Lett (2010) 20: 3746-9 [PMID:20471253]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]